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Venlafaxine: acute and chronic effects on 5-hydroxytryptamine levels in rat brain in vivo.

Abstract：

:Venlafaxine is a dual serotonin (5-hydroxytryptamine, 5-HT) and noradrenaline uptake inhibitor which has been claimed to have an onset of antidepressant action which is faster than for other comparable drugs. The effects of venlafaxine on brain 5-HT levels in vivo have not yet been examined. Acute administration of venlafaxine to rats by i.p. injection resulted in dose-dependent increases in cortical and hippocampal 5-HT levels, as measured by in vivo microdialysis, over the range 5-20 mg/kg. The effect of venlafaxine (10 mg/kg i.p.) was potentiated by prior administration of pindolol (10 mg/kg s.c.) in hippocampus but not in frontal cortex. Daily administration of venlafaxine (5 mg/kg i.p.) for 4 weeks did not change basal 5-HT levels in either brain area. The effect of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT, 0.2 mg/kg s.c.) to reduce 5-HT levels was unaffected by chronic venlafaxine at this dose, indicating that there was no change in sensitivity of presynaptic 5-HT1A autoreceptors.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Gur E,Dremencov E,Lerer B,Newman ME

doi

10.1016/s0014-2999(99)00164-8

keywords:

subject

Has Abstract

pub_date

1999-05-07 00:00:00

pages

17-24

issue

1

eissn

0014-2999

issn

1879-0712

pii

S0014-2999(99)00164-8

journal_volume

372

pub_type

杂志文章

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