Abstract:
:The effect of selective D1 receptor agonists on acetylcholine (ACh) release in the striatum was investigated using in vivo microdialysis. Administration of the reactive enantiomer, (+)-SKF 38393 (2, 10 mg/kg s.c.), doses which elevate grooming and sniffing behaviour, increased ACh release by 40 and 75%, respectively. Another D1 receptor agonist CY 204-283 (1 mg/kg s.c.) also produced a 75% increase in ACh output. The racemate (+/-)-SFK 38393 (20 mg/kg s.c.) increased ACh output by 60% and this was completely blocked by the D1 receptor antagonist SCH 23390 (0.3 mg/kg s.c.). In contrast, administration of the D2 receptor antagonist raclopride (1 mg/kg s.c.), 60 min after (+/-)-SKF 38393 (20 mg/kg s.c.), further increased ACh release. These results suggest that activation of D1 receptors increases ACh release in vivo and that D1 and D2 receptors have opposing roles in the regulation of striatal ACh release.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Damsma G,Tham CS,Robertson GS,Fibiger HCdoi
10.1016/0014-2999(90)90456-gsubject
Has Abstractpub_date
1990-09-21 00:00:00pages
335-8issue
2-3eissn
0014-2999issn
1879-0712pii
0014-2999(90)90456-Gjournal_volume
186pub_type
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