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Down-regulated VEGF expression in the diabetic heart is normalized by an endothelin ETA receptor antagonist.

Abstract：

:Recently, down-regulation of vascular endothelial growth factor (VEGF) in the heart was suggested as a potential molecular explanation for the increased risk of cardiovascular morbidity and mortality in patients with diabetes. Increased endothelin-1 production is reported in diabetes. Here, we report that down-regulated VEGF expression in the diabetic rat heart is normalized by an endothelin ETA receptor antagonist, suggesting that endothelin antagonism may be a novel therapeutic strategy for diabetic heart.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Jesmin S,Miyauchi T,Goto K,Yamaguchi I

doi

10.1016/j.ejphar.2006.04.041

subject

Has Abstract

pub_date

2006-08-07 00:00:00

pages

184-5

issue

1-3

eissn

0014-2999

issn

1879-0712

pii

S0014-2999(06)00419-5

journal_volume

542

pub_type

杂志文章

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