Effects of carbamazepine and valproic acid on brain immunoreactive somatostatin and gamma-aminobutyric acid in amygdaloid-kindled rats.

abstract：:The anticonvulsant activity of riluzole against sound-induced seizures was studied in the DBA/2 mouse model. Riluzole (0.1-4 mg kg(-1), intraperitoneal (i.p.)) produced dose-dependent effects with ED(50) values for the suppression of tonic, clonic and wild running phases of 0.72, 1.38 and 2.71 mg kg(-1), respectively....

journal_title：European journal of pharmacology

authors： De Sarro G,Siniscalchi A,Ferreri G,Gallelli L,De Sarro A

更新日期：2000-11-10 00:00:00

abstract：:To evaluate the possible role of 5-HT 1A and 5-HT 2A receptors in the anticonvulsant effect of swim stress, mice were pre-treated with agonists and antagonists of these receptors prior to exposure to stress and the intravenous infusion of picrotoxin. 8-OH-DPAT ((+/-)-8-hydroxy-2-(di-n-propylamino) tetralin) and WAY-10...

journal_title：European journal of pharmacology

authors： Pericić D,Lazić J,Jazvinsćak Jembrek M,Svob Strac D

更新日期：2005-12-19 00:00:00

abstract：:The binding of tritium-labelled BIBP3226, N2-(diphenylacetyl)-N-[(4-hydroxy-phenyl)methyl]-D-arginine amide, to human neuroblastoma SK-N-MC cells was investigated. [3H]BIBP3226 reversibly binds to neuropeptide Y receptors of the Y1 subtype expressed in SK-N-MC cells with a KD of 2.1 +/- 0.3 nM (mean +/- S.E.M., n = 3)...

journal_title：European journal of pharmacology

authors： Entzeroth M,Braunger H,Eberlein W,Engel W,Rudolf K,Wienen W,Wieland HA,Willim KD,Doods HN

更新日期：1995-05-24 00:00:00

abstract：:Bitter taste receptors (Tas2rs) initiate a bitter taste signaling involving the activation of taste-specific G protein gustducin and phosphodiesterases (PDEs); it leads to the decrease of cytosolic level of cyclic adenosine monophosphate (cAMP) in taste cells. Recent studies have identified the expression of Tas2rs in...

journal_title：European journal of pharmacology

authors： Liu M,Qian W,Subramaniyam S,Liu S,Xin W

更新日期：2020-04-05 00:00:00

abstract：:Neuropathic pain has been suggested to be resistant to treatment with opiates. Such perceived lack of opioid responsiveness may be due to the dose-range over which specific opioid compounds have been studied as well as the efficacy of these compounds. Dihydroetorphine is a novel opiate that demonstrates significantly ...

journal_title：European journal of pharmacology

authors： Martin TJ,Hairston CT,Lutz PO,Harris LS,Porreca F

更新日期：1998-09-11 00:00:00

abstract：:The mesolimbic dopaminergic innervation is supposed to be involved in the mechanisms of central effects exerted by various classes of psychotropic drugs. Antidepressants have been found to interact with the brain dopaminergic system as well, although the precise central location of this interaction is unknown. Some da...

journal_title：European journal of pharmacology

authors： Plaznik A,Kostowski W

更新日期：1987-03-31 00:00:00

abstract：:The study compared the efficacy of acute versus chronic metrifonate treatment to improve initial and reversal learning of the water maze spatial navigation task in medial septal-lesioned rats. Acute oral administration of 30 mg/kg metrifonate at 30 min, but not at 150 or 360 min, before training improved the initial a...

journal_title：European journal of pharmacology

authors： Riekkinen M,Schmidt BH,Riekkinen P Jr

更新日期：1997-11-05 00:00:00

abstract：:We directly compared the effects of YM337, the Fab fragment of the humanized monoclonal antibody C4G1, on platelet aggregation and template bleeding time with those of abciximab, the Fab fragment of the human/murine chimeric monoclonal antibody 7E3, in rhesus monkeys. The duration of inhibition of platelet aggregation...

journal_title：European journal of pharmacology

authors： Suzuki K,Sakai Y,Hisamichi N,Taniuchi Y,Sato K,Terazaki C,Kaku S,Kawasaki T,Yano S,Inagaki O,Masuho Y

更新日期：1997-10-08 00:00:00

abstract：:A comparison has been made of the abilities of salbutamol, forskolin and prenalterol to relax guinea-pig tracheal rings contracted equivalently with either prostaglandin F2 alpha (PGF2 alpha) or carbachol. In the absence of spontaneous tension, 10(-6) M PGF2 alpha and 4 X 10(-7) M carbachol induced equivalent contract...

journal_title：European journal of pharmacology

authors： Heaslip RJ,Giesa FR,Rimele TJ,Grimes D

更新日期：1986-08-22 00:00:00

abstract：:We have investigated the effect of inhaled HOE 140, a novel bradykinin B2 receptor antagonist, against bradykinin- and vagal stimulation-induced airway microvascular leakage and bronchoconstriction in anesthetized guinea-pigs. Lung resistance was measured for 6 min after challenge, followed by measurement of extravasa...

journal_title：European journal of pharmacology

authors： Sakamoto T,Sun J,Barnes PJ,Chung KF

更新日期：1994-01-14 00:00:00

abstract：:Bronchoconstrictor responses were measured in lungs isolated from spontaneously hypertensive (SHR) and normotensive rats, perfused via the airways. Lungs from SHRs were more responsive than lungs from normotensive rats to methacholine, 5-hydroxytryptamine (5-HT), arachidonic acid or prostaglandin H(2). The responses o...

journal_title：European journal of pharmacology

authors： Kwasniewski FH,Landgraf RG,Bakhle YS,Jancar S

更新日期：2004-03-19 00:00:00

abstract：:Cyclophosphamide is a potent alkylating agent used in cancer chemotherapy and immunosuppression. The present study is aimed at evaluating the role of a potent antioxidant lipoic acid in cyclophosphamide induced hyperlipidemic cardiomyopathy. Adult male Wistar rats were divided into four treatment groups. Two groups re...

journal_title：European journal of pharmacology

authors： Mythili Y,Sudharsan PT,Sudhahar V,Varalakshmi P

更新日期：2006-08-14 00:00:00

abstract：:The effects of inosine on sinus rate and atrial contractile force were investigated using the isolated and blood-perfused canine atrium which was perfused with arterial blood from a donor dog. Injected inosine (100-3000 micrograms) consistently induced positive chronotropic and inotropic effects. However, the larger d...

journal_title：European journal of pharmacology

authors： Furukawa Y,Chiba S

更新日期：1980-10-31 00:00:00

abstract：:The abilities of typical and atypical neuroleptic agents to antagonise at striatal dopamine receptors were determined in the rat. Neuroleptic agents were injected unilaterally into the striatum and asymmetric body posturing/circling behaviour (always ipsilateral to the side of neuroleptic injection) assessed (1) to ne...

journal_title：European journal of pharmacology

authors： Costall B,Kelly ME,Naylor RJ

更新日期：1983-12-09 00:00:00

abstract：:Secondary hyperparathyroidism is a common complication in patients with chronic kidney disease and frequently persists after kidney transplantation. Paricalcitol, a selective vitamin D receptor activator, is indicated in the management of this disorder and recent evidences have suggested that this drug has other benef...

journal_title：European journal of pharmacology

authors： Pérez V,Sánchez-Escuredo A,Lauzurica R,Bayés B,Navarro-Muñoz M,Pastor MC,Cañas L,Bonet J,Romero R

更新日期：2013-06-05 00:00:00

abstract：:The effect of noradrenaline on 5-hydroxytryptamine (5-HT) release from isolated mouse ileal tissues was investigated. Noradrenaline, but not isoprenaline, at 1 microM stimulated 5-HT release, an effect which was inhibited by yohimbine, an alpha(2)-adrenoceptor antagonist, but not by bunazosin, an alpha(1)-adrenoceptor...

journal_title：European journal of pharmacology

authors： Hirafuji M,Ogawa T,Kato K,Hamaue N,Endo T,Parvez H,Minami M

更新日期：2001-12-07 00:00:00

abstract：:Low levels of serotonin may reduce the density of the serotonin transporter (SERT) by either increasing trafficking or reducing synthesis; a "neuroadaptive response". To determine whether 3,4-methylenedioxymethamphetamine (MDMA)-induced reductions in SERT density could be related to such a mechanism, p-chlorophenylala...

journal_title：European journal of pharmacology

authors： Boot BP,Mechan AO,McCann UD,Ricaurte GA

更新日期：2002-10-25 00:00:00

abstract：:The (+) and (-) enantiomers of the substituted 2-aminotetralin, N-0437 were evaluated in vivo for their dopaminergic activity, using biochemical as well as behavioural models. In presynaptic models, i.e. antagonism of gamma-butyrolactone-induced dihydroxyphenylalanine elevations and the induction of hypomotility, both...

journal_title：European journal of pharmacology

authors： Van der Weide J,Tendijck ME,Tepper PG,De Vries JB,Dubocovich ML,Horn AS

更新日期：1988-02-09 00:00:00

abstract：:Tamsulosin (10(-10)-10(-9) M) or prazosin (10(-9)-10(-8) M) concentration dependently blocked the tension responses to electrical field stimulation (0.3 ms duration, 80 V and 20 Hz) in human hyperplastic prostate with lC50 values of (1.93 +/- 0.26) x 10(-10) M and (2.11 +/- 0.21) x 10(-9) M, respectively. The relative...

journal_title：European journal of pharmacology

authors： Chueh SC,Guh JH,Chen J,Lai MK,Ko FN,Teng CM

更新日期：1996-06-03 00:00:00

abstract：:In rat stomach fundus, contractions induced by Ca2+ (1.8 mM) were strikingly potentiated by thapsigargin. This potentiation was partially inhibited by the blockers of Ca2+ release activated channels (CRACs), miconazole and SK&F96365 ([1-[beta-[3-(4-methoxyphenyl)propoxy]-4-methoxyphenethyl]-1H-imidazole, HCL]) and sli...

journal_title：European journal of pharmacology

authors： Smaili SS,Cavalcanti PM,Oshiro ME,Ferreira AT,Jurkiewicz A

更新日期：1998-01-19 00:00:00

abstract：:The effects of 2-methylthio ATP, an ATP analogue that is more specific for the P2Y receptor, were investigated on insulin secretion in the anesthetized dog in vivo. 2-Methylthio ATP was infused directly into the pancreaticoduodenal artery for 15 min. The infusion was performed so as to obtain a pancreaticoduodenal art...

journal_title：European journal of pharmacology

authors： Ribes G,Bertrand G,Petit P,Loubatières-Mariani MM

更新日期：1988-10-11 00:00:00

abstract：:Pulmonary hypertension (PH) mainly results from excessive proliferation of pulmonary artery smooth muscle cells (PASMCs) and displays mitochondrial abnormalities such as mitochondrial fragmentation. Epigallocatechin-3-gallate (EGCG), an efficient antiproliferative compound in green tea, has recently been demonstrated ...

journal_title：European journal of pharmacology

authors： Zhu TT,Zhang WF,Luo P,He F,Ge XY,Zhang Z,Hu CP

更新日期：2017-08-15 00:00:00

abstract：:The novel substituted benzamide eticlopride, (S)-(-)-5-chloro-3-ethyl-N-[(1-ethyl-2-pyrrolidinyl)methyl]-6-methoxy salicylamide hydrochloride (A38503; FLB 131), was radiolabelled to high specific activity and used for in vivo receptor binding studies in the rat brain. Intravenous injections of [3H]eticlopride resulted...

journal_title：European journal of pharmacology

authors： Köhler C,Hall H,Gawell L

更新日期：1986-01-21 00:00:00

abstract：:The anticonvulsant compound oxcarbazepine and its principal 10-monohydroxy metabolite protected potently against electroshock-induced tonic hindlimb extension. Maximal plasma concentrations depended on dose and were reached < or = 1 h after an oral dose of oxcarbazepine and < 2 h after monohydroxy derivative. In mice,...

journal_title：European journal of pharmacology

authors： Wamil AW,Schmutz M,Portet C,Feldmann KF,McLean MJ

更新日期：1994-12-27 00:00:00

abstract：:The present investigation was designed to identify potential biomarker(s) and assess the involvement of inflammatory pathway in dimethylnitrosamine (DMN)-induced liver fibrosis in rats. Following DMN-treatment (10 mg/ml/kg, i.p., given three consecutive days each week for 4 weeks) body and liver weights were significa...

journal_title：European journal of pharmacology

authors： Saha JK,Xia J,Sandusky GE,Chen YF,Gerlitz B,Grinnell B,Jakubowski JA

更新日期：2007-12-01 00:00:00

abstract：:A possible new common action of immunosuppressants, besides suppression of the genes for cytokines like interleukin-2, was investigated in in vivo models. Dexamethasone (0.1 mg/kg, s.c.) failed to suppress ischemic paw edema in mice 1 h after its injection, but maximal suppression was achieved at 3 h (20%) whereafter ...

journal_title：European journal of pharmacology

authors： Oyanagui Y

更新日期：1998-03-05 00:00:00

abstract：:The targets which mediate the actions of the volatile general anaesthetic isoflurane are unknown. Based on pharmacological studies using GABA(A) receptor antagonists it has recently been suggested that GABA(A) receptors would not mediate the immobilizing action of isoflurane. Using the beta3(N265M) knock-in mouse mode...

journal_title：European journal of pharmacology

authors： Lambert S,Arras M,Vogt KE,Rudolph U

更新日期：2005-05-23 00:00:00

abstract：:Studies have shown a cardioprotective role of thyroid hormones (THs) in cardiac remodeling after acute myocardial infarction (MI). However, there is no data in the literature examining the influence of TH administration on the aortic tissue in an animal model of MI. This study aimed to evaluate the effects of thyroid ...

journal_title：European journal of pharmacology

authors： Ortiz VD,de Castro AL,Campos C,Fernandes RO,Bonetto JHP,Siqueira R,Conzatti A,Fernandes TRG,Belló-Klein A,Araujo ASR

更新日期：2016-11-15 00:00:00

abstract：:Emodin, 1,3,8-trihydroxy-6-methyl-anthraquinone, is an anthraquinone derivative from the roots of Rheum officinale Baill that has been used to treat many diseases in digestive system for thousands of years. This study is to disclose the mechanism of Emodin to treat cholestatic hepatitis via anti-inflammatory pathway. ...

journal_title：European journal of pharmacology

authors： Ding Y,Zhao L,Mei H,Zhang SL,Huang ZH,Duan YY,Ye P

更新日期：2008-08-20 00:00:00

abstract：:The rat vas deferens has been considered to be the tissue of choice to study alpha-adrenergic drugs. However, some of these agonists have elicited complex responses in this organ. Therefore, detailed characterization of alpha-adrenoceptor-mediated responses of the rat vas deferens was the aim of this work. Experiments...

journal_title：European journal of pharmacology

authors： Díaz-Toledo A,Martí MC

更新日期：1988-11-08 00:00:00