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Stimulation of 5-HT 1A receptors increases the seizure threshold for picrotoxin in mice.

Abstract：

:To evaluate the possible role of 5-HT 1A and 5-HT 2A receptors in the anticonvulsant effect of swim stress, mice were pre-treated with agonists and antagonists of these receptors prior to exposure to stress and the intravenous infusion of picrotoxin. 8-OH-DPAT ((+/-)-8-hydroxy-2-(di-n-propylamino) tetralin) and WAY-100635 (a selective agonist and antagonist of 5-HT 1A receptors), DOI (1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane) and ketanserin (a 5-HT 2A/2C receptor agonist and antagonist) were used. Results demonstrated that 1 and 3 mg/kg of 8-OH-DPAT increased the doses of picrotoxin producing running/bouncing clonus, tonic hindlimb extension and death in stressed and unstressed mice, respectively. Pre-treatment with WAY (0.3 mg/kg) prevented the effect of 8-OH-DPAT (3 mg/kg). DOI (2.5 mg/kg) and ketanserin (1 mg/kg) failed to affect the seizure threshold for picrotoxin. The results show that stimulation of 5-HT 1A receptors exerts anticonvulsant actions in stressed and unstressed mice, while stimulation of 5-HT 2A/2C receptors does not interfere with the effect of stress on picrotoxin-induced convulsions.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Pericić D,Lazić J,Jazvinsćak Jembrek M,Svob Strac D

doi

10.1016/j.ejphar.2005.10.021

keywords:

subject

Has Abstract

pub_date

2005-12-19 00:00:00

pages

105-10

issue

1-3

eissn

0014-2999

issn

1879-0712

pii

S0014-2999(05)01082-4

journal_volume

527

pub_type

杂志文章

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