Abstract:
:Exposure to cold (4 degrees C) of catheterized rats acclimated to 20 degrees C resulted in a progressive increase in plasma noradrenaline (NA) concentrations which reached values consistently more than twice the basal ones (20 degrees C) by about 30 min. No further increase in plasma NA levels were detected when the cold exposure was continued for 24 h. Plasma adrenaline (A) and dopamine levels did not change at any time studied. Adrenalectomized rats exposed to cold exhibited percent rises in plasma NA similar to those in intact rats. An increase in plasma A levels concomitant with that of NA was observed following exposure to cold of rats in which either basal catecholamine release was impaired by chlorisondamine or the vasoconstrictor response was impeded by phentolamine. Propranolol did not modify the acute neurosympathetic response to cold. Exposure to cold (4 degrees C) for short periods of time combined with the measurement of plasma catecholamines is proposed as a useful and reproducible method for studying a pure neurosympathetic response in the rat.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Picotti GB,Carruba MO,Ravazzani C,Cesura AM,Galva MD,Da Prada Mdoi
10.1016/0014-2999(81)90478-7subject
Has Abstractpub_date
1981-01-29 00:00:00pages
321-9issue
3eissn
0014-2999issn
1879-0712pii
0014-2999(81)90478-7journal_volume
69pub_type
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journal_title:European journal of pharmacology
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