Endothelin and 5-hydroxytryptamine on rat pulmonary artery in pulmonary hypertension.

abstract：:There is now clinical evidence that l-sulpiride has antidepressant effects when administered at low, non-neuroleptic doses. Down-regulation of beta-receptor-linked adenylate cyclase is a well-documented adaptive response to chronic administration of antidepressant drugs. In this study, we investigated dopamine recepto...

journal_title：European journal of pharmacology

authors： Sigala S,Rizzonelli P,Zanelli E,Forgione A,Missale C,Spano P

更新日期：1991-06-25 00:00:00

abstract：:The antagonist potencies of SCH 23390 and domperidone have been determined at vascular and neuronal dopamine receptors in the rabbit isolated splenic artery and rectococcygeus muscle, respectively. SCH 23390 was a potent, competitive antagonist at vascular (pA2 = 10.65) but not neuronal (pA2 less than 6.0) receptors. ...

journal_title：European journal of pharmacology

authors： Hilditch A,Drew GM

更新日期：1985-10-08 00:00:00

abstract：:The spontaneous myogenic activity of the isolated rat portal vein was inhibited by atrial natriuretic factor or by sodium nitroprusside. These compounds were not effective on the tone induced by PAF-acether or carbachol. 8-Bromo cyclic GMP and dibutyryl cyclic AMP inhibited myogenic activity and reduced the agonist-in...

journal_title：European journal of pharmacology

authors： Hellegouarch A,Auguet M,Guillon JM,Baranes J,Pirotzky E,Braquet P

更新日期：1988-01-12 00:00:00

abstract：:This study determined the in vitro functional profile of 1-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-methoxy-3,4-dihydro-2-quinolinone monomethanesulfonate (OPC-14523) at rat and human serotonin (5-HT) 5-HT1A receptors and binding affinity of OPC-14523 at human frontocortical 5-HT1A receptors. OPC-14523 (1 microM...

journal_title：European journal of pharmacology

authors： Jordan S,Chen R,Koprivica V,Hamilton R,Whitehead RE,Tottori K,Kikuchi T

更新日期：2005-07-11 00:00:00

abstract：:Neurofibrillary tangles aggregated from hyperphosphorylated tau protein are the main pathological feature of Alzheimer's disease (AD). Complement C3 (or C3a) is the core component of the complement system and is associated with AD pathological processes. However, it remains unclear whether C3a or the C3a receptor has ...

journal_title：European journal of pharmacology

authors： Hu J,Yang Y,Wang M,Yao Y,Chang Y,He Q,Ma R,Li G

更新日期：2019-05-05 00:00:00

abstract：:Ethanol (160-640 mM) produces a biphasic action on the indirectly stimulated rat phrenic nerve--diaphragm preparation. This consists of a potentiation followed by a blockade of muscle contraction. Concomitant with the increase in the force of contraction was the appearance of multiple neural action potentials recorded...

journal_title：European journal of pharmacology

authors： Cooper SA,Dretchen KL

更新日期：1975-04-01 00:00:00

abstract：:FR134043, disodium(Z,1S,15S,8S,24S,27R,29S,34S,37R)-29-ben zyl-21-ethylidene-27-hydroxy-15-isobutyrylamino-34-isopropyl-31,37 -dimethyl-10,16,19,22,30,32,35,38-octaoxo-36-oxa-9,11,17,20,23,28, 31,33-octaazatetracyclo[16.13.6.1(24),(28).0(3),(8)]octatricont a-3,5,7-trien-5,6-diyl disulfate, is a water-soluble inhibitor...

journal_title：European journal of pharmacology

authors： Shinguh Y,Yamazaki A,Inamura N,Fujie K,Okamoto M,Nakahara K,Notsu Y,Okuhara M,Ono T

更新日期：1998-03-26 00:00:00

abstract：:Inflammatory bowel disease (IBD) is characterized by chronic, recurring inflammation of the digestive tract. Current therapeutic approaches are limited and include biologics and steroids such as anti-TNFα monoclonal antibodies and corticosteroids, respectively. Significant adverse drug effects can occur for chronic us...

journal_title：European journal of pharmacology

authors： Sanderlin EJ,Marie M,Velcicky J,Loetscher P,Yang LV

更新日期：2019-06-05 00:00:00

abstract：:Studies were designed to examine the influence of endothelin type A receptor (ETA) blockade on the hypertensive and renal response to 4 day treatment with the nitric oxide (NO) synthase inhibitor, L-nitroarginine methyl ester (L-NAME), and cyclosporine. In the first series of experiments, male Sprague-Dawley rats main...

journal_title：European journal of pharmacology

authors： Pollock DM,Polakowski JS,Opgenorth TJ,Pollock JS

更新日期：1998-04-03 00:00:00

abstract：:Calcitonin gene-related peptide (CGRP), a 37-amino acid neuropeptide, is found in the central nervous system as well as in the heart. CGRP shows high sequence homology with amylin, salmon calcitonin, and adrenomedullin. This study aimed to investigate the effect of CGRP on atrial hemodynamics and atrial natriuretic pe...

journal_title：European journal of pharmacology

authors： Piao FL,Cao C,Han JH,Kim SZ,Kim SH

更新日期：2004-01-12 00:00:00

abstract：:We have investigated the mode of cardiovascular action of the stimulant methylhexaneamine (MHA) in terms of direct or indirect adrenergic actions in anaesthetised rats. Male and female rats were anaesthetised with pentobarbitone and pressor (changes in diastolic blood pressure) and cardioaccelerator responses to MHA w...

journal_title：European journal of pharmacology

authors： Alsufyani HA,Docherty JR

更新日期：2019-01-15 00:00:00

abstract：:This study aimed to investigate the effect of long-term oral nicotine administration on insulin resistance in an animal model of obesity. Eight-week-old male Zucker fatty rats (ZFRs) were administered nicotine tartrate dihydrate (4.6 mg/kg/day) in the drinking water. The control group was pair-fed. The body weights an...

journal_title：European journal of pharmacology

authors： Liu RH,Mizuta M,Matsukura S

更新日期：2003-01-01 00:00:00

abstract：:The present study aimed to determine whether nefiracetam, N-(2,6-dimethylphenyl)-2-(2-oxo-1-pyrrolidinyl) acetamide, a cognition enhancer, has an effect on learning and memory function in sustained cerebral ischemia, and whether the effect, if any, may accompany modification of the cholinergic or gamma-aminobutyric ac...

journal_title：European journal of pharmacology

authors： Fukatsu T,Miyake-Takagi K,Nagakura A,Omino K,Okuyama N,Ando T,Takagi N,Furuya Y,Takeo S

更新日期：2002-10-18 00:00:00

abstract：:Intake of nicotine has been related in many cases to acute or chronic hypertension. Using the patch-clamp technique the effect of nicotine on voltage-dependent K+ channel currents in rat tail artery smooth muscle cells was studied. Nicotine at concentrations of 1-100 microM or 0.3-3 mM increased or decreased, respecti...

journal_title：European journal of pharmacology

authors： Tang G,Hanna ST,Wang R

更新日期：1999-01-08 00:00:00

abstract：:Intracellular recordings were made from myenteric neurons of the guinea-pig duodenum and the responses to local ejection of several substance P (SP) analogs were examined. It was found that senktide (succinyl-[Asp6,Me-Phe8]SP-(6-11)), a selective analog for the NK-3 (SP-N) receptor, was particularly effective in depol...

journal_title：European journal of pharmacology

authors： Hanani M,Chorev M,Gilon C,Selinger Z

更新日期：1988-08-24 00:00:00

abstract：:Clomipramine is a tricyclic antidepressant for psychiatric disorders that can induce QT prolongation, which may lead to torsades de pointes. Since blockade of cardiac human ether-a-go-go-related gene (hERG) channels is an important cause of acquired long QT syndrome, we investigated the acute effects of clomipramine o...

journal_title：European journal of pharmacology

authors： Jo SH,Hong HK,Chong SH,Won KH,Jung SJ,Choe H

更新日期：2008-09-11 00:00:00

abstract：:We aimed to determine the presence of oxidative stress in rhinitis medicamentosa (RM) and to evaluate the effect of erdosteine (ED) on mucosal changes in a rat model. Twenty-four male rats were used in this experimental study. Three groups were created. Group 1 (n=8) was the control group. Two puffs of 0.05% oxymetazo...

journal_title：European journal of pharmacology

authors： Dokuyucu R,Cevik C,Ozler GS,Ozgur T,Arli C,Sefil F,Yonden Z

更新日期：2014-11-05 00:00:00

abstract：:Disulfiram (700 mg/kg, p.o.) significantly increased the brain levels of serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) in rats. Ethanol (1 g/kg and 2 x 1.5 g/kg, i.p.) did not affect the 5-HT level, but at the higher dose it significantly increased the 5-HIAA level. When disulfiram was given in combination ...

journal_title：European journal of pharmacology

authors： Fukumori R,Minegishi A,Satoh T,Kitagawa H,Yanaura S

更新日期：1980-01-25 00:00:00

abstract：:Following pretreatment with 6-OH-dopamine, the sympathetic nerve endings of the iris and skeletal muscle of mice and rats were not longer detectable by cytochemistry for noradrenaline. In the same animals, the specific binding of [3H] ouabain to intact soleus muscles was not significantly different from that measured ...

journal_title：European journal of pharmacology

authors： Clausen T,Hansen O,Larsson LI

更新日期：1981-07-10 00:00:00

abstract：:To investigate the mechanism underlying sulpiride-induced catalepsy, we simultaneously examined cataleptic behavior and the kinetics of the dopamine receptor antagonist, sulpiride of dopamine, and the dopamine metabolite 3,4-dihydroxyphenylacetic acid (DOPAC), using in vivo voltammetry. After intrastriatal administrat...

journal_title：European journal of pharmacology

authors： Horikawa HP,Nakazato T,Hikosaka O

更新日期：1997-05-12 00:00:00

abstract：:Growing evidences suggest the presence of several similarities in the molecular mechanisms underlying the neurodegenerative diseases and metabolic abnormalities. Adults who develop Metabolic Syndrome (MS) are at a higher risk of developing Alzheimer's disease (AD). Pharmacological agents, like dipeptidyl peptidase-4 (...

journal_title：European journal of pharmacology

authors： Yossef RR,Al-Yamany MF,Saad MA,El-Sahar AE

更新日期：2020-12-15 00:00:00

abstract：:Sensitization to the discriminative stimulus effects of psychostimulants is not fully understood. Therefore, the present study was designed to investigate the development of sensitization to the discriminative stimulus of methamphetamine in rats. A dose-response curve for methamphetamine and a generalization test for ...

journal_title：European journal of pharmacology

authors： Suzuki T,Fukuoka Y,Mori T,Miyatake M,Narita M

更新日期：2004-09-13 00:00:00

abstract：:Apomorphine-induced locomotor stimulation was investigated in the developing rat following injection with 6-hydroxydopa at birth. Treatment with 6-hydroxydopa potentiated locomotor responsiveness to apomorphine in the 20-day-old rat. The 6-hydroxydopa-treated animal at 30 days, however, was less sensitive to the drug ...

journal_title：European journal of pharmacology

authors： Nomura Y,Segawa T

更新日期：1978-07-15 00:00:00

abstract：:Skeletal myogenesis comprises myoblast replication and differentiation into striated multinucleated myotubes. Agents that interfere with myoblast replication are important tools for the understanding of myogenesis. Recently, we showed that cholesterol depletion by methyl-β-cyclodextrin (MCD) enhances the differentiati...

journal_title：European journal of pharmacology

authors： Portilho DM,Soares CP,Morrot A,Thiago LS,Butler-Browne G,Savino W,Costa ML,Mermelstein C

更新日期：2012-11-05 00:00:00

abstract：:Sprague-Dawley rats received oral doses of enalapril maleate (5 mg/kg), a potent, nonsulfhydryl, angiotensin converting enzyme inhibitor, or saline. Sixty min later, morphine sulfate, 5 mg/kg, or saline was injected subcutaneously. Response to a thermal stimulus was monitored before and up to 5 h ter morphine injectio...

journal_title：European journal of pharmacology

authors： Mojaverian P,Swanson BN,Ferguson RK

更新日期：1984-02-17 00:00:00

abstract：:Endothelin (ET) and its receptor characteristics were studied in hyper- and hypo-thyroid states in the rats. Hyperthyroidism was induced by daily administration of thyroxine (0.1 mg/kg i.p.) for 8 weeks, while hypothyrodism was induced by daily administration of methimazole (10 mg/kg i.p.) for 8 weeks. The chronic adm...

journal_title：European journal of pharmacology

authors： Rebello S,Thompson EB,Gulati A

更新日期：1993-06-11 00:00:00

abstract：:Receptor activation of G-proteins can be measured by agonist-stimulated [35S]GTP gamma S binding in the presence of excess guanosine diphosphate (GDP). To determine whether opioid and cannabinoid receptor-mediated G-protein activation correlate with their receptor densities, this study compared opioid- and cannabinoid...

journal_title：European journal of pharmacology

authors： Sim LJ,Selley DE,Xiao R,Childers SR

更新日期：1996-06-20 00:00:00

abstract：:The present study was designed to evaluate the preventive effects of p-coumaric acid on lysosomal dysfunction and myocardial infarct size in isoproterenol induced myocardial infarcted rats. Male albino Wistar rats were pretreated with p-coumaric acid (8 mg/kg body weight) daily for a period of 7 days after which isopr...

journal_title：European journal of pharmacology

authors： Jyoti Roy A,Stanely Mainzen Prince P

更新日期：2013-01-15 00:00:00

abstract：:The effects of four fluoroquinolones (sparfloxacin, fleroxacin, ofloxacin and levofloxacin) on K(+) currents were investigated in pyramidal neurons acutely isolated from rat hippocampus, to evaluate their relative potencies for inhibiting these channels. Using patch-clamp electrophysiological techniques, we found that...

journal_title：European journal of pharmacology

authors： Zhang LR,Li MH,Cheng NN,Chen BY,Wang YM

更新日期：2003-02-21 00:00:00

abstract：:Age-related changes in the modulatory action of nitric oxide (NO) on cyclic GMP levels and Na(+),K(+)-ATPase activity in the proximal rat trachea were investigated using sodium nitroprusside, 8-bromo-cyclic GMP and okadaic acid. At 24 months, both control activities of Na(+), K(+)-ATPase and Mg(2+)-ATPase were decreas...

journal_title：European journal of pharmacology

authors： Scavone C,Glezer I,Demarchi Munhoz C,de Sena Bernardes C,Pekelmann Markus R

更新日期：2000-01-24 00:00:00