Abstract:
:Several aspects of the role of corticotropin-releasing factor (CRF) in the forced swimming test were investigated in this study by using two different administration schedules. I.c.v. microinjection of CRF produced a dose-dependent increase in swimming activity when the administration schedule originally reported for this test to screen antidepressant drugs was followed. The most effective doses were 1 and 3 microg of CRF. A lower dose of CRF (0.5 microg) was also effective when repetitive experimental stress was present. CRF receptor antagonist, alpha-helical CRF-(9-41) (alpha-helical CRF-(9-41)), was able to block CRF-induced increases in swimming in all sessions of the forced swimming test. However, the effects of CRF and CRF receptor antagonist depended on the administration schedule. A decrease in swimming in the forced swimming test was observed when CRF and CRF receptor antagonist were given together, using a different administration schedule. I.c.v. CRF was ineffective and CRF receptor antagonist alone produced an increase in swimming when administered according to this schedule. These behavioural responses were maintained after twelve days without any treatment. The results of the current study suggest that endogenous CRF seems to play a determinant role in behavioural responses in the forced swimming test. The involvement of the level of activation and memory processes in these behavioural responses is discussed.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
García-Lecumberri C,Ambrosio Edoi
10.1016/s0014-2999(97)01515-xsubject
Has Abstractpub_date
1998-02-05 00:00:00pages
17-26issue
1eissn
0014-2999issn
1879-0712pii
S0014-2999(97)01515-Xjournal_volume
343pub_type
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journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
pub_type: 杂志文章
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journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
pub_type: 杂志文章
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