2-Aminoethylmethyl-sulfone (AEMS): a potent stimulator of ATP-dependent calcium uptake.

abstract：:Donepezil (E2020) is a novel cholinesterase inhibitor for the treatment of Alzheimer's disease. Recent studies show that it may act on targets other than acetylcholinesterase in the brain. In the present study, the actions of donepezil on voltage-gated Na+ and K+ channels were investigated in rat dissociated hippocamp...

journal_title：European journal of pharmacology

authors： Yu B,Hu GY

更新日期：2005-01-31 00:00:00

abstract：:The (+) and (-) enantiomers of the substituted 2-aminotetralin, N-0437 were evaluated in vivo for their dopaminergic activity, using biochemical as well as behavioural models. In presynaptic models, i.e. antagonism of gamma-butyrolactone-induced dihydroxyphenylalanine elevations and the induction of hypomotility, both...

journal_title：European journal of pharmacology

authors： Van der Weide J,Tendijck ME,Tepper PG,De Vries JB,Dubocovich ML,Horn AS

更新日期：1988-02-09 00:00:00

abstract：:Molecular identification of two new transient receptor potential (TRP) channels, TRPM8 and TRPA1, has prompted an intense interest in their functional roles. We report that an acute exposure to the TRPM8/TRPA1 agonist icilin (0.01-100 microM), but not TRPV1 agonist capsaicin (10 microM), causes an atypical dose-relate...

journal_title：European journal of pharmacology

authors： Rawls SM,Gomez T,Ding Z,Raffa RB

更新日期：2007-12-01 00:00:00

abstract：:The analgesic effect of cyclazocine microinjected into the diencephalon of rats was studied by using the bradykinin-induced flexor reflex test. The dorsal portion of the medial hypothalamic area was sensitive to cyclazocine with respect to the production of analgesia (ED50 2.6 micrograms/rat). Microinjections of morph...

journal_title：European journal of pharmacology

authors： Kawajiri S,Satoh M

更新日期：1985-04-23 00:00:00

abstract：:It has been suggested that administration of a cannabinoid CB(1) (SR141716A ¿N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2, 4-dichlorophenyl)-4-methyl-1-H-pyrazole-3-carboxamide) and CB(2) (SR144528 ¿N-[(1S)-endo-1, 3, 3-trimethyl bicyclo ¿2.2.1 heptan-2-yl]-5-(4-chloro-3-methylphenyl)-1-(4-methylbenzyl)-pyr azo le- 3-ca...

journal_title：European journal of pharmacology

authors： Beaulieu1 P,Bisogno1 T,Punwar S,Farquhar-Smith WP,Ambrosino G,Di Marzo V,Rice AS

更新日期：2000-05-19 00:00:00

abstract：:Intravenous administration of E. coli lipopolysaccharide (LPS) inhibited the migration of neutrophils into the pleural cavity that occurs following challenge with intrapleural carrageenin. Treatment of animals with levamisole (10 mg/kg i.p.) 30 min after the intravenous administration of LPS almost restored carrageeni...

journal_title：European journal of pharmacology

authors： Rocha NP,Ferreira SH

更新日期：1986-03-11 00:00:00

abstract：:Acetyl-CoA acetyltransferase (1-O-alkyl-sn-glycero-3-phosphocholine) is a key enzyme in paf-acether biosynthesis. Its immunological activation as related to paf-acether formation was investigated in mast cells derived from mouse bone marrow. The action of ketotifen, a prophylactic anti-asthma drug, on the antigen-indu...

journal_title：European journal of pharmacology

authors： Joly F,Bessou G,Benveniste J,Ninio E

更新日期：1987-12-01 00:00:00

abstract：:Dichlorobenzamil, phenamil and other amiloride analogs (1-100 microM) elicit transient tension in rabbit skinned muscle fibers. Tension requires preloading of Ca(2+) into the sarcoplasmic reticulum, is facilitated by low-[Mg(2+)] solutions, abolished by ruthenium red or by functional disruption of the sarcoplasmic ret...

journal_title：European journal of pharmacology

authors： Ponte CG,Estrela RC,Suarez-Kurtz G

更新日期：2000-03-10 00:00:00

abstract：:Stearoyl-CoA Desaturase 1 (SCD1) is a central enzyme that catalyzes the biosynthesis of monounsaturated fatty acids from saturated fatty acids. SCD1 is an emerging target in obesity and insulin resistance due to the improved metabolic profile obtained when the enzyme is genetically inactivated. Here, we have investiga...

journal_title：European journal of pharmacology

authors： Issandou M,Bouillot A,Brusq JM,Forest MC,Grillot D,Guillard R,Martin S,Michiels C,Sulpice T,Daugan A

更新日期：2009-09-15 00:00:00

abstract：:These studies examined the opioid and non-opioid in vivo and in vitro actions of PD117,302 (((±)-trans-N-methyl-N-[2-(l-pyrrolidinyl)-cyclohexyl]benzo[b]thiophene-4-acetamide), a kappa (κ)-opioid receptor agonist. PD117,302 selectively labeled the κ-opioid receptor in guinea pig cerebellar membranes and in mice the ED...

journal_title：European journal of pharmacology

authors： Pugsley MK,Saint DA,Hayes ES,Abraham S,Walker MJ

更新日期：2015-08-15 00:00:00

abstract：:A comparison has been made of the abilities of salbutamol, forskolin and prenalterol to relax guinea-pig tracheal rings contracted equivalently with either prostaglandin F2 alpha (PGF2 alpha) or carbachol. In the absence of spontaneous tension, 10(-6) M PGF2 alpha and 4 X 10(-7) M carbachol induced equivalent contract...

journal_title：European journal of pharmacology

authors： Heaslip RJ,Giesa FR,Rimele TJ,Grimes D

更新日期：1986-08-22 00:00:00

abstract：:Herein, we report an extensive investigation of the neuroprotective effects of the compound (Z)-alpha-[2-thiazol-2-yl)imidazol-4-yl]-N-tert-butylnitrone (S34176) and the prototypic nitrone alpha-phenyl-N-tert-butylnitrone (PBN), in different in vivo paradigms of neuronal degeneration. Administration of S34176 (75 mg/k...

journal_title：European journal of pharmacology

authors： Lockhart B,Roger A,Bonhomme N,Goldstein S,Lestage P

更新日期：2005-03-28 00:00:00

abstract：:Sibutramine is a serotonin-norepinephrine reuptake inhibitor indicated for the management of obesity in conjunction with a reduced calorie diet. Though sibutramine was originally evaluated for possible use as an antidepressant, its research development was eventually redirected to evaluate it as an anorexiant. The pha...

journal_title：European journal of pharmacology

authors： Luque CA,Rey JA

更新日期：2002-04-12 00:00:00

abstract：:After recovery from a first intraplantar or intrathoracic stimulation with bradykinin, repeated daily provocation with this peptide resulted in a progressive loss of its ability to cause paw or pleural oedema, reaching 0-20% of the control within seven and four consecutive provocations, respectively. The phenomenon wa...

journal_title：European journal of pharmacology

authors： Martins MA,Pasquale CP,Bozza PT,Silva PM,Faria Neto HC,COrdeiro RS

更新日期：1992-09-10 00:00:00

abstract：:The potency of the dihydropyridine calcium channel blocker, PN 200-110 was assessed in vitro against contractions induced by potassium (20-55 mM) and histamine (1-300 microM) in rabbit thoracic aorta, coronary, basilar, renal and central ear arteries. PN 200-110 was particularly effective against potassium responses i...

journal_title：European journal of pharmacology

authors： Bijak A,Pasternac A,McPherson GA,Bevan JA

更新日期：1986-12-16 00:00:00

abstract：:The effects of several slow channel blockers were compared on the normal fast action potentials (APs) and the slow APs of guinea pig Purkinje fibers. In spontaneously-firing Purkinje fibers perfused with normal Tyrode solution, mesudipine (analog of nifedipine) at 10(-7) and 10(-6) M, had no significant effect on the ...

journal_title：European journal of pharmacology

authors： Molyvdas PA,Sperelakis N

更新日期：1983-03-25 00:00:00

abstract：:Sickness behavior is a series of behavioral and psychological changes that develop in inflammatory disease, including infections and cancers. Administration of the bacterial endotoxin lipopolysaccharide (LPS) induces sickness behavior in rodents. Genipin, an aglycon derived from an iridoid glycoside geniposide extract...

journal_title：European journal of pharmacology

authors： Araki R,Hiraki Y,Yabe T

更新日期：2014-10-15 00:00:00

abstract：:An antagonist of morphine analgesia, N-cyclopropylmethylnorazidomorphine (CAM) inhibited the"wet shakes" appearing during spontaneous or nalorphine-precipitated morphine abstinence. CAM inhibited the pinna reflex more strongly than did morphine and selectively antagonized quipazine-induced head twitches; its inhibitio...

journal_title：European journal of pharmacology

authors： Vetulani J,Bednarczyk B,Reichenberg K

更新日期：1978-08-01 00:00:00

abstract：:In slices of rat occipital cortex preincubated with 3H-noradrenaline, methioine-enkephalin diminished the overflow of tritium evoked by electrical field stimulation or by 20 mM potassium. The effect was not modified by phentolamine, but was antagonized by naloxone. Giver alone, naloxone slightly increased the potassiu...

journal_title：European journal of pharmacology

authors： Taube HD,Borowski E,Endo T,Starke K

更新日期：1976-08-01 00:00:00

abstract：:The effect of three calcium entry blockers--verapamil, nifedipine and felodipine--on diuresis, natriuresis, the renin-aldosterone axis, and atrial natriuretic peptide (ANP) levels was studied in 30 previously untreated patients with mild to moderate essential hypertension. All three blockers produced significant antih...

journal_title：European journal of pharmacology

authors： Shamiss A,Peleg E,Rosenthal T,Ezra D

更新日期：1993-03-16 00:00:00

abstract：:Although, several effects of glucosamine and its sulfated form (sulfated glucosamine) have been proposed for the suppression of osteoarthritis, their exact mechanisms have not been completely elucidated. This study explains the novel possibility of involvement of sulfated glucosamine in improving cellular antioxidant ...

journal_title：European journal of pharmacology

authors： Mendis E,Kim MM,Rajapakse N,Kim SK

更新日期：2008-01-28 00:00:00

abstract：:Subcutaneous (s.c.) administration of compound 48/80 (3.0 mg/kg) to conscious rats produced a time-dependent long-lasting increase of plasma renin activity (PRA). A dose-related increase of the hematocrit was also observed after injection of compound 48/80. The onset of the hematocrit increase preceded that of PRA inc...

journal_title：European journal of pharmacology

authors： Izumi H,Ho S,Michelakis AM,Aoki T

更新日期：1985-02-26 00:00:00

abstract：:Administration of drugs activating cannabinoid CB(1) receptors in the brain induces memory deficit in rodents, and blockade of these receptors may restore memory capacity in these animals. Central administration of beta-amyloid or beta-amyloid fragments may also lead to memory disturbances. This study was undertaken t...

journal_title：European journal of pharmacology

authors： Mazzola C,Micale V,Drago F

更新日期：2003-09-23 00:00:00

abstract：:The present study was undertaken to investigate whether gap junctional communication could be involved in morphine-induced antinociceptive response using blockers of the gap junctional channel, carbenoxolone and Gap27. Intrathecal pretreatment with either carbenoxolone or Gap27 caused a dose-dependent attenuation of m...

journal_title：European journal of pharmacology

authors： Suzuki M,Narita M,Nakamura A,Suzuki T

更新日期：2006-03-27 00:00:00

abstract：:The effect of depletion of catecholamines by tyramine or reserpine on the bradykinin-induced relaxation of the rat duodenum aan rabbit ileum was the object of this study. The relaxation was not affected by catecholamine depletion due to repeated addition of tyramine to the isolated organs from either normal or reserpi...

journal_title：European journal of pharmacology

authors： Ufkes JG,Van der Meer C

更新日期：1975-08-01 00:00:00

abstract：:Alzheimer's disease (AD) is a chronic neurodegenerative disorder that leads to disturbances of cognitive functions. Although the primary cause of AD remains unclear, brain acetylcholine deficiency, oxidative stress and neuroinflammation may be considered the principal pathogenic factors. The present study was construc...

journal_title：European journal of pharmacology

authors： Abd-El-Fattah MA,Abdelakader NF,Zaki HF

更新日期：2014-01-15 00:00:00

abstract：:Androgens relax several smooth muscles, including the airways. They also contract ileum and myocardium via nongenomic mechanisms. To find out whether androgens modulate airway smooth muscles in different species and further assess their mechanism of action, regarding the role of beta-adrenoceptors, polyamines and extr...

journal_title：European journal of pharmacology

authors： Bordallo J,de Boto MJ,Meana C,Velasco L,Bordallo C,Suárez L,Cantabrana B,Sánchez M

更新日期：2008-12-28 00:00:00

abstract：:Of eleven aporphine analogues tested on striatal adenylate cyclase only (-)-apomorphine and (+/-)-N-n-propyl-norapomorphine (+/-(NPA)) were effective in stimulating the cyclase from rat brain. Inactive compounds included (+/-)-isoapomorphine, (-)-1,2-dihydroxyaporphine and (+/-)-10-hydroxy-N-n-propylnoraporphine. (+)-...

journal_title：European journal of pharmacology

authors： Miller RJ,Kelly PH,Neumeyer JL

更新日期：1976-01-01 00:00:00

abstract：:Vasoconstrictor responses elicited by periarterial electrical nerve stimulation were analyzed pharmacologically in the canine isolated, perfused intermediate auricular artery. Phentolamine (10 microM) significantly inhibited the vasoconstrictor responses to stimulation at 5 Hz and over but not those to stimulation at ...

journal_title：European journal of pharmacology

authors： Haniuda K,Nakane T,Chiba S

更新日期：1997-08-27 00:00:00

abstract：:Rat hearts were perfused at 37 degrees C with three clearly-defined protocols: the Ca2+ paradox, the O2 paradox and with 20 mM caffeine. Each protocol involved an initial priming (stage 1) and a subsequent full activation (stage 2) of the damage system of the sarcolemma. Raising [K+]o from 5.4 to 6.5 mM in the Ca2+ pa...

journal_title：European journal of pharmacology

authors： Harding RJ,Duncan CJ

更新日期：1996-12-05 00:00:00