Inhibition of "wet shakes" during morphine abstinence by an antagonist of opiate analgesia.

abstract：:In addition to its well-known interaction with ionotropic and metabotropic receptors, glutamate may, at high concentrations, interfere with a cystine-glutamate antiport designated as Xc- and lead to a significant decrease in cystine uptake and intracellular glutathione level. These effects, in turn, may induce death i...

journal_title：European journal of pharmacology

authors： Froissard P,Monrocq H,Duval D

更新日期：1997-05-12 00:00:00

abstract：:This study examined whether a clinically relevant concentration of the volatile anaesthetic halothane modifies the endothelium-dependent relaxation produced by acetylcholine (3 nM-10 microM), histamine (1 pM-0.1 microM) and anti-human immunoglobulin E (1:1000) in human isolated pulmonary arteries submaximally precontr...

journal_title：European journal of pharmacology

authors： Higueras J,Sarría B,Ortiz JL,Cortijo J,Maruenda A,Barberá M,Morcillo EJ

更新日期：1997-05-20 00:00:00

abstract：:Dynorphin (1-100 nM) dose dependently inhibited both spontaneous and electrically evoked endogenous dopamine (DA) release from slices of the nucleus accumbens of untreated rats. When this inhibitory effect was compared, it was significantly reduced in rats pretreated (for 9 days) with methamphetamine (6 mg/kg per day ...

journal_title：European journal of pharmacology

authors： Yokoo H,Yamada S,Yoshida M,Tanaka M,Nishi S

更新日期：1992-11-03 00:00:00

abstract：:Increased glycolysis under hypoxic stress is a fundamentally important feature of non-small cell lung cancer (NSCLC) cells, but molecular mechanisms of hypoxia on glycolysis remain elusive. Herein, we aimed to explore whether lncRNAs and miRNAs are involved in the glycolytic reprogramming under hypoxic conditions. The...

journal_title：European journal of pharmacology

authors： Shi J,Wang H,Feng W,Huang S,An J,Qiu Y,Wu K

更新日期：2019-11-05 00:00:00

abstract：:Previously, we demonstrated the enhanced affinity of opioid receptors for naloxone in striatal slices from morphine-dependent mice. In our present study, binding characteristics of the mu opioid receptor agonists, [D-Ala2,MePhe4,Gly-ol5]enkephalin (DAMGO) and dihydromorphine, the delta opioid receptor agonist, [D-Ala2...

journal_title：European journal of pharmacology

authors： Abdelhamid EE,Takemori AE

更新日期：1991-06-06 00:00:00

abstract：:The behavioral effects of methamphetamine (METH) are mediated by the striatum, which is divided into the patch compartment, which mediates limbic and reward functions, and the matrix compartment, which mediates sensorimotor tasks. METH treatment results in repetitive behavior that is related to enhanced relative activ...

journal_title：European journal of pharmacology

authors： Horner KA,Logan MC,Fisher TJ,Logue JB

更新日期：2017-02-05 00:00:00

abstract：:Pulmonary and systemic hemodynamic effects of delta 9-tetrahydrocannabinol (delta 9-THC) in conscious dogs and in those anesthetized with morphine (3 mg/kg, i.m.) plus alpha-chloralose (100 mg/kg i.v.) were evaluated in this study. A decrease in the heart rate, cardiac output (PBF) and a concomitant increase in the pu...

journal_title：European journal of pharmacology

authors： Jandhyala BS,Hamed AT

更新日期：1978-12-15 00:00:00

abstract：:Sesamin is a major component in lignans of sesame seed oil, known to possess potent anti-oxidative capacity. In this study, the variation of heme oxygenase (HO)-1, a kind of anti-oxidative enzyme, by sesamin in murine macrophage cell line RAW 264.7 cells was investigated. Lipopolysaccharide (LPS; 10μg/ml) exposure ten...

journal_title：European journal of pharmacology

authors： Fukunaga M,Ohnishi M,Shiratsuchi A,Kawakami T,Takahashi M,Motomura M,Egusa K,Urasaki T,Inoue A

更新日期：2014-10-15 00:00:00

abstract：:It has been suggested that administration of a cannabinoid CB(1) (SR141716A ¿N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2, 4-dichlorophenyl)-4-methyl-1-H-pyrazole-3-carboxamide) and CB(2) (SR144528 ¿N-[(1S)-endo-1, 3, 3-trimethyl bicyclo ¿2.2.1 heptan-2-yl]-5-(4-chloro-3-methylphenyl)-1-(4-methylbenzyl)-pyr azo le- 3-ca...

journal_title：European journal of pharmacology

authors： Beaulieu1 P,Bisogno1 T,Punwar S,Farquhar-Smith WP,Ambrosino G,Di Marzo V,Rice AS

更新日期：2000-05-19 00:00:00

abstract：:Unilateral ureteral obstruction (UUO) is a well-established method to study interstitial fibrosis of the kidney. In this study, we investigated the effects of a calcium channel blocker, amlodipine, on UUO-induced renal interstitial fibrosis in mice. UUO significantly increased the fibrotic area in the obstructed kidne...

journal_title：European journal of pharmacology

authors： Honma S,Nakamura K,Shinohara M,Mitazaki S,Abe S,Yoshida M

更新日期：2016-06-05 00:00:00

abstract：:Serotonergic and dopaminergic involvement in hyperthermia induced by a serotonin (5-hydroxytryptamine, 5-HT)-releasing drug, p-chloroamphetamine, was investigated in mice. Neither the 5-HT transporter inhibitor fluoxetine nor the 5-HT depleter p-chlorophenylalanine affected p-chloroamphetamine-induced hyperthermia. Th...

journal_title：European journal of pharmacology

authors： Sugimoto Y,Ohkura M,Inoue K,Yamada J

更新日期：2001-11-02 00:00:00

abstract：:Rosmarinic acid (RA) is a polyphenolic compound with various pharmacological properties, including, anti-inflammatory, immunomodulatory, and neuroprotective, as well as having antioxidant and anticancer activities. This study evaluated the effects and mechanisms of RA in two racially different triple-negative breast c...

journal_title：European journal of pharmacology

authors： Messeha SS,Zarmouh NO,Asiri A,Soliman KFA

更新日期：2020-10-15 00:00:00

abstract：:Peripheral nerve injury, which gives rise to persistent chronic pain, has become an area of intense research activity, largely because it represents a disorder with a high unmet medical need. In this study, serum biomarkers of the spinal nerve ligation model were successfully investigated with the metabolomic method. ...

journal_title：European journal of pharmacology

authors： Mao YF,Liu XR,Liao XZ,Lv YH,Xu H,Deng XM,Yan SK,Xiong YC,Zhang WD

更新日期：2009-08-01 00:00:00

abstract：:The effects of acute or repeated treatment of male albino BKW mice with caerulein, a cholecystokinin octapeptide (CCK-8) agonist, and with devazepide (MK-329) and L-365,260, antagonists at CCKA ('peripheral') and CCKB ('central') receptors respectively, on motor activity and [propionyl-3H]propionylated-CCK-8 ([3H]pCCK...

journal_title：European journal of pharmacology

authors： Vasar E,Stephenson JD,Meldrum BS

更新日期：1991-09-24 00:00:00

abstract：:Dinitrosyl iron complexes (DNIC) with glutathione exert a cytotoxic effect on endometrioid tumours in rats with surgically induced experimental endometriosis. Intraperitoneal treatment of rats (Group 1) with DNIC (12.5μmoles/kg, daily, for 12 days), beginning with day 4 after the surgical operation (implantation of tw...

journal_title：European journal of pharmacology

authors： Burgova EN,Tkachev NА,Adamyan LV,Mikoyan VD,Paklina OV,Stepanyan AA,Vanin AF

更新日期：2014-03-15 00:00:00

abstract：:Guinea pig neurotensin differs from other mammalian neurotensin by the substitution of proline by serine at position 7. [Ser7]neurotensin produced a concentration-dependent contraction of the guinea pig oesophagus and rat fundus, a biphasic effect (initial relaxation followed by more sustained contraction) on the guin...

journal_title：European journal of pharmacology

authors： Katsoulis S,Conlon JM

更新日期：1987-08-21 00:00:00

abstract：:Ascorbate has both antioxidant and pro-oxidant activities. We have previously shown that plasma levels of ascorbate induce constriction and blockade of dilatation mediated by endothelium-derived hyperpolarizing factor (EDHF). In this study we sought to determine if these detrimental actions were mediated by a prooxida...

journal_title：European journal of pharmacology

authors： Nelli S,Craig J,Martin W

更新日期：2009-07-01 00:00:00

abstract：:Beat-to-beat alternations of the cardiac monophasic action potential, known as electrical alternans, were studied at drug concentrations that have known arrhythmogenic outcomes. Electrical alternans were elicited from the heart of anesthetized guinea pigs, both in the absence and presence of drugs that inhibit the del...

journal_title：European journal of pharmacology

authors： Fossa AA,Wisialowski T,Wolfgang E,Wang E,Avery M,Raunig DL,Fermini B

更新日期：2004-02-20 00:00:00

abstract：:Primary cultures of rat cerebellar granule neurons express 5-lipoxygenase, an enzyme from the inflammatory pathway of arachidonic acid. Outside the central nervous system (CNS) 5-lipoxygenase participates in cell proliferation. We hypothesized that 5-lipoxygenase is needed for proliferation of immature cerebellar gran...

journal_title：European journal of pharmacology

authors： Uz T,Manev R,Manev H

更新日期：2001-04-20 00:00:00

abstract：:This study examined the potential of the selective extra-synaptic α5-GABAA receptor inhibitor S44819 (Egis-13529) to improve cognitive performance in preclinical models of vascular cognitive impairment (VCI). Chronic hypoperfusion of the brain in mice was induced by permanent occlusion of the right common carotid arte...

journal_title：European journal of pharmacology

authors： Gacsályi I,Móricz K,Gigler G,Megyeri K,Machado P,Antoni FA

更新日期：2018-09-05 00:00:00

abstract：:We have studied the effects of withdrawal from chronic clonidine treatment in the adult male spontaneously hypertensive rat (SHR). SHR received clonidine, 0.1 mg X kg-1 X day-1 i.v. for 10 days. Clonidine was delivered via osmotic minipumps. After 7 days of treatment there was a 16.5 +/- 2.5 mm Hg fall in mean arteria...

journal_title：European journal of pharmacology

authors： Atkinson J,Lambas-Senas L,Parker M,Boillat N,Luthi P,Sonnay M,Seccia M,Renaud B

更新日期：1986-02-11 00:00:00

abstract：:PPARα belongs to the peroxisome-proliferator-activated receptors (PPARs) family that consists of PPARα, PPARδ, and PAPRγ. Activation of PPARα by ligands including fatty acids and their derivatives as well as some synthetic compounds regulates tumor progression in various tissues. Activated PPARα inhibits or promotes t...

journal_title：European journal of pharmacology

authors： Gao J,Yuan S,Jin J,Shi J,Hou Y

更新日期：2015-10-15 00:00:00

abstract：:With the aim of studying the mechanism by which peripherally injected interleukin-1 increases the serum levels of insulin in conscious rats, the effects of indomethacin, a cyclooxygenase inhibitor, on interleukin-1-induced hyperinsulinemia were examined using male Wistar rats implanted with intra-atrial cannulas. The ...

journal_title：European journal of pharmacology

authors： Uehara A,Okumura T,Kumei Y,Takasugi Y,Namiki M

更新日期：1991-01-03 00:00:00

abstract：:We have previously reported that 15-hydroxyeicosatetraenoic acid (15-HETE), a metabolite of arachidonic acid by 15-lipoxygenase, causes pulmonary vasoconstriction via increasing the intracellular Ca(2+) concentration ([Ca(2+)]i). However, the multiple sources of Ca(2+) that contribute to Ca(2+) elevation during and af...

journal_title：European journal of pharmacology

authors： Zheng X,Li Q,Tang X,Liang S,Chen L,Zhang S,Wang Z,Guo L,Zhang R,Zhu D

更新日期：2008-12-28 00:00:00

abstract：:1,2-[bis(1,2-benzisoselenazolone-3(2H)-ketone)]ethane (BBSKE, PCT: CN02/00412), a novel thioredoxin reductase inhibitor previously synthesized in our lab, has been demonstrated to inhibit the growth of a variety of human cancer cells and to induce apoptosis. Here we report on the potential molecular mechanism of apopt...

journal_title：European journal of pharmacology

authors： Lan L,Zhao F,Wang Y,Zeng H

更新日期：2007-01-26 00:00:00

abstract：:We assessed the effects of active site-directed, fibrinogen recognition exosite (FRE)-directed and bifunctional thrombin inhibitors, on shear-induced platelet reactivity (adhesion/aggregation) and dynamic coagulation (coagulation of flowing blood). An in vitro test for shear-induced haemostatic plug formation and dyna...

journal_title：European journal of pharmacology

authors： Taka T,Konishi Y,Slon-Usakiewicz J,Medvedkin V,Tsuda Y,Okada Y,Seki J,Yamamoto J

更新日期：2000-10-13 00:00:00

abstract：:The involvement of delta opioid receptors in supraspinal analgesia was investigated. With this aim, opioids that produced analgesia in the tail immersion test were administered i.c.v. to mice a few minutes before the irreversible antagonist, beta-funaltrexamine (beta-FNA). Protection of the respective analgesic effect...

journal_title：European journal of pharmacology

authors： Sánchez-Blázquez P,Garzón J

更新日期：1989-01-02 00:00:00

abstract：:The object of the present paper was to investigate the in vivo pharmacological profile of the dihydropyridine neuropeptide Y Y(1) receptor antagonist 1,4-Dihydro-4-[3-[[[[3-[spiro(indene-4,1'-piperidin-1-yl)]propyl]amino]carbonyl]amino]phenyl]-2,6-dimethyl-3,5-pyridine dicarboxylic acid, dimethylester (H 394/84). The ...

journal_title：European journal of pharmacology

authors： Malmström RE,Balmér KC,Weilitz J,Nordlander M,Sjölander M

更新日期：2001-04-20 00:00:00

abstract：:The effect and role of nitric oxide (NO) in the regulation of ion transport in the mouse cecum were investigated. L-arginine, used to increase NO production, increased short-circuit current (Isc), a measure of ion transport, in a concentration-dependent manner with a maximal increase of 193.8+/-65.5 microA/cm2. This i...

journal_title：European journal of pharmacology

authors： Homaidan FR,Martello LA,Melson SJ,Burakoff R

更新日期：1998-05-29 00:00:00

abstract：:Several anticancer drugs are ineffective against brain tumor and do not impact patient survival because they fail to cross the blood-brain tumor barrier (BTB) effective levels. One such agent temozolomide is commonly used in brain tumor patients, which works better when combined with radiation or other anticancer agen...

journal_title：European journal of pharmacology

authors： Ningaraj NS,Sankpal UT,Khaitan D,Meister EA,Vats T

更新日期：2009-01-14 00:00:00