Role of dorsal and median raphe nuclei in lower lip retraction in rats.

abstract：:The decrease in blood flow in response to dopamine (DA) injected intraarterially (i.a.) into the femoral or renal vascular beds was examined in the anaesthetised dog. DA or noradrenaline (NA) were 10 times more potent as vasoconstrictor agents in the femoral than in the renal vasculature. In the femoral bed, the DA in...

journal_title：European journal of pharmacology

authors： Duval N,Hicks PE,Langer SZ

更新日期：1985-02-05 00:00:00

abstract：:Methoctramine, a selective M2 alpha muscarinic receptor antagonist, was examined for its ability to inhibit carbachol-induced drinking in the rat. Intracerebroventricularly (i.c.v.) administered methoctramine was devoid of activity up to a dose of 100 nmol/rat, whereas higher doses were toxic under our experimental co...

journal_title：European journal of pharmacology

authors： Massi M,Polidori C,Melchiorre C

更新日期：1989-04-25 00:00:00

abstract：:The intracerebral injection technique was used to apply dopamine directly into dopamine-containing areas of the mesolimbic system, the nucleus accumbens septi, tuberculum olfactorium and nucleus amygdaloideus centralis. 200 mug dopamine injected bilaterally into the nucleus accumbens septi caused a stereotyped sniffin...

journal_title：European journal of pharmacology

authors： Costall B,Naylor RJ

更新日期：1975-05-01 00:00:00

abstract：:The involvement of a central mechanism in the antiemetic effect of AS-8112 ((R)-5-bromo-N-(1-ethyl-4-methylhexahydro-1H-1,4-diazepin-6-yl)-2-methoxy-6-methylamino-3-pyridinecarboxamide x 2 fumarate), a novel and potent dopamine D2, D3, and 5-HT(3) receptor antagonist, was investigated in ferrets. Intracerebroventricul...

journal_title：European journal of pharmacology

authors： Yoshikawa T,Yoshida N,Oka M

更新日期：2001-11-23 00:00:00

abstract：:Tryptase, a serine protease synthesized by and stored in mast cells, is implicated as an important mediator in the pathogenesis of airway inflammation. In this study, tryptase was evaluated for its ability to induce microvascular leakage into the airways of guinea pigs. Dose- and time-dependent increases in airway mic...

journal_title：European journal of pharmacology

authors： Greenfeder S,Sehring S,McHugh N,Corboz M,Rivelli M,Anthes JC,Billah M,Egan RW,Chapman RW

更新日期：2001-05-11 00:00:00

abstract：:Intracellular accumulation of calcium is thought to play an integral role in the progression of ischemic injury and cell death. We infused the calcium entry blocker, nitrendipine (1.5 micrograms/kg per min), into cats in order to investigate the importance of extracellular Ca2+ influx during hemorrhagic shock. Nitrend...

journal_title：European journal of pharmacology

authors： Hock CE,Su JY,Lefer AM

更新日期：1984-01-13 00:00:00

abstract：:We recently reported that wood smoke inhalation initially (within 5 min) causes airway injury and subsequently produces both airway and parenchymal injury after a delay (within 2 h). In this study, we investigated the mediator mechanisms of this delayed smoke-induced lung injury in 126 anesthetized and artificially ve...

journal_title：European journal of pharmacology

authors： Lin YS,Ho CY,Tang GJ,Kou YR

更新日期：2001-08-10 00:00:00

abstract：:The effects of an inhibitor of calmodulin, trifluoperazine (TFP), were determined on the electrical activity of cultured cell reaggregates derived from chick embryonic hearts (15-day-old). The cells exhibited naturally occurring slowly rising action potentials (APs) having a maximum rate of rise (+Vmax) of less than 3...

journal_title：European journal of pharmacology

authors： Bkaily G,Sperelakis N,Eldefrawi M

更新日期：1984-10-01 00:00:00

abstract：:Acute dystonic reactions are motor side effects that occur soon after the initiation of neuroleptic treatment. Although earlier studies indicate that these abnormal movements can be induced in animals and humans via activation of sigma receptors, the relative contribution of the different sigma receptor subtypes is un...

journal_title：European journal of pharmacology

authors： Matsumoto RR,Pouw B

更新日期：2000-08-04 00:00:00

abstract：:The positive chronotropic effect of angiotensin II was studied on the isolated spontaneously beating cat right atria. Angiotensin II and prostacyclin produced similar positive chronotropic and inotropic effects which were not affected by beta-adrenoceptor and histamine H2-receptor blockers. [Sar1,Ile8] angiotensin II,...

journal_title：European journal of pharmacology

authors： Türker RK

更新日期：1982-09-24 00:00:00

abstract：:Corticotropin-releasing factor (CRF) has been suggested to play an important role in the development of drug dependence and withdrawal. Based on the recent finding that CRF receptor antagonists inhibit the stress-induced relapse to opiate dependence and attenuate anxiety-like responses related to cocaine withdrawal, t...

journal_title：European journal of pharmacology

authors： Lu L,Liu D,Ceng X

更新日期：2001-03-01 00:00:00

abstract：:Herein, we examined the direct coupling of human dopamine D1 receptors to G(s) proteins using an antibody capture assay together with a detection technique employing scintillation proximity assay beads. Using a specific antibody, dopamine (DA) and the selective dopamine D1 receptor agonists, 6-chloro-7,8-dihydroxy-1-p...

journal_title：European journal of pharmacology

authors： Cussac D,Pasteau V,Millan MJ

更新日期：2004-02-06 00:00:00

abstract：:In rats, surgical injury of the neocortex enhances the level of procholecystokinin-mRNA in the ipsilateral cortex. This increase in procholecystokinin gene expression was significantly reduced by the blockers of catecholamine re-uptake nomifensine (4 mg/kg), cocaine (5 mg/kg) and (+)-oxaprotiline (1.5 mg/kg) given i.m...

journal_title：European journal of pharmacology

authors： Mondeh JD,Olenik C,Götz E,Uhl A,Meyer DK

更新日期：1993-08-10 00:00:00

abstract：:The inhibitory effects of adenosine, ATP, 5'-adenylyl methylene diphosphonate (beta, gamma-meATP) and adenosine 5'-alpha, beta-methylene triphosphonate (alpha, beta-meATP) were compared on the cholinergic twitch responses to transmural stimulation of the guinea-pig ileum. Adenosine, ATP and beta, gamma-meATP reduced t...

journal_title：European journal of pharmacology

authors： Moody CJ,Burnstock G

更新日期：1982-01-08 00:00:00

abstract：:In this study, we determined the protective potential of trans resveratrol against oxygen-glucose deprivation (OGD) induced reactive oxygen species mediated apoptotic damages in PC12 cells. In vitro model of ischemic cerebral stroke was created by keeping cells in an OGD condition for 6h followed by 24h reoxygenation....

journal_title：European journal of pharmacology

authors： Agrawal M,Kumar V,Kashyap MP,Khanna VK,Randhawa GS,Pant AB

更新日期：2011-09-01 00:00:00

abstract：:In the guinea-pig isolated ileum, beta-(2-thienyl)-gamma-aminobutyric acid (BTG; 100-500 microM) reversibly and competitively (pA2 = 4.3 +/- 0.1) antagonised the baclofen-induced (5-100 microM) depression of cholinergic twitch contractions, but not that to adenosine or morphine. By contrast, in rat neocortical slice p...

journal_title：European journal of pharmacology

authors： Ong J,Kerr DI,Berthelot P,Vaccher C,Flouquet N,Debaert M

更新日期：1992-10-06 00:00:00

abstract：:A close relationship between the renin-angiotensin system and the pathophysiology of diabetic retinopathy has been suggested, several angiotensin II type 1 receptor (angiotensin AT1 receptor) antagonists being effective in animal models. Therefore, we examined the efficacy of an angiotensin AT1 receptor antagonist, ol...

journal_title：European journal of pharmacology

authors： Nakamura H,Inoue T,Arakawa N,Shimizu Y,Yoshigae Y,Fujimori I,Shimakawa E,Toyoshi T,Yokoyama T

更新日期：2005-04-11 00:00:00

abstract：:The aim of this study was to determine the anticonvulsant effects of osthole {[7-methoxy-8-(3-methyl-2-butenyl)-2H-1-benzopyran-2-one]--a natural coumarin derivative} in the mouse maximal electroshock-induced seizure model. The antiseizure effects of osthole were determined at 15, 30, 60, and 120 min after its systemi...

journal_title：European journal of pharmacology

authors： Luszczki JJ,Andres-Mach M,Cisowski W,Mazol I,Glowniak K,Czuczwar SJ

更新日期：2009-04-01 00:00:00

abstract：:Neuropeptide Y has direct vasoconstrictor actions and potentiates the effects of other vasoconstrictor agents. To find out whether both effects of neuropeptide Y are mediated via the same receptor and intracellular mechanism, the interaction between neuropeptide Y and angiotensin II was studied in rabbit femoral arter...

journal_title：European journal of pharmacology

authors： Cressier F,Criscione L,Hofbauer KG

更新日期：1995-01-05 00:00:00

abstract：:Protective effect of quercetin and alpha-tocopherol on experimental reflux oesophagitis in rats was investigated. Rats received quercetin, (100 mg/kg), alpha-tocopherol (16 mg/kg), omeprazole (30 mg/kg) given at 1 h prior to surgery. Quercetin and alpha-tocopherol significantly inhibited the oesophagitis index to 1.33...

journal_title：European journal of pharmacology

authors： Rao CV,Vijayakumar M

更新日期：2008-07-28 00:00:00

abstract：:Increasing evidence displays that microRNAs (miRNAs) participate in the development of various human malignancies, including esophageal squamous cell carcinoma (ESCC). MicroRNA-33a-5p (miR-33a-5p) has recently been reported to function as a tumor suppressor in many human cancers. However, the expression and role of mi...

journal_title：European journal of pharmacology

authors： Zhang C,Wang L,Yang J,Fu Y,Li H,Xie L,Cui Y

更新日期：2019-10-15 00:00:00

abstract：:Endogenous Nitric Oxide (NO) plays a key role in the physiological regulation of airway functions. In response to various stimuli activated inflammatory cells (e.g., eosinophils and neutrophils) generate oxidants ("oxidative stress") which in conjunction with exaggerated enzymatic release of NO and augmented NO metabo...

journal_title：European journal of pharmacology

authors： Ricciardolo FL,Di Stefano A,Sabatini F,Folkerts G

更新日期：2006-03-08 00:00:00

abstract：:Since its clinical inception, tamoxifen (TAM) has proved to be a powerful tool in treating estrogen receptor-positive breast cancers while exhibiting manageable side effects. Although TAM was synthesized as an estrogen receptor antagonist, reports have found that a significant fraction of women with estrogen receptor-...

journal_title：European journal of pharmacology

authors： Radin DP,Patel P

更新日期：2016-06-15 00:00:00

abstract：:Cisplatin is widely used chemotherapeutic drug and have some serious side effects as tissue toxicity and nausea and vomiting. Aprepitant is used in clinic as an anti-emetic drug for cisplatin treated patient to prevent nausea and vomiting. We aimed to investigate the protective effects of Aprepitant on cisplatin-induc...

journal_title：European journal of pharmacology

authors： Un H,Ugan RA,Kose D,Bayir Y,Cadirci E,Selli J,Halici Z

更新日期：2020-08-05 00:00:00

abstract：:Spinal 5-HT1A receptor subtypes are involved in regulation of nociception. This study was performed to investigate the effect of stimulation of these receptors on wide dynamic range neurones in the spinal cord. Extracellular single unit recordings of dorsal horn neurones were performed in intact urethane-anaesthetized...

journal_title：European journal of pharmacology

authors： Gjerstad J,Tjolsen A,Hole K

更新日期：1996-12-30 00:00:00

abstract：:SL 84.0418 (2-(4,5-dihydro-1H-imidazol-2-yl)-1,2,4,5-tetrahydro-2-propyl-pyrrolo[3, 2,1- hi]-indole hydrocholoride) is a novel alpha 2-adrenoceptor antagonist which possesses anti-hyperglycaemic properties in vitro study, we tested its effects on insulin release from isolated mouse islets. In the presence of 15 mM glu...

journal_title：European journal of pharmacology

authors： Jonas JC,Plant TD,Angel I,Langer SZ,Henquin JC

更新日期：1994-03-11 00:00:00

abstract：:The effect of GABA (gamma-aminobutyric acid system) receptor agonists and antagonists on naloxone-induced jumping in morphine-dependent mice was examined. Intraperitoneal (i.p.) or intracerebroventricular (i.c.v.) injection of different doses of the GABA(B) receptor agonist, baclofen (2.5, 5 and 10 mg/kg), reduced nal...

journal_title：European journal of pharmacology

authors： Zarrindast MR,Mousa-Ahmadi E

更新日期：1999-09-24 00:00:00

abstract：:The influence of GABA-ergic stimulation on the centrally evoked pressor and tachycardic responses to substance P (SP) was investigated in conscious rats. Intracerebroventricular (i.c.v.) pretreatment with the potent GABA agonist muscimol attenuated the pressor responses to i.c.v. administered SP in a dose-dependent an...

journal_title：European journal of pharmacology

authors： Schneider B,Ganten D,Lang RE,Unger T

更新日期：1986-11-12 00:00:00

abstract：:The purpose of the present study was to test whether kava extract and its constituents kawain, dihydrokawain, methysticin, dihydromethysticin and yangonin provide protection against ischemic brain damage. To this end, we used a model of focal cerebral ischemia in mice and rats. Ischemia was induced by microbipolar coa...

journal_title：European journal of pharmacology

authors： Backhauss C,Krieglstein J

更新日期：1992-05-14 00:00:00

abstract：:The vasodilator profile of synthetic atrial natriuretic factor (ANF) was characterized using isolated vascular preparations. Nanomolar concentrations of ANF relaxed rabbit aortic rings contracted by serotonin, histamine, methoxamine or angiotensin II. The synthetic peptide was most effective (IC50 = 1.3 X 10(-10) M) i...

journal_title：European journal of pharmacology

authors： Winquist RJ,Faison EP,Nutt RF

更新日期：1984-06-15 00:00:00