Effects of phentolamine, phenoxybenzamine and desipramine on clonidine-induced blockade of cardiac acceleration in the dog.

abstract：:The endocannabinoid system appears to have an important role in specific aspects of learning and memory, yet there has been no systematic study of the role of cannabinoid receptors in contextual fear conditioning. The present study examined the effects of cannabinoid CB(1) receptor blockade on the acquisition, consoli...

journal_title：European journal of pharmacology

authors： Arenos JD,Musty RE,Bucci DJ

更新日期：2006-06-13 00:00:00

abstract：:Forskolin, a potent activator of adenylate cyclase, and isoprenaline, an unselective beta-adrenoceptor agonist, were studied in vitro on tissues from guinea-pig with respect to relaxation of the carbachol-contracted trachea, increase in the force of contraction of the papillary muscle and depression of subtetanic cont...

journal_title：European journal of pharmacology

authors： Waldeck B,Widmark E

更新日期：1985-06-19 00:00:00

abstract：:Ro 40-5967 [(1S,2S)-2-[2[3-(2-benzamidopropyl]- methylamino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-isopropyl-2-naphthyl- methoxyacetate] is a new Ca2+ channel antagonist active at L-type channels. Radioligand binding studies in cardiac tissue show that Ro 40-5967 does not inhibit 1,4-dihydropyridine binding, but does in...

journal_title：European journal of pharmacology

authors： Rutledge A,Triggle DJ

更新日期：1995-07-04 00:00:00

abstract：:Male mice from 14 strains were injected i.p. with tremorine (3.0 mg/kg) or oxotremorine (0.15 or 0.1 mg/kg). Large inter-strain differences in the degree and duration of the subsequent hypothermia were noted. 2 strains, BALB/c and Simpson, were particularly sensitive to the hypothermic effect of oxotremorine. The offs...

journal_title：European journal of pharmacology

authors： Lush IE,Andrews KM

更新日期：1978-05-01 00:00:00

abstract：:We have examined the effect of various chemokines on neuronal toxicity in culture. In mixed cortical cultures, challenged with a brief pulse of N-methyl-D-aspartate (NMDA, 60 microM, 10 min), chemokines were either present for 2 h preceding the pulse or they were co-applied with NMDA and then kept in the medium for th...

journal_title：European journal of pharmacology

authors： Bruno V,Copani A,Besong G,Scoto G,Nicoletti F

更新日期：2000-07-07 00:00:00

abstract：:Previous studies of myocardium have shown that ischemic preconditioning could be mimicked by nitroglycerin through stimulating the release of calcitonin gene-related peptide (CGRP). The present study examined whether nitroglycerin could also provide a preconditioning stimulus in the peripheral vascular bed (the anse i...

journal_title：European journal of pharmacology

authors： Dun Y,Hao YB,Wu YX,Zhang Y,Zhao RR

更新日期：2001-11-02 00:00:00

abstract：:Guinea pig neurotensin differs from other mammalian neurotensin by the substitution of proline by serine at position 7. [Ser7]neurotensin produced a concentration-dependent contraction of the guinea pig oesophagus and rat fundus, a biphasic effect (initial relaxation followed by more sustained contraction) on the guin...

journal_title：European journal of pharmacology

authors： Katsoulis S,Conlon JM

更新日期：1987-08-21 00:00:00

abstract：:Mizoribine is a disease-modifying anti-rheumatic drug (DMARD) that is used in the treatment of rheumatoid arthritis. However, clinical use of the drug is restricted to a few Asian countries due to a lack of comprehensive evidence on its effectiveness. The inhibitory effect of the drug on human osteoclastogenesis was i...

journal_title：European journal of pharmacology

authors： Lee YA,Yang HI,Park EK,Bang JS,Choi HM,Oh DH,Lee SH,Hong SJ,Jo YJ,Yoo MC,Kim KS

更新日期：2009-03-01 00:00:00

abstract：:The distribution of P2-purinoceptors in pre-capillary resistance vessels was studied in vitro, using Krebs perfused rabbit ears and in vivo, in autoperfused hindquarters, intestinal and renal vasculatures of pentobarbitone anaesthetised cats. ATP (10(-10)-10(-6) mol i.a.) caused dose-dependent vasodilatation which, in...

journal_title：European journal of pharmacology

authors： Taylor EM,Parsons ME,Wright PW,Pipkin MA,Howson W

更新日期：1989-02-28 00:00:00

abstract：:Endothelins, 21-amino acid peptides involved in the pathogenesis of various diseases, bind to endothelin ET(A) and ET(B) receptors to initiate their effects. Here, we characterize the pharmacology of A-216546 ([2S-(2,2-dimethylpentyl)-4S-(7-methoxy-1,3-benzodioxol-5-yl )-1-(N,N-di(n-butyl) aminocarbonylmethyl)-pyrroli...

journal_title：European journal of pharmacology

authors： Wu-Wong JR,Dixon DB,Chiou WJ,Dayton BD,Novosad EI,Adler AL,Wessale JL,Calzadilla SV,Hernandez L,Marsh KC,Liu G,Szczepankiewicz B,von Geldern TW,Opgenorth TJ

更新日期：1999-02-05 00:00:00

abstract：:The effect of a leukotriene D(4) receptor antagonist, (3-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl(3-dimethyl amino-3-oxo propyl)thio)methyl)thio) propanoic acid (L-660,711; MK-571), was investigated on nociceptive responses in mice using three different assays: acetic-acid-induced abdominal constrictions, formalin ...

journal_title：European journal of pharmacology

authors： Gök S,Onal A,Cinar MG,Evinç A

更新日期：1999-12-15 00:00:00

abstract：:Approximately 3% of the world׳s population suffers from chronic infections with hepatitis C virus (HCV). Although current treatment regimes are capable of effectively eradicating HCV infection from these patients, the cost of these combinations of direct-acting antivirals are prohibitive. Approximately 80% of untreate...

journal_title：European journal of pharmacology

authors： Douglas DN,Kneteman NM

更新日期：2015-07-15 00:00:00

abstract：:Cannabinoid CB(2) receptor is reported to be expressed in varying amounts in different human immune subpopulations. To examine the expression pattern of CB(2) in the mouse, immune cell subpopulations were purified and studied by semiquantitative Reverse Transcription-Polymerase Chain Reaction (RT-PCR). CB(2) mRNA was ...

journal_title：European journal of pharmacology

authors： Lee SF,Newton C,Widen R,Friedman H,Klein TW

更新日期：2001-07-06 00:00:00

abstract：:Rats were given powdered diet containing L-DOPA (together with the peripheral decarboxylase inhibitor carbidopa) for a period of 6 months. The estimated daily intake was in the range 20-30 mg/kg. Initially, at 1 week and 1 month, L-DOPA-fed rats exhibited enhanced spontaneous locomotor activity, but this fell to withi...

journal_title：European journal of pharmacology

authors： Pycock C,Dawbarn D,O'Shaughnessy C

更新日期：1982-04-23 00:00:00

abstract：:Geniposide (GE) can effectively inhibit diabetic nephropathy (DN), but its mechanism is unclear. The objective of this study was to explore the antidiabetic nephropathy effects of GE both in high fat diet/streptozotocin-induced DN mice and in high glucose-induced podocyte model. Renal function in DN mice was evaluated...

journal_title：European journal of pharmacology

authors： Li F,Chen Y,Li Y,Huang M,Zhao W

更新日期：2020-11-05 00:00:00

abstract：:Present study was undertaken to evaluate the protective effect of 1,2,3,4,6-penta-O-galloyl-β-d-glucopyranose (PGG) against transient global ischemia/reperfusion (I/R)-induced brain injury in rats. Sixty minutes of global ischemia, followed by 24h of reperfusion caused significant alterations in cognition and memory (...

journal_title：European journal of pharmacology

authors： Viswanatha GL,Shylaja H,Mohan CG

更新日期：2013-11-15 00:00:00

abstract：:It has been previously demonstrated that selegiline, an irreversible monoamine oxidase B (MAO-B) inhibitor, potentiates glial reaction to injury and possesses some 'trophic-like' activities which do not depend on the inhibition of MAO-B and which are probably associated with the induction of astrocyte-derived neurotro...

journal_title：European journal of pharmacology

authors： Semkova I,Wolz P,Schilling M,Krieglstein J

更新日期：1996-11-07 00:00:00

abstract：:There is evidence for the existence of functional interactions between nicotine and cannabinoids and opioid compounds in adult experimental animals. However, there is scarce information about these relationships in young animals. In the present study we evaluated short and long-term effects of a subchronic nicotine tr...

journal_title：European journal of pharmacology

authors： Marco EM,Granstrem O,Moreno E,Llorente R,Adriani W,Laviola G,Viveros MP

更新日期：2007-02-14 00:00:00

abstract：:The effect of several pyrolysate mutagens on the benzodiazepine and GABA receptors was investigated. Of amino-gamma-carbolines, Trp-P-1 antagonized the suppressive effect of diazepam on the pentylenetetrazol-induced convulsions and death, whereas Trp-P-2 by itself precipitated seizures and death in male mice. Both Trp...

journal_title：European journal of pharmacology

authors： Muraki T,Yamazoe Y,Kato R

更新日期：1984-02-10 00:00:00

abstract：:A microdialysis/smallbore chromatographic system was used to monitor changes in extracellular dopamine concentration in the striatum of the rat following administration of drugs that block catecholamine uptake. Analysis of 0.5 microliter of dialysate every 5 min showed dose-dependent elevations in extracellular dopami...

journal_title：European journal of pharmacology

authors： Church WH,Justice JB Jr,Byrd LD

更新日期：1987-07-23 00:00:00

abstract：:Chronic restraint stress (CRS) is known to cause metabolic and neurological complications in a number of ways. Prolonged exposure to stress evident by increased corticosterone level led to impaired altered insulin signaling and oxidative stress in mice, in the present study. Impaired insulin signaling or insulin resis...

journal_title：European journal of pharmacology

authors： Mourya A,Akhtar A,Ahuja S,Sah SP,Kumar A

更新日期：2018-09-15 00:00:00

abstract：:Glucocorticoids inhibit inducible-type NO synthase activity in a variety of cell types. We report here that proteins recovered from the medium of dexamethasone-treated J774 macrophages (1, 10, 100 microg/ml) inhibited lipopolysaccharide-stimulated nitrite generation by 10.0 +/- 3.0%, 32.3 +/- 5.3% and 55.0 +/- 6.0%, r...

journal_title：European journal of pharmacology

authors： D'Acquisto F,Cicatiello L,Iuvone T,Ialenti A,Ianaro A,Esumi H,Weisz A,Carnuccio R

更新日期：1997-11-19 00:00:00

abstract：:Nicotine is one of the most representative components in cigarette smoke leading to gastric ulceration. Both ornithine decarboxylase and potassium ion (K(+)) channels are essential for cell growth and wound repair. The aim of the present study is to elucidate the causative relationship of these two factors during woun...

journal_title：European journal of pharmacology

authors： Shin VY,Liu ES,Koo MW,Luo JC,So WH,Cho CH

更新日期：2002-05-24 00:00:00

abstract：:The melanocortin subtype 4 (MC4) receptor has been postulated to be involved in stress and stress-related behavior. We made use of melanocortin MC4 receptor agonists and antagonist to investigate the relationship between the melanocortin MC4 receptor and stress related disorders. The nonspecific melanocortin receptor ...

journal_title：European journal of pharmacology

authors： Chaki S,Ogawa S,Toda Y,Funakoshi T,Okuyama S

更新日期：2003-08-01 00:00:00

abstract：:The use-dependent effects of bunazosin on the maximal rate of rise (Vmax) of the action potential and conduction velocity were studied in isolated papillary muscles of guinea-pig. Standard microelectrode techniques were used to monitor the conduction and action potential of the muscles. In the presence of 30 microM bu...

journal_title：European journal of pharmacology

authors： Hasegawa J,Noguchi N,Sawaguchi M,Doi T,Hisatome I,Kotake H,Mashiba H

更新日期：1990-12-04 00:00:00

abstract：:We have cloned the calf predominant pancreatic cholecystokinin B (CCKB)/gastrin receptor cDNA. It encodes a 454 amino acid protein with 90% identity with the CCKB/gastrin receptor cloned in other species and tissues. However, the calf pancreatic CCKB/gastrin receptor contains a pentapeptide cassette within the third i...

journal_title：European journal of pharmacology

authors： Dufresne M,Escrieut C,Clerc P,Le Huerou-Luron I,Prats H,Bertrand V,Le Meuth V,Guilloteau P,Vaysse N,Fourmy D

更新日期：1996-02-15 00:00:00

abstract：:Pretreatment of rats with intraventricular 6-hydroxydopamine produced considerable destruction of noradrenergic and dopaminergic nerve terminals as indicated by depletions in synaptosomal catecholamine contents. However, 6-hydroxydopamine pretreatment did not result in diminished release of ATP during depolarization o...

journal_title：European journal of pharmacology

authors： Potter PE,White TD

更新日期：1982-05-07 00:00:00

abstract：:This study compared the peripheral analgesic effects of a novel opioid agonist 14-O-methylmorphine-6-O-sulfate (14-O-MeM6SU), to that of non-peptide (morphine, fentanyl) and peptide opioid agonists (Met-enkephalin; met-ENK and β-endorphin; β-END) in a model of localized inflammatory pain evoked by intraplantar (i.pl.)...

journal_title：European journal of pharmacology

authors： Khalefa BI,Mousa SA,Shaqura M,Lackó E,Hosztafi S,Riba P,Schäfer M,Ferdinandy P,Fürst S,Al-Khrasani M

更新日期：2013-08-05 00:00:00

abstract：:The stress-induced hyperthermia procedure, in which effects of drugs on basal (T(1)) and stress-induced body temperature (T(2)) are measured, predicts anxiolytic drug effect. Serotonergic drugs alter these responses and here, we studied the role of 5-HT(1A) receptors in stress-induced hyperthermia by using 5-HT(1A) re...

journal_title：European journal of pharmacology

authors： Van Bogaert M,Oosting R,Toth M,Groenink L,van Oorschot R,Olivier B

更新日期：2006-11-21 00:00:00

abstract：:Inhibition of intrathecal substance P-elicited behavior by mu-, delta- and kappa-opioids was compared. In both the substance P behavioral test and the tail flick antinociceptive test, intrathecal [D-Ala2, Met5]enkephalinamide and [D-Ala2, D-Leu5]enkephalin (DADL) were equipotent, morphine and ethylketazocine were less...

journal_title：European journal of pharmacology

authors： Hylden JL,Wilcox GL

更新日期：1982-12-17 00:00:00