Abstract：
:The functions of the 5-HT(4) receptor in the gastrointestinal tract are complex, depending on the species and anatomical regions, and localization of the receptor was not clear. The present study attempted to examine the localization of the 5-HT(4) receptor in the colon of human for comparison with that in guinea pig colon. Human specimens of sigmoid colon and the distal colon of guinea pig were used for in vitro receptor autoradiography using [125I]SB207710, (1-n-butyl-4-piperidinyl) methyl-8-amino-7-iodo-1, 4-benzodioxane-5-carboxylate, as a ligand. [125I]SB207710 binding sites were distributed over the muscle layer of human colon, in the myenteric plexus and in the muscle. In the guinea pig colon, a much higher density was detected in the myenteric plexus than in the muscle. Therefore, in the human and guinea pig colon, the 5-HT(4) receptor was located both in the myenteric plexus and in the muscle, and in the guinea pig colon, the receptor was located more predominantly in the myenteric plexus of the muscle than it is in the human colon.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Sakurai-Yamashita Y,Yamashita K,Kanematsu T,Taniyama Kdoi
10.1016/s0014-2999(99)00642-1keywords:
subject
Has Abstractpub_date
1999-11-03 00:00:00pages
281-5issue
3eissn
0014-2999issn
1879-0712pii
S0014-2999(99)00642-1journal_volume
383pub_type
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