Regional cyclic GMP content in incubated tissue slices of rat brain.

abstract：:The effects of group 2- versus group 3-selective metabotropic glutamate (mGlu) receptor agonists were examined against forskolin (10 microM)-, vasoactive intestinal peptide (VIP; 1 microM)- and 5'-N-ethylcarboxamidoadenosine (NECA; 10 microM)-stimulated cAMP accumulations in adult rat hippocampal slices (in the presen...

journal_title：European journal of pharmacology

authors： Wright RA,Schoepp DD

更新日期：1996-02-22 00:00:00

abstract：:3H-Glycine was released by 50 mM K+ in a calcium-dependent manner from rat substantia nigra slices. This release was abolished by GABA (0.1-1 mM) and muscimol (0.1 mM). Taurine and beta-alanine were without effect on evoked 3H-glycine release. The effect of GABA (0.5 mM) was reversed picrotoxin (50 micro M). These res...

journal_title：European journal of pharmacology

authors： Kerwin R,Pycock C

更新日期：1980-06-13 00:00:00

abstract：:The (+)-enantiomer of the dihydropyridine 202-791 produced coronary constrictor and positive inotropic effects in Langendorff-perfused rat hearts whereas (--)-202-791 showed coronary dilator and negative inotropic effects. Both enantiomers showed the vascular effects at lower concentrations than the myocardial effects...

journal_title：European journal of pharmacology

authors： Uematsu T,Cook NS,Hof RP,Vozeh S,Follath F

更新日期：1986-04-29 00:00:00

abstract：:Indoline derivatives functions as an inhibitors of epidermal growth factor receptor (EGFR) with the anticancer potential against various cancers. We aim to investigate anti-breast cancer effects and mechanism of action of novel indoline derivatives. Molecular docking of seven indoline derivates with EGFR revealed, N-(...

journal_title：European journal of pharmacology

authors： Palanivel S,Murugesan A,Subramanian K,Yli-Harja O,Kandhavelu M

更新日期：2020-08-15 00:00:00

abstract：:T-type Ca(2+) currents were recorded in 2 mM Ca(2+) from HEK293 cells stably expressing the low voltage-activated Ca(2+) channel sub-unit alpha(1I). These currents were inhibited by the known Ca(2+) channel antagonist mibefradil with an IC(50) close to 1 microM. SB-209712 (1,6,bis¿1-[4-(3-phenylpropyl)piperidinyl]¿hex...

journal_title：European journal of pharmacology

authors： McNaughton NC,Warre R,Cooper DG,Nasir S,Ranson JL,Randall A

更新日期：2000-10-27 00:00:00

abstract：:The effects of degradative enzymes and enzyme inhibitors were examined on the inhibitory actions of adenosine, AMP and ATP on atrial muscle and on the cholinergic responses of the ileum to transmural stimulation of the guinea-pig, in order to determine whether ATP responses are mediated by its breakdown products, AMP ...

journal_title：European journal of pharmacology

authors： Moody CJ,Meghji P,Burnstock G

更新日期：1984-01-13 00:00:00

abstract：:We previously reported that both nitric oxide (NO) generated from NO synthase by bombesin and NO generated from SIN-1 (NO donor) activate the brain cyclooxygenase (COX) (COX-1 for bombesin), thereby eliciting the secretion of both catecholamines (CA) from the adrenal medulla by brain thromboxane A(2)-mediated mechanis...

journal_title：European journal of pharmacology

authors： Tanaka K,Shimizu T,Lu L,Yokotani K

更新日期：2012-03-15 00:00:00

abstract：:The aim of the present study was to find out the mechanism by which the inflammatory mediator, bradykinin, induces an increase of the cytosolic Ca(2+) concentration ([Ca(2+)](i)) in enteric neurons. For this purpose, ganglia in the isolated submucosa from rat colon were loaded with the Ca(2+)-sensitive dye, fura-2, an...

journal_title：European journal of pharmacology

authors： Rehn M,Diener M

更新日期：2012-04-15 00:00:00

abstract：:This study investigates the effect and the underlying mechanism of 2',3-dihydroxy-5-methoxybiphenyl (RIR-2), a lignan extracted from the roots of Rhaphiolepis indica (L.) Lindl. ex Ker var. tashiroi Hayata ex Matsum. & Hayata (Rosaceae), on N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP)-induced respiratory burst...

journal_title：European journal of pharmacology

authors： Liao HR,Chen IS,Liu FC,Lin SZ,Tseng CP

更新日期：2018-06-15 00:00:00

abstract：:The influence of inflammatory cells on airway reactivity was investigated on arachidonic acid-induced relaxations of guinea-pig trachea and on arachidonic acid metabolism in guinea-pig tracheal epithelial cells. The presence of either eosinophils or neutrophils (1.0 x 10(7) cells/ml), from bronchoalveolar lavage, decr...

journal_title：European journal of pharmacology

authors： Prié S,Conroy DM,Gleich GJ,Sirois P

更新日期：1996-12-19 00:00:00

abstract：:The mode of binding of [3H]BQ-123 (cyclo(-D-Trp-D-Asp-[prolyl-3,4 (n)-[3H]]Pro-D-Val-Leu)), an endothelin receptor antagonist radioligand, was evaluated in the human neuroblastoma cell line SK-N-MC at 37 degrees C. Scatchard analysis indicated the presence of a single class of [3H]BQ-123 binding sites with a high affi...

journal_title：European journal of pharmacology

authors： Ihara M,Yamanaka R,Ohwaki K,Ozaki S,Fukami T,Ishikawa K,Towers P,Yano M

更新日期：1995-02-14 00:00:00

abstract：:Bilateral injections of alpha-methylnoradrenaline into the area of the nucleus tractus solitarii of the brain stem caused a dose-dependent decrease of systemic arterial blood pressure and heart rate of anesthetized rats. The effects were prevented and even reversed by a preceding injection of the alpha-adrenoceptor bl...

journal_title：European journal of pharmacology

authors： Nijkamp FP,De Jong W

更新日期：1975-06-01 00:00:00

abstract：:These studies examined the opioid and non-opioid in vivo and in vitro actions of PD117,302 (((±)-trans-N-methyl-N-[2-(l-pyrrolidinyl)-cyclohexyl]benzo[b]thiophene-4-acetamide), a kappa (κ)-opioid receptor agonist. PD117,302 selectively labeled the κ-opioid receptor in guinea pig cerebellar membranes and in mice the ED...

journal_title：European journal of pharmacology

authors： Pugsley MK,Saint DA,Hayes ES,Abraham S,Walker MJ

更新日期：2015-08-15 00:00:00

abstract：:The relationship between morphine tolerance and pituitary-adrenocortical activity was examined. In rats made tolerant to morphine by implantation of morphine-containing pellets, there was a significant reduction in plasma levels of beta-endorphin-like immunoreactivity (beta-END-LI), whereas no significant changes in c...

journal_title：European journal of pharmacology

authors： Antonio Martínez J,Vargas ML,Fuente T,Del Rio Garcia J,Milanés MV

更新日期：1990-06-21 00:00:00

abstract：:We examined whether the Ca2+ channel function in the resting state alters the resting tone in femoral and carotid arteries from spontaneously hypertensive rats (SHR) at early hypertensive stages (6 and 4 weeks of age), and data were compared with findings in age-matched normotensive Wistar-Kyoto rats (WKY). Strips of ...

journal_title：European journal of pharmacology

authors： Asano M,Matsuda T,Hayakawa M,Ito KM,Ito K

更新日期：1993-11-15 00:00:00

abstract：:Baicalein was a major bioactive flavonoid derived from Radix Scutellariae in Xiao-Chai-Hu-Tang which was commonly used to treat chronic hepatitis and liver fibrosis in China. The aim of this study was to assess whether chronic baicalein administration could prevent liver fibrosis induced by carbon tetrachloride (CCl(4...

journal_title：European journal of pharmacology

authors： Sun H,Che QM,Zhao X,Pu XP

更新日期：2010-04-10 00:00:00

abstract：:Endothelial differentiation gene (EDG) receptors are a new family of eight G protein-coupled receptors for the lysophospholipids lysophosphatitic acid and sphingosine-1-phosphate. In the present experiments, the expression of EDG receptors in rat and human alveolar macrophages was studied by reverse transcription-poly...

journal_title：European journal of pharmacology

authors： Hornuss C,Hammermann R,Fuhrmann M,Juergens UR,Racké K

更新日期：2001-10-19 00:00:00

abstract：:The spontaneous myogenic activity of the isolated rat portal vein was inhibited by atrial natriuretic factor or by sodium nitroprusside. These compounds were not effective on the tone induced by PAF-acether or carbachol. 8-Bromo cyclic GMP and dibutyryl cyclic AMP inhibited myogenic activity and reduced the agonist-in...

journal_title：European journal of pharmacology

authors： Hellegouarch A,Auguet M,Guillon JM,Baranes J,Pirotzky E,Braquet P

更新日期：1988-01-12 00:00:00

abstract：:Insulin resistance in skeletal muscle is a major risk factor for the development of type 2 diabetes (T2D). In this study, we investigated the effect of icariin on insulin resistance in C2C12 mouse skeletal muscle cells. C2C12 myoblasts were differentiated into myotubes for five days, then treated with icariin (50 and ...

journal_title：European journal of pharmacology

authors： Han Y,Jung HW,Park YK

更新日期：2015-07-05 00:00:00

abstract：:The effects of gentamicin, an aminoglycoside antibiotic, on changes in the catecholamine levels in the rat striatum, hypothalamus, adrenal medulla and vas deferens were studied. When rats were i.v. injected with gentamicin (1.0 mg/kg), the catecholamine content of all tissues increased 2-4 h after injection. The incre...

journal_title：European journal of pharmacology

authors： Mikami M,Tachikawa E,Kashimoto T

更新日期：1992-01-07 00:00:00

abstract：:The present study was undertaken to investigate the effects of intracavernosal injections of adrenomedullin, a novel hypotensive peptide, on penile erection in anesthetized cats. Responses to adrenomedullin were compared to those elicited by intracavernosal injection of the control triple-drug combination (1.65 mg pap...

journal_title：European journal of pharmacology

authors： Champion HC,Wang R,Shenassa BB,Murphy WA,Coy DH,Hellstrom WJ,Kadowitz PJ

更新日期：1997-01-14 00:00:00

abstract：:The alpha 1-receptor agonist methoxamine reduced, by a prazosin sensitive mechanism, the nerve stimulation evoked release of norepinephrine in the rat caudal artery. The effect of methoxamine was also antagonized by the purinoceptor antagonist 8-(p-sulfophenyl)theophylline suggesting an involvement of endogenous purin...

journal_title：European journal of pharmacology

authors： Shinozuka K,Sedaa KO,Bjur RA,Westfall DP

更新日期：1991-01-17 00:00:00

abstract：:We examined whether the proteinase-activated receptor-2 (PAR2) agonist, H-Ser-Leu-Ile-Gly-Arg-Leu-NH2 (SLIGRL-NH2), could induce scratching behavior in mice. Intradermal injections of SLIGRL-NH2 (10-50 microg) evoked dose dependent scratching. This behavior peaked near 5 min and returned to preinjection levels within ...

journal_title：European journal of pharmacology

authors： Shimada SG,Shimada KA,Collins JG

更新日期：2006-01-20 00:00:00

abstract：:The effect of NZ-107 (4-bromo-5-(3-ethoxy-4-methoxybenzylamino)-3(2H)-pyridazinone) on late-phase airway responses and airway hyperreactivity was investigated in the guinea pig. Challenge with inhaled ovalbumin in conscious guinea pigs actively sensitized with inhaled ovalbumin caused triphasic bronchial obstruction, ...

journal_title：European journal of pharmacology

authors： Iwama T,Shikada K,Yamamoto A,Sakashita M,Hibi M,Tanaka S

更新日期：1991-07-09 00:00:00

abstract：:PK20M (Dmt-D-Lys-Phe-Phe-OH) is a novel modified endomorphin-2 (EM-2) peptide producing strong dose- and time-dependent antinociceptive activity. Yet its prototype, endogenous EM-2, has been reported to trigger respiratory and vascular effects such as apnea and hypotension. The purpose of this study was to investigate...

journal_title：European journal of pharmacology

authors： Wojciechowski P,Kleczkowska P,Mollica A,Stefanucci A,Kaczyńska K

更新日期：2020-10-15 00:00:00

abstract：:Pulmonary hypertension (PH) mainly results from excessive proliferation of pulmonary artery smooth muscle cells (PASMCs) and displays mitochondrial abnormalities such as mitochondrial fragmentation. Epigallocatechin-3-gallate (EGCG), an efficient antiproliferative compound in green tea, has recently been demonstrated ...

journal_title：European journal of pharmacology

authors： Zhu TT,Zhang WF,Luo P,He F,Ge XY,Zhang Z,Hu CP

更新日期：2017-08-15 00:00:00

abstract：:The cellular localisation and distribution of mRNAs encoding beta-adrenoceptor subtypes in human lung were studied by in situ hybridisation and Northern blot analysis. The 851-bp SmaI/PvuII fragment of human beta 1-adrenoceptor cDNA, the 439-bp SmaI fragment of human beta 2-adrenoceptor cDNA and the 975-bp SmaI fragme...

journal_title：European journal of pharmacology

authors： Mak JC,Nishikawa M,Haddad EB,Kwon OJ,Hirst SJ,Twort CH,Barnes PJ

更新日期：1996-04-29 00:00:00

abstract：:The pharmacological features of dopamine receptors in identifiable giant neurone types of a snail (Achatina fulica Férussac) were studied. Under voltage clamp, two neurone types, LVMN (left ventral multiple spike neurone) and d-RPeAN (dorsal-right pedal anterior neurone), produced an inward current (Iin) in response t...

journal_title：European journal of pharmacology

authors： Emaduddin M,Liu GJ,Takeuchi H

更新日期：1995-09-05 00:00:00

abstract：:We examined whether danazol has a direct action on ovarian steroid secretion and/or uterine prostaglandin (PG) F2 alpha catabolic activity in immature rats in which the first ovulation was induced and in adult ovariectomized rats. The preovulatory surge of estradiol and progesterone was markedly suppressed together wi...

journal_title：European journal of pharmacology

authors： Kogo H,Takasaki K,Yatabe Y,Nishikawa M,Takeo S,Tamura K

更新日期：1992-01-28 00:00:00

abstract：:Flesinoxan acts as a full 5-HT1A receptor agonist and displays anxiolytic and anti-depressant properties. 5-HT1A receptor agonists, including flesinoxan, increase corticosterone (B) levels in the blood and reduces 5-HT1A receptor mRNA expression in the hippocampus. In this study, we examined whether the 5-HT1A recepto...

journal_title：European journal of pharmacology

authors： Sibug RM,Compaan JC,Meijer OC,Van der Gugten J,Olivier B,De Kloet ER

更新日期：1998-07-24 00:00:00