Abstract:
:Glucose is the primary energy fuel of life. A glucose transporter, the sodium-glucose transporter (SGLT), is receiving attention as a novel therapeutic target in disease. This review summarizes the physiological role of SGLT in cerebral ischemia, cancer, cardiac disease, and intestinal ischemia, which has encouraged analysis of SGLT function. In cerebral ischemia and cardiomyopathy, SGLT-1 is involved in worsening of the injury. In addition, SGLT-1 promotes the development of cancer. On the other hand, SGLT-1 has a protective effect against cardiac and intestinal ischemia. Interestingly, SGLT-1 expression levels are increased in some diseased tissue, such as in cerebral ischemia and cancer. This suggests that SGLT-1 may have an important role in many diseases. This review discusses the potential of SGLT as a target for novel therapeutic agents.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Yamazaki Y,Harada S,Tokuyama Sdoi
10.1016/j.ejphar.2018.01.003subject
Has Abstractpub_date
2018-03-05 00:00:00pages
25-31eissn
0014-2999issn
1879-0712pii
S0014-2999(18)30009-8journal_volume
822pub_type
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