Periadolescent morphine exposure alters subsequent behavioral sensitivity to morphine in adult rats.

abstract：:The effect of chlorethylclonidine on alpha 1-adrenoceptor subtypes and arterial blood pressure has been evaluated. Chlorethylclonidine significantly reduced the alpha 1-adrenoceptor population. Chlorethylclonidine treatment had no significant effect on resting systemic arterial blood pressure or heart rate and shifted...

journal_title：European journal of pharmacology

authors： Piascik MT,Butler BT,Pruitt TA

更新日期：1990-05-16 00:00:00

abstract：:The goal of these investigations was to study the role of tachykinin NK2 receptors in neonatal spinal cords using the selective NK2 receptor agonist [beta-Ala8]neurokinin A-(4-10) and the new NK2 receptor antagonist GR 94800. Experiments were performed with superfused hemisected rat and gerbil spinal cords. Dorsal roo...

journal_title：European journal of pharmacology

authors： Lepre M,Olpe HR,Evans RH,Brugger F

更新日期：1994-06-02 00:00:00

abstract：:Denudatin B is an antiplatelet agent isolated from the flower buds of Magnolia fargesii. We studied the effects of denudatin B on the vasoconstriction of rat thoracic aorta induced by high potassium (K+) solution, norepinephrine (NE) and caffeine, and to elucidate its mode of action. The contraction of rat aorta cause...

journal_title：European journal of pharmacology

authors： Yu SM,Chen CC,Huang YL,Tsai CW,Lin CH,Huang TF,Teng CM

更新日期：1990-10-02 00:00:00

abstract：:There is now evidence from human studies to suggest that cardiac beta-adrenoceptor density and coupling to adenylate cyclase may be regulated in a subtype selective fashion. An animal model was used to investigate this further. Rats were infused for 6 days with the non-selective full agonist isoprenaline (n = 6) or th...

journal_title：European journal of pharmacology

authors： Arnold IR,Mistry R,Barnett DB

更新日期：1993-05-15 00:00:00

abstract：:Co-dergocrine (Hydergine), an ergot preparation composed of four dihydrogenated peptide ergot alkaloids (dihydroergocornine, dihydroergocristine, dihydro-alpha-ergokryptine, dihydro-beta-ergokryptine, 3:3:2:1), has been reported to exert in vivo effects suggesting an interaction with dopaminergic systems. The present ...

journal_title：European journal of pharmacology

authors： Markstein R

更新日期：1982-12-24 00:00:00

abstract：:The action of a novel 5-HT3 receptor antagonist, AS-5370, has been studied on two electrophysiological models for 5-HT3 receptors: whole-cell patch-clamp recordings from mouse neuroblastoma-rat glioma (NG108-15) cells and grease-gap recordings from rat isolated vagus nerve. The 5-hydroxytryptamine (5-HT)-induced fast ...

journal_title：European journal of pharmacology

authors： Newberry NR,Sprosen TS,Watkins CJ,Leslie RA,Grahame-Smith DG

更新日期：1992-08-14 00:00:00

abstract：:Vasopressin ([Arg(8)]vasopressin)-induced contraction was characterized using receptor agonists and antagonists for vasopressin and channel blockers in the rat basilar artery ring preparations. Vasopressin induced rhythmic contractions superimposed on a contraction in endothelium-intact preparations but not in denuded...

journal_title：European journal of pharmacology

authors： Katori E,Ohta T,Nakazato Y,Ito S

更新日期：2001-03-23 00:00:00

abstract：:The effect of ouabain (10(-3) M) on contractile responses of SHR (spontaneously hypertensive rat) and WKY (Wistar-Kyoto rat) aortas and mesenteric arteries was studied. Ouabain addition caused a rapid contraction of aortic strips with a steeper rate of rise and a larger maximal force development in strips from SHR tha...

journal_title：European journal of pharmacology

authors： Morita S,Iwasaki T,Nagai K,Miyata S,Kawai Y

更新日期：1988-07-14 00:00:00

abstract：:Recently, it has been shown that release of cytochrome c from the mitochondria to the cytosol is required for activation of the caspase-3-dependent cascade in apoptosis, and also for alpha-synuclein aggregation. In the present study, we examined the effects of talipexole and pramipexole on the release of cytochrome c ...

journal_title：European journal of pharmacology

authors： Kakimura J,Kitamura Y,Takata K,Kohno Y,Nomura Y,Taniguchi T

更新日期：2001-04-06 00:00:00

abstract：:Lemnalol (8-isopropyl-5-methyl-4-methylene-decahydro-1,5-cyclo-naphthalen-3-ol) is a natural compound isolated from the marine soft coral Lemnalia cervicorni. In the present study, the anti-inflammatory and anti-nociceptive properties of lemnalol were investigated in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells...

journal_title：European journal of pharmacology

authors： Jean YH,Chen WF,Duh CY,Huang SY,Hsu CH,Lin CS,Sung CS,Chen IM,Wen ZH

更新日期：2008-01-14 00:00:00

abstract：:The aim of this study was to investigate the contribution of the Na(+)/H(+) exchanger to cerebral ischemia using SM-20220 (N-(aminoiminomethyl)-1-methyl-1H-indole-2-carboxamide methanesulfonate), a newly synthesized compound. In in vitro experiments, we evaluated the inhibitory effect of SM-20220 on the Na(+)/H(+) exc...

journal_title：European journal of pharmacology

authors： Kuribayashi Y,Itoh N,Kitano M,Ohashi N

更新日期：1999-10-27 00:00:00

abstract：:Endothelium-dependent contraction elicited by high concentrations of acetylcholine was described in hypertensive as well as in aged normotensive rats. The contribution of endothelium-derived constricting factor (EDCF) to norepinephrine-induced contraction is still unknown. We aimed to compare EDCF participation to nor...

journal_title：European journal of pharmacology

authors： Líšková S,Petrová M,Karen P,Kuneš J,Zicha J

更新日期：2011-09-30 00:00:00

abstract：:Nerve growth factor (NGF) is known to regulate the development and survival of select populations of neurons via its binding/activation of the TrkA and p75(NTR) receptors. However, in some physiological circumstances NGF dysregulation can result in debilitating pathologies, including diabetic neuropathies, interstitia...

journal_title：European journal of pharmacology

authors： Eibl JK,Strasser BC,Ross GM

更新日期：2013-05-15 00:00:00

abstract：:Stimulation of muscarinic M1-receptors in isolated rabbit vas deferens by McN-A-343 inhibited electrically induced twitch contractions susceptible to competitive blockade by (+)-, (+/-), (-)-telenzepine and pirenzepine (pA2 = 9.12, 8.86, 6.98 and 7.79, respectively). The inhibition of twitch contractions by 10(-6) M M...

journal_title：European journal of pharmacology

authors： Eltze M

更新日期：1990-05-03 00:00:00

abstract：:The purpose of the current study was to assess neuropeptidergic alterations during a phase of the drug addiction cycle associated with drug craving as compared to a time period when the drug had been recently self-administered. Male Wistar rats were allowed to self-administer cocaine, heroin or saline for 6 h for 5 co...

journal_title：European journal of pharmacology

authors： Cappendijk SL,Hurd YL,Nylander I,van Ree JM,Terenius L

更新日期：1999-01-22 00:00:00

abstract：:High glucose is one of the possible causes for osteoporosis and fracture in diabetes mellitus. Our previous study showed that silibinin can increase osteogenic effect by stimulating osteogenic genes expression in human bone marrow stem cells (hBMSCs). However, no study has yet investigated the effect of silibinin on o...

journal_title：European journal of pharmacology

authors： Ying X,Chen X,Liu H,Nie P,Shui X,Shen Y,Yu K,Cheng S

更新日期：2015-10-15 00:00:00

abstract：:Scopolamine, a non-selective muscarinic receptor antagonist has widespread central nervous system effects. Muscarinic receptors located in the central nervous system play a vital role in the modulation of impulsivity. The objective of the current study was to evaluate the effect of scopolamine on impulsivity using dif...

journal_title：European journal of pharmacology

authors： Jayarajan P,Nirogi R,Shinde A

更新日期：2013-11-15 00:00:00

abstract：:The aim of our review is to summarize common genetic variations of some receptors associated with clinical consequences, which were not outlined in the previous special issue of this journal. Because of the multiple pathomechanisms of diseases, a set of genetic variation can play a role in the development of pathologi...

journal_title：European journal of pharmacology

authors： Császár A,Abel T

更新日期：2001-02-23 00:00:00

abstract：:Most currently prescribed antidepressants act by selectively increasing the synaptic availability of serotonin or norepinephrine, or through action on both serotonin and norepinephrine. However, most therapies require several weeks of treatment before improvement of symptoms is observed and not all patients respond to...

journal_title：European journal of pharmacology

authors： Shaw AM,Boules M,Zhang Y,Williams K,Robinson J,Carlier PR,Richelson E

更新日期：2007-01-19 00:00:00

abstract：:The aim of the present study was to correlate the impairment of cognitive function induced by scopolamine with the activity of dopaminergic synapses in brain areas which are innervated by the mesocortical limbic system (e.g. hippocampus and frontal cortex) or by the mesostriatal system (e.g. striatum and nucleus accum...

journal_title：European journal of pharmacology

authors： Memo M,Missale C,Trivelli L,Spano PF

更新日期：1988-05-10 00:00:00

abstract：:2-n-Butyl-4-chloro-5-hydroxymethyl-1-[(2'-(1H-tetrazol-5-yl)bip hen yl-4-yl)methyl]imidazole, potassium salt (Losartan) (previous name, DuP 753 or MK 954) is a nonpeptide angiotensin II receptor antagonist. This study was performed to investigate the ability of Losartan to inhibit the angiotensin II-induced stimulatio...

journal_title：European journal of pharmacology

authors： Ko Y,Görg A,Appenheimer M,Wieczorek AJ,Düsing R,Vetter H,Sachinidis A

更新日期：1992-10-01 00:00:00

abstract：:The effects of ICS 205-930 [3 alpha-tropanyl)-1H-indole-3-carboxylic acid ester), an antagonist of 5-HT at neuronal M receptors, were examined in anaesthetised greyhounds subject to acute coronary artery occlusion and reperfusion. Intravenous administration of 0.3 or 2.0 mg kg-1 of ICS 205-930 did not significantly al...

journal_title：European journal of pharmacology

authors： Coker SJ,Dean HG,Kane KA,Parratt JR

更新日期：1986-08-15 00:00:00

abstract：:Methotrexate is a disease modifying anti-rheumatic drug that is widely used for the treatment of rheumatoid arthritis. Nimesulide is a non-steroidal anti-inflammatory drug which is frequently used as adjuvant therapy for symptomatic alleviation of rheumatoid arthritis. In this study, we have evaluated the potential in...

journal_title：European journal of pharmacology

authors： Al-Abd AM,Inglis JJ,Nofal SM,Khalifa AE,Williams RO,El-Eraky WI,Abdel-Naim AB

更新日期：2010-10-10 00:00:00

abstract：:The experiments concerned the effect of parenteral administration of GM1 monosialoganglioside inner ester on the uptake of [3H]dopamine ([3H]DA) in synaptosomes prepared from the corpus striatum of rats with a unilateral lesion of the nigrostriatal pathway. In the animals treated with the ganglioside, starting on the ...

journal_title：European journal of pharmacology

authors： Raiteri M,Versace P,Marchi M

更新日期：1985-12-03 00:00:00

abstract：:The inhibitory effect of cytochalasin B on contraction of smooth muscle cells isolated from guinea-pig taenia coli was investigated. Cytochalasin B (10-70 microM) inhibited the high K+ (70 mM)-induced contraction in a dose-dependent manner, and the maximum and the half-maximum effects were obtained at 50 and 15 microM...

journal_title：European journal of pharmacology

authors： Obara K,Yabu H

更新日期：1994-04-01 00:00:00

abstract：:Quick stretching of a helical strip of dog basilar artery at a rate of 10 cm/s to 140% of the slack length of the muscle evoked a delayed contraction. A small amount of hemolysate (0.01-0.2 mg/ml as hemoglobin), which increased the basal tone by 10-15% of the maximum contracture produced by 80 mM K+, potentiated the s...

journal_title：European journal of pharmacology

authors： Nakayama K,Tanaka Y,Fujishima K

更新日期：1989-10-04 00:00:00

abstract：:A deamination product of histidine, urocanic acid, accumulates in the skin of mammals as trans-urocanic acid. Ultraviolet (UV) irradition converts it to the cis-isomer that is an important mediator in UV-induced immunosuppression. We have recently shown that urocanic acid interferes with the agonist binding to GABA(A)...

journal_title：European journal of pharmacology

authors： Uusi-Oukari M,Soini SL,Heikkilä J,Koivisto A,Neuvonen K,Pasanen P,Sinkkonen ST,Laihia JK,Jansén CT,Korpi ER

更新日期：2000-07-14 00:00:00

abstract：:We investigated the involvement of dopamine D1 and D2 receptor subtypes in the effects of GBR 12909, a selective dopamine uptake inhibitor, on latent learning in the performance of a water-finding task and on locomotor activity in mice. GBR 12909 (10 and 20 mg/kg) impaired latent learning, and this effect was countera...

journal_title：European journal of pharmacology

authors： Ichihara K,Nabeshima T,Kameyama T

更新日期：1993-04-06 00:00:00

abstract：:It has been shown that inflammation of rat paws elicits accumulation of opioid peptide beta-endorphin-containing immune cells in the inflamed subcutaneous tissue, contributing to immunocyte-produced pain suppression. However, the possible mechanisms involved in the pharmacological application of beta-endorphin in rat ...

journal_title：European journal of pharmacology

authors： Stanojević S,Mitić K,Vujić V,Kovacević-Jovanović V,Dimitrijević M

更新日期：2006-11-07 00:00:00

abstract：:Voltage-gated potassium (Kv) channels are the largest superfamily of potassium (K) channels. A variety of Kv channels are expressed in the vascular smooth muscle cells (SMC). Studies have shown that gestational diabetes mellitus (GDM) and pregnancy-induced hypertension (PIH) cause various changes in the human umbilica...

journal_title：European journal of pharmacology

authors： Djokic V,Jankovic S,Labudovic-Borovic M,Rakocevic J,Stanisic J,Rajkovic J,Novakovic R,Kostic M,Djuric M,Gostimirovic M,Gojkovic-Bukarica L

更新日期：2020-09-05 00:00:00