Abstract:
:Phenoxybenzamine greatly attenuated phenylephrine-induced contractions of dog saphenous vein in vitro, but had less effect on contractions induced by clonidine. The phenoxybenzamine-resistant responses to clonidine were not affected by prazosin or by corynanthine but were competitively antagonized by yohimbine (pA2 8.2). It is concluded that exposure of saphenous vein to phenoxybenzamine resulted in blockade of alpha 1-adrenoceptors to the extent that there remained a virtually homogeneous population of postsynaptic alpha 2-adrenoceptors. The effects of agents at postsynaptic alpha 2-adrenoceptors can be studied on this preparation without the complications caused by the presence of functional alpha 1-adrenoceptors.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Constantine JW,Lebel W,Archer Rdoi
10.1016/0014-2999(82)90219-9subject
Has Abstractpub_date
1982-12-03 00:00:00pages
325-9issue
3-4eissn
0014-2999issn
1879-0712pii
0014-2999(82)90219-9journal_volume
85pub_type
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