Stimulant effect of the beta-carboline FG 7142 in the open-field test.

abstract：:Sigma 1 receptor (σ₁ receptor) is a unique ligand-regulated molecular chaperone located mainly in the endoplasmic reticulum and the plasma membrane. σ₁ receptor is activated under stress or pathological conditions and interacts with several neurotransmitter receptors and ion channels to modulate their function. The ef...

journal_title：European journal of pharmacology

authors： Zamanillo D,Romero L,Merlos M,Vela JM

更新日期：2013-09-15 00:00:00

abstract：:Amputation of the mouse tail tip (2.5 cm) caused long term thermal and mechanical hyperalgesia in the remaining part of the tail. Hyperalgesia of the hindpaw to noxious heat (55 degrees C) and cold (0 degrees C) stimuli were also observed. Hyperalgesia at both the tail and hindpaw had a rapid onset (< or = 30 min) and...

journal_title：European journal of pharmacology

authors： Zhuo M

更新日期：1998-05-22 00:00:00

abstract：:Acute kidney injury (AKI) is defined as a rapid loss of kidney function characterised by inflammation and cell death, ultimately leading to further functional and structural renal alterations. Based on experimental and epidemiological pieces of evidence, AKI may progress to chronic kidney disease (CKD) even after a re...

journal_title：European journal of pharmacology

authors： Ogbadu J,Singh G,Aggarwal D

更新日期：2019-12-15 00:00:00

abstract：:The actions of gamma-aminobutyric acid (GABA) and the receptor selective agonists, muscimol (GABAA) and baclofen (GABAB), on motor activity of the longitudinal muscle-myenteric plexus of guinea-pig distal colon were studied in vitro. Preparations exhibited spontaneous contractions that were blocked by scopolamine (1 m...

journal_title：European journal of pharmacology

authors： Minocha A,Galligan JJ

更新日期：1993-01-12 00:00:00

abstract：:In the present study 12 of 13 untreated pigs died of ventricular fibrillation during three 10 min episodes of left anterior descending coronary artery occlusion interrupted by 20 min of reperfusion. The selective beta-adrenoceptor antagonist bevantolol in a dose of 1.5 mg X kg-1, but not 0.5 mg X kg-1, offered nearly ...

journal_title：European journal of pharmacology

authors： Verdouw PD,Van Bremen RH,Verkeste CM,Van der Giessen WJ

更新日期：1985-05-20 00:00:00

abstract：:An 8-arm radial maze task was used to assess the possible role of the opiate system in the spatial memory of the rat. Increasing doses of etonitazene (0.005-0.06 mg/kg i.p.) and morphine (2.5-100 mg/kg i.p.) significantly impaired performance in the working memory components of the task. For both drugs this impairment...

journal_title：European journal of pharmacology

authors： Braida D,Gori E,Sala M

更新日期：1994-12-27 00:00:00

abstract：:The effects of several slow channel blockers were compared on the normal fast action potentials (APs) and the slow APs of guinea pig Purkinje fibers. In spontaneously-firing Purkinje fibers perfused with normal Tyrode solution, mesudipine (analog of nifedipine) at 10(-7) and 10(-6) M, had no significant effect on the ...

journal_title：European journal of pharmacology

authors： Molyvdas PA,Sperelakis N

更新日期：1983-03-25 00:00:00

abstract：:MK-801, phenobarbital and clonazepam blocked convulsions elicited in mice by bicuculline. Treatment with Ro 15-1788 antagonized the anticonvulsant action of clonazepam, but not MK-801 or phenobarbital. The anticonflict effect in the rat of chlordiazepoxide, but not MK-801, was antagonized by Ro 15-1788. Despite having...

journal_title：European journal of pharmacology

authors： Clineschmidt BV

更新日期：1982-10-15 00:00:00

abstract：:The effect of the pro-inflammatory cytokine, interleukin-1beta on an NMDA receptor-independent form of synaptic plasticity brought about by the application of the K+ channel blocker tetraethylammonium, was examined in the rat dentate gyrus in vitro. Field excitatory postsynaptic potentials (EPSPs) were recorded from t...

journal_title：European journal of pharmacology

authors： Coogan AN,O'Connor JJ

更新日期：1999-06-18 00:00:00

abstract：:To determine whether a mu opioid agonist modulates the effects of a kappa opioid agonist in squirrel monkeys responding under a shock titration procedure, morphine was administered in combination with an ED75 dose of U50,488. Morphine (0.03-0.3 mg/kg) did not alter U50,488's early peak effects (15-25 min post-injectio...

journal_title：European journal of pharmacology

authors： Craft RM,Dykstra LA

更新日期：1993-04-06 00:00:00

abstract：:Receptor autoradiography was used to examine the distribution of muscarinic cholinoceptors ([3H]QNB), alpha 2-adrenoceptors ([3H]rauwolscine), beta-adrenoceptors ([125I]CYP) and substance P receptors ([125I]BHSP) in rabbit aorta, pulmonary artery, rat aorta, dog aorta, splenic, renal and coronary arteries, bovine aort...

journal_title：European journal of pharmacology

authors： Stephenson JA,Summers RJ

更新日期：1987-01-28 00:00:00

abstract：:The involvement of a central mechanism in the antiemetic effect of AS-8112 ((R)-5-bromo-N-(1-ethyl-4-methylhexahydro-1H-1,4-diazepin-6-yl)-2-methoxy-6-methylamino-3-pyridinecarboxamide x 2 fumarate), a novel and potent dopamine D2, D3, and 5-HT(3) receptor antagonist, was investigated in ferrets. Intracerebroventricul...

journal_title：European journal of pharmacology

authors： Yoshikawa T,Yoshida N,Oka M

更新日期：2001-11-23 00:00:00

abstract：:A cDNA clone coding for the guinea pig leukotriene B4 (BLT) receptor has been isolated from a lung cDNA library. The guinea pig BLT receptor has an open reading frame corresponding to 348 amino acids and shares 73% and 70% identity with human and mouse BLT receptors, respectively. Scatchard analysis of membranes prepa...

journal_title：European journal of pharmacology

authors： Boie Y,Stocco R,Sawyer N,Greig GM,Kargman S,Slipetz DM,O'Neill GP,Shimizu T,Yokomizo T,Metters KM,Abramovitz M

更新日期：1999-09-10 00:00:00

abstract：:We recently observed that the 5-hydroxytryptamine (5-HT)(1A) receptor antagonist N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)-cycloh exanecarboxamide (WAY 100635) enhanced antipsychotic-induced catalepsy, which we hypothesized to be due to a blockade of tonic 5-HT(1A) receptor activation. Here, we ex...

journal_title：European journal of pharmacology

authors： Prinssen EP,Koek W,Kleven MS

更新日期：2000-04-28 00:00:00

abstract：:The histamine H3 agonist, (R)-alpha-methylhistamine (alpha-MeHA, 10(-10) to 10(-5) M), caused a concentration-dependent inhibition of the sympathetic contractile response to electrical field stimulation of guinea pig isolated atria, but alpha-MeHA did not alter the basal tension or the contraction induced by exogenous...

journal_title：European journal of pharmacology

authors： Luo XX,Tan YH,Sheng BH

更新日期：1991-11-12 00:00:00

abstract：:Corticotropin-releasing factor (CRF) is a neurohormone that mediates stress, anxiety, and affects serotonergic activity. Studies have shown that CRF has dose-dependent opposing effects on serotonergic activity. This effect has been hypothesized to be differentially mediated by CRF(1) and CRF(2) receptors in the dorsal...

journal_title：European journal of pharmacology

authors： Lukkes JL,Forster GL,Renner KJ,Summers CH

更新日期：2008-01-14 00:00:00

abstract：:After incubation of rat cortical cell cultures with the human immunodeficiency virus type 1 (HIV-1) coat protein gp120 for 12 h, cells showed fragmentation of DNA at internucleosomal linkers, the characteristic feature of apoptosis. In a quantitative approach, it was determined that the percentage of DNA fragmentation...

journal_title：European journal of pharmacology

authors： Müller WE,Schröder HC,Ushijima H,Dapper J,Bormann J

更新日期：1992-07-01 00:00:00

abstract：:Aim of this study was to extend the knowledge on the antineoplastic effect of aloe-emodin (AE), a natural hydroxyanthraquinone compound, both in metastatic human melanoma cell lines and in primary stem-like cells (melanospheres). Treatment with AE caused reduction of cell proliferation and induction of SK-MEL-28 and A...

journal_title：European journal of pharmacology

authors： Tabolacci C,Cordella M,Turcano L,Rossi S,Lentini A,Mariotti S,Nisini R,Sette G,Eramo A,Piredda L,De Maria R,Facchiano F,Beninati S

更新日期：2015-09-05 00:00:00

abstract：:Reduced NO levels due to the deficiency of tetrahydrobiopterin (BH(4)) contribute to impaired vasodilation in pulmonary hypertension. Due to the chemically unstable nature of BH(4), it was hypothesised that oxidatively stable analogues of BH(4) would be able to support NO synthesis to improve endothelial dysfunction i...

journal_title：European journal of pharmacology

authors： Kunuthur SP,Milliken PH,Gibson CL,Suckling CJ,Wadsworth RM

更新日期：2011-01-10 00:00:00

abstract：:D-amino acid oxidase (DAAO) is an astroglial enzyme abundantly present in the pain sensing regions including brain and spinal cord. There have been studies indicating an upregulation and increased activity of DAAO in different pain models. Furthermore, the upregulation of DAAO also results in the development of morphi...

journal_title：European journal of pharmacology

authors： Sharma J,Kulshrestha R,Singh N,Jaggi AS

更新日期：2019-07-15 00:00:00

abstract：:Eight compounds that bind to the benzodiazepine binding site on the gamma-amino butyric acid(A) (GABA(A)) receptor were assessed for their influence on contextual memory, an aspect of memory affected in various cognitive disorders including Alzheimer's disease. Using a Pavlovian fear-conditioning paradigm, each ligand...

journal_title：European journal of pharmacology

authors： DeLorey TM,Lin RC,McBrady B,He X,Cook JM,Lameh J,Loew GH

更新日期：2001-08-24 00:00:00

abstract：:The Na(+)/Ca(2+)exchanger (NCX) principal function is taking 1 Ca(2+) out of the cytoplasm and introducing 3 Na(+). The increase of cytoplasmic Na(+) concentration induces the NCX reverse mode (NCX(REV)), favoring Ca(2+) influx. NCX(REV) can be inhibited by: KB-R7943 a non-specific compound that blocks voltage-depende...

journal_title：European journal of pharmacology

authors： Flores-Soto E,Reyes-García J,Sommer B,Chavez J,Barajas-López C,Montaño LM

更新日期：2012-01-15 00:00:00

abstract：:Pristinamycin IA is a cyclo-peptidic macrolactone antibiotic belonging to the streptogramin family. In the present work, the interaction of pristinamycin IA with the multidrug transporter P-glycoprotein was investigated in the differentiated human intestinal epithelial cell line Caco-2. Pristinamycin IA specifically i...

journal_title：European journal of pharmacology

authors： Phung-Ba V,Warnery A,Scherman D,Wils P

更新日期：1995-01-16 00:00:00

abstract：:In a recent study we have shown that it was possible to recognize and record two independent behavioural patterns elicited by apomorphine (s.c.): one behaviour characterized by increased locomotion, sniffing and repetitive head and limb movements and another, characterized by compulsive gnawing. In the present study w...

journal_title：European journal of pharmacology

authors： Ljungberg T,Ungerstedt U

更新日期：1977-11-15 00:00:00

abstract：:Thoracic preganglionic sympathetic nerve activity, blood pressure, heart rate and femoral arterial conductance were recorded in anaesthetised, paralysed cats. Cumulative dose-response curves were constructed for 8-OH-DPAT, ipsapirone and clonidine. All three drugs caused dose-related falls in blood pressure which were...

journal_title：European journal of pharmacology

authors： Ramage AG,Fozard JR

更新日期：1987-06-19 00:00:00

abstract：:The consequences of the consumption of cannabinoids with other drugs of abuse are of particular medical relevance. Several studies investigated the ability of cannabinoids to induce a locomotor cross-sensitization to other addictive drugs, but results remain inconsistent. Therefore, we investigated in mice the consequ...

journal_title：European journal of pharmacology

authors： Hagues G,Costentin J,Duterte-Boucher D

更新日期：2008-05-31 00:00:00

abstract：:The anticonvulsant activity of 1-methyl-1,2,3,4-tetrahydroisoquinoline (MeTHIQ--an endogenous parkinsonism-preventing substance) administered alone and in combination with four conventional antiepileptic drugs (carbamazepine, phenytoin, phenobarbital and valproate) was determined in the mouse maximal electroshock-indu...

journal_title：European journal of pharmacology

authors： Luszczki JJ,Antkiewicz-Michaluk L,Czuczwar SJ

更新日期：2009-01-14 00:00:00

abstract：:Statins are well-known inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, which block the mevalonate pathway. The activity of statins not only decreases cholesterol levels but also ameliorates inflammation and modulates the immune system. In this study, we investigated the effects of simvastatin ...

journal_title：European journal of pharmacology

authors： Sahid MNA,Liu S,Kiyoi T,Maeyama K

更新日期：2017-11-05 00:00:00

abstract：:The mechanisms underlying the hypothermic effect of ethanol have been investigated in rats. At an ambient temperature of 26 degrees C, at which tail skin blood flow will normally be expected to play a role in regulating core temperature, no change in tail cutaneous temperature occurred during the period in which the c...

journal_title：European journal of pharmacology

authors： Lomax P,Bajorek JG,Bajorek TA,Chaffee RR

更新日期：1981-05-22 00:00:00

abstract：:Epidermal growth factor (EGF) (10-100 ng ml-1) induced a rapidly developing relaxation of precontracted rabbit mesenteric artery rings within 30 min of exposure. Indomethacin or protein synthesis inhibitors prevented or acutely reversed the effect of EGF on the preparation and an erbstatin analogue significantly reduc...

journal_title：European journal of pharmacology

authors： Petitclerc E,Poubelle PE,Marceau F

更新日期：1994-06-23 00:00:00