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Class I mGlu receptor antagonist 1-aminoindan-1,5-dicarboxylic acid blocks contextual but not cue conditioning in rats.

Abstract：

:It is widely believed that metabotropic glutamate (mGlu) receptors play a potential role in memory formation. However, the particular function of different classes of mGluRs, or even subtypes, remains elusive. We show here that intraperitoneal injection of the class I selective antagonist 1-aminoindan-1,5-dicarboxylic acid (AIDA) in concentrations of 0.18 or 1.8 mg/kg 25 min prior to acquisition training blocks hippocampus-dependent contextual, but not hippocampus-independent cue, conditioning in rats. These data provide the first evidence for a specific role of mGlu receptors, class I in particular, in hippocampus-dependent learning tasks.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Nielsen KS,Macphail EM,Riedel G

doi

10.1016/s0014-2999(97)85402-7

subject

Has Abstract

pub_date

1997-05-20 00:00:00

pages

105-8

issue

2-3

eissn

0014-2999

issn

1879-0712

pii

S0014-2999(97)85402-7

journal_volume

326

pub_type

杂志文章

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