Lycopene, quercetin and tyrosol prevent macrophage activation induced by gliadin and IFN-gamma.

abstract：:The in vivo bronchoconstrictor effect of tachykinins in Fisher 344 rats is accompanied by release into the airways of 5-hydroxytryptamine (5-HT). 5-HT is possibly derived from mast cells. In the present study the presumed mast cell-tachykinin interaction was studied in isolated trachea from Fisher 344 rats. Contractio...

journal_title：European journal of pharmacology

authors： Joos GF,Lefebvre RA,Bullock GR,Pauwels RA

更新日期：1997-11-12 00:00:00

abstract：:The antagonist effects of ketanserin and 2'-methyl-4'-(5-methyl-1,2,4)oxadiazol-3-yl)-biphenyl-[4-carboxyli c acid 4-methoxy-3-(4-methyl-piperazin-1-yl)-phenyl]-amide (GR 127,935) were compared to naratriptan-induced inhibition of cAMP formation in C6-glial cell lines stably expressing human 5-HT1D or 5-HT1B receptor ...

journal_title：European journal of pharmacology

authors： Pauwels PJ,Colpaert FC

更新日期：1996-04-04 00:00:00

abstract：:Cumulative dose-response curves of Ca2+-induced tension increments were studied in K+-depolarized helical strips of dog coronary arteries. Adenosine 10(-4) M reduced the Ca2+ sensitivity of the strips without altering the maximal tension with full Ca2+ activation. In contrast, acidosis of pH 7.05 significantly diminis...

journal_title：European journal of pharmacology

authors： Turnheim K,Pittner H,Kolassa N,Kraupp O

更新日期：1977-01-21 00:00:00

abstract：:Pteropodine and isopteropodine are heteroyohimbine-type oxindole alkaloid components of Uncaria tomentosa (Willd.) DC, a Peruvian medicinal plant known as cat's claw. In this study, the effects of these alkaloids on the function of Ca(2+)-activated Cl(-) currents evoked by stimulation of G protein-coupled muscarinic M...

journal_title：European journal of pharmacology

authors： Kang TH,Matsumoto K,Tohda M,Murakami Y,Takayama H,Kitajima M,Aimi N,Watanabe H

更新日期：2002-05-24 00:00:00

abstract：:Pharmacokinetic and pharmacodynamic parameters of the selective serotonin reuptake inhibitor 1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-5-phtalancarbonitril (citalopram) were determined in order to find optimal conditions for augmentation of its effect on extracellular serotonin [5-hydroxytryptamine (5-HT)] through ...

journal_title：European journal of pharmacology

authors： Cremers TI,de Boer P,Liao Y,Bosker FJ,den Boer JA,Westerink BH,Wikström HV

更新日期：2000-05-26 00:00:00

abstract：:Citrus flavonoids are acknowledged for numerous pharmacological activities, including the myorelaxant effect on various smooth muscles. However, there is no data on their effect on jejunum contractility. Therefore, the aim of the study at hand was to evaluate the impact of hesperetin and diosmetin along with their gly...

journal_title：European journal of pharmacology

authors： Mendel M,Chłopecka M,Dziekan N,Karlik W

更新日期：2016-11-15 00:00:00

abstract：:Type 2 diabetes mellitus (T2DM) is one of the risk factors for Parkinson's disease (PD). Insulin desensitisation has been observed in the brains of patients, which may promote neurodegeneration. Incretins are a family of growth factors that can re-sensitise insulin signalling. We have previously shown that mimetics of...

journal_title：European journal of pharmacology

authors： Yuan Z,Li D,Feng P,Xue G,Ji C,Li G,Hölscher C

更新日期：2017-10-05 00:00:00

abstract：:A series of potent bombesin antagonists based on the reduced C-terminal peptide bond modification which in the past resulted in the first really potent antagonists are compared for effects on bombesin-stimulated amylase release from and binding to rat and guinea pig pancreatic acini. It was found that the original mem...

journal_title：European journal of pharmacology

authors： Coy D,Wang LH,Jiang NY,Jensen R

更新日期：1990-11-06 00:00:00

abstract：UNLABELLED:The influence of different nonsteroidal anti-inflammatory drugs (NSAIDs) and of a proton pump inhibitor on the healing parameters of a chronic gastric ulcer was evaluated. Wistar rats were used after the induction of a chronic acetic acid ulcer. The animals were treated orally for 8 and 15 days, twice daily,...

journal_title：European journal of pharmacology

authors： Berenguer B,Alarcón de la Lastra C,Moreno FJ,Martín MJ

更新日期：2002-05-03 00:00:00

abstract：:The mechanism by which dibutyryl cyclic AMP (db-cAMP) induces vasodilatation was examined in isolated rat aorta. The contraction induced by norepinephrine (NE) was more sensitive to the inhibitory effect of db-cAMP than that induced by high K+, and the contraction induced by lower concentrations of each stimulant was ...

journal_title：European journal of pharmacology

authors： Abe A,Karaki H

更新日期：1992-02-18 00:00:00

abstract：:The therapeutic efficacy of antidepressant drugs that inhibit the reuptake of serotonin (5-hydroxytryptamine, 5-HT) may be enhanced by blocking their indirect activation of 5-HT(1A) autoreceptors, which mediate feedback inhibition of serotonergic neuronal activity. In this study, we examined the effects of venlafaxine...

journal_title：European journal of pharmacology

authors： Bjorvatn B,Fornal CA,Martín FJ,Metzler CW,Jacobs BL

更新日期：2000-09-15 00:00:00

abstract：:Receptor for advanced glycation end-products (RAGE) is involved in the pathogenesis of diabetic nephropathy. FPS-ZM1, a selective RAGE inhibitor, in combination with valsartan were investigated for their protective potentials on the renal markers of tubular injury in streptozotocin-induced diabetic rats. Rats were ass...

journal_title：European journal of pharmacology

authors： Sanajou D,Ghorbani Haghjo A,Argani H,Roshangar L,Rashtchizadeh N,Ahmad SNS,Ashrafi-Jigheh Z,Bahrambeigi S,Asiaee F,Rashedi J,Aslani S

更新日期：2019-01-05 00:00:00

abstract：:We examined the effects of (+/-)-(E)-4-ethyl-2-[(E)-hydroxyimino]-5-nitro-3-hexenamide (FK409), a nitric oxide (NO) donor, on renal actions and norepinephrine overflow induced by renal nerve stimulation in anesthetized dogs, with or without N(G)-nitro-L-arginine (NOARG), a NO synthase inhibitor. Renal nerve stimulatio...

journal_title：European journal of pharmacology

authors： Tadano K,Matsuo G,Hashimoto T,Matsumura Y

更新日期：1998-01-12 00:00:00

abstract：:Rings of canine bronchi were suspended for isometric tension recording. Contractions produced by exogenously added acetylcholine were inhibited by pirenzepine and pancuronium. The pKB values were 6.76 for pirenzepine (calculated at 10(-6) M) and 5.30 and 5.13 for pancuronium (calculated at 10(-5) and 3 X 10(-5) M, res...

journal_title：European journal of pharmacology

authors： O'Rourke ST,Flavahan NA,Vanhoutte PM

更新日期：1987-08-04 00:00:00

abstract：:Pleurisy was induced in rats by an intrapleural injection of 0.5 ml of 1% kaolin. The exudation of plasma into the pleural cavity showed two peaks at 20 min and 3-5 h after the kaolin injection. The volume of the pleural fluid increased gradually up to 5 h. The effects of treatment with mepyramine, methysergide, capto...

journal_title：European journal of pharmacology

authors： Hori Y,Jyoyama H,Yamada K,Takagi M,Hirose K,Katori M

更新日期：1988-08-02 00:00:00

abstract：:Basic fibroblast growth factor (bFGF) is a heparin-binding polypeptide with potent trophic and protective effects on brain neurons, glia and endothelia. In previous studies, we showed that intravenously administered bFGF reduced the volume of cerebral infarcts following permanent occlusion of the middle cerebral arter...

journal_title：European journal of pharmacology

authors： Ren JM,Finklestein SP

更新日期：1997-05-26 00:00:00

abstract：:Recent studies have reported elevated expression levels in active rheumatoid arthritis patients of the cluster of differentiation (CD) 147 on CD14(+) peripheral blood monocytes and as a result, CD147 may be a target for the development of a novel rheumatoid arthritis therapy. This report describes the inhibitory effec...

journal_title：European journal of pharmacology

authors： Huang J,Xie B,Li Q,Xie X,Zhu S,Wang M,Peng W,Gu J

更新日期：2013-01-05 00:00:00

abstract：:Recently we have demonstrated that 20-hydroxy-5,8,11,14-eicosatetraenoic acid (20-HETE) constricts rat aortic rings and that this effect is cyclooxygenase- and endothelium-dependent. Incubation of 20-HETE with ram seminal vesicles, a rich source of cyclooxygenase, led to the identification of vasoconstrictor metabolit...

journal_title：European journal of pharmacology

authors： Escalante B,Omata K,Sessa W,Lee SG,Falck JR,Schwartzman ML

更新日期：1993-04-22 00:00:00

abstract：:Na+-H+ exchange inhibitors may reduce myocardial damage after reperfusion. However, their effects on microvascular deterioration are not known. We examined the potency of a novel Na+-H+ exchange inhibitor, SM-20550 [ N-(Aminoiminomethyl)-1,4-dimethyl-1H-indole-2-carboxamide methanesulfonate], and its effects on microv...

journal_title：European journal of pharmacology

authors： Ito Y,Imai S,Ui G,Nakano M,Imai K,Kamiyama H,Naganuma F,Matsui K,Ohashi N,Nagai R

更新日期：1999-06-25 00:00:00

abstract：:Influenza is a major disease in humans. The reemergence of avian influenza A viruses has indicated that hyperinflammatory responses are closely related to the severity of disease. Influenza virus infection induces nuclear transcription factor kappaB (NF-kappaB) activation. NF-kappaB and NF-kappaB-dependent gene produc...

journal_title：European journal of pharmacology

authors： Onose A,Hashimoto S,Hayashi S,Maruoka S,Kumasawa F,Mizumura K,Jibiki I,Matsumoto K,Gon Y,Kobayashi T,Takahashi N,Shibata Y,Abiko Y,Shibata T,Shimizu K,Horie T

更新日期：2006-07-17 00:00:00

abstract：:The use of antipsychotic medication has consistently been associated with serious side effects including weight gain and metabolic abnormalities. Strategies for mitigating these side effects have been tested, yet effective interventions have not been identified. The current study tested whether two recently identified...

journal_title：European journal of pharmacology

authors： Belanoff JK,Blasey CM,Clark RD,Roe RL

更新日期：2011-03-25 00:00:00

abstract：:The identity of the muscarinic receptor subtype in the chick ileum was investigated in functional and binding studies. Preliminary studies [Choo, L.-K., Mitchelson, F., Napier, P. 1988. J. Auton. Pharmacol. 8, 259-266] suggested apparent avian and mammalian family differences in the muscarinic receptor profile of ilea...

journal_title：European journal of pharmacology

authors： Darroch S,Irving HR,Mitchelson FJ

更新日期：2000-08-18 00:00:00

abstract：:Histone deacetylases (HDACs) can regulate cancer progression and its inhibitors (HDACIs) have been widely used for cancer therapy. Valproic acid (VPA, 2-propylpentanoic acid) can inhibit the class I HDAC and suppress the malignancy of solid cancers. Our present study revealed that 1 mM VPA, which has no effect on cell...

journal_title：European journal of pharmacology

authors： Zhang S,Tang Z,Qing B,Tang R,Duan Q,Ding S,Deng D

更新日期：2019-12-15 00:00:00

abstract：:The effects of tacrine (5 mg/kg i.p.) in lithium chloride (LiCl; 12 mEq/kg i.p.)-pretreated (24 h beforehand) animals and of kainate (10 mg/kg i.p.) on brain citrulline, the co-product of nitric oxide (NO) synthesis, were studied in rats. High performance liquid chromatography analysis of whole brain tissue homogenate...

journal_title：European journal of pharmacology

authors： Bagetta G,Rodinò P,Paoletti AM,Arabia A,Massoud R,Nisticò G

更新日期：1995-12-27 00:00:00

abstract：:Although cyclosporine A (CsA) is a potent immunomodulating agent and is commonly used as a systemic agent for the management of psoriasis patients, current clinical treatments are not always effective due to the clinical inefficacy of low-doses and numerous harmful effects of higher doses. Currently, the combined use ...

journal_title：European journal of pharmacology

authors： Kim CH,Kim JY,Lee AY

更新日期：2015-06-05 00:00:00

abstract：:In contrast to the pronounced fall in 5HT levels and synaptosomal uptake caused by p-chloroamphetamine, bilateral lesions of the B-9 cell group caused minimal regional changes, except for 35% decreases in the metathalamus-thalamus. We conclude therefore that the prolonged biochemical effects of p-chloroamphetamine are...

journal_title：European journal of pharmacology

authors： Massari VJ,Sanders-Bush E

更新日期：1975-09-01 00:00:00

abstract：:Primary cultures of rat cerebellar granule cells are shown to possess a high density (283 +/- 48 fmol/mg of protein) of muscarinic receptor sites, defined using N-[3H]methylscopolamine [( 3H]NMS), with a KD of 0.18 +/- 0.01 nM measured after culture in vitro for 7 days. Displacement of specific [3H]NMS binding demonst...

journal_title：European journal of pharmacology

authors： Whitham EM,Challiss RA,Nahorski SR

更新日期：1991-03-25 00:00:00

abstract：:Aminoguanidine is an inhibitor of inducible nitric oxide synthase (iNOS) and is of potential clinical usefulness. Treatment of mice with anti-Fas antibodies (150 microg/kg, i.v.) induced elevation of plasma alanine aminotransferase activity at 4 h and this elevation was inhibited by pretreatment of mice with aminoguan...

journal_title：European journal of pharmacology

authors： Okamoto T,Okabe S

更新日期：2000-09-08 00:00:00

abstract：:Alterations in iron homeostasis are well described in obese patients. The effects of iron chelators on adipose tissue and other organs affected by obesity have been the interest of experimental studies, both in vivo and in vitro. The aim of this review was to update the available information indicating the potential o...

journal_title：European journal of pharmacology

authors： Rodrigues de Morais T,Gambero A

更新日期：2019-10-15 00:00:00

abstract：:The physiological role of NPFF/FMRFa family of peptides appears to be complex and exact mechanism of action of these peptides is not yet completely understood. In same line of scrutiny, another analog of YGGFMKKKFMRFamide (YFa), a chimeric peptide of met-enkephalin and FMRFamide, was rationally designed and synthesize...

journal_title：European journal of pharmacology

authors： Vats ID,Chaudhary S,Sharma A,Nath M,Pasha S

更新日期：2010-07-25 00:00:00