Attenuation of hydrochlorothiazide-induced hypokalemia in dogs by a beta-adrenergic blocking drug, timolol.

abstract：:We discovered a novel compound, YM-126414 [1,3, 3-trimethyl-2-(2-phenylaminovinyl)-3H-indolium perchlorate], which stimulates glucose uptake in skeletal muscle cells in vitro. This compound increased the rate of consumption of glucose by C2C12 mouse myoblast cells in a dose-dependent manner (EC(50)=10 nM). To investig...

journal_title：European journal of pharmacology

authors： Shimokawa T,Kagami M,Kato M,Kurosaki E,Shibasaki M,Katoh M

更新日期：2000-12-20 00:00:00

abstract：:Isolated rat diaphragms were treated with the oxime HI-6, 25 min after the start of soman exposure for 5, 15, 20 or 25 min. Recovery of neuromuscular transmission (NMT) was smaller and the subsequent spontaneous failure of NMT greater when soman exposure was longer. Diaphragms taken from anaesthetized atropinized soma...

journal_title：European journal of pharmacology

authors： Van Helden HP,Wolthuis OL

更新日期：1983-05-06 00:00:00

abstract：:Discovery in the early 1990s of caveolin-1, the structural protein responsible for maintaining the ohm shape of caveolae, greatly enhanced investigations to elucidate the role of these little caves in the plasma membrane. Perhaps one of the most important realizations concerning caveolae and caveolin is that these ele...

journal_title：European journal of pharmacology

authors： Xu Y,Buikema H,van Gilst WH,Henning RH

更新日期：2008-05-13 00:00:00

abstract：:The characteristics of beta-adrenoceptors on frog and chick erythrocytes have been compared to those present on rat erythrocyte, lung and cerebral cortical membranes. The receptors have been examined using the specific ligand [3H]dihydroalprenolol ([3H]DHA) with conventional filtration techniques. The equilibrium diss...

journal_title：European journal of pharmacology

authors： Dickinson KE,Nahorski SR

更新日期：1981-08-27 00:00:00

abstract：:We have examined the effects of intrathecally (i.t.) administered CP-96,345, a non-peptide NK1 receptor ligand, on the spinal nociceptive flexor reflex and on the facilitation of this reflex evoked by i.t. substance P (SP), neurokinin A (NKA) and electrical conditioning stimulation of cutaneous C-afferents. CP-96,345 ...

journal_title：European journal of pharmacology

authors： Xu XJ,Dalsgaard CJ,Wiesenfeld-Hallin Z

更新日期：1992-06-17 00:00:00

abstract：:It has been shown previously that both forms of interleukin-1, 1 alpha and 1 beta, produce dose-dependent relaxation of the rat gastric fundus in vitro, accompanied by an increased production and release of eicosanoids. This effect appears to be mediated, at least in part, by leukotrienes, since the inhibition of 5-li...

journal_title：European journal of pharmacology

authors： Montuschi P,Tringali G,Mirtella A,Parente L,Preziosi P,Navarra P

更新日期：1995-02-24 00:00:00

abstract：:Accumulating evidence has suggested that Glypican-5 (GPC5) is a tumor suppressor gene in many types of cancers. However, whether GPC5 is involved in glioma remains unknown. This study was designed to explore the expression, biological function and regulatory mechanism of GPC5 in glioma. Our results demonstrated that G...

journal_title：European journal of pharmacology

authors： Hong X,Zhang Z,Pan L,Ma W,Zhai X,Gu C,Zhang Y,Bi X,Huang W,Pei H,Liu Z

更新日期：2019-07-05 00:00:00

abstract：:Ginger (rhizomes of Zingiber officinale) has been shown to exert potent anti-emetic properties, but its mode of action has not yet been elucidated. Among its active constituents, [6]-, [8]- and [10]-gingerol as well as [6]-shogaol were shown in different in vivo studies to be at least partly responsible for the drug's...

journal_title：European journal of pharmacology

authors： Abdel-Aziz H,Windeck T,Ploch M,Verspohl EJ

更新日期：2006-01-13 00:00:00

abstract：:The [3H]nitrendipine binding activity of sarcolemmal fragments isolated from aerobically perfused or ischemic rat hearts was studied. After 90 min aerobic perfusion, two populations of binding sites were detected--high affinity sites with KD of 0.24 +/- 0.04 nM and Bmax 313 +/- 110 fmol/mg protein, and low affinity si...

journal_title：European journal of pharmacology

authors： Nayler WG,Dillon JS,Elz JS,McKelvie M

更新日期：1985-09-10 00:00:00

abstract：:The effects of famotidine on the cardiac repolarization process were assessed using four different levels of test systems described in the draft stage guideline ICH S7B. A supratherapeutic concentration of famotidine (10(-5) M), which is >8 times higher than C(max) obtained after its therapeutic dose, neither inhibite...

journal_title：European journal of pharmacology

authors： Sugiyama A,Satoh Y,Takahara A,Nakamura Y,Shimizu-Sasamata M,Sato S,Miyata K,Hashimoto K

更新日期：2003-04-11 00:00:00

abstract：:To investigate a possible role of 8-isoprostaglandin F2alpha in inflammation, 8-isoprostaglandin F2alpha and prostaglandin E2 levels were determined by enzyme immunoassay (EIA) in carrageenan-induced air pouch model in rats. In this model, 8-isoprostaglandin F2alpha and prostaglandin E2 levels were found to be increas...

journal_title：European journal of pharmacology

authors： Ciçek Ozdöl N,Melli M

更新日期：2004-12-15 00:00:00

abstract：:Previous studies with both intact cells and ram seminal vesicles microsomes have shown that the specific PGHS-2 inhibitors NS-398 (N-[2-(cyclohexyloxy)-4-nitrophenyl]methanesulfonamide) and DuP-697 (5-bromo-2[4-fluorophenyl]-3-[4-methylsulfonylphenyl]-thiophene) attenuate the inhibition of PGHS-1 caused by aspirin and...

journal_title：European journal of pharmacology

authors： Burde T,Rimon G

更新日期：2002-10-25 00:00:00

abstract：:A substantial proportion of depressed patients do not respond to current antidepressant drug therapies. So far, antidepressant drugs have been developed based on the "monoaminergic hypothesis" of depression, which considers a synaptic deficiency in 5-hydroxytryptamine (5-HT; serotonin) or noradrenaline as main cause. ...

journal_title：European journal of pharmacology

authors： Leggio GM,Salomone S,Bucolo C,Platania C,Micale V,Caraci F,Drago F

更新日期：2013-11-05 00:00:00

abstract：:Partial bladder outlet obstruction of the pig is considered as a valuable preclinical model for evaluating the profile of compounds for the treatment of bladder overactivity. In this study, we characterized the pharmacological properties of isolated bladder smooth muscle from pigs following partial outlet obstruction ...

journal_title：European journal of pharmacology

authors： Milicic I,Buckner SA,Daza A,Coghlan M,Fey TA,Brune ME,Gopalakrishnan M

更新日期：2006-02-17 00:00:00

abstract：:We have investigated the effects of the ethacrynic acid derivative 4-(2-butyl-6,7-dichloro-2-cyclopentyl-indan-1-on-5-yl) oxobutyric acid (DCPIB), an inhibitor of the volume-sensitive anion channel (VSAC), on electrical activity and insulin secretion in rat pancreatic beta-cells. DCPIB inhibited whole-cell VSAC curren...

journal_title：European journal of pharmacology

authors： Best L,Yates AP,Decher N,Steinmeyer K,Nilius B

更新日期：2004-04-05 00:00:00

abstract：:The administration of ethyl beta-carboline-3-carboxylate (beta-CCE), a ligand for benzodiazepine receptors, did not affect the cerebellar cyclic GMP level in mice, but giving beta-CCE together with diazepam significantly inhibited the diazepam-induced decrease in cyclic GMP. The fact that no antagonism was observed wh...

journal_title：European journal of pharmacology

authors： Fujimoto M,Kawasaki K,Matsushita A,Okabayashi T

更新日期：1982-05-21 00:00:00

abstract：:The tolerance to analgesia and dependence liability of dihydroetorphine following topical application were investigated in hairless rats with and without formalin-induced inflammation. The analgesic effect of dihydroetorphine (s.c.) was 4600- to 7200-fold more potent than that of morphine. In non-inflamed rats, the an...

journal_title：European journal of pharmacology

authors： Ohmori S,Fang L,Kawase M,Saito S,Morimoto Y

更新日期：2001-07-06 00:00:00

abstract：:Cocaine interacts with sigma receptors, suggesting that these sites are important for many of its behavioral effects. Therefore, two novel sigma receptor ligands, BD1008 (N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-2-(1-pyrrolidinyl)ethylamine) and BD1063 (1-[2-(3,4-dichlorophenyl)ethyl]-4-methylpiperazine), were evaluat...

journal_title：European journal of pharmacology

authors： McCracken KA,Bowen WD,Matsumoto RR

更新日期：1999-01-15 00:00:00

abstract：:Tibolone is a synthetic steroid that has been extensively prescribed to treat climacteric symptoms and to prevent postmenopausal osteoporosis. Because menopause is a condition associated with increased incidence of metabolic disturbances and hepatic steatosis, the aim of this work was to evaluate the actions of tibolo...

journal_title：European journal of pharmacology

authors： de Oliveira MC,Martins-Maciel ER,Comar JF,Yamamoto NS,Bracht A,Ishii-Iwamoto EL,Salgueiro-Pagadigorria CL

更新日期：2011-10-01 00:00:00

abstract：:Statin medications diminish cholesterol biosynthesis and are commonly prescribed to reduce cardiovascular disease. Statins also reduce production of ubiquinol, a vital component of mitochondrial energy production; ubiquinol reduction may contribute to rhabdomyolysis. Human rhabdomyosarcoma cells were treated with eith...

journal_title：European journal of pharmacology

authors： Vaughan RA,Garcia-Smith R,Bisoffi M,Conn CA,Trujillo KA

更新日期：2013-07-05 00:00:00

abstract：:ATP, ADP, adenosine and AMP, but not adenine, inosine, or GMP, caused dose-related intestinal contractions when injected as intra-arterial bolus doses in vascularly perfused isolated segments of dog small bowel. The stimulatory effects of these agents were decreased by receptor densitization during exposure to high co...

journal_title：European journal of pharmacology

authors： Northway MG,Burks TF

更新日期：1980-07-11 00:00:00

abstract：:Pulmonary artery rings were prepared from rats (group I to VI, n = 5-7 per group) in order to investigate if a beta-adrenoceptor antagonist interferes with the effect of alpha-adrenoceptor blockade. In I, four cumulative noradrenaline (NA) dose-response curves (10(-9) to 10(-3) M) were constructed. In II, NA curves we...

journal_title：European journal of pharmacology

authors： Abdelrahman A,Nguyen H,Pang CC

更新日期：1990-05-31 00:00:00

abstract：:Gender-related differences in susceptibility to stress and stress-related disorders such as depression, and in response to treatment with antidepressants have been observed, but the underlying molecular mechanisms are still unknown. Considering the role of glucocorticoid hormones in the systemic reaction against stres...

journal_title：European journal of pharmacology

authors： Elaković I,Brkljacić J,Matić G

更新日期：2009-04-17 00:00:00

abstract：:A deamination product of histidine, urocanic acid, accumulates in the skin of mammals as trans-urocanic acid. Ultraviolet (UV) irradition converts it to the cis-isomer that is an important mediator in UV-induced immunosuppression. We have recently shown that urocanic acid interferes with the agonist binding to GABA(A)...

journal_title：European journal of pharmacology

authors： Uusi-Oukari M,Soini SL,Heikkilä J,Koivisto A,Neuvonen K,Pasanen P,Sinkkonen ST,Laihia JK,Jansén CT,Korpi ER

更新日期：2000-07-14 00:00:00

abstract：:Patients with somatic mutations of epigenetic regulators are characterized by aberrant chromatin modification patterns. Recent mechanistic studies pairing chemical tool compounds and deep-sequencing technology have greatly broadened our understanding of epigenetic regulation in glioma progression and underpinned alter...

journal_title：European journal of pharmacology

authors： Chen YH,Zeng WJ,Wen ZP,Cheng Q,Chen XP

更新日期：2018-08-15 00:00:00

abstract：:A few decades ago, cardiac muscle was discovered to possess signalling pathways that, when activated, protect the myocardium against the damage induced by ischaemia-reperfusion. The ability of cardiac muscle to protect itself against injury has been termed 'cardioprotection'. Many compounds and procedures can trigger ...

journal_title：European journal of pharmacology

authors： Jovanović A

更新日期：2018-08-15 00:00:00

abstract：:Antinociceptive effects of various neuroleptics in animal acute pain-models have been described, mediated trough different pathways including the opioid system. In this study, we assessed the antinociceptive effects of the atypical neuroleptic drug amisulpride, which acts as a selective blocker of dopamine D2 and D3 r...

journal_title：European journal of pharmacology

authors： Weizman T,Pick CG,Backer MM,Rigai T,Bloch M,Schreiber S

更新日期：2003-10-08 00:00:00

abstract：:Although carbetapentane produces skin (peripheral) infiltrative analgesia, the underlying mechanism of carbetapentane in local anesthesia is not well understood. The purpose of the study was to examine the effect of carbetapentane on voltage-gated Na(+) channels and its efficacy on spinal (central) anesthesia. We eval...

journal_title：European journal of pharmacology

authors： Leung YM,Tzeng JI,Kuo CS,Chen YW,Chu CC,Wang JJ

更新日期：2013-08-15 00:00:00

abstract：:Donepezil (E2020) is a novel cholinesterase inhibitor for the treatment of Alzheimer's disease. Recent studies show that it may act on targets other than acetylcholinesterase in the brain. In the present study, the actions of donepezil on voltage-gated Na+ and K+ channels were investigated in rat dissociated hippocamp...

journal_title：European journal of pharmacology

authors： Yu B,Hu GY

更新日期：2005-01-31 00:00:00

abstract：:Galantamine is a reversible inhibitor of acetylcholinesterase and an allosteric-potentiating ligand of the nicotinic acetylcholine receptors. It is used for treating mild-to-moderate Alzheimer's disease. Interestingly, QT interval prolongation on the electrocardiogram (ECG), malignant ventricular arrhythmias and synco...

journal_title：European journal of pharmacology

authors： Vigneault P,Bourgault S,Kaddar N,Caillier B,Pilote S,Patoine D,Simard C,Drolet B

更新日期：2012-04-15 00:00:00