Abstract：
:[D-Met2,Pro5]enkephalinamide (DMPEA) strongly activated cardioinhibitory vagal efferents and elicited bradycardia when perfused through the cerebroventricular system of anaesthetized dogs. These effects were concentration-dependent but plateaued at an intraventricular concentration of 200 micrograms/ml. At this maximally effective concentration, the vagal discharge rate was fourfold higher and the heart rate was lowered by 28% compared to the controls. These effects were reversed by naloxone (40 micrograms/ml). There was no significant change in blood pressure. Vagal discharge rate and heart rate correlated closely and inversely with each other with r values ranging between -0.75 and -0.95. Opiate receptors in brain structures bordering the cerebroventricular system are the most likely mediators of the effects of DMPEA. The opiate receptor/endorphin system may therefore play a role in the physiological control of cardiac vagal tone and thus of heart rate.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Inoue K,Nashan B,Arndt JOdoi
10.1016/0014-2999(85)90216-xsubject
Has Abstractpub_date
1985-04-02 00:00:00pages
233-9issue
2eissn
0014-2999issn
1879-0712pii
0014-2999(85)90216-Xjournal_volume
110pub_type
杂志文章abstract：:The adenosine A(2A) receptor in the basal ganglia is involved in the control of movement and plays a role in movement disorders such as Parkinsonism. Developing ligands to evaluate that receptor by noninvasive methods such as positron emission tomography has a high priority. In vitro radioligand binding guides the sel...
journal_title：European journal of pharmacology
pub_type： 杂志文章
doi：10.1016/j.ejphar.2009.06.025
更新日期：2009-08-15 00:00:00
abstract：:The suppression of pro-inflammatory cytokine-induced inflammation responses is an attractive pharmacological target for the development of therapeutic strategies for inflammatory bowel disease (IBD). In the present study, we evaluated the anti-inflammatory properties of flavonoid isoliquiritigenin (ISL) in intestinal ...
journal_title：European journal of pharmacology
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更新日期：2017-02-05 00:00:00
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journal_title：European journal of pharmacology
pub_type： 杂志文章
doi：10.1016/0014-2999(95)00129-9
更新日期：1995-06-12 00:00:00
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journal_title：European journal of pharmacology
pub_type： 杂志文章
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更新日期：2008-02-12 00:00:00
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journal_title：European journal of pharmacology
pub_type： 杂志文章
doi：10.1016/s0014-2999(00)00383-6
更新日期：2000-07-07 00:00:00
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journal_title：European journal of pharmacology
pub_type： 杂志文章
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更新日期：1999-06-11 00:00:00
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journal_title：European journal of pharmacology
pub_type： 杂志文章
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更新日期：1991-05-17 00:00:00
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journal_title：European journal of pharmacology
pub_type： 杂志文章,评审
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更新日期：2019-04-15 00:00:00
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journal_title：European journal of pharmacology
pub_type： 杂志文章
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更新日期：1999-02-19 00:00:00
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journal_title：European journal of pharmacology
pub_type： 杂志文章
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更新日期：1994-06-02 00:00:00
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journal_title：European journal of pharmacology
pub_type： 杂志文章
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更新日期：1994-05-17 00:00:00
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journal_title：European journal of pharmacology
pub_type： 杂志文章
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更新日期：2017-11-15 00:00:00
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journal_title：European journal of pharmacology
pub_type： 杂志文章
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更新日期：2000-11-03 00:00:00
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journal_title：European journal of pharmacology
pub_type： 杂志文章
doi：10.1016/0014-2999(93)90147-a
更新日期：1993-04-28 00:00:00
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journal_title：European journal of pharmacology
pub_type： 杂志文章
doi：10.1016/s0014-2999(00)00367-8
更新日期：2000-07-07 00:00:00
abstract：:The antiatherosclerotic effect of statins has been attributed to their hypocholesterolemic action. We therefore evaluated the effect, in vitro, of the addition of the serum of patients taking fluvastatin on human smooth muscle cells in order to ascertain the effect of the drug on cell proliferation and apoptosis. We f...
journal_title：European journal of pharmacology
pub_type： 杂志文章
doi：10.1016/s0014-2999(99)00122-3
更新日期：1999-04-09 00:00:00
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journal_title：European journal of pharmacology
pub_type： 杂志文章
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更新日期：1990-07-31 00:00:00
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journal_title：European journal of pharmacology
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pub_type： 杂志文章
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更新日期：2010-12-01 00:00:00
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journal_title：European journal of pharmacology
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更新日期：2000-10-13 00:00:00
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journal_title：European journal of pharmacology
pub_type： 杂志文章
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journal_title：European journal of pharmacology
pub_type： 杂志文章
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更新日期：2012-02-29 00:00:00
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journal_title：European journal of pharmacology
pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：European journal of pharmacology
pub_type： 杂志文章
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更新日期：1989-06-20 00:00:00
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journal_title：European journal of pharmacology
pub_type： 杂志文章
doi：10.1016/0014-2999(96)00040-4
更新日期：1996-04-11 00:00:00
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journal_title：European journal of pharmacology
pub_type： 杂志文章
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更新日期：2015-10-05 00:00:00
abstract：:The presence of neuronal nicotinic acetylcholine receptors in rabbit corpus cavernosum tissue and possible mechanisms underlying the potentiation of electrical field stimulation induced relaxation by nicotine were analyzed. In corpus cavernosum tissue strips nicotine (3 x 10(-5) M) and acetylcholine (10(-3) M) produce...
journal_title：European journal of pharmacology
pub_type： 杂志文章
doi：10.1016/j.ejphar.2006.11.053
更新日期：2007-03-08 00:00:00
abstract：:Effluents from perfused acetylcholine-relaxed endothelium segments of rabbit aorta (or canin femoral artery) contained endothelium-derived relaxing factors (EDRF) which dilated the endothelium-free segments of rabbit femoral artery (or side branches of canine femoral artery). The half-life of EDRF was 24 +/- 3 s for t...
journal_title：European journal of pharmacology
pub_type： 杂志文章
doi：10.1016/0014-2999(84)90071-2
更新日期：1984-11-27 00:00:00
