Abstract:
:We report here the synergistic antithrombotic effect of aurintricarboxylic acid in combination with a snake venom-derived disintegrin, triflavin, in a photochemically induced thrombosis model in rats. The time to initiation of thrombus was prolonged by i.v. bolus injection of aurintricarboxylic acid at 10 mg/kg. In contrast, time to occlusion was dose-dependently prolonged by both agents, this prolongation being significant with aurintricarboxylic acid at 10 mg/kg i.v. and with triflavin at more than 3 mg/kg i.v. Interestingly, the combination of aurintricarboxylic acid at 3 mg/kg i.v. and triflavin at 1 mg/kg i.v. prolonged not only the initiation of thrombus, but also the time to occlusion.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Hisamichi N,Kawasaki T,Suzuki K,Kaku S,Sakai Y,Taniuchi Y,Sato K,Inagaki O,Tomioka K,Yanagisawa I,Takenaka T,Yanagi K,Ohshima Ndoi
10.1016/0014-2999(96)00547-xsubject
Has Abstractpub_date
1996-09-19 00:00:00pages
69-73issue
1eissn
0014-2999issn
1879-0712pii
001429999600547Xjournal_volume
312pub_type
杂志文章abstract::Pentoxifylline, a methylxanthine derivative, has been widely used to improve erythrocyte deformability and capillary blood circulation in patients with claudication and cerebrovascular disorders as well as in animals with sepsis. Here, we investigate the effects of pentoxifylline on the hypotension, vascular hyporeact...
journal_title:European journal of pharmacology
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