Participation of branched-chain amino acid analogues in multivalent repression.

Abstract:

:Two isoleucine analogues and two leucine analogues were examined for their ability to replace the natural amino acid preventing the accumulation of threonine deaminase-forming potential. The procedure used to study repression by the analogues distinguishes between true repression and the formation of inactive enzyme by the analogue in question. The leucine analogue 4-azaleucine was found to replace leucine in multivalent repression of threonine deaminase-forming potential in Escherichia coli but not in Salmonella typhimurium. Another leucine analogue, trifluoroleucine, was only partially effective in causing repression in either organism. The isoleucine analogue 4-azaisoleucine was ineffective in replacing isoleucine in repression. In contrast, 4-thiaisoleucine effectively replaced isoleucine in the repression of threonine deaminase-forming potential in S. typhimurium and E. coli.

journal_name

J Bacteriol

journal_title

Journal of bacteriology

authors

Wasmuth JJ,Umbarger HE

doi

10.1128/JB.116.2.562-570.1973

subject

Has Abstract

pub_date

1973-11-01 00:00:00

pages

562-70

issue

2

eissn

0021-9193

issn

1098-5530

journal_volume

116

pub_type

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