A comparison of Fe 4 S 4 clusters in high-potential iron protein and in ferredoxin.

abstract：:For the design of potent subunit vaccines, it is of paramount importance to identify all antigens immunologically recognized by a patient population infected with a pathogen. We have developed a rapid and efficient procedure to identify such commonly recognized antigens, and here we provide a comprehensive in vivo ant...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Etz H,Minh DB,Henics T,Dryla A,Winkler B,Triska C,Boyd AP,Söllner J,Schmidt W,von Ahsen U,Buschle M,Gill SR,Kolonay J,Khalak H,Fraser CM,von Gabain A,Nagy E,Meinke A

更新日期：2002-05-14 00:00:00

abstract：:Quinate:NAD(+) 3-oxidoreductase (EC 1.1.1.24) from carrot cell suspension cultures has previously been shown to be activated by phosphorylation and inactivated by dephosphorylation. Here it is shown that the reactivation of the inactivated quinate:NAD(+) oxidoreductase is an enzyme-mediated process that requires ATP a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ranjeva R,Refeno G,Boudet AM,Marmé D

更新日期：1983-09-01 00:00:00

abstract：:When propagated on arl strains (a subclass of Escherichia coli hyper-rec mutants), lambda "Red-" duplication phages accumulated an enhanced potential for recombination. The physical properties of the recombinogenic phages thus obtained ("Arl-" phages) were similar to those of phages grown on arl+ bacteria. However, Ar...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hays JB,Korba BE

更新日期：1979-12-01 00:00:00

abstract：:The human Thy-1 gene has been isolated and sequenced and compared to the rat and mouse Thy-1 genes. All three genes are organized in the same way: one exon encoding the majority of the signal peptide, another encoding the transmembrane segment, and a third encoding the remainder of the protein. One major structural di...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seki T,Spurr N,Obata F,Goyert S,Goodfellow P,Silver J

更新日期：1985-10-01 00:00:00

abstract：:Inactivation of the p53 pathway represents the most common molecular defect of human cancer. But in the setting of melanoma, a highly aggressive and invariably fatal malignancy in its advanced disseminated form, mutation/deletion of p53 is relatively rare, whereas its positive regulator ARF is often lost. Here, we sho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ha L,Ichikawa T,Anver M,Dickins R,Lowe S,Sharpless NE,Krimpenfort P,Depinho RA,Bennett DC,Sviderskaya EV,Merlino G

更新日期：2007-06-26 00:00:00

abstract：:One of the major surprises of the molecular analysis of major histocompatibility complex (MHC) genes is the large number of class I (K/D)-related sequences in the genome. Both restriction fragment length polymorphisms and cosmid cloning experiments showed them all to be closely linked to the MHC. Until now little info...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schepart BS,Woodward JG,Palmer MJ,Macchi MJ,Basta P,McLaughlin-Taylor E,Frelinger JA

更新日期：1985-08-01 00:00:00

abstract：:Rare high-3He/4He signatures in ocean island basalts (OIB) erupted at volcanic hotspots derive from deep-seated domains preserved in Earth's interior. Only high-3He/4He OIB exhibit anomalous 182W-an isotopic signature inherited during the earliest history of Earth-supporting an ancient origin of high 3He/4He. However,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jackson MG,Blichert-Toft J,Halldórsson SA,Mundl-Petermeier A,Bizimis M,Kurz MD,Price AA,Harðardóttir S,Willhite LN,Breddam K,Becker TW,Fischer RA

更新日期：2020-12-08 00:00:00

abstract：:Experimental lemurs either were infected orally with the agent of bovine spongiform encephalopathy (BSE) or were maintained as uninfected control animals. Immunohistochemical examination for proteinase-resistant protein (prion protein or PrP) was performed on tissues from two infected but still asymptomatic lemurs, ki...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bons N,Mestre-Frances N,Belli P,Cathala F,Gajdusek DC,Brown P

更新日期：1999-03-30 00:00:00

abstract：:The global prevalence of prediabetes and type 2 diabetes (T2D) is increasing, and it is contributing to the susceptibility to diabetes and its related epidemic in offspring. Although the impacts of paternal impaired fasting blood glucose and glucose intolerance on the metabolism of offspring have been well established...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wei Y,Yang CR,Wei YP,Zhao ZA,Hou Y,Schatten H,Sun QY

更新日期：2014-02-04 00:00:00

abstract：:Small molecules produced by Actinobacteria have played a prominent role in both drug discovery and organic chemistry. As part of a larger study of the actinobacterial symbionts of fungus-growing ants, we discovered a small family of three previously unreported piperazic acid-containing cyclic depsipeptides, gerumycins...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sit CS,Ruzzini AC,Van Arnam EB,Ramadhar TR,Currie CR,Clardy J

更新日期：2015-10-27 00:00:00

abstract：:Stable isotope values of carbon (delta13C) and nitrogen (delta15N) in blood, feathers, eggshell, and bone have been used in seabird studies since the 1980s, providing a valuable source of information on diet, foraging patterns, and migratory behavior in these birds. These techniques can also be applied to fossil mater...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Emslie SD,Patterson WP

更新日期：2007-07-10 00:00:00

abstract：:Cell cycle progression is tightly regulated by cyclin-dependent kinases (CDKs). The ankyrin-repeat protein p19INK4d functions as a key regulator of G1/S transition; however, its molecular mode of action is unknown. Here, we combine cell and structural biology methods to unravel the mechanism by which p19INK4d controls...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kumar A,Gopalswamy M,Wolf A,Brockwell DJ,Hatzfeld M,Balbach J

更新日期：2018-03-27 00:00:00

abstract：:Dead and dying cells release nucleic acids. These extracellular RNAs and DNAs can be taken up by inflammatory cells and activate multiple nucleic acid-sensing toll-like receptors (TLR3, 7, 8, and 9). The inappropriate activation of these TLRs can engender a variety of inflammatory and autoimmune diseases. The redundan...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee J,Sohn JW,Zhang Y,Leong KW,Pisetsky D,Sullenger BA

更新日期：2011-08-23 00:00:00

abstract：:There has been recent experimental support for efficiency wage theories of the labor market. This short paper initiates the larger process of evaluating the boundary conditions of the gift- exchange phenomenon. In particular, we will see whether behavior consistent with the fair wage-effort hypothesis can emerge and b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rigdon ML

更新日期：2002-10-01 00:00:00

abstract：:Overexpression of membrane proteins in Escherichia coli frequently leads to the formation of aggregates or inclusion bodies, which is undesirable for most studies. Ideally, one would like to optimize the expression conditions by monitoring simultaneously and rapidly both the amounts of properly folded and aggregated m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Geertsma ER,Groeneveld M,Slotboom DJ,Poolman B

更新日期：2008-04-15 00:00:00

abstract：:The delivery of AMPA receptors to the plasma membrane is a critical step both for the synaptic delivery of these receptors and for the regulation of synaptic transmission. To directly visualize fusion events of transport vesicles containing the AMPA receptor GluA2 subunit with the plasma membrane we used pHluorin-tagg...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Araki Y,Lin DT,Huganir RL

更新日期：2010-06-15 00:00:00

abstract：:Newly formed hepatic granulomas around Schistosoma mansoni eggs become progressively smaller during the chronic (greater than or equal to 15 weeks after infection) phase of the disease. This reduction in granuloma size, termed "modulation," is known to be caused in part by a T lymphocyte that can adoptively transfer m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Green WF,Colley DG

更新日期：1981-02-01 00:00:00

abstract：:A graph-theoretic condition is given for the existence of stable solutions to the Volterra-Lotka equations. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yorke JA,Anderson WN

更新日期：1973-07-01 00:00:00

abstract：:Certain Escherichia coli mutants defective in phosphatidylglycerol biosynthesis accumulate two novel glycolipids, designated X and Y. Lipid X is a diacylglucosamine 1-phosphate bearing beta-hydroxymyristoyl groups at positions 2 and 3, and lipid Y has the same structure as X, except for the additional presence of a pa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nishijima M,Amano F,Akamatsu Y,Akagawa K,Tokunaga T,Raetz CR

更新日期：1985-01-01 00:00:00

abstract：:Two formal models of clonal attenuation [Kirkwood, T. B. L. & Holliday, R. (1975) J. Theor. Biol. 53, 481-496; Shall, S. & Stein, W. D. (1979) J. Theor. Biol. 76, 219-231] are considered in the light of recent data on the changing distribution of replicative potential among individual cultured fibroblasts on subclonin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Prothero J,Gallant JA

更新日期：1981-01-01 00:00:00

abstract：:WE REEXAMINED TWO QUESTIONS CONCERNING LYT ANTIGENS OF CYTOTOXIC T CELLS OF THE MOUSE: is Lyt-1 antigen expressed on cytotoxic effector cells and can cytotoxicity be blocked by antibody to Lyt antigens in the absence of added complement? A 3-hr (51)Cr-release assay with splenic effector cells and leukemia or myeloma t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nakayama E,Shiku H,Stockert E,Oettgen HF,Old LJ

更新日期：1979-04-01 00:00:00

abstract：:There exist a limited but growing number of biological metal centers whose properties lie conspicuously outside the realm of known inorganic chemistry. The synthetic analogue approach, broadly directed, offers a powerful exploratory tool that can define intrinsic chemical possibilities for these sites while simultaneo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee SC,Holm RH

更新日期：2003-04-01 00:00:00

abstract：:In all photosynthetic organisms, light energy is used to drive electrons from a donor chlorophyll species via a series of acceptors across a biological membrane. These light-induced electron-transfer processes display a remarkably high quantum efficiency, indicating a near-complete inhibition of unproductive charge re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Makita H,Hastings G

更新日期：2017-08-29 00:00:00

abstract：:The x-ray structure of rubredoxin has been refined by energy minimization. The computed structure is constrained to have standard bond lengths, bond angles, and planar trans peptide groups. Also, since most of the steric overlaps have been relieved, it has a very low energy. As judged by the root mean square (RMS) dev...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rasse D,Warme PK,Scheraga HA

更新日期：1974-09-01 00:00:00

abstract：:Although aminoacyl-tRNA synthetases (ARSs) are essential for protein synthesis, they also function as regulators and signaling molecules in diverse biological processes. Here, we screened 11 different human ARSs to identify the enzyme that is secreted as a signaling molecule. Among them, we found that lysyl-tRNA synth...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Park SG,Kim HJ,Min YH,Choi EC,Shin YK,Park BJ,Lee SW,Kim S

更新日期：2005-05-03 00:00:00

abstract：:In the retina, dopamine plays a central role in neural adaptation to light. Progress in the study of dopaminergic amacrine (DA) cells has been limited because they are very few (450 in each mouse retina, 0.005% of retinal neurons). Here, we applied transgenic technology, single-cell global mRNA amplification, and cDNA...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gustincich S,Contini M,Gariboldi M,Puopolo M,Kadota K,Bono H,LeMieux J,Walsh P,Carninci P,Hayashizaki Y,Okazaki Y,Raviola E

更新日期：2004-04-06 00:00:00

abstract：:Tobacco mosaic virus (TMV) was reconstituted from the RNA of a common strain (OM) and the protein of a watermelon strain of cucumber green mottle mosaic virus (CGMMV-W), which is a member of the tobamovirus group. In 0.25 M phosphate buffer at 25 degrees C, CGMMV-W protein existed mainly as 21S aggregates. When this p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fukuda M,Okada Y

更新日期：1982-10-01 00:00:00

abstract：:A vestigial, nonphotosynthetic plastid has been identified recently in protozoan parasites of the phylum Apicomplexa. The apicomplexan plastid, or "apicoplast," is indispensable, but the complete sequence of both the Plasmodium falciparum and Toxoplasma gondii apicoplast genomes has offered no clue as to what essentia...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Waller RF,Keeling PJ,Donald RG,Striepen B,Handman E,Lang-Unnasch N,Cowman AF,Besra GS,Roos DS,McFadden GI

更新日期：1998-10-13 00:00:00

abstract：:Previous studies have shown changes in membrane properties of neurons in rat deep cerebellar nuclei (DCN) as a function of development, but due to technical difficulties in obtaining viable DCN slices from adult animals, it remains unclear whether there are learning-related alterations in the membrane properties of DC...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang D,Smith-Bell CA,Burhans LB,O'Dell DE,Bell RW,Schreurs BG

更新日期：2018-10-02 00:00:00

abstract：:The genes encoding the histone acetyl-transferases (HATs) CREB binding protein (CREBBP) and EP300 are recurrently mutated in the activated B cell-like and germinal center (GC) B cell-like subtypes of diffuse large B cell lymphoma (DLBCL). Here, we introduced a patient mutation into a human DLBCL cell line using CRISPR...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hashwah H,Schmid CA,Kasser S,Bertram K,Stelling A,Manz MG,Müller A

更新日期：2017-09-05 00:00:00