Cross-pathway regulation: histidine-mediated control of histidine, tryptophan, and arginine biosynthetic enzymes in Neurospora crassa.

Abstract:

:In Neurospora crassa, histidine starvation of histidine mutants resulted in derepression of histidine, tryptophan, and arginine biosynthetic enzymes. The same tripartite derepression occurred in wild-type strain 74A when it was grown in medium supplemented with 3-amino-1,2,4-triazole, an inhibitor of histidine biosynthesis. Histidine-mediated derepression of tryptophan and arginine biosynthetic enzymes was not due to a lowered intracellular concentration of tryptophan or arginine, respectively. A discussion of possible mechanisms and of similar studies in prokaryotic and eukaryotic organisms is presented.

journal_name

J Bacteriol

journal_title

Journal of bacteriology

authors

Carsiotis M,Jones RF,Wesseling AC

doi

10.1128/JB.119.3.893-898.1974

subject

Has Abstract

pub_date

1974-09-01 00:00:00

pages

893-98

issue

3

eissn

0021-9193

issn

1098-5530

journal_volume

119

pub_type

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