Induced sensitization of normal laboratory animals to Brucella abortus endotoxin.

Abstract:

:A Boivin preparation of Brucella abortus, unlike common enterobacterial endotoxins, failed to depress water intake or increase numbers of hemolysin-producing spleen cells in mice, or to cause delayed inflammatory reactions in rabbit skin. Reactivity to the B. abortus endotoxin was found only in animals which were previously given the endotoxin with, but not necessarily in, complete Freund's adjuvant. Previous treatment with the endotoxin in saline or with only the adjuvant was ineffective. Sensitization appeared within 10 days and waned after 5 weeks. Passive sensitization was obtained with sensitized donor spleen cells but not with serum. Serum antibody titers did not correlate with the appearance and disappearance of sensitization.

journal_name

J Bacteriol

journal_title

Journal of bacteriology

authors

Freedman HH,Fox AE,Willis RS,Schwartz BS

doi

10.1128/JB.95.2.286-290.1968

subject

Has Abstract

pub_date

1968-02-01 00:00:00

pages

286-90

issue

2

eissn

0021-9193

issn

1098-5530

journal_volume

95

pub_type

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