Biochemical mechanism of nitrofurantoin resistance in Vibrio el tor.

Abstract:

:Vibrio el tor cells contain a constitutive reductase enzyme which converts nitrofurantoin to an active principle that is responsible for the observed antibacterial activity of the drug. Acquisition of resistance of this strain towards nitrofurantoin is associated with the loss of this reductase. This enzyme is located in the periplasmic region of the nitrofurantoin-sensitive cells, and seems to play an important role in transporting the drug into the cells.

journal_title

Folia microbiologica

authors

Ghosh Dastidar P,Sinha AM,Ghosh S,Chatterjee GC

doi

10.1007/BF02927181

subject

Has Abstract

pub_date

1979-01-01 00:00:00

pages

487-94

issue

6

eissn

0015-5632

issn

1874-9356

journal_volume

24

pub_type

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