Abstract:
:Naturally occurring plant phenolics, p-coumaric acid (PA), caffeic acid (CA), ferulic acid (FA) and gentisic acid (GA) (25-100 nmol/L) had protective effects on acridine orange (AO; 216 mumol/L)- and ofloxacin (3 mumol/L)-induced genotoxicity in Salmonella typhimurium. FA, GA and CA exhibited a significant concentration-dependent protective effect against the genotoxicity of AO and ofloxacin, with the exception of PA, which at all concentrations tested abolished the AO and ofloxacin genotoxicity. UV spectrophotometric measurements showed the interaction of PA, FA, GA and CA with AO but not with ofloxacin; this interaction is obviously responsible for the reduction of AO-induced S. typhimurium mutagenicity. In the case of ofloxacin the antimutagenic effect of PA, FA, GA and CA is assumed to be a result of their ability to scavenge reactive oxygen species (ROS) produced by ofloxacin.
journal_name
Folia Microbiol (Praha)journal_title
Folia microbiologicaauthors
Belicová A,Krizková L,Nagy M,Krajcovic J,Ebringer Ldoi
10.1007/BF02817994keywords:
subject
Has Abstractpub_date
2001-01-01 00:00:00pages
511-4issue
6eissn
0015-5632issn
1874-9356journal_volume
46pub_type
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