Phenolic acids reduce the genotoxicity of acridine orange and ofloxacin in Salmonella typhimurium.

Abstract:

:Naturally occurring plant phenolics, p-coumaric acid (PA), caffeic acid (CA), ferulic acid (FA) and gentisic acid (GA) (25-100 nmol/L) had protective effects on acridine orange (AO; 216 mumol/L)- and ofloxacin (3 mumol/L)-induced genotoxicity in Salmonella typhimurium. FA, GA and CA exhibited a significant concentration-dependent protective effect against the genotoxicity of AO and ofloxacin, with the exception of PA, which at all concentrations tested abolished the AO and ofloxacin genotoxicity. UV spectrophotometric measurements showed the interaction of PA, FA, GA and CA with AO but not with ofloxacin; this interaction is obviously responsible for the reduction of AO-induced S. typhimurium mutagenicity. In the case of ofloxacin the antimutagenic effect of PA, FA, GA and CA is assumed to be a result of their ability to scavenge reactive oxygen species (ROS) produced by ofloxacin.

journal_title

Folia microbiologica

authors

Belicová A,Krizková L,Nagy M,Krajcovic J,Ebringer L

doi

10.1007/BF02817994

keywords:

subject

Has Abstract

pub_date

2001-01-01 00:00:00

pages

511-4

issue

6

eissn

0015-5632

issn

1874-9356

journal_volume

46

pub_type

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