Production of extracellular enzymes in continuous culture.

Abstract:

:The production of bacterial enzymes in batch fermentations is compared with results obtained in continuous culture. When studying the production of alpha-amylase in Bacillus subtilis it was found that instability of the enzyme synthesis was due to nonhomogeneity of the population rather than to "the culture's history" (i.e. succession of several physiological states necessary for the enzyme production). The plasmid contained in the production clone was found to be the factor responsible for the alpha-amylase production. Predominance of the production clone or of the nonproduction one depends on the cultivation conditions used. As compared with batch cultivation the continuous production yields higher enzyme concentrations under optimal conditions and the fermentor productivity may be four to five times higher.

journal_title

Folia microbiologica

authors

Fencl Z,Pazlarová J

doi

10.1007/BF02883137

subject

Has Abstract

pub_date

1982-01-01 00:00:00

pages

340-9

issue

5

eissn

0015-5632

issn

1874-9356

journal_volume

27

pub_type

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