Abstract:
:The present study confirmed histopathologically the suggestion that pulmonary edema may underlie the fulminant death following microinjection of kainic acid into many medullary sites in rats anesthetized with pentobarbital sodium. We also observed a sustained elevation in systemic arterial pressure, cardiac contractility and heart rate before the animal succumbed to kainate neurotoxicity. It is suggested that the increased systemic hydrostatic pressure may retrogradely promote pulmonary hypertension that precipitates pulmonary edema.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Chan SH,Chong AP,Ong BT,Chong OK,Lim HCdoi
10.1016/0304-3940(85)90572-5subject
Has Abstractpub_date
1985-12-18 00:00:00pages
341-6issue
3eissn
0304-3940issn
1872-7972pii
0304-3940(85)90572-5journal_volume
62pub_type
杂志文章abstract::The major human neurodegenerative diseases are characterised by ubiquitin-positive intraneuronal inclusions, however the precise nature of the ubiquitin modifications in these structures is unclear. Using a monoclonal antibody specific for Lys63-linked polyubiquitin we have performed the first immunohistochemical anal...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2009.05.074
更新日期:2009-09-04 00:00:00
abstract::We used an intracellular microelectrode technique to study the mechanisms of action of two isoforms (human and rat) of calcitonin gene-related peptide (CGRP) on the evoked and spontaneous quantal secretion of acetylcholine (ACh) in mouse diaphragm motor synapses. Recordings of miniature endplate potentials (MEPPs) and...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2016.06.014
更新日期:2016-08-15 00:00:00
abstract::The potassium conductance (gK) blockers tetraethylammonium (TEA) and 4-aminopyridine (4-AP) strongly excited experimental neuromas that had spontaneous discharge, but had minimal effects on acutely cut nerves and on old, quiescent neuromas. Resting gK apparently moderates hyperexcitability in active neuromas. ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(83)90299-9
更新日期:1983-09-30 00:00:00
abstract::Neural stem cells (NSCs) are pluripotent cells capable of differentiation into dopaminergic (DA) neurons, which are the major cell types damaged in Parkinson's disease (PD). Therefore, NSCs are considered the most promising cell source for cell replacement therapy of PD. However, the poor differentiation and maturatio...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2014.04.019
更新日期:2014-06-13 00:00:00
abstract::We evaluated the neuroprotective effects of systemically administered magnesium against N-methyl-D-aspartate (NMDA)-mediated brain injury in perinatal rats. Postnatal day (PND) 7 rats received unilateral intrastriatal injections of 25 nmol NMDA followed 15 min later by single or multiple doses of magnesium intraperito...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(90)90569-u
更新日期:1990-02-05 00:00:00
abstract::Mitogen-activated protein kinases (MAPK) can be activated by opioids such as morphine via opioid receptor, and their activations have been observed in synaptic plasticity, learning, memory and addiction. Long-term exposure to morphine may induce physical dependence, manifested as somatic withdrawal symptoms such as di...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2009.11.030
更新日期:2010-01-14 00:00:00
abstract::The effect of unilateral electrical stimulation of the posterior interposate nucleus of the cerebellum was examined on the activity of the nigro-striatal dopaminergic pathways on both sides of the brain in alpha-chloralose anaesthetized cats. Push-pull cannulae were inserted into both caudate nuclei and both substanti...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(80)90079-8
更新日期:1980-04-01 00:00:00
abstract::Erythropoietin (EPO) has recently been shown to have a neuroprotective effect in animal models of traumatic brain injury (TBI). However, the precise mechanisms remain unclear. Cerebral inflammation plays an important role in the pathogenesis of secondary brain injury after TBI. We, therefore, tried to analyze how reco...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2007.08.022
更新日期:2007-10-02 00:00:00
abstract::Extracellular dopamine and noradrenaline concentrations in the medial prefrontal cortex were determined using online microdialysis in freely moving rats during classical appetitive or aversive conditioning to a contextual conditioned stimulus (CS). As CS we used placement in a Skinner box where either foot shocks or f...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(99)00601-1
更新日期:1999-09-17 00:00:00
abstract::Our previous study has shown that both electroacupuncture (EA) and vagus nerve stimulation (VNS) can inhibit cortical epileptiform activities induced by pentylenetetrazole (PTZ). The current study compared the effects of EA and VNS on thalamic neuronal responses to PTZ-induced epileptiform activities. Under general an...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2008.06.032
更新日期:2008-08-22 00:00:00
abstract::We have s.c. injected with kainic acid (12 mg/kg) normal adult rats as well as rats rendered microencephalic by selectively timed administration of the DNA alkylating agent methylazoxymethanol acetate (MAM) to the mother during pregnancy. Histological examination of the brains revealed that normal animals underwent ne...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(96)13081-0
更新日期:1996-10-25 00:00:00
abstract::Serotonin transporter (5-HTT) is a key component of the serotonergic neurotransmitter system. Few studies have focused on polymorphisms of the serotonin transporter and antipsychotic response and, in particular, there have so far been no published studies on the association between the serotonin transporter and respon...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2006.09.014
更新日期:2007-02-27 00:00:00
abstract::The uptake of 2-deoxy-[14C]glucose (2-DG) by motor neurons in adult rat hypoglossal nuclei was studied 3 days after subepineural injection of 'crude' soluble protein extracts from intact and injured peripheral nerves into normal hypoglossal nerves. Injured nerve extracts were obtained from 'proximal' and 'distal' segm...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(88)90400-4
更新日期:1988-01-22 00:00:00
abstract::The degree of contamination by blood in macroscopically clear cerebrospinal fluid (CSF) from the rat was assessed by the red blood cell count. Amino acid concentrations in the same samples were determined using high performance liquid chromatography. A significant positive correlation between the number of erythrocyte...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(86)90606-3
更新日期:1986-08-29 00:00:00
abstract::The present study has employed in vitro autoradiography to study the distribution and density of [3H]zolpidem binding sites, which are regarded as an index of ethanol-sensitive gamma-aminobutyric acid (GABA)A receptors, in the brains of alcohol-preferring Fawn-Hooded (FH) rats compared to non-alcohol preferring Wistar...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(97)00867-7
更新日期:1997-12-05 00:00:00
abstract::It has been shown that Fasciculins (FAS), polypeptides isolated from the venom of the green mamba Dendroaspis angusticeps, provoke a powerful inhibition of peripheral acetylcholinesterase (AChE). In the present study, 0.5 microliter of increasing concentrations (10-500 micrograms/ml) of FAS were injected into the stri...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(87)90612-4
更新日期:1987-06-01 00:00:00
abstract::The effects of acute treatment with 1,2,3,4-tetrahydro-9-aminoacridine (THA), a 4-aminopyridine derivative clinically effective in Alzheimer's disease, on beta-adrenoceptor-linked cyclic AMP accumulation have been investigated in cortical and hippocampal structures of young and middle-aged rats. In a first series of e...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(91)90431-r
更新日期:1991-10-28 00:00:00
abstract::In decerebrated rabbits, reflexes were evoked in medial gastrocnemius motoneurones by mechanical stimulation of the heel, using four pinch strengths from 183 (innocuous) to 4577 (noxious) mN. The alpha(2)-adrenoceptor antagonist idazoxan (1-156 microg intrathecal (i.th.) significantly increased responses to pinch stre...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(01)02005-5
更新日期:2001-08-10 00:00:00
abstract::Normal cerebellar tissue, obtained from 15-day-old CBA/JNCij mouse embryos, was transplanted into the cerebellum of 4-week-old weaver mice. At the 6th week after the transplantation, the grafted tissue was distinguishable from the host cerebellum, developing a trilaminar organization. The formation of synapses by the ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(87)90437-x
更新日期:1987-08-31 00:00:00
abstract::Several lines of evidence suggest that the amygdala is altered functionally in humans with temporal lobe epilepsy, but little is known about neuronal interactions in the amygdala of humans or animals with chronic epilepsy. Using extracellular and intracellular recordings in horizontal slices, we tested the hypothesis ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(97)13326-2
更新日期:1997-01-24 00:00:00
abstract::Protein misfolding cyclic amplification (PMCA) is a highly sensitive technique used to detect minute amounts of scrapie prion protein (PrP(Sc)), a major protein component of the infectious agents associated with prion diseases. Although exponential in vitro amplification of hamster scrapie PrP(Sc) has been established...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2006.11.056
更新日期:2007-02-21 00:00:00
abstract::After hypoxic-ischemic insult iron deposited in the brain catalyzes formation of reactive oxygen species. Newborn rats, showing reduced physiological body temperature and their hyperthermic counterparts injected with deferoxamine (DF), a chelator of iron, are protected both against iron-mediated neurotoxicity and agai...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2016.06.022
更新日期:2016-08-15 00:00:00
abstract::Dimensions and innervation of muscle fibers in locust jumping muscle from 1st instar larva and adult are compared. Fibers innervated by only one motoneuron were investigated. During postembryonic development, the size, but not the number, of muscle fibers increases. The number of synaptic contacts per fiber increases ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(81)90436-5
更新日期:1981-12-23 00:00:00
abstract::Direct administration of interleukin-1beta (IL-1beta) into the lateral cerebral ventricle of rat brain, in addition to inducing febrile responses, upregulated the immunoreactivity of tryptophan hydroxylase in the preoptic anterior hypothalamus. The fever induced by IL-1beta was significantly attenuated by pretreatment...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2005.01.074
更新日期:2005-06-10 00:00:00
abstract::Thermogenetics is a promising innovative neurostimulation technique, which enables robust activation of single neurons using thermosensitive cation channels and IR stimulation. The main advantage of IR stimulation compared to conventional visible light optogenetics is the depth of penetration (up to millimeters). Due ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2018.09.038
更新日期:2018-11-20 00:00:00
abstract::It is well known that genetic variants play a critical role in the pathogenesis of Alzheimer's disease (AD). In 2009, a genome-wide association study (GWAS) demonstrated that a single nucleotide polymorphism (SNP), rs6656401, in complement receptor 1 (CR1) is significantly associated with late-onset Alzheimer's diseas...
journal_title:Neuroscience letters
pub_type: 杂志文章,meta分析
doi:10.1016/j.neulet.2012.08.032
更新日期:2012-10-03 00:00:00
abstract::Neurocalcin, a newly discovered calcium-binding protein belonging to the recoverin-like superfamily, was detected immunohistochemically in tufted cells from the rat olfactory bulb. More precisely, only periglomerular tufted cells and some tufted cells from the external plexiform layer were expressing neurocalcin. West...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(93)90285-s
更新日期:1993-10-29 00:00:00
abstract::During neuronal development, the neuroepithelial stem cells (NSCs) initially undergo proliferative divisions, later switching to neurogenic ones whereby one NSC and a post-mitotic neuron are generated. We recently showed that a member of the PRDM family of transcriptional regulators, PRDM4/SC1, recruits a type II prot...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2013.06.051
更新日期:2013-08-29 00:00:00
abstract::Whole-cell patch clamp recordings were obtained during motor activity from electrically identified motoneurons within the spinal cord of the chick embryo maintained in vitro. Most recordings were performed on E11-E13 motoneurons although it was also possible to record from younger cells (E7-E9). Voltage clamp recordin...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(91)90263-s
更新日期:1991-07-22 00:00:00
abstract::This report concerns an ultrastructural study of the synapses present on the surface of somata of normal-looking Betz cells in the fifth layer of motor cortex of seven patients with amyotrophic lateral sclerosis (ALS). Specimens from 12 age-matched, neurologically normal control individuals were included for compariso...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(99)00374-2
更新日期:1999-06-11 00:00:00