Abstract:
:A sensitive microtitre radioimmunoassay was developed for detection of IgM antibodies to delta antigen. The assay was based on the selective binding of IgM from test sera to antihuman IgM (u-chain specific) fixed to wells of a microtitre plate, and utilized delta antigen extracted from the liver of an experimentally infected chimpanzee. This test proved to be useful in distinguishing between coinfection and superinfection with the hepatitis delta virus (HDV). Transient anti-delta IgM responses were observed in patients coinfected with HDV, while prolonged elevated IgM levels were found in HBsAg carriers with chronic liver disease superinfected with HDV. Two distinct serological patterns were observed in both coinfection and superinfection. In coinfection, only 50% of patients with detectable anti-delta IgM went on to develop a long-lasting antibody response. Following superinfection with HDV either stationary or fluctuating levels of IgM antibody were demonstrated. In patients with fluctuating antibody levels, the presence or absence of IgM antibody related to the level of viral replication.
journal_name
J Med Viroljournal_title
Journal of medical virologyauthors
Dimitrakakis M,Waters MJ,Wootton A,Gust Idoi
10.1002/jmv.1890200403subject
Has Abstractpub_date
1986-12-01 00:00:00pages
305-11issue
4eissn
0146-6615issn
1096-9071journal_volume
20pub_type
杂志文章abstract::HIV-1 infections due to non-B subtypes are increasing rapidly in number and spreading across Europe. The genetic nature of HIV-1 non-B variants containing subtype G sequences at the protease (PR)-coding region are described from 48 unrelated subjects living in Spain. Phylogenetic analyses of the HIV-1 reverse transcri...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.20280
更新日期:2005-03-01 00:00:00
abstract::Cytomegalovirus (CMV) is the most common congenital infection in humans and a leading cause of sensorineural hearing loss. Ganciclovir (6 mg/kg twice daily for 42 days) has been shown to reduce hearing deterioration and is used in clinical practice. Vaccines and passive administration of antibody are being evaluated i...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.24654
更新日期:2017-03-01 00:00:00
abstract::Although analytical treatment interruption is used as a strategy to test immunotherapeutic agents in HIV-infection, it may pose a risk for study participants. The potential risks of short-term interruption of antiretroviral therapy (ART) during treatment with an autologous dendritic cell immune-based therapy (AGS-004-...
journal_title:Journal of medical virology
pub_type: 杂志文章,随机对照试验
doi:10.1002/jmv.23297
更新日期:2012-06-01 00:00:00
abstract::The aim of the study was to evaluate cytomegalovirus (CMV) and Epstein-Barr virus (EBV) DNA salivary shedding in HIV-positive men who have sex with men (MSM) and to determine whether viro-immunological parameters and long-term (24 months) plasma HIV RNA (pHIV) detection may predict herpesviruses replication. A total o...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.24441
更新日期:2016-07-01 00:00:00
abstract::The putative interferon sensitivity determining region (ISDR) in the NS5a region of the hepatitis C virus (HCV) was analyzed in 13 interferon alpha (IFN-alpha) treated patients representing genotypes 1a, 1b, and 2b. These patients had previously been followed longitudinally during treatment with respect to viral load ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9071(199809)56:1<33::aid-jmv6>3
更新日期:1998-09-01 00:00:00
abstract::SARS-COV-2 (COVID-19) is a novel virus that has caused over 28 million cases worldwide and over 900,000 deaths since early 2020, rightfully being classified as a pandemic. COVID-19 is diagnosed via PCR testing which looks at cycle threshold values of two genes, N2 and E. This study examined cycle threshold values of C...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.26835
更新日期:2021-02-02 00:00:00
abstract::Severe hand, foot, and mouth disease (HFMD) is sometimes associated with critical complications that can cause substantial child mortality. Activity of the vitamin D receptor (VDR) may influence the outcomes of enterovirus 71 (EV71) infection. This case-control study aimed to assess the association of single-nucleotid...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.25349
更新日期:2019-04-01 00:00:00
abstract::Major differences exist between HIV-1 and HIV-2 in terms of epidemiology, pathogenicity, sensitivity to antiretrovirals. Determining the type of HIV infecting a patient is essential for management. The aim of this study was to evaluate the ability of simple/rapid tests to differentiate between HIV-1 and/or HIV-2 infec...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.24282
更新日期:2015-12-01 00:00:00
abstract::In end-stage renal disease patients treated by hemodialysis with HBeAg-negative chronic hepatitis B virus (HBV) infection, the evaluation of the presence of viral replication is essential in the assessment for renal transplantation. Data on HBV viral load, prevalence of precore mutations, as well as the influence of H...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.20691
更新日期:2006-10-01 00:00:00
abstract::The role of a novel virus, designated as TT virus (TTV), as a cause of chronic liver disease has not been well defined. We investigated the prevalence of TTV among 69 patients with chronic liver disease of unknown etiology and 50 volunteer blood donors with normal transaminase levels. TTV DNA was amplified by polymera...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/1096-9071(200011)62:3<392::aid-jmv12>3.0.c
更新日期:2000-11-01 00:00:00
abstract::A retinal pigment epithelial (RPE) cell line (K-1034) was examined for its susceptibility to human herpesvirus 6 variant A (HHV-6A). Exposure of K-1034 cells to HHV-6A induced the formation of multinucleated giant cells, which was suppressed by an inhibitor of viral DNA synthesis. In the giant cells, herpesvirus nucle...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:
更新日期:1997-10-01 00:00:00
abstract::Potential risk factors for the development of hepatocellular carcinoma were analysed in 40 Caucasian patients with this malignancy. A higher proportion (14 of 40; 35%) had evidence of hepatitis C virus (HCV) infection than had evidence of either hepatitis B virus (HBV) carriage (17.5%) or alcohol abuse (30%). In all 1...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890380215
更新日期:1992-10-01 00:00:00
abstract::Recent studies have suggested a pathogenic role of human parvovirus B19 (B19) in the development of acute fulminant liver failure in children. The hypothesis was based on the detection of B19 DNA in 8 of 10 explanted livers of children requiring liver transplantation. In the present study, explanted livers from 43 adu...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.2047
更新日期:2001-10-01 00:00:00
abstract::Identification of high-risk HPV genotypes in patients is essential for vaccination and prevention programs while the geographic distribution of cervical cancer varies widely. HPV 16 is the major cause of cervical cancer followed by HPV 18, HPV 31, HPV 52, or HPV 58 depending on geographic area. In this study, the dist...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.23769
更新日期:2014-04-01 00:00:00
abstract::Adenovirus infections are usually mild or even asymptomatic, but infections with the virus are being recognized increasingly as a major cause of mortality and morbidity in the immunocompromised, particularly hematological stem cell transplant patients where infections can be life threatening and mortality may reach 60...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.22204
更新日期:2011-11-01 00:00:00
abstract::At present eight hepatitis B virus (HBV) genotypes have been characterized: A to H. The most common genotype in Northern Europe is genotype A. So far there is no record of the specific HBV genotype distribution in Iceland. Iceland has a small population whose homogeneity has changed due to increasing migration during ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.20480
更新日期:2005-12-01 00:00:00
abstract::False negativity in a commercial anti-HIV kit (IMx HIV-1/HIV-2 3rd Generation Plus (code 8B32) was investigated, and the kit that superseded it (IMx HIV-1/HIV-2 III Plus, code 8C98) was evaluated. In a comparison on 574 freshly collected anti-HIV-1-positive specimens, 97.2% were more reactive in 8C98 than in 8B32; 35....
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:
更新日期:1998-10-01 00:00:00
abstract::Analysis of genetic variation in 16 varicella-zoster virus (VZV) isolates selected at random and circulating in the Irish population between March 2002 and February 2003 was carried out. A 919 bp fragment of the glycoprotein E gene (open reading frame 68) encompassing codon 150, at which a non-synonymous mutation defi...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.20048
更新日期:2004-05-01 00:00:00
abstract::To study the association between hepatitis B and schistosomiasis, 1,234 Egyptian males, ages 18 to 24, were interviewed, examined, and tested for Schistosoma mansoni infection and HBsAg. Sera from 91 (7.4%) of the study subjects were positive for HBsAg, and S. mansoni was found in the stools of 26.3%. There was no cor...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890230203
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abstract::In order to assess the efficacy of interferon-alpha on hepatitis C viral RNA in patients with chronic hepatitis C, we analyzed the levels of HCV RNA in sera and liver tissues of 16 patients pre- and posttreatment using a semiquantitative polymerase chain reaction method. Fifteen of 16 patients were positive for anti-H...
journal_title:Journal of medical virology
pub_type: 临床试验,杂志文章,多中心研究
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更新日期:1993-05-01 00:00:00
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journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/(SICI)1096-9071(199603)48:3<278::AID-JMV11
更新日期:1996-03-01 00:00:00
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journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21012
更新日期:2007-12-01 00:00:00
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journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.26338
更新日期:2021-02-01 00:00:00
abstract::The presence of hepatitis GB virus C (GBV-C), also known as hepatitis G virus (HGV), and hepatitis C virus (HCV) were investigated in sera from 45 hemophiliacs from nine locations in Nicaragua using a nested polymerase chain reaction (PCR). Primers used to detect GBV-C and HCV derived from the helicase region and 5'UT...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:
更新日期:1997-06-01 00:00:00
abstract::Previous studies demonstrated that in vitro infection with influenza A viruses altered several functions of human monocytes-macrophages but did not detectably alter functions of human lymphocytes. However, both types of cells were infected, as determined by production and surface expression of viral antigens. In the c...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890270302
更新日期:1989-03-01 00:00:00
abstract::Despite the success of antivirals in preventing clinically overt CMV disease in cardiac allograft recipients, sub-clinical active CMV infection remains a major concern because of its association with allograft rejection and vasculopathy. The measurement of CMV specific T-cell responses is a promising approach to asses...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21229
更新日期:2008-09-01 00:00:00
abstract::Coronavirus disease 2019 (COVID-19) can lead to a massive cytokine release. The use of the anti-interleukin-6 receptor monoclonal antibody tocilizumab (TCZ) has been proposed in this hyperinflammatory phase, although supporting evidence is limited. We retrospectively analyzed 88 consecutive patients with COVID-19 pneu...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.26308
更新日期:2021-02-01 00:00:00
abstract::Human polyomaviruses HPyV6, HPyV7, TSPyV, HPyV9, MWPyV, and KIPyV have been discovered between 2007 and 2012. TSPyV causes a rare skin disease trichodysplasia spinulosa in immunocompromised patients, the role of remaining polyomaviruses in human pathology is not clear. In this study, we assessed the occurrence of seru...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.24440
更新日期:2016-07-01 00:00:00
abstract::Recently developed monoclonal antibodies against the 42,000-dalton major inner capsid protein were used in an enzyme immunoassay to subgroup a total of 156 rotavirus specimens obtained from Japanese infants and young children with acute gastroenteritis during the period between December 1981 and April 1983. Only 2 spe...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890170105
更新日期:1985-09-01 00:00:00
abstract::In earlier studies, hepatitis E virus (HEV) particles were detected in the stools of patients with enterically transmitted non-A, non-B (ENANB) hepatitis, and HEV was etiologically associated with this disease. Such particles have not been observed in the liver, however. We describe the pathological findings in the li...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890310310
更新日期:1990-07-01 00:00:00