Acetylcholinesterase in the rat neurohypophysis is decreased after dehydration and released by stimulation of the pituitary stalk.

Abstract:

:Specific acetylcholinesterase and non-specific cholinesterases are present in all three lobes of the rat pituitary gland. This paper describes two new observations on hypophyseal acetylcholinesterase. Firstly, a prolonged increase of neurohormone secretion evoked by dehydration and sodium loading was accompanied by a decrease in the acetylcholinesterase activity localized to the neural lobe, where acetylcholinesterase has previously been demonstrated in fine nerve fibres. Secondly, electrical stimulation of the pituitary stalk in vitro elicited the release of acetylcholinesterase and non-specific cholinesterases from the combined neural and intermediate lobe indicating that the enzyme can be released from nerve endings in the hypophysis by action potentials. The observed loss of enzyme activity during dehydration may be the consequence of a prolonged activation of cholinergic nerves in the gland, leading to an increased release of acetylcholinesterase, which is not immediately replaced by fresh enzyme. The decrease in acetylcholinesterase in the neural lobe during dehydration may also be connected with its peptidase function and thus with the previously observed loss of substance P from the neural lobe during dehydration [Holzbauer et al. (1984) Neurosci. Lett. 47, 23-28].

journal_name

Neuroscience

journal_title

Neuroscience

authors

Alexandrova M,Holzbauer M,Racke K,Sharman DF

doi

10.1016/0306-4522(87)90132-1

subject

Has Abstract

pub_date

1987-05-01 00:00:00

pages

421-7

issue

2

eissn

0306-4522

issn

1873-7544

pii

0306-4522(87)90132-1

journal_volume

21

pub_type

杂志文章
  • Stress, anxiety, and dendritic spines: what are the connections?

    abstract::Stressful life events, especially those that induce fear, can produce a state of anxiety that is useful for avoiding similar fearful and potentially dangerous situations in the future. However, they can also lead to exaggerated states, which over time can produce mental illness. These changing states of readiness vers...

    journal_title:Neuroscience

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuroscience.2012.04.021

    authors: Leuner B,Shors TJ

    更新日期:2013-10-22 00:00:00

  • Epigenetic mechanisms in pubertal brain maturation.

    abstract::Puberty is a critical period of development during which the reemergence of gonadotropin-releasing hormone secretion from the hypothalamus triggers a cascade of hormone-dependent processes. Maturation of specific brain regions including the prefrontal cortex occurs during this window, but the complex mechanisms underl...

    journal_title:Neuroscience

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuroscience.2013.11.014

    authors: Morrison KE,Rodgers AB,Morgan CP,Bale TL

    更新日期:2014-04-04 00:00:00

  • The peripheral antinociceptive effect of morphine in a rat model of facial pain.

    abstract::The present study compared the peripheral and systemic antinociceptive effect of morphine on formalin-induced facial pain behavior in the rat. Formalin (5%, 50 microliters) was injected subcutaneously into the vibrissal pad of adult rats (250-300 g). Morphine sulfate at doses of 100-1000 micrograms was subcutaneously ...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(95)00565-x

    authors: Eisenberg E,Vos BP,Strassman AM

    更新日期:1996-05-01 00:00:00

  • Analysis and biophysical interpretation of bistable behaviour in thalamocortical neurons.

    abstract::Thalamocortical neurons display a wide spectrum of activity patterns that are the expressions of the non-linear interactions between the various voltage-gated ion channels. Here, we show how bistable behaviour can emerge in these neurons, and how it is brought about by the steady-state residual ("window") component of...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(98)00118-3

    authors: Tóth TI,Hughes SW,Crunelli V

    更新日期:1998-11-01 00:00:00

  • Dynamic and spatial features of the inhibitory pallidal GABAergic synapses.

    abstract::The globus pallidus, one of the basal ganglia nuclei, plays a major role in both basal ganglia physiology and pathophysiology. The globus pallidus is innervated mainly by striatal spiny neurons and globus pallidus collaterals. These GABAergic synapses constitute 90% of the input to globus pallidus cells. Despite the d...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2005.05.069

    authors: Rav-Acha M,Sagiv N,Segev I,Bergman H,Yarom Y

    更新日期:2005-01-01 00:00:00

  • Investigating motor initiation and inhibition deficits in patients with Parkinson's disease and freezing of gait using a virtual reality paradigm.

    abstract::Freezing of gait (FOG) is a common, disabling symptom of Parkinson's disease (PD) that is associated with deficits in motor initiation and inhibition. Understanding of underlying neurobiological mechanisms has been limited by difficulties in eliciting and objectively characterizing such gait phenomena in the clinical ...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2016.09.019

    authors: Georgiades MJ,Gilat M,Ehgoetz Martens KA,Walton CC,Bissett PG,Shine JM,Lewis SJ

    更新日期:2016-11-19 00:00:00

  • Ecology and neurobiology of toxin avoidance and the paradox of drug reward.

    abstract::Current neurobiological theory of drug use is based on the observation that all addictive drugs induce changes in activity of dopaminergic circuitry, interfering with reward processing, and thus enhancing drug seeking and consumption behaviors. Current theory of drug origins, in contrast, views almost all major drugs ...

    journal_title:Neuroscience

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuroscience.2009.01.077

    authors: Hagen EH,Sullivan RJ,Schmidt R,Morris G,Kempter R,Hammerstein P

    更新日期:2009-04-21 00:00:00

  • Genetic differences in hippocampal synaptic plasticity.

    abstract::Synaptic plasticity is considered a physiological substrate for learning and memory [Lynch MA (2004) Long-term potentiation and memory. Physiol Rev 84:87-136] that contributes to maladaptive learning in drug addiction [Schoenbaum G, Roesch MR, Stalnaker TA (2006) Orbitofrontal cortex, decision-making and drug addictio...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2009.03.061

    authors: Prakash S,Ambrosio E,Alguacil LF,Del Olmo N

    更新日期:2009-06-30 00:00:00

  • Endoplasmic reticulum (ER) stress protein responses in relation to spatio-temporal dynamics of astroglial responses to status epilepticus in rats.

    abstract::In the present study, we investigated whether endoplasmic reticulum (ER) stress is associated with neuronal- and astroglial-death in the hippocampus using LiCl-pilocarpine-induced status epilepticus (SE) rat model. Glucose-related protein (GRP) 78 and protein disulfide isomerase (PDI) expressions were transiently incr...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2015.08.061

    authors: Ko AR,Kim JY,Hyun HW,Kim JE

    更新日期:2015-10-29 00:00:00

  • Disintegration of the spatial organization of behavior in experimental autoimmune dementia.

    abstract::Experimental autoimmune dementia is a rat model designed to examine the potential role of anti-cholinergic neurons antibodies in neuronal degeneration in dementia and Alzheimer's disease. We have previously shown that sera of patients with Alzheimer's disease contain antibodies which bind specifically to the high mole...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(93)90564-v

    authors: Eilam D,Szechtman H,Faigon M,Dubovik V,Feldon J,Michaelson DM

    更新日期:1993-09-01 00:00:00

  • Concerted enhancement of calcium influx, neurotransmitter release and protein phosphorylation by a phorbol ester in cultured brain neurons.

    abstract::We have recently shown that the phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate enhances the depolarization induced, calcium dependent release of [3H]dopamine from cultured brain neurons in the rat. In the present study the effects of 12-O-tetradecanoyl-phorbol-13-acetate on the kinetic parameters of depolarizatio...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(86)90140-5

    authors: Zurgil N,Yarom M,Zisapel N

    更新日期:1986-12-01 00:00:00

  • Benzodiazepines block long-term potentiation in slices of hippocampus and piriform cortex.

    abstract::The effects of two benzodiazepines, diazepam and triazolam, on long-term potentiation were tested in slices of hippocampus and piriform cortex. The drugs had little influence on baseline synaptic responses but both were very effective in blocking LTP elicited by theta pattern stimulation. The effects were fully revers...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(92)90071-9

    authors: del Cerro S,Jung M,Lynch G

    更新日期:1992-07-01 00:00:00

  • Uridine enhances neurite outgrowth in nerve growth factor-differentiated PC12 [corrected].

    abstract::During rapid cell growth the availability of phospholipid precursors like cytidine triphosphate and diacylglycerol can become limiting in the formation of key membrane constituents like phosphatidylcholine. Uridine, a normal plasma constituent, can be converted to cytidine triphosphate in PC12 [corrected] cells and in...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2005.03.050

    authors: Pooler AM,Guez DH,Benedictus R,Wurtman RJ

    更新日期:2005-01-01 00:00:00

  • Comparing the after-effects of continuous theta burst stimulation and conventional 1 Hz rTMS on semantic processing.

    abstract::Our aim was to evaluate continuous theta burst stimulation (cTBS) as a tool to induce temporary impairment (virtual lesion) in semantic processing. Four groups with 20 subjects each were stimulated. In the three experimental groups the stimulation site was the left superior temporal cortex. Stimulation was either 1Hz ...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2012.12.033

    authors: Brückner S,Kiefer M,Kammer T

    更新日期:2013-03-13 00:00:00

  • Presynaptic Dopamine D2 Receptors Modulate [3H]GABA Release at StriatoPallidal Terminals via Activation of PLC → IP3 → Calcineurin and Inhibition of AC → cAMP → PKA Signaling Cascades.

    abstract::Striatal dopamine D2 receptors activate the PLC → IP3 → Calcineurin-signaling pathway to modulate the neural excitability of En+ Medium-sized Spiny GABAergic neurons (MSN) through the regulation of L-type Ca2+ channels. Presynaptic dopaminergic D2 receptors modulate GABA release at striatopallidal terminals through L-...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2017.12.041

    authors: Jijón-Lorenzo R,Caballero-Florán IH,Recillas-Morales S,Cortés H,Avalos-Fuentes JA,Paz-Bermúdez FJ,Erlij D,Florán B

    更新日期:2018-02-21 00:00:00

  • Neurotensin-containing projections from the retrosplenial cortex to the anterior ventral thalamic nucleus in the rat.

    abstract::The neurotensin-containing projections from the retrosplenial cortex to the anterior ventral thalamus were demonstrated by electrolytic lesion studies and fluorescent retrograde tracing combined with immunocytochemistry. Three-to-five-day-old rats were used, because the immunoreactivity of neurotensin fibers in anteri...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(88)90102-9

    authors: Fukami K,Kiyama H,Shiotani Y,Tohyama M

    更新日期:1988-09-01 00:00:00

  • Visual form predictions facilitate auditory processing at the N1.

    abstract::Auditory-visual (AV) events often involve a leading visual cue (e.g. auditory-visual speech) that allows the perceiver to generate predictions about the upcoming auditory event. Electrophysiological evidence suggests that when an auditory event is predicted, processing is sped up, i.e., the N1 component of the ERP occ...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2016.09.023

    authors: Paris T,Kim J,Davis C

    更新日期:2017-02-20 00:00:00

  • Dopaminergic modulation of striatal neurons, circuits, and assemblies.

    abstract::In recent years, there has been a great deal of progress toward understanding the role of the striatum and dopamine in action selection. The advent of new animal models and the development of optical techniques for imaging and stimulating select neuronal populations have provided the means by which identified synapses...

    journal_title:Neuroscience

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuroscience.2011.08.051

    authors: Surmeier DJ,Carrillo-Reid L,Bargas J

    更新日期:2011-12-15 00:00:00

  • Effect of social isolation on CB1 and D2 receptor and fatty acid amide hydrolase expression in rats.

    abstract::Rearing rats in isolation has been shown to produce behavioral and neurochemical alterations similar to those observed in psychoses such as schizophrenia. Also, a dysregulation in both the endocannabinoid and dopaminergic systems has been implicated in schizophrenia. The aim of this study was to determine if there are...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2007.10.043

    authors: Malone DT,Kearn CS,Chongue L,Mackie K,Taylor DA

    更新日期:2008-03-03 00:00:00

  • ErbB receptors and PKC regulate PC12 neuronal-like differentiation and sodium current elicitation.

    abstract::Excitability, neurite outgrowth and their specification are very important features in the establishment of neuronal differentiation. We have studied a conditioned medium (CM) from sciatic nerve which is able to induce a neuronal-like differentiation of PC12 cells. Previously, we have demonstrated that supplementing t...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2013.01.026

    authors: García L,Castillo C,Carballo J,Rodríguez Y,Forsyth P,Medina R,Martínez JC,Longart M

    更新日期:2013-04-16 00:00:00

  • Adenosine preferentially suppresses serotonin2A receptor-enhanced excitatory postsynaptic currents in layer V neurons of the rat medial prefrontal cortex.

    abstract::Serotonin induces 'spontaneous' (non-electrically evoked) excitatory postsynaptic currents in layer V pyramidal neurons in the prefrontal cortex. This is likely due to a serotonin2A receptor-mediated focal release of glutamate onto apical dendrites. In addition, activation of the serotonin2A receptor selectively enhan...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(01)00170-1

    authors: Stutzmann GE,Marek GJ,Aghajanian GK

    更新日期:2001-01-01 00:00:00

  • Substance P modifies the 6-hydroxydopamine induced alteration of postnatal development of central noradrenaline neurons.

    abstract::Systemic treatment of new-born rats with the catecholamine neurotoxin 6-hydroxydopamine leads to a permanent and selective alteration of the postnatal development of the central noradrenaline neurons, in particular of the locus coeruleus system. The changes involve a pronounced and permanent degeneration of distant ne...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(82)90113-0

    authors: Jonsson G,Hallman H

    更新日期:1982-01-01 00:00:00

  • Humanized Foxp2 specifically affects cortico-basal ganglia circuits.

    abstract::It has been proposed that two amino acid substitutions in the transcription factor FOXP2 have been positively selected during human evolution and influence aspects of speech and language. Recently it was shown that when these substitutions are introduced into the endogenous Foxp2 gene of mice, they increase dendrite l...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2010.11.042

    authors: Reimers-Kipping S,Hevers W,Pääbo S,Enard W

    更新日期:2011-02-23 00:00:00

  • Relationship between noise-induced hearing-loss, persistent tinnitus and growth-associated protein-43 expression in the rat cochlear nucleus: does synaptic plasticity in ventral cochlear nucleus suppress tinnitus?

    abstract::Aberrant, lesion-induced neuroplastic changes in the auditory pathway are believed to give rise to the phantom sound of tinnitus. Noise-induced cochlear damage can induce extensive fiber growth and synaptogenesis in the cochlear nucleus, but it is currently unclear if these changes are linked to tinnitus. To address t...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2011.07.056

    authors: Kraus KS,Ding D,Jiang H,Lobarinas E,Sun W,Salvi RJ

    更新日期:2011-10-27 00:00:00

  • Effects of capsazepine against capsaicin- and proton-evoked excitation of single airway C-fibres and vagus nerve from the guinea-pig.

    abstract::We have examined the effects of low pH and the selectivity of the capsaicin antagonist capsazepine on single sensory fibres innervating the guinea-pig trachea in vitro, and on the whole isolated vagus nerve. Application of a pH 5 solution for 1 min to the exposed receptive fields of single fibres caused excitation of ...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(95)00115-y

    authors: Fox AJ,Urban L,Barnes PJ,Dray A

    更新日期:1995-08-01 00:00:00

  • Increased activity in the form of endurance training increases calcitonin gene-related peptide content in lumbar motoneuron cell bodies and in sciatic nerve in the rat.

    abstract::The relative content of calcitonin gene-related peptide in lumbar motoneuron cell bodies (semiquantitative immunohistochemistry) and sciatic nerve was examined in rats who had previously undergone a 16-week period of endurance training on a motor-driven treadmill. Soleus motoneurons were identified in the spinal cord ...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(98)00406-0

    authors: Gharakhanlou R,Chadan S,Gardiner P

    更新日期:1999-01-01 00:00:00

  • Oxytocin and Stress: Neural Mechanisms, Stress-Related Disorders, and Therapeutic Approaches.

    abstract::Clinical reports show that oxytocin (OT) is related to stress-related disorders such as depression, anxiety disorder, and post-traumatic stress disorder. Two key structures in the brain should be paid special attention with regard to stress regulation, namely, the hypothalamus and the hippocampus. The former is the re...

    journal_title:Neuroscience

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuroscience.2019.07.046

    authors: Matsushita H,Latt HM,Koga Y,Nishiki T,Matsui H

    更新日期:2019-10-01 00:00:00

  • gamma-Aminobutyric acid and 5-hydroxytryptamine interrelationship in the rat nucleus raphe dorsalis: combination of radioautographic and immunocytochemical techniques at light and electron microscopy levels.

    abstract::Serotonin and gamma-aminobutyric acid (GABA) neurons in the nucleus raphe dorsalis were identified by immunocytochemistry using antibodies to 5-hydroxytryptamine or GABA. The pattern of the 5-hydroxytryptamine and GABA immunostaining presented similar features: 5-hydroxytryptamine or GABA immunoreactive somata were fu...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(87)90336-8

    authors: Harandi M,Aguera M,Gamrani H,Didier M,Maitre M,Calas A,Belin MF

    更新日期:1987-04-01 00:00:00

  • Neurobiological effects of a null mutation depend on genetic context: comparison between two hotfoot alleles of the delta-2 ionotropic glutamate receptor.

    abstract::Hotfoot is a mutant mouse with an ataxic phenotype which has been shown to be due to a mutation in the Grid2 gene. In this paper, we compare molecular, morphological, electrophysiological and behavioral features of two Grid2 alleles: Grid2(ho-4J) and Grid2(ho-Nancy). We first show that these two mutations are deletion...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(01)00193-2

    authors: Lalouette A,Lohof A,Sotelo C,Guénet J,Mariani J

    更新日期:2001-01-01 00:00:00

  • Calretinin immunoreactivity in the monkey hippocampal formation--II. Intrinsic GABAergic and hypothalamic non-GABAergic systems: an experimental tracing and co-existence study.

    abstract::Our light and electron microscopic studies (Seress L., Nitsch R. and Leranth C. (1993) Neuroscience 55, 775-796.) indicated that in the hippocampus of the African Green monkey, calretinin is exclusively present in non-pyramidal cells. Calretinin-positive axons formed a prominent band at the border of the dentate molec...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(93)90442-i

    authors: Nitsch R,Leranth C

    更新日期:1993-08-01 00:00:00