Abstract：
:Hydrazine (Hz) mutagenicity was observed in a test using Escherichia coli B/r strain, WP2 uvrA and was enhanced by the addition of rat liver microsomal fraction containing a generating system, while the enhanced mutagenicity was diminished by the addition of metyrapone to the microsome-free levels. On the other hand, an NADPH-dependent difference spectrum of the metabolic intermediate of Hz-complex, characterized by a maximum level of 448 nm, was also inhibited by metyrapone. The results show that the oxidative intermediates, which are diimide and its precursor, hydrazine free radical [Biochem. Biophys. Res. Commun., 133 (1986) 1086], are responsible not only for hepatotoxicity but also for the enhancement of genotoxicity or mutagenicity.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
Noda A,Ishizawa M,Ohno K,Sendo T,Noda Hdoi
10.1016/0378-4274(86)90006-8subject
Has Abstractpub_date
1986-05-01 00:00:00pages
131-7issue
2eissn
0378-4274issn
1879-3169pii
0378-4274(86)90006-8journal_volume
31pub_type
杂志文章abstract：:This study was designed to compare the pulmonary cellular proliferative effects of inhaled, size-separated preparations of chrysotile asbestos fibres with similar aerosol fibre concentrations of para-aramid fibrils. Following fibre preparation, rats were exposed for 2 weeks to aerosols of p-aramid fibrils or chrysotil...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(96)03751-4
更新日期：1996-11-01 00:00:00
abstract：:Dietary administration of di-2-ethylhexyl phthalate (DEHP; 2%) to male rats caused testicular atrophy. Serum non-esterified fatty acid increased while cholesterol, triglyceride and phospholipid decreased in treated rats. Testicular concentration of cholesterol and non-esterified fatty acid increased in DEHP-treated ra...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(84)90011-0
更新日期：1984-10-01 00:00:00
abstract：:The exposure to cuprizone (CPZ) leads to demyelination in the central nervous system in rodents. To examine the developmental effects of CPZ exposure on hippocampal neurogenesis, pregnant rats were treated with 0, 0.1 or 0.4% CPZ in the diet from gestational day 6 to day 21 after delivery. On postnatal day 21, male of...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2015.01.022
更新日期：2015-05-05 00:00:00
abstract：:The liver carcinogen N-nitrosodimethylamine (NDMA) has to be metabolically activated by specific cytochromes before it can react with cellular macromolecules (e.g. proteins or DNA). Although hepatocytes are believed to be responsible for this activation, the liver tumours originate mainly from non-parenchymal cells (N...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/s0378-4274(01)00400-3
更新日期：2001-09-15 00:00:00
abstract：:Allyl alcohol-induced LDH leakage from isolated rat hepatocytes was preceded by a decrease in rhodmine 123 retention, signifying a loss of mitochondrial membrane potential. Addition of dithiothreitol (DTT) prevented the drop in membrane potential and completely prevented cell killing by allyl alcohol. In contrast, cyc...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(95)03426-9
更新日期：1995-11-15 00:00:00
abstract：:Although CSL box jellyfish antivenom (AV) remains the primary treatment for Chironex fleckeri envenoming, there has been considerable debate regarding its clinical effectiveness. Animal studies have shown that AV is largely ineffective in preventing C. fleckeri-induced cardiovascular collapse. This study examined the ...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2009.02.008
更新日期：2009-06-01 00:00:00
abstract：:It has been reported that lead could induce apoptosis in a variety of cell types. Although mitochondrion is regarded as the most pertinent pathway in mediating apoptosis, the exact mechanisms of lead-induced apoptosis are still largely unknown. Furthermore, there is little information about expressions and regulations...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2006.06.643
更新日期：2006-10-10 00:00:00
abstract：:The development of efficacious and safe new human pharmaceuticals continues to be highly dependent on well-designed and carefully executed animal toxicology studies. Although the protocols of most toxicology studies now conform to a standard format, careful selection of the most appropriate and relevant laboratory spe...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/s0378-4274(98)00263-x
更新日期：1998-12-28 00:00:00
abstract：:Male rats are the most frequently used experimental animals in drug toxicity tests. However, there are clear sex-related differences in toxicity of various drugs and chemicals in rats. These differences, in most cases, are closely connected with the sex-related differences in hepatic drug metabolisms. Recent studies i...
journal_title：Toxicology letters
pub_type： 杂志文章,评审
doi：10.1016/0378-4274(92)90245-f
更新日期：1992-12-01 00:00:00
abstract：:3'-Hydroxyacetanilide has been previously studied as a nontoxic regioisomer of the analgesic acetaminophen (4'-hydroxyacetanilide). The radiolabeled derivative has been shown to covalently bind to liver proteins at levels similar to that observed with hepatotoxic doses of radiolabeled acetaminophen with no evidence of...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/s0378-4274(97)00100-8
更新日期：1998-01-16 00:00:00
abstract：:Inorganic arsenic has strong human carcinogenic potential, but the availability of an animal model to study toxicity is extremely limited. Here, we used the transgenic zebrafish line Tg(k18(2.9):RFP) as an animal model to study arsenite toxicity. This line was chosen because the red fluorescent protein (RFP) is expres...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2005.10.024
更新日期：2006-06-01 00:00:00
abstract：INTRODUCTION:An increased health problem in industrialised countries is the contemporary concern of public and scientific community as well. This has been attributed in part to accumulated environmental pollutants especially radioactive substances and the use of nuclear power plants worldwide. However, the outcome of c...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2017.10.004
更新日期：2018-01-05 00:00:00
abstract：:Oltipraz (OPZ) is a known inducer of glutathione S-transferases and a mechanism-based inhibitor of cytochrome P450 1A2. Given the detoxification characteristics of this compound, the transcriptional effects of OPZ, along with the related naturally occurring compounds 3H-1,2-dithiole-3-thione (D3T) and sulforaphane (SF...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2004.06.006
更新日期：2004-11-28 00:00:00
abstract：:The effect of zinc (Zn) administration on the uptake and retention of cadmium (Cd), copper (Cu) and Zn in liver, kidneys and testes of cadmium exposed rats was investigated. Exposure to Cd caused a significant increase in the uptake of these metals in the 3 organs. The administration of Zn after the Cd exposure had li...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(80)90165-4
更新日期：1980-02-01 00:00:00
abstract：:1,3,5-Trinitro-2-acetyl pyrrole (TNAP) is a product derived from the reaction of 2-acetyl pyrrole with nitrite in the model of Maillard browning systems. This compound is moderately mutagenic to the Salmonella strains TA98 and TA100 and is markedly cytotoxic to mouse C3H10T1/2 cells. Experiments are performed to inves...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/s0378-4274(96)03801-5
更新日期：1996-12-16 00:00:00
abstract：:On chronic administration of 20 microliter of chilli extract to the cheek pouch of hamsters till death, 23% of the hamsters developed shrunken eye balls and closing of the eyelids. This effect was not observed in hamsters which received a single application of the potent carcinogen methylacetoxymethyl nitrosamine (DMN...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(85)90002-5
更新日期：1985-10-01 00:00:00
abstract：:Fusarenon-X (FX), a type B trichothecene mycotoxin, is mainly produced by Fusarium crookwellense, which occurs naturally in agricultural commodities, such as wheat and barley. FX has been shown to exert a variety of toxic effects on multiple targets in vitro. However, the embryonic toxicity of FX in vivo remains uncle...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2014.06.843
更新日期：2014-08-17 00:00:00
abstract：:In addition to evidence that inhalation of ambient particulate matter (PM) can increase cardiopulmonary morbidity and mortality, the brain may also constitute a site adversely effected by the environmental presence of airborne particulate matter. We have examined the association between exposure to PM and adverse CNS ...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2008.03.001
更新日期：2008-05-05 00:00:00
abstract：:The genotoxicity of polycyclic aromatic hydrocarbons (PAHs) and nitrated PAHs may be influenced by the interaction of the compounds. In this study, our data showed that benzo[a]pyrene (BaP)-DNA adduct levels were decreased in a dose-dependent manner when the human hepatoma cell line HepG2 simultaneously treated with B...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2005.10.002
更新日期：2006-03-01 00:00:00
abstract：:Inhalation of ultrafine particulate matter (PM) in air pollution increases cardiovascular mortality by passing into systemic circulation and possibly affecting endothelial cell (EC) function. This study identified the chemical constituents, including polycyclic aromatic hydrocarbons (PAHs), in diesel exhaust particula...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2007.08.014
更新日期：2007-11-01 00:00:00
abstract：:A considerable body of research over the past fifteen years establishes that in laboratory animals the Ah (aromatic hydrocarbon) receptor (AhR) mediates most, if not all, toxic effects of halogenated aromatic hydrocarbons such as polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, and polyhalogenated bip...
journal_title：Toxicology letters
pub_type： 杂志文章,评审
doi：10.1016/0378-4274(94)90139-2
更新日期：1994-01-01 00:00:00
abstract：:The purpose of this study was to evaluate the neurotoxic potential of the pesticide fipronil (FIP) towards the differentiation of mouse N2a neuroblastoma cells. At concentrations of 1, 5 and 10 μM that were not cytotoxic, as shown by two different cell viability assays, FIP impaired potently after 24h the development ...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2010.12.009
更新日期：2011-02-25 00:00:00
abstract：:Long-term excessive intake of fluoride (F) could lead to chronic fluorosis. To explore the underlying molecular mechanisms, present study is designed to elucidate the effect of fluoride on proteome expression of bone in sodium fluoride (NaF)-treated SD rats. Hematoxylin and eosin (H&E) staining was used to determine t...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2018.04.006
更新日期：2018-07-01 00:00:00
abstract：:Norepinephrine-induced contractility and relaxation to acetylcholine of isolated aortas taken from normal and chronic alcoholic rats were measured. Similar experiments were performed adding serum from normal (NS) or alcoholic rats (AS), with or without norepinephrine and acetylcholine. Responses of normal and alcoholi...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(94)03180-0
更新日期：1995-02-01 00:00:00
abstract：:This work studies the potential subacute toxicological effects of the aqueous extract of Baccharis genistelloides (AEBg) and demonstrates a new anti-arthritic therapeutic effect. The treatment of the collagen-induced arthritis (CIA) group with 4.2 mg/kg AEBg induced an important decrease (75%) in CIA severity in all a...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2004.07.004
更新日期：2004-12-01 00:00:00
abstract：:The people studied were male volunteers without occupational and dietary exposure to PAH: 27 smokers (10 cigarettes or more) and 27 non-smokers matched for age and socio-professional category. For each person, all the 24h voided urine samples were reassembled in a single sample. 1-Hydroxypyrene (1-OHPy) and 3-hydroxyb...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2005.09.019
更新日期：2006-04-10 00:00:00
abstract：:Male rats were administered diets containing monobutyl (MBP), mono-iso-butyl (MIBP), monooctyl (MOP) or mono-2-ethylhexyl phthalate (MEHP) for 1 week, and serum lipid compositions were determined. Non-esterified fatty acid was increased and triglycerides and total cholesterol were decreased in all monoester-treated gr...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(82)90012-1
更新日期：1982-11-01 00:00:00
abstract：:Cellular senescence is characterized by irreversible cell arrest and is associated with the development of chronic diseases, including cancer. Here, we investigated the induction of cellular senescence during liver carcinogenesis. Liver cancer was induced in Fischer 344 rats with a weekly intraperitoneal injection of ...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/j.toxlet.2015.11.011
更新日期：2016-01-22 00:00:00
abstract：:Pneumotoxicity of butylated hydroxytoluene (BHT) applied to the skin of CD-1 mice was investigated and compared with that of butylated hydroxyanisole (BHA). To 6 groups of 10 male mice and 10 female mice 0.1 ml of dimethylsulfoxide (DMSO) solutions containing 0, 5, 10, 20, or 30 mg of BHT or 30 mg of BHA were topicall...
journal_title：Toxicology letters
pub_type： 杂志文章
doi：10.1016/0378-4274(86)90151-7
更新日期：1986-11-01 00:00:00
abstract：:Apoptosis is a type of programmed cell death involved in growth control of tissues. It is considered as a cellular suicide functionally opposite to mitosis. It may serve to remove "unwanted" damaged or dangerous, e.g. precancerous, cells. Chemical compounds can interfere with the regulatory network which controls apop...
journal_title：Toxicology letters
pub_type： 杂志文章,评审
doi：10.1016/0378-4274(92)90233-a
更新日期：1992-12-01 00:00:00
