Identification of activated pathways in lung adenocarcinoma based on network strategy.

abstract：Aim of Study:The roles of autophagy performed in chemotherapy-induced cell death or proliferation inhibition were still in debate. In this study, we aimed to disclose the function of autophagy in chemotherapy of HCT-116 colon cells. Materials and Methods:Pharmacological and genetic methods were applied to induce and i...

journal_title：Journal of cancer research and therapeutics

authors： Yang JW,Zhang QH,Liu T

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND:Activating mutations in the epidermal growth factor (EGFR) gene confer sensitivity to the tyrosine kinase inhibitors (TKIs) in patients with advanced non-small cell lung cancer (NSCLC). TKI treatment efficacy and EGFR mutation implications were evaluated in clinically selected advanced NSCLC patients treated...

journal_title：Journal of cancer research and therapeutics

authors： Ovcaricek T,Cufer T,Kern I,Sodja E,Sadikov A

更新日期：2013-04-01 00:00:00

abstract：Aims:Platinum-based chemotherapy is considered as the first-line treatment for nonsmall cell lung cancer (NSCLC) patients. However, platinum resistance and toxicity are major obstacles to its clinical applications. The two P-type ATPases ATP7A and ATP7B have been identified to play an essential role in the transport of...

journal_title：Journal of cancer research and therapeutics

authors： Li YQ,Zhang XY,Chen J,Yin JY,Li XP

更新日期：2018-01-01 00:00:00

abstract：:An 18 years female was admitted with right-sided chest pain, dry cough, and low-grade fever and weight loss for last 1 month. On examination, patient had features of superior vena cava (SVC) syndrome with right-sided pleural effusion. Chest X-ray showed mediastinal widening with nonhomogenous opacity mainly in the per...

journal_title：Journal of cancer research and therapeutics

authors： Patra A,Kundu S,Pal A,Saha S

更新日期：2015-10-01 00:00:00

abstract：:Carcinoma of the lip is a slow-growing locally-advanced disease with low metastatic potential. Distant skeletal metastasis is reported very rarely and the vertebral column is the most common site. A 58-year-old male smoker presented with pain and massive swelling of the left scapula for six months. He also noticed a s...

journal_title：Journal of cancer research and therapeutics

authors： Bandyopadhyay R,Nag D,Bandyopadhyay SK

更新日期：2010-07-01 00:00:00

abstract：OBJECTIVE:Head and neck squamous cell carcinoma (HNSCC) represents as a common malignancy with increasing incidence in the worldwide. The fact of its poor survival rate urgently requires developing efficient predictive biomarkers for clinical use. MicroRNAs (miRNAs) recently represent as a novel direction for early dia...

journal_title：Journal of cancer research and therapeutics

authors： Wang H,Zhang G,Wu Z,Lu B,Yuan D,Li X,Lu Z

更新日期：2015-10-01 00:00:00

abstract：Background:Conventional magnetic resonance imaging (MRI) does not accurately evaluate lymph node (LN) status, which is essential for the treatment and prognosis assessment in patients with rectal cancer. Objective:The aim of this study is to evaluate the diagnostic value of intravoxel incoherent motion (IVIM) MRI in d...

journal_title：Journal of cancer research and therapeutics

authors： Long L,Zhang H,He X,Zhou J,Guo D,Liu X

更新日期：2019-01-01 00:00:00

abstract：:We report a case of a 63-year-old lady presenting with pain in the right hypochondrium, jaundice, anorexia, and firm tender hepatomegaly with remarkably high serum alkaline phosphatase. Abdominal ultrasonography revealed a hypoechoic solid space-occupying lesion in right lobe of liver which was cytologically diagnosed...

journal_title：Journal of cancer research and therapeutics

authors： Pal S,Chattopadhyay B,Chatterjee A,Bhattacharya B

更新日期：2014-01-01 00:00:00

abstract：Aim of Study:To examine the function of lenalidomide (LEN) on the human multidrug resistance (MDR)-type gastric cancer line SGC7901/vincristine (VCR) via regulating Notch signaling. Materials and Methods:Quantitative polymerase chain reaction was used for checking the genes of Notch, DNA methyltransferase (DNMT), RBP-...

journal_title：Journal of cancer research and therapeutics

authors： Ding W,Zeng T,Tao W,Ge W,Deng J,Lei H,Xiao Y,Liao F

更新日期：2018-01-01 00:00:00

abstract：Aim:Tumor-associated macrophages (TAMs) play a decisive role in the regulation of tumor progression by manipulating tumor oncogenesis, angiogenesis, and immune functions within tumor microenvironments. Tumor progression is frequently associated with a phenotypic switch from M1 to M2 in TAM. Activation of signal transdu...

journal_title：Journal of cancer research and therapeutics

authors： Seyedi Z,Hashemzadeh MR,Colagar AH,Jaafari MR

更新日期：2018-07-01 00:00:00

abstract：Objective:The aim of this study was to explore the clinical value of capsule endoscopy in the diagnosis of small intestine neoplastic lesions. Materials and Methods:A retrospective analysis was conducted on the clinical data of 108 patients who underwent capsule endoscopic examination in the Endoscopy Center of Xinxia...

journal_title：Journal of cancer research and therapeutics

authors： Li X,Gui Y,Shen F,Zhao CL,Yang Y,Han W

更新日期：2018-01-01 00:00:00

abstract：:Symptoms of nausea and vomiting can present a diagnostic challenge for physicians. In this article, we report a patient who was found to have synchronous presentation of an ependymoma and pancreatic cancer. This case illustrates some of the diagnostic challenges in patients with constitutional symptoms. Furthermore, i...

journal_title：Journal of cancer research and therapeutics

authors： Chowdhry VK,Carter DA,Shapiro A

更新日期：2013-10-01 00:00:00

abstract：:Burkitt's lymphoma is an uncommon form of non-Hodgkin's lymphoma (NHL) in adults and represents < 5% of NHL adults. Burkitt's lymphoma involving primarily the appendicular skeleton is rarely described. We present the case of a young man with primary Burkitt's lymphoma involving the humerus as the only site of disease....

journal_title：Journal of cancer research and therapeutics

authors： Geetha N,Sreelesh KP,Nair RA,Jacob PM

更新日期：2015-10-01 00:00:00

abstract：:A rare and unique variant of breast cancer--metaplastic matrix producing carcinoma, is presented. Surgery has been the mainstay of treatment. The role of adjuvant postoperative radiotherapy, as has been used in this patient, has been reviewed. ...

journal_title：Journal of cancer research and therapeutics

authors： Kumar P,Agarwal T,Krishnani N,Singh S,Datta NR

更新日期：2006-04-01 00:00:00

abstract：Context:The metastasis of liver cancer is a major cause of clinical treatment failure, restrain, and control the cancer metastasis is the major strategy of the treatment and prevention of the disease. Special AT-rich sequence-binding protein 1 (SATB1) gene was overexpressed in many malignant tumors and considered as a ...

journal_title：Journal of cancer research and therapeutics

authors： Xu C,Guo H,Kong D,Pang D,Ding Y

更新日期：2018-12-01 00:00:00

abstract：:Choriocarcinoma is the most malignant tumor of gestational trophoblast origin. Metastasis to brain is considered a poor prognostic indicator. Recent advances in adjuvant radiotherapy and chemotherapy have led to an excellent outcome of these patients. Craniotomy is indicated in selected cases with cerebral metastases....

journal_title：Journal of cancer research and therapeutics

authors： Dadlani R,Furtado SV,Ghosal N,Prasanna KV,Hegde AS

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:Prostate-specific membrane antigen (PSMA) is a widely used targeted molecule in prostate patients. The present research, attempts to support the hypothesis that PSMA expression in prostate cancer stem cell-like (CSC) cell populations may be correlated with nanog and other transcription factors in different s...

journal_title：Journal of cancer research and therapeutics

authors： Maria T,Panagiotis A,Marina C,Eleni K,Ioanna V,Georgia M,Ioannis P

更新日期：2014-01-01 00:00:00

abstract：Background:Lung cancer is the leading cause of cancer-related deaths worldwide. The high resistance of this type of cancer to radiotherapy and chemotherapy is the greatest challenge for the complete eradication of cancer cells. Although the combination of chemotherapeutic agents has some promising results, severe side ...

journal_title：Journal of cancer research and therapeutics

authors： Kahkesh MH,Salehi Z,Najafi M,Ghobadi A,Izad M,Shirazi A

更新日期：2020-10-01 00:00:00

abstract：Background and Objectives:Human chorionic gonadotropin-β (hCGβ) is a hormone glycoprotein usually secreted by trophoblastic cells in early pregnancy and helps in growth and development of the embryo. While many trophoblastic and nontrophoblastic malignancies express elevated levels of hCGβ in serum, increased immunohis...

journal_title：Journal of cancer research and therapeutics

authors： Meda S,Reginald BA,Reddy BS

更新日期：2018-07-01 00:00:00

abstract：AIMS:Several studies suggested that systemic lupus erythematosus (SLE) were associated with the risk of lung cancer. However, other studies did not confirm the result. Therefore, we conducted a meta-analysis to investigate this association. MATERIALS AND METHODS:A systematic literature search was conducted using the P...

journal_title：Journal of cancer research and therapeutics

authors： Wu Y,Hou Q

更新日期：2016-04-01 00:00:00

abstract：:Primary spinal glioblastoma multiforme (GBM) is a rare entity, which is invariably associated with poor outcome. Standard treatment is surgery followed by post-operative radiotherapy. Due to paucity of cases role of chemotherapy is investigational. We intend to report two cases of primary spinal GBM treated with radia...

journal_title：Journal of cancer research and therapeutics

authors： Mallick S,Madan R,Julka PK

更新日期：2015-07-01 00:00:00

abstract：AIMS:To find out the efficacy of epidural analgesia in providing continuous pain relief for patients undergoing brachytherapy for cervical cancer. SETTINGS:Teaching Hospital. DESIGN:Retrospective Study. MATERIALS AND METHODS:A total of 152 patients of cervical cancer received epidural analgesia during 18 to 21 hours...

journal_title：Journal of cancer research and therapeutics

authors： Janaki MG,Nirmala S,Kadam AR,Ramesh BS,Sunitha KS

更新日期：2008-04-01 00:00:00

abstract：:Large pedunculated esophageal lipoma is uncommon. The presenting symptoms of esophageal lipoma are dysphagia, regurgitated mass, and persistent sensation of a lump in the throat. The most frequent location of the tumor pedicle is the upper esophageal sphincter. Here, we present the case of a 52-year-old man who had th...

journal_title：Journal of cancer research and therapeutics

authors： Qinying W,Wei L,Shuihong Z

更新日期：2015-10-01 00:00:00

abstract：:Krukenberg tumor is bilateral ovarian carcinoma's metastasizing most commonly from a gastric primary followed by a colon. We report a case of 36-year-old female with bilateral ovarian mass diagnosed as Krukenberg with a work up for locating the primary site. In this case, we discuss widely the clinical aspects with hi...

journal_title：Journal of cancer research and therapeutics

authors： Umakanthan S,Bukelo MM,Hardik K

更新日期：2015-10-01 00:00:00

abstract：Purpose:The purpose of this study was to evaluate the organs at risk (OARs) doses for lung tumors in gated radiotherapy (RT) compared to conventional RT using the four-dimensional extended cardiac-torso (4D-XCAT) digital phantom in a simulation study. Materials and Methods:4D-XCAT digital phantom was used to create 32...

journal_title：Journal of cancer research and therapeutics

authors： Shahzadeh S,Gholami S,Aghamiri SMR,Mahani H,Nabavi M

更新日期：2020-07-01 00:00:00

abstract：:The nucleus of a mammalian cell undergoes profound reorganization when the cell enters mitosis and a number of proteins involved at various levels of the cell cycle have been characterized. The presence of mitotic-specific proteins has been reported and their roles are important in understanding the mechanics of cell ...

journal_title：Journal of cancer research and therapeutics

authors： Maddaly R,Deepa PV,Pai GM,Preetha B,Ghosh S,Paul SF

更新日期：2006-07-01 00:00:00

abstract：OBJECTIVE:The objective of this study was to compare robotic-prostatectomy plus adjuvant radiation therapy (RPRAT) versus primary RT for high-risk prostate cancer (HRPCa). MATERIALS AND METHODS:A retrospective chart review was performed for the HRPCa patients treated in our institution between 2000 and 2010. One hundr...

journal_title：Journal of cancer research and therapeutics

authors： Singh P,Desai P,Arora S,Pham AH,Wernicke AG,Smith M,Nori D,Clifford Chao KS,Parashar B

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:The perioperative use of epirubicin, cisplatin, and fluorouracil (ECF) significantly improves outcomes in patients with gastric and gastro-oesophageal (GO) cancers but is cumbersome to administer. Given the equivalence of epirubicin, oxaliplatin, and capectabine (EOX) with ECF in advanced setting, we analyze...

journal_title：Journal of cancer research and therapeutics

authors： Sirohi B,Barreto SG,Singh A,Batra S,Mittra A,Rastogia S,Ramadwar M,Shetty N,Goel M,Shrikhande SV

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:Tumor markers are a major part of the secondary prevention and thus the detection of malignancies. Neoplasms often have an increased concentration of sialic acid on the tumor cell surface and are shed or secreted by some of these cells which increase the concentration in blood. MATERIALS AND METHODS:The stu...

journal_title：Journal of cancer research and therapeutics

authors： Joshi M,Patil R

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND:Administering drugs outside the terms of their official labeling is called off-label use. In the West, oncologists often use drugs off-label, which offers several advantages especially while treating patients with multiple comorbidities or advanced cancer. The practice of off-label prescribing of anticancer ...

journal_title：Journal of cancer research and therapeutics

authors： Gota V,Patial P

更新日期：2011-01-01 00:00:00