Off-label use of anti-cancer drugs in India: to be or not to be!

abstract：CONTEXT:The diagnosis of malignant and potentially malignant epithelial lesions of oral mucosa cannot be based solely on clinical findings. The histologic evaluation of a representative biopsy specimen thus becomes necessary. The site for biopsy, however, is always a subjective choice that sometimes raises doubts about...

journal_title：Journal of cancer research and therapeutics

authors： Nayyar AS,Khan M,Bafna UD,Ahmed S,Chaluvaiah GH

更新日期：2014-07-01 00:00:00

abstract：:Neuroblastoma is a tumor of pediatric age group and is extremely rare in adults. Common sites involved in adults are almost similar to that seen in children like retroperitoneum, adrenal gland, pelvis and mediastinum. Ovarian neuroblastoma has never been reported in the literature before. We, hereby, present a case of...

journal_title：Journal of cancer research and therapeutics

authors： Singh M,Arora P,Singh S,Bohara S,Khurana N,Zutshi V,Kumar R

更新日期：2010-07-01 00:00:00

abstract：Objective:The aim of this study is to probe in the inhibitory effects of ginsenoside Rg3 on the expression of hypoxia-induced factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF) in human gastric cancer cells. Materials and Methods:Human gastric cancer BGC823 cells were divided into the control group and e...

journal_title：Journal of cancer research and therapeutics

authors： Li B,Qu G

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Oral cancer is the third most common form of malignancies in India. In many cases it develops at the site of premalignant lesion. Transformation of normal tissue to premalignant lesion and further to oral cancer results in alteration in glycolytic pathway and hence the lactate dehydrogenase levels. Therefore...

journal_title：Journal of cancer research and therapeutics

authors： Shetty SR,Chadha R,Babu S,Kumari S,Bhat S,Achalli S

更新日期：2012-01-01 00:00:00

abstract：:Often in metastatic disease, biopsy confirmation of suspicious central nervous system (CNS) lesions is not mandated according to the American College of Radiology, International Radiosurgery Association, and the National Comprehensive Cancer Network. We present a case of an individual who was thought to have metastati...

journal_title：Journal of cancer research and therapeutics

authors： Gestaut MM,Strober ED,Jhavar SG,Patel MK

更新日期：2017-10-01 00:00:00

abstract：Background:Ghrelin plays a role in mechanisms related to cancer progression - including cell proliferation, invasion and migration, and resistance to apoptosis in the cell lines from several cancers. We investigated the role of ghrelin levels in cancer cachexia-anorexia in patients with locally advanced nonsmall-cell l...

journal_title：Journal of cancer research and therapeutics

authors： Uysal P,Afsar CU,Sozer V,Inanc B,Agaoglu F,Gural Z,Fazlıoglu NY,Cuhadaroglu C,Uzun H

更新日期：2020-07-01 00:00:00

abstract：PURPOSE:To investigate feasibility and safety of GliaSite brachytherapy for treatment of central nervous system (CNS) tumors following neurosurgical resection. We report mature results of long-term follow-up, outcomes and toxicity. MATERIALS AND METHODS:In the period from 2004 to 2007, 10 consecutive adult patients wi...

journal_title：Journal of cancer research and therapeutics

authors： Wernicke AG,Sherr DL,Schwartz TH,Pannullo SC,Stieg PE,Boockvar JA,Ivanidze J,Moliterno JA,Parashar B,Trichter S,Sabbas AM,Nori D

更新日期：2010-01-01 00:00:00

abstract：Background:The symptoms of patients with malignant biliary obstruction (MBO) could be effectively alleviated with percutaneous transhepatic biliary drainage (PTBD). Postoperative infections were considered as challenging issues for clinicians. In this study, the risk factors of biliary infection in patients after PTBD ...

journal_title：Journal of cancer research and therapeutics

authors： Yu H,Yuanyuan S,Guo Z,Xing W,Si T,Guo X,Liu F

更新日期：2018-01-01 00:00:00

abstract：:Renal cell carcinoma, unclassified constitute about 3-4% of all renal carcinomas. It essentially is a tumor where more than morphological variants or subtypes are seen in a single tumor. Usually there is a mixture of 2-3 different types. However, in this particular case there were at least 5 different types of morphol...

journal_title：Journal of cancer research and therapeutics

authors： Chander B,Preet K,Bharti R,Deb P

更新日期：2015-10-01 00:00:00

abstract：:Primary amyloidosis of bladder is a rare disease that closely resembles bladder cancer on clinical presentation with painless gross hematuria. Pathologically this is a totally benign non-neoplastic lesion and its association with urothelial carcinoma of the bladder is rare. We herein report a 64-year-old diabetic male...

journal_title：Journal of cancer research and therapeutics

authors： Gupta P,Hanamshetti S,Kulkarni JN

更新日期：2012-04-01 00:00:00

abstract：:Cutaneous metastasis from transitional cell bladder carcinoma is a rare clinical entity associated with poor prognosis. We present a case of cutaneous metastasis arising from a transitional cell bladder carcinoma in a male patient who had undergone a radical cystectomy and bilateral ureterostomy 17 months previously. ...

journal_title：Journal of cancer research and therapeutics

authors： Salemis NS,Gakis C,Zografidis A,Gourgiotis S

更新日期：2011-04-01 00:00:00

abstract：PURPOSE:This retrospective study aims to assess the cut-off value of thyroglobulin (Tg) levels in nux or metastatic well-differentiated thyroid cancers (DTCs) with normal anti-Tg levels using with fluorodeoxyglucose/positron emission tomography/computed tomography (FDG PET/CT). MATERIALS AND METHODS:We reviewed FDG PE...

journal_title：Journal of cancer research and therapeutics

authors： Döner RK,Sager S,Görtan FA,Topuz ÖV,Akyel R,Vatankulu B,Baran A,Teksoz S,Sönmezoglu K

更新日期：2016-04-01 00:00:00

abstract：OBJECTIVE:The purpose of this meta-analysis was to evaluate the effects of Fufangkushen injection combined with chemotherapy in the treatment of stomach cancer. MATERIALS AND METHODS:The relevant clinical trials about Fufangkushen injection combined with chemotherapy in the treatment of stomach cancer were search in t...

journal_title：Journal of cancer research and therapeutics

authors： Li J,Wu M,Tian Q,Xie G,Hu Y,Meng Q,Zhang M

更新日期：2014-08-01 00:00:00

abstract：AIM:To determine the efficacy of belly board device in patients receiving postoperative radiation for gynecological malignancies in terms of setup error and acute small bowel toxicity. MATERIALS AND METHODS:Patients requiring postoperative radiation for gynecological malignancies were prospectively randomized to eithe...

journal_title：Journal of cancer research and therapeutics

authors： Anjanappa M,Raghavan RK,James FV,Kumar A,Mathews S,Bhaskaran S,Sreedevi SV,Jayaprakash PG

更新日期：2017-07-01 00:00:00

abstract：:Primary mediastinal synovial sarcomas are exceedingly uncommon tumors. Herein, we present the case of primary mediastinal synovial sarcoma (monophasic spindle cell-shaped variant) fully occupying the right hemithorax in a 37-year-old woman who presented to clinic with a 2-month history of right-sided chest pain and sh...

journal_title：Journal of cancer research and therapeutics

authors： Abu-Zaid A,AlNajjar A,Alotaibi S,Alshawaf R,Alqeshtaini N,Alhaidar R,Mohammed S,AlKattan K

更新日期：2018-04-01 00:00:00

abstract：OBJECTIVE:The objective of this study was to compare the completely thoracoscopic anatomic segmentectomy with lobectomy to treat stage I(A) peripheral lung cancer <2 cm. MATERIALS AND METHODS:A retrospective study was performed that 54 cases stage I(A) peripheral lung cancer patients were selected, including 26 cases ...

journal_title：Journal of cancer research and therapeutics

authors： Zhang L,Ma W,Li Y,Jiang Y,Ma G,Wang G

更新日期：2013-09-01 00:00:00

abstract：OBJECTIVE:This study evaluates the magnetic resonance imaging (MRI) manifestation of intradural extramedullary (IDEM) tumors to improve the imaging diagnostic level. MATERIALS AND METHODS:From January 2005 to December 2012, a retrospective analysis of the MRI examination was performed on 108 patients with IDEM tumors ...

journal_title：Journal of cancer research and therapeutics

authors： Gu R,Liu JB,Zhang Q,Liu GY,Zhu QS

更新日期：2014-10-01 00:00:00

abstract：Aims:This study aims at assessing the volume changes that occur in the targets (gross tumor volume and planning target volume [PTV]) and the organs at risk in squamous cell carcinoma of the head and neck during radiotherapy and assessing the dose changes that occur as a result of them. Settings and Design:This was a p...

journal_title：Journal of cancer research and therapeutics

authors： Ilangovan B,Venkatraman M,Balasundaram S

更新日期：2020-04-01 00:00:00

abstract：PURPOSE:To report our experience of stereotactic radiosurgery (SRS) in consecutively treated patients with arteriovenous malformations (AVMs). MATERIALS AND METHODS:Of the 87 patients, 23 patients qualified and were treated with SRS as per predefined protocol according to AVM size, location, neurological status, prior...

journal_title：Journal of cancer research and therapeutics

authors： Jalali R,Dutta D,Srinivas C,Munshi A,Limaye U,Goel A,Deshpande D,Sarin R

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND:Tumor markers are a major part of the secondary prevention and thus the detection of malignancies. Neoplasms often have an increased concentration of sialic acid on the tumor cell surface and are shed or secreted by some of these cells which increase the concentration in blood. MATERIALS AND METHODS:The stu...

journal_title：Journal of cancer research and therapeutics

authors： Joshi M,Patil R

更新日期：2010-07-01 00:00:00

abstract：:Symptoms of nausea and vomiting can present a diagnostic challenge for physicians. In this article, we report a patient who was found to have synchronous presentation of an ependymoma and pancreatic cancer. This case illustrates some of the diagnostic challenges in patients with constitutional symptoms. Furthermore, i...

journal_title：Journal of cancer research and therapeutics

authors： Chowdhry VK,Carter DA,Shapiro A

更新日期：2013-10-01 00:00:00

abstract：:Dermatofibrosarcoma protuberans (DFSP) is a low-grade tumor with rare metastasis. A 26-year-old male presented with multiple cutaneous nodular lesions of DFSP since 3 months along with distant metastasis to the brain, pleura, and muscles that were detected on investigations. The case is being reported due to its rare ...

journal_title：Journal of cancer research and therapeutics

authors： Mahajan BB,Sumir K,Singla M

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:The profiles of lipids in normal and cancerous tissues may differ revealing information about cancer development and progression. Lipids being surface active, changes in lipid profiles can manifest as altered surface activity profiles. Langmuir monolayers offer a convenient model for evaluating surface activ...

journal_title：Journal of cancer research and therapeutics

authors： Preetha A,Banerjee R,Huilgol N

更新日期：2005-07-01 00:00:00

abstract：:Foot is an uncommon site for chondrosarcoma and involvement of phalanges is extremely rare. Here, a case of low-grade chondrosarcoma of the distal phalanx of the right great toe in a 37-year-old male patient is being reported. The patient complained of gradual swelling of the right great toe and pain for last 2 years....

journal_title：Journal of cancer research and therapeutics

authors： Mondal SK

更新日期：2012-01-01 00:00:00

abstract：Background:Colorectal cancer (CRC) is the second most diagnosed cancer often identified during the later stages of carcinogenesis. Orientin, a C-glycoside of luteolin, is well known for its versatile therapeutic action toward oxidative stress-induced cellular response may exert chemoprevention against CRC. Materials a...

journal_title：Journal of cancer research and therapeutics

authors： Thangaraj K,Natesan K,Settu K,Palani M,Govindarasu M,Subborayan V,Vaiyapuri M

更新日期：2018-10-01 00:00:00

abstract：Aims:This study is carried out to report on the knowledge and practice regarding breast self-examination (BSE) among women from the city of Mosul in Iraq and to evaluate the prevalence of performing clinical breast examination (CBE) and mammography among them. Settings and Design:A descriptive, cross-sectional survey ...

journal_title：Journal of cancer research and therapeutics

authors： Al-Qazaz HK,Yahya NA,Ibrahim DK

更新日期：2020-10-01 00:00:00

abstract：Aim:Tumor-associated macrophages (TAMs) play a decisive role in the regulation of tumor progression by manipulating tumor oncogenesis, angiogenesis, and immune functions within tumor microenvironments. Tumor progression is frequently associated with a phenotypic switch from M1 to M2 in TAM. Activation of signal transdu...

journal_title：Journal of cancer research and therapeutics

authors： Seyedi Z,Hashemzadeh MR,Colagar AH,Jaafari MR

更新日期：2018-07-01 00:00:00

abstract：:Adenoid cystic carcinomas (ACC) of the head and neck are relatively rare tumors, consisting of approximately 10-15% of all salivary gland neoplasms. ACC, a slow-growing aggressive malignant tumor of salivary gland commonly seen in the submandibular, sublingual, minor salivary glands is seldom found in the parotid. Cal...

journal_title：Journal of cancer research and therapeutics

authors： Shenoy VS,Kamath MP,Sreedharan S,Suhas SS

更新日期：2015-07-01 00:00:00

abstract：Objective:The objective of this study is to review the multidetector computed tomography (MDCT) findings of synchronous lymphoma and other solid malignancies. Patients and Methods:This retrospective study included 18 patients confirmed with diagnosis of lymphoma and other solid malignancies. They were 8 women and 10 m...

journal_title：Journal of cancer research and therapeutics

authors： El-Badrawy A,Gadelhak B,Helmy EM,Farouk O,Fady T,Refky B,Elzaafarany M,Emarah Z,Taalab MM,Eisa N,El-Etreby SA,Bahgat MH,El-Badrawy MK,Elalfy H,Besheer T,El-Mesery A,Akl MF,Megahed N,Khashaba EO

更新日期：2020-01-01 00:00:00

abstract：Background:Several studies have investigated hypopharyngeal cancer (HC) risk in combination with xenobiotic metabolism-related genetic polymorphisms and the burden of alcohol consumption and smoking in European countries but not in East Asian countries. Patients and Methods:This hospital-based case-control study invol...

journal_title：Journal of cancer research and therapeutics

authors： Yamashita Y,Ikegami T,Suzuki M,Hirakawa H,Maeda H,Yamada S,Deng Z,Kondo S,Kinjyo H,Kiyuna A,Agena S,Uehara T,Ganaha A

更新日期：2019-07-01 00:00:00