Psychotropic medication use during pregnancy and gestational age at delivery.

Abstract:

PURPOSE:The purpose of this study was to evaluate the association between psychotropic medication use during pregnancy and gestational age at delivery, after adjusting for depressive symptom and perceived stress severity. METHODS:We analyzed data on singleton live births from 2914 female Pregnancy Study Online participants, aged 21 to 45, with a reported conception from 6/2013 to 6/2018. Women reported psychotropic medication use at 8 to 12 weeks' and ~32 weeks' gestation. We measured depressive symptoms using the Major Depressive Inventory and perceived stress using the 10-item Perceived Stress Scale. Data on gestational age at delivery were based on self-reports and/or birth certificates. We used restricted mean survival time models, stratifying by severity of depressive symptoms (Major Depression Inventory <25 vs. ≥25) and perceived stress (Perceived Stress Scale <20 vs. ≥20). RESULTS:Two hundred and ten (7.2%) participants reported using psychotropic medications during pregnancy. Mean gestational age at delivery among women who never used psychotropic medications was 38.2 weeks (95% confidence interval: 37.7, 38.7), whereas it was 37.3 weeks (95% confidence interval: 36.7, 37.9) among women who used psychotropic medications during pregnancy. Results were similar across strata of depressive symptoms and perceived stress. CONCLUSIONS:Our data indicate that the association between psychotropic medication use and gestational age at delivery is not confounded by indication.

journal_name

Ann Epidemiol

journal_title

Annals of epidemiology

authors

Haviland MJ,Nillni YI,Fox MP,Savitz DA,Hatch EE,Rothman KJ,Hacker MR,Wang TR,Wise LA

doi

10.1016/j.annepidem.2020.08.010

subject

Has Abstract

pub_date

2021-01-01 00:00:00

pages

34-41.e2

eissn

1047-2797

issn

1873-2585

pii

S1047-2797(20)30291-X

journal_volume

53

pub_type

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