Cytomegalovirus seroprevalence in pregnant women in the western region of Romania: A large-scale study.

Abstract:

:Cytomegalovirus (CMV) infection is the most common congenital infection worldwide, and remains a significant cause of the neurological deficiency and sensory deafness in developed countries. Maternal primary infection, reactivation or reinfection during pregnancy may lead to fetal infection and congenital CMV syndrome. The purpose of this study was to analyze the CMV seroprevalence according to demographic features of pregnant women in western Romania as well as the evolution of CMV immunity in two time intervals. IgG anti-CMV antibodies were tested in sera of 8,951 pregnant women during two successive intervals: 2008-2010 (n=1466) and 2015-2018 (n=7485). The CMV seroprevalence in women of reproductive age decreased from 94.6 to 91.80% in the last decade. The seroprevalence was higher in women from rural areas compared with those from urban areas. These results show that the western region of Romania has a low-risk profile for primary CMV infection during pregnancy due to a large number of seropositive women. However, this risk has increased in the last ten years, from 5.4 to 8.2%, which may show the need to implement a national screening program.

journal_name

Exp Ther Med

authors

Gorun F,Motoi S,Malita D,Navolan DB,Nemescu D,Olariu TR,Craina M,Vilibic-Cavlek T,Ciohat I,Boda D,Dobrescu A

doi

10.3892/etm.2020.8945

subject

Has Abstract

pub_date

2020-09-01 00:00:00

pages

2439-2443

issue

3

eissn

1792-0981

issn

1792-1015

pii

ETM-0-0-8945

journal_volume

20

pub_type

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