Gambogic acid suppresses colon cancer cell activity in vitro.

abstract：:Rutin has a variety of pharmacological actions, including radical reactivity, and protective activity against lipid peroxidation, viruses and acute pancreatitis; thus, it may be used as a treatment for many diseases. The present study aimed to investigate whether rutin inhibits coronary heart disease through extracell...

journal_title：Experimental and therapeutic medicine

authors： Lv L,Yao Y,Zhao G,Zhu G

更新日期：2018-01-01 00:00:00

abstract：:We previously reported on single-incision laparoscopic surgery applied to laparoscopically assisted vaginal hysterectomy (LAVH) cases. We accumulated single-incision LAVH cases to evaluate this operation, including its learning curve. Since July 2009, we planned to perform single-incision LAVH in 50 cases. Operative t...

journal_title：Experimental and therapeutic medicine

authors： Koyanagi T,Motomura S

更新日期：2011-09-01 00:00:00

abstract：:Organic cation transporter member 2 (OCT2) is an N-glycosylated transporter that has been shown to be closely associated with the transport of antitumor drugs. Oxaliplatin, a platinum-based drug, is used for the chemotherapy of colorectal cancer (CRC). However, oxaliplatin resistance is a major challenge in the treatm...

journal_title：Experimental and therapeutic medicine

authors： Cong X,Liu X,Dong X,Fang S,Sun Z,Fan J

更新日期：2021-02-01 00:00:00

abstract：:The underlying mechanisms of arterial remodeling (AR) remain unclear. Studies have indicated that decellularized scaffolds stimulate the differentiation of fibroblasts into myofibroblasts and promote the accumulation of the extracellular matrix (ECM). In the present study, the impact of ECM changes following AR on vas...

journal_title：Experimental and therapeutic medicine

authors： Xin H,Wang Z,Wu S,Wang P,Tao X,Xu C,You L

更新日期：2019-07-01 00:00:00

abstract：:The therapeutic effect of saikosaponin a (SSa) on hyperlipidemic pancreatitis (HP) is not completely understood. The aim of the present study was to investigate the therapeutic effect and the underlying mechanism of SSa using a rat model of HP. Following successful establishment of the HP rat model, different doses of...

journal_title：Experimental and therapeutic medicine

authors： Feng P,Xu Y,Tong B,Tong X,Bian Y,Zhao S,Shen H

更新日期：2020-02-01 00:00:00

abstract：:Saw palmetto extract can induce the apoptosis of prostate cancer cells. The aim of the present study was to investigate the effect of saw palmetto extract on the phosphatidylinositol 3-kinase (PI3K)/Akt signaling transduction pathway in human glioma U87 and U251 cell lines. Suspensions of U87 and U251 cells in a logar...

journal_title：Experimental and therapeutic medicine

authors： Yang Y,Hui L,Yuqin C,Jie L,Shuai H,Tiezhu Z,Wei W

更新日期：2014-08-01 00:00:00

abstract：:Aortic valve (AoV) stenosis is the third most common cardiovascular disease. The pathogenesis of AoV stenosis is associated with an inflammatory process where MMPs serve important roles. The aim of the present study was to determine the association between matrix metalloproteinases (MMPs), tissue inhibitors of metallo...

journal_title：Experimental and therapeutic medicine

authors： Lurins J,Lurina D,Svirskis S,Nora-Krukle Z,Tretjakovs P,Mackevics V,Lejnieks A,Rapisarda V,Baylon V

更新日期：2019-04-01 00:00:00

abstract：:The host response to spinal cord injury (SCI) can lead to an ischemic environment that can induce cell death. Therapeutic interventions using neurotrophic factors have focused on the prevention of such reactions in order to reduce this cell death. Vascular endothelial growth factor (VEGF) is a potent angiogenic and va...

journal_title：Experimental and therapeutic medicine

authors： Yu H,Lin B,He Y,Zhang W,Xu Y

更新日期：2015-05-01 00:00:00

abstract：:Autophagy has been shown to be involved in the pathophysiology of developmental seizure-induced brain damage. The present study aimed to examine whether E-64d, an autophagy inhibitor, was able to facilitate developmental seizure-induced hippocampal mossy fiber sprouting, in particular sprouting-associated zinc transpo...

journal_title：Experimental and therapeutic medicine

authors： Ni H,Zhang LL,Ren SY,Sun BL

更新日期：2016-07-01 00:00:00

abstract：:The role of apolipoprotein E (Apo E) gene polymorphisms in the etiology of recurrent pregnancy loss (RPL) is not clearly understood. We evaluated this polymorphism in unexplained pregnancy losses in a group of Turkish women. In our prospective case-control study, 45 well-characterized RPL cases were examined for their...

journal_title：Experimental and therapeutic medicine

authors： Korkmazer E,Ustunyurt E,Tekin B,Cilingir O

更新日期：2013-05-01 00:00:00

abstract：:Primary congenital glaucoma (PCG) is one of the primary causes of blindness in children and is characterized by congenital trabecular meshwork and anterior chamber angle dysplasia. While being a rare condition, PCG severely impairs the quality of life of affected patients. However, the pathogenesis of PCG remains to b...

journal_title：Experimental and therapeutic medicine

authors： Ling C,Zhang D,Zhang J,Sun H,Du Q,Li X

更新日期：2020-08-01 00:00:00

abstract：:The aim of the present study was to investigate whether chronic administration of basic fibroblast growth factor (bFGF) following angioplasty in a dog model of atherosclerotic iliac stenosis may restore endothelium function and prevent restenosis (RS). In total, 40 dogs with atherosclerotic stenosis of the right iliac...

journal_title：Experimental and therapeutic medicine

authors： Ran F,Liu C,Liu Z,Shang T,Zhou M,Qiao T

更新日期：2014-05-01 00:00:00

abstract：:Lung cancer, a major health problem affecting the epithelial lining of the lower respiratory tract, is considered to be one of the deadliest types of cancer in males and females and it is well-known that smoking is the chief cause of lung cancer. In addition to smoking and environmental factors, genetic susceptibility...

journal_title：Experimental and therapeutic medicine

authors： Baykara O,Tansarikaya M,Demirkaya A,Kaynak K,Tanju S,Toker A,Buyru N

更新日期：2013-02-01 00:00:00

abstract：:We investigated the clinical value of fractional flow reserve (FFR) for the prognostic evaluation of patients with percutaneous coronary intervention. We enrolled 120 patients who were admitted to the hospital to undergo percutaneous coronary intervention for acute coronary syndromes between May 2014 and June 2015. Th...

journal_title：Experimental and therapeutic medicine

authors： Zhao Q,Ji Z,Li X,Di Y,An H,Wei B,Yang L,Chen W

更新日期：2018-01-01 00:00:00

abstract：:Pulmonary carcinoid tumors represent bronchopulmonary neuroendocrine neoplasms which might synthetize serotonin, histamine, bombesin or other types of hormones responsible for the development of a broad spectrum of signs and symptoms, known as carcinoid syndrome. Data of 98 patients submitted to surgery for bronchial ...

journal_title：Experimental and therapeutic medicine

authors： Savu C,Melinte A,Lukadi JL,Mirvald C,Savu C,Belu E,Diaconu C,Iliescu L,Balescu I,Stiru O,Bratu O,Gorecki G,Bacalbasa N

更新日期：2020-12-01 00:00:00

abstract：:The present study retrospectively analyzed 19 patients diagnosed with paraquat (PQ) poisoning with the aim to investigate the effect of activated charcoal hemoperfusion on renal function and PQ elimination. The results indicated that 7 patients died and 12 survived. Non-oliguric renal failure occurred in all of the 7 ...

journal_title：Experimental and therapeutic medicine

authors： Sun L,Yan PB,Zhang Y,Wei LQ,Li GQ

更新日期：2018-03-01 00:00:00

abstract：:Electroacupuncture (EA) may stimulate neurogenesis in animal models of ischemic stroke; however, the associated mechanisms are not clear. The present study aimed to evaluate the neurogenesis efficacy of EA on ischemic stroke and the underlying associated mechanisms. A model of middle cerebral artery occlusion (MCAO) w...

journal_title：Experimental and therapeutic medicine

authors： Tan F,Wang J,Liu JX,Wang C,Li M,Gu Y

更新日期：2018-12-01 00:00:00

abstract：:A previous study by our group found that electro-acupuncture (EA) at the Shenting (DU24) and Baihui (DU20) acupoints ameliorates cognitive impairment in rats with cerebral ischemia-reperfusion (I/R) injury. However, the precise mechanism of action has remained largely unknown. The present study investigated whether br...

journal_title：Experimental and therapeutic medicine

authors： Lin R,Li X,Liu W,Chen W,Yu K,Zhao C,Huang J,Yang S,Peng H,Tao J,Chen L

更新日期：2017-09-01 00:00:00

abstract：:The aim of the present study was to evaluate the predictive efficiency of mean platelet volume (MPV) and platelet size deviation width (PDW) for bone marrow failure (BMF) in thrombocytopenic patients. Platelet count, MPV and PDW data were retrieved from the records of 574 unselected thrombocytopenic patients from betw...

journal_title：Experimental and therapeutic medicine

authors： Xu RL,Zheng ZJ,Ma YJ,Hu YP,Zhuang SH

更新日期：2013-01-01 00:00:00

abstract：:Paeoniflorin serves important cellular roles, exerting anti-cancer, anti-inflammatory and anti-pulmonary fibrosis effects and possesses immune-modulatory properties. However, the exact role of paeoniflorin in the pathogenesis of osteoarthritis (OA) remains unclear. The aim of the present study was to investigate the e...

journal_title：Experimental and therapeutic medicine

authors： Hu PF,Sun FF,Jiang LF,Bao JP,Wu LD

更新日期：2018-08-01 00:00:00

abstract：:Red cell distribution width (RDW) has been found to be a novel prognostic biomarker in patients with coronary artery disease (CAD); however, the association between RDW and the risk of heart events in patients with CAD is yet to be fully elucidated. Thus, the aim of the present study was to determine whether an elevat...

journal_title：Experimental and therapeutic medicine

authors： Li W,Li X,Wang M,Ge X,Li F,Huang B,Peng J,Li G,Lu L,Yu Z,Ma J,Xu L,Jin M,Si H,Wan R

更新日期：2015-04-01 00:00:00

abstract：:This study describes the case of a 41-year-old woman admitted for anterograde memory loss, right facial grimacing and right arm posturing that had begun 1 month previously. Cranial magnetic resonance-diffusion weighted imaging and -fluid-attenuated inversion recovery imaging revealed a hyperintense signal in the left ...

journal_title：Experimental and therapeutic medicine

authors： Liu J,Li M,Li G,Zhou C,Zhang R

更新日期：2016-01-01 00:00:00

abstract：:The aim of the present study was to isolate, culture and characterize sheep metanephric mesenchymal stem cells (MMSCs). The MMSCs were isolated from the kidney tissue of six-week-old sheep fetus. This study investigated whether primary MMSCs could be grown for 26 passages and expressed Oct-4, which is involved in the ...

journal_title：Experimental and therapeutic medicine

authors： Ji M,Bai C,Li L,Fan Y,Ma C,Li X,Guan W

更新日期：2016-12-01 00:00:00

abstract：:Ischemic stroke is a life-threatening complication with a high rate of morbidity. Circulating fatty acid binding protein 4 (FABP4) has been reported to be associated with the outcome of acute ischemic stroke. The present study aimed to illustrate the function of FABP4 in ischemic stroke. PC12 cells exposed to oxygen g...

journal_title：Experimental and therapeutic medicine

authors： Yang XL,Mi JH,Dong Q

更新日期：2021-03-01 00:00:00

abstract：:The aim of the present study was to investigate the protective effects of ischemic preconditioning on rats with renal ischemia-reperfusion injury and the effects on the expression of Bcl-2 and Bax. Thirty-six SD rats were randomly divided into three groups (n=12) including sham operation (S) group, ischemia-reperfusio...

journal_title：Experimental and therapeutic medicine

authors： Shen S,Zhou J,Meng S,Wu J,Ma J,Zhu C,Deng G,Liu D

更新日期：2017-11-01 00:00:00

abstract：:High-mobility group box 1 (HMGB1) is released after focal cerebral ischemia/reperfusion (I/R), and aggravates brain tissue damage. Ginsenoside Rb1 (Rb1), isolated from Panax ginseng, has been reported to inhibit I/R-induced cell death in the brain. The present study aimed to investigate the protective ability of GRb1 ...

journal_title：Experimental and therapeutic medicine

authors： Liu A,Zhu W,Sun L,Han G,Liu H,Chen Z,Zhuang L,Jiang W,Xue X

更新日期：2018-10-01 00:00:00

abstract：:Acute myocardial infarction (AMI) evokes a temporally coordinated immune response, in which monocytes are critically involved in the clearance of cell debris; however, excessive inflammation induced by the classical sub-population of monocytes frequently limits the endogenous reparative process. In the present study, ...

journal_title：Experimental and therapeutic medicine

authors： Zhu H,Ding Y,Zhang Y,Ding X,Zhao J,Ouyang W,Gong J,Zou Y,Liu X,Wu W

更新日期：2020-03-01 00:00:00

abstract：:The aim of this study was to detect early changes (within 1-4 h) in the brain natriuretic peptide (BNP) levels of rats with acute myocardial infarction (AMI). A total of 35 Wistar rats were established as models of AMI and 30 sham-operated rats were used as the control group. The myocardia of the two groups were obser...

journal_title：Experimental and therapeutic medicine

authors： Li J,Yin FF,Hou YL

更新日期：2013-04-01 00:00:00

abstract：:The transient receptor potential melastatin 2 (TRPM2) channel, a Ca2+ permeable channel activated by cAMP, is expressed on pancreatic β-cells and is responsible for the regulation of insulin secretion. It is known that glucose-stimulated insulin secretion (GSIS) can be potentiated by glucagon like peptide-1 (GLP-1), a...

journal_title：Experimental and therapeutic medicine

authors： Pang B,Kim S,Li D,Ma Z,Sun B,Zhang X,Wu Z,Chen L

更新日期：2017-11-01 00:00:00

abstract：:E-cadherin is a key cell adhesion molecule implicated in tumor suppression that is frequently altered in hepatocellular carcinoma (HCC), particularly in hepatitis B virus-related tumors. Here, we report that the epigenetic drugs 5-azacytidine and trichostatin A up-regulated E-cadherin expression in HCC cells. The depl...

journal_title：Experimental and therapeutic medicine

authors： Qiu X,Qiao F,Su X,Zhao Z,Fan H

更新日期：2010-05-01 00:00:00