Paeoniflorin inhibits IL-1β-induced MMP secretion via the NF-κB pathway in chondrocytes.

abstract：:The anticancer properties of epigallocatechin-3-gallate (EGCG) are documented in the treatment of several types of cancer; however, there is no relevant evidence for its efficacy in the treatment of renal cell carcinoma (RCC). In the present study, the therapeutic effects of EGCG in vitro were investigated, with parti...

journal_title：Experimental and therapeutic medicine

authors： Chen SJ,Yao XD,Peng BO,Xu YF,Wang GC,Huang J,Liu M,Zheng JH

更新日期：2016-04-01 00:00:00

abstract：:In the present study the preventive effect of polysaccharides from the large yellow croaker swim bladder (PLYCSB) on HCl/ethanol-induced gastric injury in ICR mice was investigated. A high dose of PLYCSB (50 mg/kg) was found to reduce the levels of the serum proinflammatory cytokines interleukin (IL)-1β, IL-6, IL-8, a...

journal_title：Experimental and therapeutic medicine

authors： Chen S,Zhu K,Wang R,Zhao X

更新日期：2014-07-01 00:00:00

abstract：:In the development of anti-blood cancer drugs, the chronic myelocytic leukemia (KU812), acute myelocytic leukemia (KG-1) and lymphoma (U937) cell lines are commonly used in preclinical pharmacology studies as human cancer xenograft models in mice. In the present study, mRNA expression levels of typical human ATP-bindi...

journal_title：Experimental and therapeutic medicine

authors： Takeuchi K,Shibata M,Kashiyama E,Umehara K

更新日期：2012-09-01 00:00:00

abstract：:The aim of the present study was to establish a stem cell line for multi-mode imaging (in vivo fluorescence imaging, magnetic resonance imaging and 99mTc single-photon emission computed tomography) and to study the biological activity, stemness, proliferative activity and differentiation ability of superparamagnetic i...

journal_title：Experimental and therapeutic medicine

authors： Meng Y,Liu H,Bian N,Gong J,Zhong X,Huang C,Liang W,Xu H

更新日期：2018-09-01 00:00:00

abstract：:Tumor hypoxia contributes to the development of resistance to chemotherapeutic drugs in several human cancer cell lines. Atovaquone, an anti-malaria drug approved by the US Food and Drug Administration, has recently demonstrated anti-cancer effects in vitro and in vivo in several cancer models. To assess the potential...

journal_title：Experimental and therapeutic medicine

authors： Fu C,Xiao X,Xu H,Lu W,Wang Y

更新日期：2020-12-01 00:00:00

abstract：:Pancreatic necrosectomy (PN) following percutaneous catheter drainage (PCD) is an effective method of treating patients with necrotizing pancreatitis, however, the predictive factors for PN after PCD have not yet been identified. A total of 74 patients with suspected infected necrotizing pancreatitis (INP) and peripan...

journal_title：Experimental and therapeutic medicine

authors： Cao X,Cao F,Li A,Gao X,Wang XH,Liu DG,Fang Y,Guo DH,Li F

更新日期：2017-11-01 00:00:00

abstract：:Environmental exposure, including a high-fat diet (HFD), contributes to the high prevalence of colorectal cancer by changing the composition of the intestinal microbiota. However, data examining the interaction between dietary habits and intestinal microbiota of the Chinese population is sparse. We assessed dietary ha...

journal_title：Experimental and therapeutic medicine

authors： Qian L,Gao R,Hong L,Pan C,Li H,Huang J,Qin H

更新日期：2018-08-01 00:00:00

abstract：:The study aims to investigate the clinical significance of regulating the expression of 25-hydroxyvitamin D (25-OH-VD) via microRNA (miRNA)-376c in the occurrence and development of preeclampsia (PE) in pregnant women. Peripheral blood and placental tissues were collected from pregnant women in 4 groups, including 67 ...

journal_title：Experimental and therapeutic medicine

authors： Li J,Du J,Wang Z,Wang C,Bai J,Zhang S

更新日期：2018-09-01 00:00:00

abstract：:Gastric carcinoma is one of the most common human cancers and has a poor prognosis. Receptor tyrosine kinase-like orphan receptor 2 (ROR2), which is a non-canonical receptor of the Wnt signaling pathway, has been reported to be deregulated in numerous types of human cancers, including gastric carcinoma. However, the e...

journal_title：Experimental and therapeutic medicine

authors： Yan L,Du Q,Yao J,Liu R

更新日期：2016-12-01 00:00:00

abstract：:Different neoadjuvant therapy regimens are available for rectal cancer, but the relative effects are controversial. The aim of the present network meta-analysis (NMA) was to estimate the relative efficacy and safety of neoadjuvant therapies for resectable rectal cancer. MEDLINE, EMBASE and Cochrane Central Registry of...

journal_title：Experimental and therapeutic medicine

authors： Zhong W,Xue X,Dai L,Li R,Nie K,Zhou S

更新日期：2020-04-01 00:00:00

abstract：:Engineered nanoparticles (NPs) have been increasingly used in numerous fields over the last decade. In particular, iron oxide NPs (Fe2O3NPs) and silver NPs (AgNPs) have contributed to the current increase in NP usage. However, the possible side effects of increased NP exposure remain not fully elucidated. The present ...

journal_title：Experimental and therapeutic medicine

authors： Yousef MI,Abuzreda AA,Kamel MA

更新日期：2019-12-01 00:00:00

abstract：:The present study aimed to investigate the expression of the forkhead box protein M1 (FOXM1) in the placenta of patients with preeclampsia, and its effect on trophoblasts. A total of 28 patients with preeclampsia and 30 patients without preeclampsia (controls) who underwent cesarean section and were admitted to the Af...

journal_title：Experimental and therapeutic medicine

authors： Cui X,Xu J,Ji Y,Song X,Wang J,Zhang L,Yang S,Ye Y

更新日期：2018-07-01 00:00:00

abstract：:Relative changes in B-type natriuretic peptide (BNP) and amino terminal pro-BNP (NT-proBNP) levels may help to assess the risk of congestive heart failure (CHF). However, whether these levels at the time of admission enable the prediction of outcomes with acute exacerbation remains unknown. The current study determine...

journal_title：Experimental and therapeutic medicine

authors： Dai Y,Yang J,Takagi A,Konishi H,Miyazaki T,Masuda H,Shimada K,Miyauchi K,Daida H

更新日期：2017-08-01 00:00:00

abstract：:The programmed death-1 (PD-1)/PD-ligand 1 (PD-L1) signaling pathway is a negative regulatory mechanism that inhibits T cell proliferation and cytokine production. Soluble PD-1 (sPD-1) and soluble PD-L1 (sPD-L1), are also involved in regulation of the PD-1/PD-L1 signaling pathway. In the present study, the expression l...

journal_title：Experimental and therapeutic medicine

authors： Li Y,Xiao Y,Su M,Zhang R,Ding J,Hao X,Ma Y

更新日期：2016-01-01 00:00:00

abstract：:3-Hydroxy-3-methylglutaric aciduria (3-HMG, OMIN 246450) is a rare autosomal recessive metabolic disorder caused by a deficiency of 3-hydroxy-3-methylglutaryl-CoA lyase, a key enzyme in leucine metabolism and ketone body synthesis. Acute episodes of 3-HMG may be triggered by fasting or infection, and symptoms include ...

journal_title：Experimental and therapeutic medicine

authors： Hao X,Wang J,Liu S,Chen Y,Zhang Y,Hao Y

更新日期：2016-06-01 00:00:00

abstract：:The aim of the present study was to determine the prognostic value of peroxisome proliferator-activated receptor-γ (PPAR-γ) and phosphatase and tensin homologue deleted on chromosome ten (PTEN) for bladder cancer. Data were collected from The Cancer Genome Atlas (TCGA), a public database, and were analyzed to assess P...

journal_title：Experimental and therapeutic medicine

authors： Zhang Z,Xu H,Ji J,Shi X,Lyu J,Zhu Y,Yu H,Wang F

更新日期：2019-10-01 00:00:00

abstract：:The aim of the study was to detect the expression of interleukin-1β (IL-1β) in serum of patients with perimenopausal non-organic sleep disorder (PNSD) and to study the relationship between IL-1β and the severity of insomnia and liver depression, so as to benefit the prevention of PNSD. A total of 268 cases of perimeno...

journal_title：Experimental and therapeutic medicine

authors： Li H,Chen Y,Wu H,Huang J,Ma K,Zheng J,Lv S

更新日期：2019-01-01 00:00:00

abstract：:Osteonecrosis is a condition that frequently affects patients with systemic lupus erythematosus (SLE). However, reports on severe multifocal osteonecrosis involving more than three anatomical sites in patients with SLE are scarce. The present study describes a case of SLE with multifocal osteonecrosis involving all fo...

journal_title：Experimental and therapeutic medicine

authors： Sun S,Wang Q,Gong Y,Qi X,Liu J

更新日期：2019-10-01 00:00:00

abstract：:Langerhansmporal histiocytosis (LCH) refers to a group of diseases that are characterized by the primary pathogenesis of an abnormal polyclonal proliferation of Langerhans cells that affect different structures of the human body, including the temporal bone. Thus far, the etiology of LCH remains unclear. Diagnosis of ...

journal_title：Experimental and therapeutic medicine

authors： Ni M,Yang X

更新日期：2017-03-01 00:00:00

abstract：:Successful eyelid reconstructions have been reported when using an axial nasal chondromucosal flap based on the dorsal nasal artery. The present study aimed to present a detailed anatomical description of the blood supply of the lateral nasal region and the angular artery, in order to propose the angular vessels as a ...

journal_title：Experimental and therapeutic medicine

authors： Hou D,Fang L,Zhao Z,Zhou C,Yang M

更新日期：2013-03-01 00:00:00

abstract：:The present study aimed to explore the effects of dexmedetomidine combined with etomidate on the expression levels of interleukin (IL)-17A and S-100β in rats with postoperative cognitive dysfunction (POCD). A total of 50 SD rats were randomly allocated into the control group, model group, etomidate group (Eto group), ...

journal_title：Experimental and therapeutic medicine

authors： Yu X,Xie Y

更新日期：2020-12-01 00:00:00

abstract：:Previously, we performed a molecular pharmacological study that applied a combination of DNA microarray-based gene expression profiling and drug sensitivity tests in vitro with a view to designing an improved chemotherapeutic strategy for advanced lung cancer. Utilizing recent key technological advances in proteomics,...

journal_title：Experimental and therapeutic medicine

authors： Hino M,Matsuda K,Miyanaga A,Kuribayasi H,Mizutani H,Noro R,Minegishi Y,Okano T,Seike M,Kawakami A,Yoshimura A,Ogawa N,Uesaka H,Kudoh S,Gemma A

更新日期：2010-01-01 00:00:00

abstract：:Cisplatin (DDP) is a commonly used chemotherapy drug; however, the side effects associated with its use, particularly acute kidney injury (AKI), limit its clinical application. Puerarin is a natural flavonoid extracted from the Chinese medical herb Radix puerariae, which has been reported to alleviate DDP-induced neph...

journal_title：Experimental and therapeutic medicine

authors： Wu Z,Li C,Li Q,Li J,Lu X

更新日期：2020-10-01 00:00:00

abstract：:The present study investigated the clinical characteristics and diagnosis of modern laryngeal tuberculosis (TB). A total of 61 patients that were pathologically diagnosed with laryngeal TB between 1998 and 2012 were retrospectively analyzed using laryngoscopy methods. The primary symptoms of laryngeal TB observed in t...

journal_title：Experimental and therapeutic medicine

authors： Zhao N,Zhang Y,Li K

更新日期：2017-11-01 00:00:00

abstract：:There is currently no available cure or universally effective treatment for dry eye (DE). The aim of the present study was to investigate the clinical efficacy of transcutaneous electrical stimulation (TES) combined with artificial tears in treating DE. Patients diagnosed with DE were referred for therapy with TES com...

journal_title：Experimental and therapeutic medicine

authors： Cai MM,Zhang J

更新日期：2020-12-01 00:00:00

abstract：:The aim of this study was to investigate the safety, feasibility and mid-term results of laparoscopy-assisted surgery in the treatment of locally advanced gastric antral cancer. The clinical data of 50 patients who received laparoscopy-assisted surgery (Group A) and 62 patients who were treated by conventional laparot...

journal_title：Experimental and therapeutic medicine

authors： Fang F,Han F,Ding YL,Wang HJ

更新日期：2013-09-01 00:00:00

abstract：:Lentinus (L.) edodes (shiitake mushroom) is used as a traditional medicine in Asia. One of the components of L. edodes, eritadenine (an adenosine analog alkaloid), has been shown to reduce cholesterol levels. The hypocholesterolemic action of eritadenine appears to be achieved through the modification of hepatic phosp...

journal_title：Experimental and therapeutic medicine

authors： Yang H,Hwang I,Kim S,Hong EJ,Jeung EB

更新日期：2013-12-01 00:00:00

abstract：:Human osteoarthritis (OA) has been reclassified as a systemic musculoskeletal disorder involving activation of the innate and adaptive immune systems. Elevated pro-inflammatory cytokines may serve a key function in the development of the disease. 1,25-Dihydroxyvitamin D3 and dexamethasone (vitD3/Dex) may inhibit infla...

journal_title：Experimental and therapeutic medicine

authors： Wang G,Zhang J,Fang Y,Cao W,Xu B,Chen X

更新日期：2019-01-01 00:00:00

abstract：:Tumor endothelial cells (TECs) have been isolated from solid tumors by using immunological magnetic beads and magnetic active cell sorting, and lead to a more precise way to investigate tumor angiogenesis as well as screening of vascular targeting drugs. However, the question of which endothelial marker is a stable mo...

journal_title：Experimental and therapeutic medicine

authors： Qian H,Yang L,Zhao W,Chen H,He S

更新日期：2018-10-01 00:00:00

abstract：:Gastric ulcer is one of the most common chronic gastrointestinal diseases characterized by a significant defect in the mucosal barrier. Helicobacter pylori (H. pylori) infection and the frequent long-term use of non-steroidal anti-inflammatory drugs are major factors involved in gastric ulcer development. Acid inhibit...

journal_title：Experimental and therapeutic medicine

authors： Khoder G,Al-Menhali AA,Al-Yassir F,Karam SM

更新日期：2016-07-01 00:00:00