3-Hydroxy-3-methylglutaric aciduria with bilateral basal ganglia lesion: A case report.

abstract：:Schwann cell proliferation and differentiation is critical for the remyelination of injured peripheral nerves. Ferulic acid (FA) is a widely used antioxidant agent with neuroprotective properties. However, the potentially beneficial effects of FA on Schwann cells are unknown. Therefore, the present study was designed ...

journal_title：Experimental and therapeutic medicine

authors： Zhu X,Li K,Guo X,Wang J,Xiang Y

更新日期：2016-09-01 00:00:00

abstract：:UNBS5162, a naphthalimide derivative, has a strong anticancer effect and low clinical hematological toxicity. UNBS5162 has been shown to have an anticancer effect in numerous cancer types, except triple negative breast cancer (TNBC). To explore this issue, TNBC MDA-MB-231 cells were selected, and the effect of UNBS516...

journal_title：Experimental and therapeutic medicine

authors： Yue X,Li M,Chen D,Xu Z,Sun S

更新日期：2018-11-01 00:00:00

abstract：:The aim of the present study was to determine how Endostar inhibits tumor angiogenesis and increases radiation sensitivity when combined with radiotherapy. In vitro studies were conducted to analyze the expression levels of transforming growth factor-β1 (TGF-β1), hypoxia-inducible factor 1 (HIF-1α) and basic fibroblas...

journal_title：Experimental and therapeutic medicine

authors： Wu Y,Zheng Y,Shen Z,Ge W,Xie Y,Li C

更新日期：2014-04-01 00:00:00

abstract：:Cardiac fibrosis is a common phenomenon in different types of heart diseases, such as ischemic heart disease, inherited cardiomyopathy mutations, diabetes, and ageing and is associated with morbidity and mortality. Increased accumulation of extracellular matrix (ECM) that impacts cardiac function, is the underlying ca...

journal_title：Experimental and therapeutic medicine

authors： Tian J,An X,Niu L

更新日期：2017-05-01 00:00:00

abstract：:Action potential (AP) contours vary considerably between the fibers of normal adult and aged left atria. The underlying ionic and molecular mechanisms that mediate these differences remain unknown. The aim of the present study was to investigate whether the L-type calcium current (ICa.L) and the L-type Ca2+ channel of...

journal_title：Experimental and therapeutic medicine

authors： Gan TY,Qiao W,Xu GJ,Zhou XH,Tang BP,Song JG,Li YD,Zhang J,Li FP,Mao T,Jiang T

更新日期：2013-10-01 00:00:00

abstract：:The use of intravenous dexmedetomidine during surgery has been shown to suppress inflammatory cytokines peri-operatively. It has also been demonstrated that dexmedetomidine may benefit cognitive function in elderly patients following surgery; however, it is not clear whether dexmedetomidine reduces postoperative cogni...

journal_title：Experimental and therapeutic medicine

authors： Li Y,He R,Chen S,Qu Y

更新日期：2015-11-01 00:00:00

abstract：:The aim of the present study was to investigate the effects and mechanisms of the Klotho gene in oxidative stress injury after myocardial infarction. Sprague-Dawley rats were divided into five groups (sham, model, pDC316, LY294002, and pDC316-Klotho). Subsequently, the superoxide dismutase (SOD), glutathione (GSH), an...

journal_title：Experimental and therapeutic medicine

authors： Xu Z,Zheng S,Feng X,Cai C,Ye X,Liu P

更新日期：2021-01-01 00:00:00

abstract：:Astragaloside IV (AS-IV) in improving liver cirrhosis injury in rats and its effect on the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt)/mechanistic target of rapamycin (mTOR) signaling pathway were observed. Rat model of liver cirrhosis was induced by injection of carbon tetrachloride (CCl4). A total of 36 ...

journal_title：Experimental and therapeutic medicine

authors： Wei R,Liu H,Chen R,Sheng Y,Liu T

更新日期：2019-01-01 00:00:00

abstract：:The aim of the present study was to investigate the functional status of dendritic cells (DCs) in nasal polyps (NP) and their interactions with T lymphocytes. The interactions between DC and T lymphocytes in the pathogenesis of NP was also studied. The expression of cluster of differentiation (CD)1a and CD83 in NP was...

journal_title：Experimental and therapeutic medicine

authors： Lin X,Zhuang X,Li C,Wang X

更新日期：2018-06-01 00:00:00

abstract：:Eyelid conditioning, including delay eyelid conditioning and trace eyelid conditioning, has been used extensively to study neural structures and mechanisms of learning and memory as a form of associative learning. In the present study, microcurrent electrical stimulation was used to stimulate the medial prefrontal cor...

journal_title：Experimental and therapeutic medicine

authors： Zheng YJ,Dong YC,Zhu C,Zhao MS

更新日期：2016-03-01 00:00:00

abstract：:The aim of this study was to determine whether the vascular endothelial growth factor (VEGF) +936C/T polymorphism confers susceptibility to gastric cancer (GC) by conducting a meta-analysis. Publications addressing the association between the VEGF +936C/T polymorphism and GC risk were selected from the Pubmed, Embase ...

journal_title：Experimental and therapeutic medicine

authors： Zhou LP,Luan H,Dong XH,Jin GJ,Man DL,Shang H

更新日期：2011-09-01 00:00:00

abstract：:Chronic inducible urticaria (CIndU) is a subgroup of chronic urticaria which can cause severe quality of life impairment by their refractory forms. The recommended treatment approach in CindU is the same as that for chronic spontaneous urticaria (CSU). However, CIndU seem to be more resistant to standard doses of H1 a...

journal_title：Experimental and therapeutic medicine

authors： Bumbăcea RS,Deaconu CG,Berghea EC

更新日期：2019-08-01 00:00:00

abstract：:Doxorubicin (DOX), a potent and widely used anticancer agent, can give rise to severe cardiotoxicity that limits its clinical use by inducing oxidative stress. Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is the central regulator of cellular responses to electrophilic/oxidative stress, which serves a critical ro...

journal_title：Experimental and therapeutic medicine

authors： Guo Z,Yan M,Chen L,Fang P,Li Z,Wan Z,Cao S,Hou Z,Wei S,Li W,Zhang B

更新日期：2018-10-01 00:00:00

abstract：:The role of contaminated clothing in the transmission of influenza A virus during an epidemic period was investigated by examining the recovery of infectious influenza virus from experimentally virus-contaminated clothing, which had been subejected to routine wearing and washing for several months or years. The amount...

journal_title：Experimental and therapeutic medicine

authors： Ikeda K,Tsujimoto K,Suzuki Y,Koyama AH

更新日期：2015-04-01 00:00:00

abstract：:Chrysin is a major active ingredient of flavonoids, known to exhibit protective effects against various types of cancer. However, the anticancer role of chrysin against hepatocellular carcinoma (HCC) and the underlying molecular mechanisms remain unclear. In order to evaluate the effects of chrysin on cell viability a...

journal_title：Experimental and therapeutic medicine

authors： Zhang Q,Ma S,Liu B,Liu J,Zhu R,Li M

更新日期：2016-07-01 00:00:00

abstract：:In the present study, the changes in the retinal nerve fiber layer (RNFL) thickness associated with Leber's hereditary optic neuropathy (LHON) were examined by Cirrus high definition-optical coherence tomography (OCT), and the correlation between the RNFL thickness and the best corrected visual acuity (BCVA) was evalu...

journal_title：Experimental and therapeutic medicine

authors： Zhang Y,Huang H,Wei S,Qiu H,Gong Y,Li H,Dai Y,Jiang Z,Liu Z

更新日期：2014-02-01 00:00:00

abstract：:MicroRNAs (miRNAs) are small, non-coding RNAs that are key regulators of gene expression by directly binding to the 3'-untranslated region of their target mRNAs, resulting in translational repression or degradation of mRNA. It has been demonstrated that miRNAs have key roles in a variety of human malignancies, includi...

journal_title：Experimental and therapeutic medicine

authors： He Y,Yu B

更新日期：2017-05-01 00:00:00

abstract：:The novel bromophenol derivative, 3-(3-bromo-5-methoxy-4-(3-(piperidin-1-yl)propoxy)benzylidene)-N-(4-bromophenyl)-2-oxoindoline-5-sulfonamide (BOS-93), was synthesized in the CAS Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences (Qingdao, China). Experimental studies ...

journal_title：Experimental and therapeutic medicine

authors： Guo C,Wang L,Zhao Y,Jiang B,Luo J,Shi D

更新日期：2019-05-01 00:00:00

abstract：:Dimethyl carbonate (DMC) is a widely used industrial chemical, which may be increasingly used in the future. However, its toxicity profile remains largely unknown. The present study was designed to investigate the effects of DMC exposure on the ovaries and the effect of autophagy activation on follicular development. ...

journal_title：Experimental and therapeutic medicine

authors： Tang Z,Zhang Z,Tang Y,Qi L,Yang F,Wang Z

更新日期：2017-12-01 00:00:00

abstract：:The aim of the present study was to evaluate the clinical efficacy and safety of intravitreal ranibizumab injections for the treatment of macular choroidal neovascularization (CNV) caused by pathological myopia. Between one and four intravitreal injections of ranibizumab were administered to 61 eyes from 61 patients w...

journal_title：Experimental and therapeutic medicine

authors： Ji L,Lv W,Xiao Y,Xu Z,Zhang X,Zhang W

更新日期：2015-09-01 00:00:00

abstract：:The aim of the present study was to determine whether the myocardial protective function of Shenmai injection (SM) during ischemia/reperfusion (I/R) is attributable to its regulation of intracellular calcium (Ca2+) and phospholamban (PLB) levels. Cultured neonatal Sprague Dawley rat cardiomyocytes were used to compare...

journal_title：Experimental and therapeutic medicine

authors： Ye LF,Zheng YR,Wang LH

更新日期：2015-10-01 00:00:00

abstract：:The aim of the present study was to examine whether the expression of focal adhesion kinase (FAK) is altered in the eutopic endometrium of female patients with adenomyosis, as compared with that of females without adenomyosis. The expression of FAK was assessed by immunohistochemical, western blot and reverse transcri...

journal_title：Experimental and therapeutic medicine

authors： Mu L,Chen W,Ma Y,Zheng W

更新日期：2015-11-01 00:00:00

abstract：:Tanshinone IIA (TSIIA) is a major component of Salvia miltiorrhiza, a Chinese herb that exhibits a therapeutic effect on polycystic ovary syndrome (PCOS). The present study replicated PCOS via the neonatal treatment of estradiol in mice. Estrous cycles, body and ovarian weight, serum levels of testosterone and estradi...

journal_title：Experimental and therapeutic medicine

authors： Jin J,Hu QY,Xu WW,Zhu WJ,Liu B,Liu J,Wang W,Zhou HF

更新日期：2019-05-01 00:00:00

abstract：:Acute cerebral ischemia/reperfusion injury (ACIR) rat model was used to investigate the effect of spermine on oxidative stress and apoptosis. Sixty healthy and clean male Sprague-Dawley rats were randomly divided into 3 groups: The sham-operated group (n=12), the model group (n=12) and the experiment group (n=36). The...

journal_title：Experimental and therapeutic medicine

authors： Du H,Ming X,Zhou S

更新日期：2017-07-01 00:00:00

abstract：:The aim of the present study was to investigate the mechanism underlying the effects of different doses of agmatine in rats with chronic epilepsy. To generate chronic epilepsy models, rats pretreated with different doses of agmatine (20, 40 and 80 mg/kg) were intraperitoneally injected with pentylenetetrazole (35 mg/k...

journal_title：Experimental and therapeutic medicine

authors： Xu H,Ou F,Wang P,Naren M,Tu D,Zheng R

更新日期：2014-07-01 00:00:00

abstract：:Application value of the minimally invasive puncture and small bone window craniotomy in hypertensive intracerebral hemorrhage was investigated to explore the effects of the above treatment methods on motor-evoked potentials (MEPs) and postoperative rehemorrhage. Patients with hypertensive intracerebral hemorrhage who...

journal_title：Experimental and therapeutic medicine

authors： Luan L,Li M,Sui H,Li G,Pan W

更新日期：2019-02-01 00:00:00

abstract：:The aim of this study was to evaluate the application of acoustic radiation force impulse (ARFI) ultrasound imaging and its potential value in the characterization of cervical cancer. ARFI ultrasound imaging of the uterine cervix was performed in 58 patients with cervical cancer prior to surgery. The diagnosis of cerv...

journal_title：Experimental and therapeutic medicine

authors： Su Y,DU L,Wu Y,Zhang J,Zhang X,Jia X,Cai Y,Li Y,Zhao J,Liu Q

更新日期：2013-06-01 00:00:00

abstract：:Mutations of the β-catenin gene are common in various cancer types. MicroRNA (miR)-24 suppresses gene expression during the cell cycle. However, the effects of miR-24 on the cell viability and autophagy of glioma cells, and how these biological processes are regulated by β-catenin are largely unclear. The current stud...

journal_title：Experimental and therapeutic medicine

authors： Chen H,Lu Q,Chen C,Di Y,Li Y,Min W,Yu Z,Dai D

更新日期：2019-08-01 00:00:00

abstract：:Infantile neuroaxonal dystrophy (INAD) is a rare neurodegenerative disorder. Phospholipase A2 group VI (PLA2G6) gene mutations have been identified in the majority of individuals with INAD. The present case report is on a Chinese female pediatric patient (age, 18 months) diagnosed with INAD with deafness. To date, onl...

journal_title：Experimental and therapeutic medicine

authors： Wang B,Wu,Tang J

更新日期：2018-08-01 00:00:00

abstract：:Sepsis is a type of systemic inflammatory response syndrome with high morbidity and mortality. Skeletal muscle dysfunction is one of the major complications of sepsis that may also influence the outcome of sepsis. The aim of the present study was to explore and identify potential mechanisms and therapeutic targets of ...

journal_title：Experimental and therapeutic medicine

authors： Yang F,Wang Y

更新日期：2018-06-01 00:00:00