abstract：:Rheumatoid arthritis (RA) is a chronic disease of connective tissue caused by intolerance to self-antigens. Regulatory T cells (Tregs) are key players in maintaining autotolerance through a variety of suppressor mechanisms. RA is generally believed to develop due to disorders in Tregs; however, there is no consensus o...

journal_title：Experimental and therapeutic medicine

authors： Shevyrev D,Tereshchenko V,Kozlov V,Sizikov A,Chumasova O,Koksharova V

更新日期：2021-03-01 00:00:00

abstract：:Ischemic stroke is a life-threatening complication with a high rate of morbidity. Circulating fatty acid binding protein 4 (FABP4) has been reported to be associated with the outcome of acute ischemic stroke. The present study aimed to illustrate the function of FABP4 in ischemic stroke. PC12 cells exposed to oxygen g...

journal_title：Experimental and therapeutic medicine

authors： Yang XL,Mi JH,Dong Q

更新日期：2021-03-01 00:00:00

abstract：:Therapeutic drug monitoring is an essential tool when managing the therapeutic use of immunosuppressant cyclosporine A (CsA) in cases with solid organ transplantation. In China, the concentration of CsA is primarily measured using immunoassays. However, existing literature recommends mass spectrometry as the current g...

journal_title：Experimental and therapeutic medicine

authors： Wang X,Qin W,Chen W,Liu H,Zhang D,Zhang X,Li P

更新日期：2021-03-01 00:00:00

abstract：:Eugenol is a naturally occurring compound that is present in a variety of plants and has previous been demonstrated to exert a number of bioactivities. However, the potential effects of Eugenol on cellular protection against oxidative stress remain poorly understood. In the present study, HEK-293 cells and the mouse f...

journal_title：Experimental and therapeutic medicine

authors： Ma L,Liu J,Lin Q,Gu Y,Yu W

更新日期：2021-02-01 00:00:00

abstract：:Notch3 is a member of the Notch family and its mutations are known to cause a hereditary human disorder called cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). However, the specific function and signaling cascade initiated by CADASIL mutants remain unknown. To gain ...

journal_title：Experimental and therapeutic medicine

authors： Lin C,Huang Z,Zhou R,Zhou Y,Shentu Y,Yu K,Zhang Y

更新日期：2021-02-01 00:00:00

abstract：:Organic cation transporter member 2 (OCT2) is an N-glycosylated transporter that has been shown to be closely associated with the transport of antitumor drugs. Oxaliplatin, a platinum-based drug, is used for the chemotherapy of colorectal cancer (CRC). However, oxaliplatin resistance is a major challenge in the treatm...

journal_title：Experimental and therapeutic medicine

authors： Cong X,Liu X,Dong X,Fang S,Sun Z,Fan J

更新日期：2021-02-01 00:00:00

abstract：:[This corrects the article DOI: 10.3892/etm.2019.8114.]. ...

journal_title：Experimental and therapeutic medicine

authors： Fang L,Xu Z,Lu J,Hong L,Qiao S,Liu L,An J

更新日期：2021-02-01 00:00:00

abstract：:Hyperlipidemia is a risk factor of kidney damage that can lead to chronic kidney disease. Studies have shown that exercise reduces kidney damage; however, the specific mechanisms underlying the protective effects of exercise remain unclear. For 12 weeks, 8-week-old male apolipoprotein E-deficient (ApoE-/-) mice were r...

journal_title：Experimental and therapeutic medicine

authors： Qian C,Yang Q,Guo L,Zhu H,You X,Liu H,Sun Y

更新日期：2021-02-01 00:00:00

abstract：:Cancer antigen 125 (CA125), encoded by the mucin 16 cell surface associated (MUC16) gene, has been widely used as a biomarker for ovarian cancer (OC) screening. However, it has yet to be elucidated as to why its levels increase with tumor progression as well as with certain other non-malignant conditions. Based on our...

journal_title：Experimental and therapeutic medicine

authors： Liu J,Li L,Luo N,Liu Q,Liu L,Chen D,Cheng Z,Xi X

更新日期：2021-02-01 00:00:00

abstract：:Cardiac fibrosis is a hallmark of cardiac remodeling associated with nearly all forms of heart disease. Clinically, no effective therapeutic drugs aim to inhibit cardiac fibrosis, owing to the complex etiological heterogeneity and pathogenesis of this disease. A two-in-one protein structure, a ubiquitous expression pr...

journal_title：Experimental and therapeutic medicine

authors： Hu F,Li M,Han F,Zhang Q,Zeng Y,Zhang W,Cheng X

更新日期：2021-02-01 00:00:00

abstract：:A severe immune response in patients with coronavirus disease 2019 (COVID-19) can cause a potentially lethal unconstrained inflammatory cytokine storm, known as cytokine release syndrome (CRS). The present study provides an overview of the biology underlying CRS and how targeted inhibition of interleukin (IL)-6 signal...

journal_title：Experimental and therapeutic medicine

authors： Chen JJ,Zhang LN,Hou H,Xu L,Ji K

更新日期：2021-01-01 00:00:00

abstract：:Patients with spontaneous isolated superior mesenteric artery (SMA) dissection (SISMAD) usually present with acute or chronic abdominal pain and are admitted to the emergency or digestive diseases department to undergo auxiliary examinations, typically abdominal plain CT or contrast-enhanced CT (CECT). Plain CT is the...

journal_title：Experimental and therapeutic medicine

authors： Tan Z,Jin Q,Fan W,Han P,Li X

更新日期：2021-01-01 00:00:00

abstract：:Air pollution can highly impact the respiratory system in healthy individuals. Studies have indicated that particles with an aerodynamic diameter of ≤2.5 µm (PM2.5) can be considered to be harmful for lung alveoli and bronchial epithelium cells. PM2.5 can be directly inhaled and can deeply penetrate into the lung alve...

journal_title：Experimental and therapeutic medicine

authors： Han X,Zhuang Y

更新日期：2021-01-01 00:00:00

abstract：:This study was designed to investigate the clinical efficacy of intravenous anesthesia on breast segmental surgery and the effects on hemodynamics of patients. A total of 267 patients were collected as research subjects. These patients underwent breast segmental surgery in Chun'an First People's Hospital from March 20...

journal_title：Experimental and therapeutic medicine

authors： Yu X,Zhou Y,Zheng X,Shao S,He H

更新日期：2021-01-01 00:00:00

abstract：:Endometriosis is a common reproductive disorder in women, with a global prevalence of 10-15%. Long noncoding RNAs (lncRNAs) are critical to gene transcription, cell cycle modulation and immune response. The lncRNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) reportedly mediates autophagy of endometr...

journal_title：Experimental and therapeutic medicine

authors： Liu X,Zhang P,Li Y,Zhao N,Han H

更新日期：2021-01-01 00:00:00

abstract：:Giant aneurysm of the posterior circulation is associated with a higher risk of rupture compared with that of the anterior circulation. Furthermore, surgical clipping and interventional embolization for giant aneurysm of the posterior circulation are more difficult and complex to perform. The present study reported on...

journal_title：Experimental and therapeutic medicine

authors： Zhang CL,Shi ZH,Yan ZZ,Ding CL,Cao JM,Wang YH,Zhang P

更新日期：2021-01-01 00:00:00

abstract：:The aim of the present study was to investigate the effects and mechanisms of the Klotho gene in oxidative stress injury after myocardial infarction. Sprague-Dawley rats were divided into five groups (sham, model, pDC316, LY294002, and pDC316-Klotho). Subsequently, the superoxide dismutase (SOD), glutathione (GSH), an...

journal_title：Experimental and therapeutic medicine

authors： Xu Z,Zheng S,Feng X,Cai C,Ye X,Liu P

更新日期：2021-01-01 00:00:00

abstract：:Systemic sclerosis (SSc) is a relatively rare autoimmune disease with skin and visceral involvement, having a yet unknown etiopathogenesis. Research has shown that professional exposure to various polluting chemicals such as dyes, aliphatic and aromatic organic solvents, inhalable silica dust or certain heavy metals, ...

journal_title：Experimental and therapeutic medicine

authors： Bobeica C,Niculet E,Craescu M,Halip AI,Popescu IA,Draganescu ML,Onisor C,Stefanescu B,Gheuca-Solovastru L

更新日期：2021-01-01 00:00:00

abstract：:This prospective study explored the link between values of C-reactive protein (CRP) in patients with SpA (ankylosing spondylitis, psoriatic arthritis, reactive arthritis, or arthritis-related inflammatory bowel disease) and functional disability in order to derive an algorithm that may predict functional disability ba...

journal_title：Experimental and therapeutic medicine

authors： Catan L,Boariu M,Amaricai E,Popa D,Puenea G,Drăgoi M,Stratul Ș,Drăgoi RG

更新日期：2021-01-01 00:00:00

abstract：:There are limited data available on the regression of fibrosis in hepatitis C virus (HCV) patients who have achieved sustained virologic response (SVR) after interferon-free treatments. Moreover, a perfect method for assessing liver fibrosis and its dynamics has not been established yet. The main objective of this stu...

journal_title：Experimental and therapeutic medicine

authors： Leuştean A,Popescu C,Nichita L,Tilişcan C,Aramă V

更新日期：2021-01-01 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) has become a significant public health risk. Long non-coding RNAs (lncRNAs) have been identified as important factors involved in the proliferation, apoptosis and inflammatory cytokine expression of lung cells. Peripheral blood samples from 66 subjects (18 non-smokers, 24 s...

journal_title：Experimental and therapeutic medicine

authors： Lei Z,Guo H,Zou S,Jiang J,Kui Y,Song J

更新日期：2021-01-01 00:00:00

abstract：:On December 31, 2019, the first case of a novel coronavirus infection was reported in Wuhan, China. The ongoing outbreak of the 2019 novel coronavirus (2019-nCoV) has caused immense global concern. According to the recommendations of the International Health Regulations Emergency Committee and the facts and cases that...

journal_title：Experimental and therapeutic medicine

authors： Feng X,Xie X,Song S,Chen W,Bian H,Rui F,Zhu Q,Ren W,Qin C,Qi J

更新日期：2021-01-01 00:00:00

abstract：:Schisandrin B (SchB) is one of the primary active components of Schisandra chinensis (Turcz.) Baill., a traditional Chinese herb that has been used to treat insomnia for hundreds of years. Our previous studies revealed that SchB exerts sedative and hypnotic effects, increasing the content of γ-aminobutyric acid (GABA)...

journal_title：Experimental and therapeutic medicine

authors： Wang M,Li N,Jing S,Wang C,Sun J,Li H,Liu J,Chen J

更新日期：2020-12-01 00:00:00

abstract：:Hypophosphatasia (HPP) is a rare hereditary systemic disease that is characterized by defective bone and/or dental mineralization, and is caused by mutations in the alkaline phosphatase gene (ALPL). The present study investigated the ALPL mutation in a Chinese Han family with HPP and studied the pathogenesis of the mu...

journal_title：Experimental and therapeutic medicine

authors： Huang H,Wang J,Liang Y,Wei X,Guo D,Sun H,Zhang X,Xu X,Xiong F

更新日期：2020-12-01 00:00:00

abstract：:The present study was an open-label, prospective, uncontrolled and multicenter clinical trial to investigate the safety and effectiveness of bevacizumab (Lumiere®) administered by the intravitreal route for the treatment of neovascular age-related macular degeneration (nAMD). A total of 22 patients without previous tr...

journal_title：Experimental and therapeutic medicine

authors： Benisek DA,Manzitti J,Scorsetti D,Rousselot Ascarza AM,Ascarza AA,Gomez Rancaño D,Quercia R,Ramirez Gismondi M,Carpio Total MA,Scorsetti ML,Spitzer E,Lombas C,Deprati M,Penna MI,Fernández F,Tinelli MA

更新日期：2020-12-01 00:00:00

abstract：:There is currently no available cure or universally effective treatment for dry eye (DE). The aim of the present study was to investigate the clinical efficacy of transcutaneous electrical stimulation (TES) combined with artificial tears in treating DE. Patients diagnosed with DE were referred for therapy with TES com...

journal_title：Experimental and therapeutic medicine

authors： Cai MM,Zhang J

更新日期：2020-12-01 00:00:00

abstract：:Atherosclerosis is the leading cause of death from vascular diseases worldwide, and endothelial cell (EC) dysfunction is the key cause of atherosclerosis. miR-155 was found to induce endothelial injury and to trigger atherosclerosis. In addition, brain and muscle ARNT-like protein-1 (Bmal1) has been found to be closel...

journal_title：Experimental and therapeutic medicine

authors： Liang S,Hu J,Zhang A,Li F,Li X

更新日期：2020-12-01 00:00:00

abstract：:Vascular calcification, characterized by the active deposition of calcium phosphate in the vascular walls, is commonly observed in aging, diabetes mellitus and chronic kidney disease. This process is mediated by different cell types, including vascular stem/progenitor cells. The anti-aging protein klotho may act as an...

journal_title：Experimental and therapeutic medicine

authors： Yu L,Li M

更新日期：2020-12-01 00:00:00

abstract：:Chronic rhinosinusitis with nasal polyps (CRSwNP) refers to chronic inflammation of the sinonasal mucosa. It can either be eosinophilic (ECRSwNP) or non-eosinophilic (non-ECRSwNP). However, immune cell infiltration in the microenvironment and pathogenesis of ECRSwNP and non-ECRSwNP are still unclear. The aim of the pr...

journal_title：Experimental and therapeutic medicine

authors： Xiong G,Xie X,Wang Q,Zhang Y,Ge Y,Lin W,Li M

更新日期：2020-12-01 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) is a component of metabolic syndrome that significantly increases the cardiovascular risk of patients with glucose metabolism alterations. This study identified the prevalence of NAFLD, predictors of NAFLD and explored the link between insulin sensitivity, insulin resistance a...

journal_title：Experimental and therapeutic medicine

authors： Vesa CM,Behl T,Nemeth S,Bratu OG,Diaconu CC,Moleriu RD,Negrut N,Zaha DC,Bustea C,Radu FI,Bungau S

更新日期：2020-12-01 00:00:00

abstract：:Chinese herbal extracts are being used increasingly to treat osteoarthritis (OA) in recent years. Baicalin (BA) is an active component of Scutellaria baicalensis Georgi extracts and protects chondrocytes against damage. The aim of the present study was to examine the mechanism of action of BA on chondrocytes from mous...

journal_title：Experimental and therapeutic medicine

authors： Wang P,Zhu P,Liu R,Meng Q,Li S

更新日期：2020-12-01 00:00:00

abstract：:Uncommon causes of nail failures and surgical reinterventions were determined. The study included 23 osteoporotic patients, 13 of whom followed a fast recovery program with early walking (FWB group). The other 10 patients were not allowed full weight bearing until 6 weeks (NFWB group). The T-score was determined befor...

journal_title：Experimental and therapeutic medicine

authors： Dragosloveanu Ş,Dragosloveanu CDM,Stanca HT,Cotor DC,Dragosloveanu CI,Stoica CI

更新日期：2020-12-01 00:00:00

abstract：:Tumor hypoxia contributes to the development of resistance to chemotherapeutic drugs in several human cancer cell lines. Atovaquone, an anti-malaria drug approved by the US Food and Drug Administration, has recently demonstrated anti-cancer effects in vitro and in vivo in several cancer models. To assess the potential...

journal_title：Experimental and therapeutic medicine

authors： Fu C,Xiao X,Xu H,Lu W,Wang Y

更新日期：2020-12-01 00:00:00

abstract：:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel coronavirus, which causes coronavirus disease 2019 (COVID-19) and affects children less frequently than adults. According to Professor Vana Papaevangelou, Professor of Paediatrics at the University of Athens School of Medicine, children comprise o...

journal_title：Experimental and therapeutic medicine

authors： Mammas IN,Theodoridou M,Spandidos DA

更新日期：2020-12-01 00:00:00

abstract：:Secreted frizzled-related protein 1 (SFRP1), which is an extracellular inhibitor involved in Wnt signalling, is downregulated by promoter hypermethylation in the early stages of colorectal tumorigenesis. Polycomb (PCG) and methyl-CpG-binding domain (MBD) proteins that serve a role in epigenetic gene regulation. The ai...

journal_title：Experimental and therapeutic medicine

authors： Yu J,Xie Y,Liu Y,Wang F,Li M,Qi J

更新日期：2020-12-01 00:00:00

abstract：:Microendoscopic discectomy (MED) is an established procedure used to treat lumbar central spinal stenosis (LCSS) and lateral recess stenosis (LRS). The Interlaminar Endoscopic Surgical System iLESSYS® Delta approach has been developed from the traditional interlaminar endoscopic technique for the treatment of LCSS and...

journal_title：Experimental and therapeutic medicine

authors： Wu B,Xiong C,Tan L,Zhao D,Xu F,Kang H

更新日期：2020-12-01 00:00:00

abstract：:Pulmonary carcinoid tumors represent bronchopulmonary neuroendocrine neoplasms which might synthetize serotonin, histamine, bombesin or other types of hormones responsible for the development of a broad spectrum of signs and symptoms, known as carcinoid syndrome. Data of 98 patients submitted to surgery for bronchial ...

journal_title：Experimental and therapeutic medicine

authors： Savu C,Melinte A,Lukadi JL,Mirvald C,Savu C,Belu E,Diaconu C,Iliescu L,Balescu I,Stiru O,Bratu O,Gorecki G,Bacalbasa N

更新日期：2020-12-01 00:00:00

abstract：:Transvaginal ultrasound (TVUS) is a standard imaging modality for differentiating patients with benign or malignant suspected adnexal mass. To date, numerous studies have assessed the diagnostic accuracy of TVUS in various settings but with variable results. Therefore, the purpose of the present study was to perform a...

journal_title：Experimental and therapeutic medicine

authors： Zhang X,Meng X,Dou T,Sun H

更新日期：2020-12-01 00:00:00

abstract：:The present study aimed to explore the effects of dexmedetomidine combined with etomidate on the expression levels of interleukin (IL)-17A and S-100β in rats with postoperative cognitive dysfunction (POCD). A total of 50 SD rats were randomly allocated into the control group, model group, etomidate group (Eto group), ...

journal_title：Experimental and therapeutic medicine

authors： Yu X,Xie Y

更新日期：2020-12-01 00:00:00

abstract：:Cardiopulmonary resuscitation (CPR) after cardiac arrest (CA) often leads to neurological deficits in the absence of effective treatment. The aim of the present basic research study was to investigate the effects of human urine-derived stem cells (hUSCs) on the recovery of neurological function in rats after CA/CPR. h...

journal_title：Experimental and therapeutic medicine

authors： Pan C,Zheng X,Wang L,Chen Q,Lin Q

更新日期：2020-11-01 00:00:00