Myocardial fibrosis in congenital and pediatric heart disease.

abstract：:The present study aimed to construct a rat model of rheumatoid arthritis (RA) to evaluate changes in pathology, the expression of inflammatory factors and regulation of signaling pathways. The protective effect of tetrandrine (Tet) on tissue lesions induced by RA was also investigated. A total of 60 Wistar rats (100-2...

journal_title：Experimental and therapeutic medicine

authors： Li X,Wu Z,He B,Zhong W

更新日期：2018-09-01 00:00:00

abstract：:In vitro differentiation of human embryonic stem cells (hESCs) into endometrium-like cells may provide a useful tool for clinical treatment. The aim of the present study was to investigate the differentiation potential of hESCs into endometrium-like cells using three methods, which included induction by feeder cells, ...

journal_title：Experimental and therapeutic medicine

authors： Yu W,Niu W,Wang S,Chen X,Sun BO,Wang F,Sun Y

更新日期：2015-07-01 00:00:00

abstract：:Undaria pinnatifida (U. pinnatifida) polysaccharides (UPPS) are considered to be the major bioactive components of U. pinnatifida. The aim of the present study was to investigate the separation, sulfated modification, characterization and monosaccharide composition of UPPS. The optimal processing conditions were as fo...

journal_title：Experimental and therapeutic medicine

authors： Wang FL,Ji YB,Yang B

更新日期：2020-07-01 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) has a high prevalence in type 2 diabetes mellitus (T2DM) patients, being one of the disorders with a relevant global burden. Cross-sectional studies have shown that patients with T2DM and NAFLD have a higher prevalence of liver fibrosis, compared with the general population. P...

journal_title：Experimental and therapeutic medicine

authors： Bica C,Sandu C,Suceveanu AI,Sarbu E,Stoica RA,Gherghiceanu F,Bohiltea RE,Stefan SD,Stoian AP

更新日期：2020-09-01 00:00:00

abstract：:The present study was an open-label, prospective, uncontrolled and multicenter clinical trial to investigate the safety and effectiveness of bevacizumab (Lumiere®) administered by the intravitreal route for the treatment of neovascular age-related macular degeneration (nAMD). A total of 22 patients without previous tr...

journal_title：Experimental and therapeutic medicine

authors： Benisek DA,Manzitti J,Scorsetti D,Rousselot Ascarza AM,Ascarza AA,Gomez Rancaño D,Quercia R,Ramirez Gismondi M,Carpio Total MA,Scorsetti ML,Spitzer E,Lombas C,Deprati M,Penna MI,Fernández F,Tinelli MA

更新日期：2020-12-01 00:00:00

abstract：:GATA4, a member of the GATA family, serves a key function in several types of cancer, including hepatoblastoma, gastric cancer and breast cancer. However, the function of GATA4 in nasopharyngeal cancer (NPC) is largely unknown. The present study revealed that GATA4 was upregulated in NPC tissue samples and the NPC cel...

journal_title：Experimental and therapeutic medicine

authors： Zhou Y,Chang H,Yang B

更新日期：2018-12-01 00:00:00

abstract：:The new enzyme-targeting radiosensitization treatment, Kochi Oxydol-Radiation Therapy for Unresectable Carcinomas, type II (KORTUC II), markedly enhances the radiotherapeutic effect of treatment for various types of locally advanced malignant neoplasms. Patients who had declined surgical treatment and systemic chemoth...

journal_title：Experimental and therapeutic medicine

authors： Hitomi J,Kubota K,Ogawa Y,Hamada N,Murata Y,Nishioka A

更新日期：2010-09-01 00:00:00

abstract：:Recent studies have demonstrated that melatonin significantly decreased all studied acute pancreatitis-associated inflammatory parameters, in addition to reducing apoptosis and necrosis associated with pancreatic injury. However, the effect of melatonin on gut barrier dysfunction and bacterial translocation has not be...

journal_title：Experimental and therapeutic medicine

authors： Sun X,Shao Y,Jin Y,Huai J,Zhou Q,Huang Z,Wu J

更新日期：2013-12-01 00:00:00

abstract：:LipoxinA4 (LXA4) is a well-known key mediator of endogenous anti-inflammation and of the resolution of inflammation. Considerable oxidative stress occurs during inflammation due to the generation of reactive oxidative species (ROS). Moreover, high levels of uric acid (UA) contribute to endothelial cell dysfunction, wh...

journal_title：Experimental and therapeutic medicine

authors： Zhou Y,You H,Zhang A,Jiang X,Pu Z,Xu G,Zhao M

更新日期：2020-08-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the most common malignant types of cancer, with a high mortality rate. Sorafenib is the sole approved oral clinical therapy against advanced HCC. However, individual patients exhibit varying responses to sorafenib and the development of sorafenib resistance has been a new chall...

journal_title：Experimental and therapeutic medicine

authors： Huang D,Yuan W,Li H,Li S,Chen Z,Yang H

更新日期：2018-09-01 00:00:00

abstract：:The present study aimed to evaluate the safety and efficiency of ciliary sulcus implantation of intraocular lens (IOL) in patients that had undergone manual small incision cataract surgery (MSICS) complicated by large posterior capsule rupture (LPCR). A total of 11 eyes taken from 11 patients in Brazzaville, Republic ...

journal_title：Experimental and therapeutic medicine

authors： Zhao J,Yu J,Wang T,Mban B

更新日期：2019-02-01 00:00:00

abstract：:The transient receptor potential melastatin 2 (TRPM2) channel, a Ca2+ permeable channel activated by cAMP, is expressed on pancreatic β-cells and is responsible for the regulation of insulin secretion. It is known that glucose-stimulated insulin secretion (GSIS) can be potentiated by glucagon like peptide-1 (GLP-1), a...

journal_title：Experimental and therapeutic medicine

authors： Pang B,Kim S,Li D,Ma Z,Sun B,Zhang X,Wu Z,Chen L

更新日期：2017-11-01 00:00:00

abstract：:Non-adherence to psoriasis treatment has an important impact in controlling chronic disease evolution and the occurrence of systemic comorbidities. Biologic therapy represents a revolutionary treatment, many of the undesirable psychological and socio-economical consequences of conventional topical or systemic therapie...

journal_title：Experimental and therapeutic medicine

authors： Mocanu M,Toader MP,Rezus E,Taranu T

更新日期：2019-12-01 00:00:00

abstract：:Diabetic nephropathy (DN) is currently a major public health problem worldwide. The objective of the present study was to evaluate the clinical effect of breviscapine injections in patients with DN. A meta-analysis was performed using the following databases to obtain published reports in any language: PubMed/MEDLINE,...

journal_title：Experimental and therapeutic medicine

authors： Liu X,Yao L,Sun D,Zhu X,Liu Q,Xu T,Wang L

更新日期：2016-09-01 00:00:00

abstract：:Rutin has a variety of pharmacological actions, including radical reactivity, and protective activity against lipid peroxidation, viruses and acute pancreatitis; thus, it may be used as a treatment for many diseases. The present study aimed to investigate whether rutin inhibits coronary heart disease through extracell...

journal_title：Experimental and therapeutic medicine

authors： Lv L,Yao Y,Zhao G,Zhu G

更新日期：2018-01-01 00:00:00

abstract：:The present study aims to investigate the effects and underlying mechanisms of miRNA-145 (miR-145) in rat models of chronic constriction injury (CCI). Rats were randomly divided into control, sham, CCI, agomiRNA (agomiR)-normal control (NC) and agomiR-145 groups (n=25 in each group); in addition, 30 rats with CCI were...

journal_title：Experimental and therapeutic medicine

authors： Pang X,Tang Y,Zhang D

更新日期：2016-12-01 00:00:00

abstract：:Successful eyelid reconstructions have been reported when using an axial nasal chondromucosal flap based on the dorsal nasal artery. The present study aimed to present a detailed anatomical description of the blood supply of the lateral nasal region and the angular artery, in order to propose the angular vessels as a ...

journal_title：Experimental and therapeutic medicine

authors： Hou D,Fang L,Zhao Z,Zhou C,Yang M

更新日期：2013-03-01 00:00:00

abstract：:We previously demonstrated that vitamin B6 suppresses tumorigenesis in the colon of mice and exerts an anti-inflammatory effect through the inhibition of NF-κB activation. As these effects resemble the pharmacological properties of thiazolidinedione (TZD), a synthetic peroxisome proliferator-activated receptor-γ (PPAR...

journal_title：Experimental and therapeutic medicine

authors： Yanaka N,Kanda M,Toya K,Suehiro H,Kato N

更新日期：2011-05-01 00:00:00

abstract：:Osteoarthritis (OA) is the most common motor system disease in the elderly, with a high incidence and a huge social and economic burden. Therefore, it is urgent to study its potential pathogenesis to improve the therapeutic effect of the disease. In this study, we constructed a number of regulator-mediated OA dysfunct...

journal_title：Experimental and therapeutic medicine

authors： Wang F,Guo Z,Yuan Y

更新日期：2020-01-01 00:00:00

abstract：:The universal endocrine pathological state affecting young individuals and adults is type 2 diabetes mellitus, which has seen a significant increase in the last 30 years, particularly in children. Genetic and evnironmental factors are the causative agents for this pathological state in children. This rapid and wide sp...

journal_title：Experimental and therapeutic medicine

authors： Xue Y,Gao M,Gao Y

更新日期：2016-10-01 00:00:00

abstract：:This study investigated changes in the level of serum 25-OH vitamin D [25-hydroxyvitamin D, 25(OH)D] in patients with non-alcoholic fatty liver disease (NAFLD) and the correlation between the severity of NAFLD and 25(OH)D. A retrospective analysis was performed on 385 NAFLD patients (NAFLD group) admitted to the Zhong...

journal_title：Experimental and therapeutic medicine

authors： Cai J,Zhang Z,Liu J,Xiao X,Wang C,Deng M,Chen L

更新日期：2020-03-01 00:00:00

abstract：:Oxidative stress results in damage to cellular structures and has been linked to numerous diseases, including cancer. Extracellular superoxide dismutase (EC-SOD) is a principal enzymatic antioxidant in extracellular space. The purpose of this study was to determine whether the expression of EC-SOD protein is altered i...

journal_title：Experimental and therapeutic medicine

authors： Yokoe H,Nomura H,Yamano Y,Fushimi K,Sakamoto Y,Ogawara K,Shiiba M,Bukawa H,Uzawa K,Takiguchi Y,Tanzawa H

更新日期：2010-07-01 00:00:00

abstract：:High mobility group box chromosomal protein 1 (HMGB1) is an important proinflammatory molecule in a number of inflammatory disorders, but little is known about its role in acute-on-chronic liver failure (ACLF). To elucidate the role of HMGB1 in ACLF, the expression of HMGB1 in liver specimens from patients with ACLF w...

journal_title：Experimental and therapeutic medicine

authors： Xu H,Li H,Qu Y,Zheng J,Lu J

更新日期：2014-10-01 00:00:00

abstract：:β-elemene is a novel, plant-derived anticancer drug, which has been used to target multiple solid tumor types. Hyperthermia is an adjuvant therapeutic modality to treat cancer. However, the underlying mechanisms associated with the efficacy of these two treatments are largely unknown. The aim of the present study was ...

journal_title：Experimental and therapeutic medicine

authors： Wu Z,Wang T,Zhang Y,Zheng Z,Yu S,Jing S,Chen S,Jiang H,Ma S

更新日期：2017-06-01 00:00:00

abstract：:Alzheimer's disease (AD) brains demonstrate decreased levels of brain-derived neurotrophic factor (BDNF) and increased levels of β-amyloid peptide (Aβ), which is neurotoxic. The present study assessed the impact of BDNF on the toxic effects of Aβ25-35-induced apoptosis and the effects on BDNF-mediated signaling using ...

journal_title：Experimental and therapeutic medicine

authors： Kim JH

更新日期：2014-12-01 00:00:00

abstract：:Resistance to platinum-based chemotherapy frequently poses a serious problem in the treatment of head and neck squamous cell carcinoma. In this study, we isolated cisplatin-resistant cells from a head and neck squamous cell carcinoma cell line. The mismatch repair (MMR) system is known as one of the cisplatin-resistan...

journal_title：Experimental and therapeutic medicine

authors： Adachi M,Ijichi K,Hasegawa Y,Nakamura H,Ogawa T,Kanematsu N

更新日期：2010-01-01 00:00:00

abstract：:The Philips Intellivue MP50 monitor provides a method for non-invasive, near-continuous blood pressure (BP) monitoring and is designed to be an alternative to direct intra-arterial BP (IABP) measurement. However, no studies have specifically compared non-invasive and invasive BP measurements using the monitor. The pre...

journal_title：Experimental and therapeutic medicine

authors： Meng X,Zang G,Fan L,Zheng L,Dai J,Wang X,Xia W,Liu J,Zhang C

更新日期：2013-07-01 00:00:00

abstract：:The present multicentre, prospective, open-label, single treatment arm study (Val-Perfect) examined the efficacy and tolerability of once-daily valsartan monotherapy (80 mg for two weeks, followed by 160 mg for eight weeks) in 195 Chinese patients with mild to moderate hypertension, using office, home, and ambulatory ...

journal_title：Experimental and therapeutic medicine

authors： Sun N,Feng Y,Gao P,Chen X,Qi L,Zhang S,Dong Y,Yang X,Li X,Chen Y,Liu L

更新日期：2017-03-01 00:00:00

abstract：:Therapeutic drug monitoring is an essential tool when managing the therapeutic use of immunosuppressant cyclosporine A (CsA) in cases with solid organ transplantation. In China, the concentration of CsA is primarily measured using immunoassays. However, existing literature recommends mass spectrometry as the current g...

journal_title：Experimental and therapeutic medicine

authors： Wang X,Qin W,Chen W,Liu H,Zhang D,Zhang X,Li P

更新日期：2021-03-01 00:00:00

abstract：:The aim of this study was to use proteomic and transcriptomic approaches to examine differences in protein and gene expression in maternal plasma between normal and preeclamptic pregnancies. Preeclampsia and control groups were compared with respect to the expression of CD34 and CD133 genes by quantitative polymerase ...

journal_title：Experimental and therapeutic medicine

authors： Sahin H,Gunel T,Benian A,Onay Ucar E,Guralp O,Kilic A

更新日期：2015-08-01 00:00:00