High mobility group box 1 release from cholangiocytes in patients with acute-on-chronic liver failure.

abstract：:The objective of this study was to investigate the protective effects of scopolamine and penehyclidine hydrochloride on acute cerebral ischemia-reperfusion injury after cardiopulmonary resuscitation, and the effect on cytokine levels. Eighty patients with cardiac arrest admitted to our hospital from June 2011 to Decem...

journal_title：Experimental and therapeutic medicine

authors： Wang D,Jiang Q,Du X

更新日期：2018-02-01 00:00:00

abstract：:This study investigated the effects of high-dose long-term antioxidant free radicals on the mortality rate, creatinine (Cr) value, partial pressure of oxygen (PaO2), alanine aminotransferase (ALT), as well as the incidence rates of lung fibrosis and dysfunction in the treatment of patients with severe paraquat (PQ) po...

journal_title：Experimental and therapeutic medicine

authors： Hu S,Qiao C,Yuan Z,Li M,Ye J,Ma H,Wang J,Xin S,Zhang J

更新日期：2018-12-01 00:00:00

abstract：:There is little information regarding the recent trend of synchronous and metachronous pulmonary metastases in patients with primary colorectal cancer. We investigated patients with sporadic colorectal cancer who underwent surgery in our department between 1990 and 2009. Clinicopathological parameters of primary cance...

journal_title：Experimental and therapeutic medicine

authors： Nozawa H,Sunami E,Nakajima J,Nagawa H,Kitayama J

更新日期：2012-03-01 00:00:00

abstract：:Genome wide association studies have revealed that the zinc finger MIZ-type containing 1 (ZMIZ1) is involved in the pathogenesis of vitiligo; however, the underlying mechanism remains unclear. The present study aimed to investigate the effects of ZMIZ1 on the proliferation, apoptosis and migration of the human melanoc...

journal_title：Experimental and therapeutic medicine

authors： Li M,Fan Y,Wang Y,Xu J,Xu H

更新日期：2020-08-01 00:00:00

abstract：:The knowledge of the expected time-to-positivity (TTP) of blood cultures by major pathogens is essential both clinically and economically. To this end, we conducted the present two-year study in our Institution, aiming to assess the TTP of all the major microorganisms including Enterobacteriaceae, Pseudomonas aerugino...

journal_title：Experimental and therapeutic medicine

authors： Moustos E,Staphylaki D,Christidou A,Spandidos DA,Neonakis IK

更新日期：2017-12-01 00:00:00

abstract：:Many studies have found the function of nitric oxide (NO) in cancer as a pro-neoplastic vs. an anti-neoplastic effector, but the role of NO in hepatocellular carcinoma (HCC) remains unclear. The present study aimed to investigate the effects of nitric oxide (NO) on the biological behavior of the human hepatocellular c...

journal_title：Experimental and therapeutic medicine

authors： Zhou L,Zhang H,Wu J

更新日期：2016-05-01 00:00:00

abstract：:Engineered nanoparticles (NPs) have been increasingly used in numerous fields over the last decade. In particular, iron oxide NPs (Fe2O3NPs) and silver NPs (AgNPs) have contributed to the current increase in NP usage. However, the possible side effects of increased NP exposure remain not fully elucidated. The present ...

journal_title：Experimental and therapeutic medicine

authors： Yousef MI,Abuzreda AA,Kamel MA

更新日期：2019-12-01 00:00:00

abstract：:The oxidation of tyrosine to 3-nitrotyrosine is irreversible, and due to this characteristic, 3-nitrotyrosine is used as a marker for oxidative stress in a range of diverse chronic and degenerative diseases. It has been established that the yeast Debaryomyces hansenii (D. hansenii) can assimilate free 3-nitrotyrosine ...

journal_title：Experimental and therapeutic medicine

authors： Calderón-Torres CM,Sarabia-Curz L,Ledesma-Soto Y,Murguía-Romero M,Terrazas LI

更新日期：2019-05-01 00:00:00

abstract：:Tumor endothelial cells (TECs) have been isolated from solid tumors by using immunological magnetic beads and magnetic active cell sorting, and lead to a more precise way to investigate tumor angiogenesis as well as screening of vascular targeting drugs. However, the question of which endothelial marker is a stable mo...

journal_title：Experimental and therapeutic medicine

authors： Qian H,Yang L,Zhao W,Chen H,He S

更新日期：2018-10-01 00:00:00

abstract：:Osteoarthritis (OA) is one of the most prevalent causes of joint disease. However, the pathological mechanisms of OA have remained to be completely elucidated, and further investigation into the underlying mechanisms of OA development and the identification of novel therapeutic targets are urgently required. In the pr...

journal_title：Experimental and therapeutic medicine

authors： Gao X,Sun Y,Li X

更新日期：2019-10-01 00:00:00

abstract：:The aim of this study was to characterize the clinical and genetic features of a 4-year-old female with merosin-deficient congenital muscular dystrophy type 1A (MDC1A). MDC1A is the most common form of congenital muscular dystrophy. MDC1A is caused by mutation of the laminin α-2 gene (LAMA2), localized to chromosome 6...

journal_title：Experimental and therapeutic medicine

authors： He Z,Luo X,Liang L,Li P,Li D,Zhe M

更新日期：2013-11-01 00:00:00

abstract：:Glucocorticoids are a class of steroid hormones commonly used for the treatment of hematological malignancies due to their ability to induce apoptosis in lymphoid cells. An understanding of the critical steps in glucocorticoid-induced apoptosis is required to identify sources of drug resistance. Previously, we found t...

journal_title：Experimental and therapeutic medicine

authors： Tome ME,Lee K,Jaramillo MC,Briehl MM

更新日期：2012-02-01 00:00:00

abstract：:The current study assessed the association between toll-like receptor 9 (TLR9) and systemic lupus erythematosus (SLE) and subsequently determined the predictive value of TLR9 in assessing the prognosis of SLE. A total of 90 newly diagnosed patients with SLE and 49 healthy control subjects were enrolled in the current ...

journal_title：Experimental and therapeutic medicine

authors： Yuan Y,Zhao L,Ye Z,Ma H,Wang X,Jiang Z

更新日期：2019-04-01 00:00:00

abstract：:An early and accurate diagnosis of pulmonary thromboembolism (PTE) remains challenging. The present study aimed to evaluate the diagnostic value of platelet-derived microparticles in PTE based on a population study. A total of 102 patients with PTE, 102 healthy controls and 40 patients suspected with PTE were enrolled...

journal_title：Experimental and therapeutic medicine

authors： Wang M,Fu Y,Xu L,Xiao L,Yue Y,Liu S,Huang Q,Li S,Li Y

更新日期：2018-10-01 00:00:00

abstract：:We investigated the clinical value of fractional flow reserve (FFR) for the prognostic evaluation of patients with percutaneous coronary intervention. We enrolled 120 patients who were admitted to the hospital to undergo percutaneous coronary intervention for acute coronary syndromes between May 2014 and June 2015. Th...

journal_title：Experimental and therapeutic medicine

authors： Zhao Q,Ji Z,Li X,Di Y,An H,Wei B,Yang L,Chen W

更新日期：2018-01-01 00:00:00

abstract：:Opioids are commonly used in cancer pain management. The present study aimed to investigate the occurrence of endocrine dysfunction in patients with cancer pain treated with opioids. The study included 20 patients with cancer-associated pain. All data were obtained from malignant tumors diagnosed and followed up at th...

journal_title：Experimental and therapeutic medicine

authors： Merdin A,Merdin FA,Gündüz Ş,Bozcuk H,Coşkun HŞ

更新日期：2016-05-01 00:00:00

abstract：:The novel orally available inhibitor of the molecular chaperone heat shock protein 90 (Hsp90), BIIB021, induces the apoptosis of various types of tumor cell in vitro and in vivo. However, the effects and mechanisms of this agent on myelodysplastic syndrome (MDS) cell lines remain unknown. The aim of this study was to ...

journal_title：Experimental and therapeutic medicine

authors： Lin S,Li J,Zhou W,Qian W,Wang B,Chen Z

更新日期：2014-06-01 00:00:00

abstract：:Discoid lateral meniscus of the knee causes a high morbidity in China. Since the traditional treatment to open the capsule and resect the meniscus often results in arthritis, it is now believed that a discoid lateral meniscus should be treated with arthroscopy to preserve part of the meniscus. The current study aimed ...

journal_title：Experimental and therapeutic medicine

authors： Cao H,Zhang Y,Qian W,Cheng XH,Ke Y,Guo XP

更新日期：2012-11-01 00:00:00

abstract：:Gardenia fruit has been used in traditional Chinese medicine for thousands of years. A previous study by the present authors indicated that the ethanol extract of gardenia fruits (EEG) primarily contains eight constituents. In the present study, the potential effects of EEG on unilateral ureteral obstruction (UUO)-ind...

journal_title：Experimental and therapeutic medicine

authors： Li X,Ma M,Zhang X,Deng L,Wang Y,Bian Z,Cai S,Peng B,Yang J,Chen Y

更新日期：2017-08-01 00:00:00

abstract：:Stereotactic body radiation therapy (SBRT) plays an important role in the treatment of early stage non-small cell lung cancer (NSCLC), particularly when patients are unable to tolerate surgical resection due to comorbid conditions or are unwilling to undergo surgery. High rates of local tumor control that may rival th...

journal_title：Experimental and therapeutic medicine

authors： Yang G,Li M,Wang Y,Wang Y,Liu X

更新日期：2013-09-01 00:00:00

abstract：:The aim of the study was to investigate the effects of high-volume continuous renal replacement therapy (HV-CRRT) on procalcitonin (PCT), tumor necrosis factor-α (TNF-α), interleukin-4 (IL-4), IL-6, IL-8 and IL-10 in acute pancreatitis complicated by acute renal failure. Eighty-six patients with acute pancreatitis com...

journal_title：Experimental and therapeutic medicine

authors： Liu C,Li M,Cao S,Wang J,Huang X,Zhong W

更新日期：2017-10-01 00:00:00

abstract：:Lung cancer, a major health problem affecting the epithelial lining of the lower respiratory tract, is considered to be one of the deadliest types of cancer in males and females and it is well-known that smoking is the chief cause of lung cancer. In addition to smoking and environmental factors, genetic susceptibility...

journal_title：Experimental and therapeutic medicine

authors： Baykara O,Tansarikaya M,Demirkaya A,Kaynak K,Tanju S,Toker A,Buyru N

更新日期：2013-02-01 00:00:00

abstract：:Currently available antiepileptic drugs are effective; however, frequently associated with adverse effects that limit their therapeutic value. Compounds that target the molecular events underlying epilepsy, with minor or no adverse effects, would be of clinical value. Matrix metalloproteinase-9 (MMP-9) and the brain-d...

journal_title：Experimental and therapeutic medicine

authors： Sun ZQ,Meng FH,Tu LX,Sun L

更新日期：2019-04-01 00:00:00

abstract：:Sepsis is a serious condition characterized by an infectious process that induces a severe systemic inflammatory response. In this study, the effects of gemfibrozil (GFZ) on the inflammatory response associated with abdominal sepsis were investigated using a rat model of cecal-ligation and puncture (CLP). Male Wistar ...

journal_title：Experimental and therapeutic medicine

authors： Cámara-Lemarroy CR,Guzman-DE LA Garza FJ,Cordero-Perez P,Ibarra-Hernandez JM,Muñoz-Espinosa LE,Fernandez-Garza NE

更新日期：2015-03-01 00:00:00

abstract：:This study demonstrates the removal of virus particles from B95-8 host cells that maintain normal activity under optimal osmotic pressure. After infecting B95-8 cells with Epstein-Barr virus (EBV) particles, the cells were treated with isosmotic solution [0.90% NaCl (330 mOsm/kg H(2)O)], hyposmotic solutions [0.36% Na...

journal_title：Experimental and therapeutic medicine

authors： Pan M,Shen J,Cai J

更新日期：2013-03-01 00:00:00

abstract：:The aim of this study was to characterize histo-chemical patterns and Das-1 and Ki67 protein expression in gastric cardia adenocarcinoma (GCA) and intestinal metaplasia (IM) lesions adjacent to GCA. Histochemical techniques, including Alcian blue/periodic acid-Schiff (AB/PAS), high iron diamine/Alcian blue (HID/AB) an...

journal_title：Experimental and therapeutic medicine

authors： Feng XS,Wang YF,Hao SG,Ru Y,Gao SG,Wang LD

更新日期：2013-06-01 00:00:00

abstract：:Acute cerebral ischemia/reperfusion injury (ACIR) rat model was used to investigate the effect of spermine on oxidative stress and apoptosis. Sixty healthy and clean male Sprague-Dawley rats were randomly divided into 3 groups: The sham-operated group (n=12), the model group (n=12) and the experiment group (n=36). The...

journal_title：Experimental and therapeutic medicine

authors： Du H,Ming X,Zhou S

更新日期：2017-07-01 00:00:00

abstract：:Renal cell carcinoma (RCC) is one of the most common urological malignancies occurring in adult human kidneys worldwide. Recent research on antitumor drugs has focused on plant extracts, a class of compounds that play critical roles in cancer treatment. The present study aimed to investigate the potential antitumor ef...

journal_title：Experimental and therapeutic medicine

authors： Zhu C,Na N,Sheng H,Feng B,Wang H,Zhu P,Zhang W,Zhang M,Deng Z

更新日期：2020-04-01 00:00:00

abstract：:Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is an acute event characterized by the worsening of a patient's respiratory symptoms. To the best of our knowledge, few studies have investigated the computed tomography (CT) manifestation of AECOPD. Thus, the aim of the present study was to examine ...

journal_title：Experimental and therapeutic medicine

authors： Cheng T,Wan H,Cheng Q,Guo YI,Qian Y,Fan L,Feng Y,Song Y,Zhou M,Li Q,Shi G,Huang S

更新日期：2016-02-01 00:00:00

abstract：:Compared to other diseases, early or atypical spinal tuberculosis (TB) is prone to being misdiagnosed due to the lack of specific clinical manifestations and misleading negative results of various laboratory analyses and imaging examinations. Various methods for diagnosing spinal TB have become research hotspots. Rece...

journal_title：Experimental and therapeutic medicine

authors： Pu F,Feng J,Yang L,Zhang L,Xia P

更新日期：2019-11-01 00:00:00