Synchronous and metachronous lung metastases in patients with colorectal cancer: A 20-year monocentric experience.

abstract：:The aim of this study was to validate the feasibility of modified frontolateral partial laryngectomy without tracheotomy using animal experiments. The glottic area before and after surgery of 6 excised canine larynges and 10 canine larynges in vivo were compared to observe whether the glottic area following modified f...

journal_title：Experimental and therapeutic medicine

authors： Xu H,Dong P,Sun Z,Xie J

更新日期：2013-02-01 00:00:00

abstract：:The objective of this study was to investigate the protective effects of scopolamine and penehyclidine hydrochloride on acute cerebral ischemia-reperfusion injury after cardiopulmonary resuscitation, and the effect on cytokine levels. Eighty patients with cardiac arrest admitted to our hospital from June 2011 to Decem...

journal_title：Experimental and therapeutic medicine

authors： Wang D,Jiang Q,Du X

更新日期：2018-02-01 00:00:00

abstract：:Fistular onion stalk is used as a traditional herbal medicine, and its extract exhibits certain beneficial effects on cardiovascular disease. In this study, the effects of fistular onion stalk extract on the pathological features, circulating inflammatory cytokines, local renin-angiotensin-aldosterone system (RAAS) an...

journal_title：Experimental and therapeutic medicine

authors： He B,Hao J,Sheng W,Xiang Y,Zhang J,Zhu H,Tian J,Zhu X,Feng Y,Xia H

更新日期：2014-09-01 00:00:00

abstract：:Macrophage autophagy has a protective role in the development of atherosclerosis; however, it turns dysfunctional in advanced lesions with an increase in p62/sequestosome-1 protein. Little is known about the role and significance of p62 accumulation in atherosclerosis. The present study investigated the association be...

journal_title：Experimental and therapeutic medicine

authors： Ning H,Liu D,Yu X,Guan X

更新日期：2017-12-01 00:00:00

abstract：:Steroid-induced avascular necrosis of the femoral head (SANFH) is a mainly bilateral complication of steroid therapy that involves extensive necrosis, and frequently occurs in young and middle-aged individuals, with a high disability rate. Autophagy is an intracellular lysosomal degradation process occurring in numero...

journal_title：Experimental and therapeutic medicine

authors： Li X,Li YS,Li LJ,Xie X,Yang Y,Deng ZH,Zeng C,Lei GH

更新日期：2017-07-01 00:00:00

abstract：:The knowledge of the expected time-to-positivity (TTP) of blood cultures by major pathogens is essential both clinically and economically. To this end, we conducted the present two-year study in our Institution, aiming to assess the TTP of all the major microorganisms including Enterobacteriaceae, Pseudomonas aerugino...

journal_title：Experimental and therapeutic medicine

authors： Moustos E,Staphylaki D,Christidou A,Spandidos DA,Neonakis IK

更新日期：2017-12-01 00:00:00

abstract：:Shikonin (SK), a naturally occurring naphthoquinone, exhibits antitumor activity. However, its precise mechanisms of action are unknown. In the present study, the effects of SK on NCI-H460 human lung cancer cells were investigated. It was found that SK reduced cell viability and induced apoptosis in the NCI-H460 cells...

journal_title：Experimental and therapeutic medicine

authors： Qu D,Chen YU,Xu XM,Zhang M,Zhang YI,Li SQ

更新日期：2015-04-01 00:00:00

abstract：:Acute lung injury (ALI) is a common and severe disease that has been associated with significant morbidity and mortality. Understanding the epidemiology of ALI is vital for its prevention and treatment. The present study aimed to analyze the epidemiology of ALI by collecting data from patients that were submitted betw...

journal_title：Experimental and therapeutic medicine

authors： Zhou D,Qiu J,Liang Y,Dai W,Yuan D,Zhou J

更新日期：2017-03-01 00:00:00

abstract：:Atherosclerosis is caused by various factors, and Glabridin may have protective effects on the cardiovascular system. The purpose of the present study was to evaluate the effects of Glabridin on atherosclerosis and evaluate whether Glabridin attenuates arteriosclerosis and endothelial permeability by suppressing the m...

journal_title：Experimental and therapeutic medicine

authors： Wang G,Sun G,Wang Y,Yu P,Wang X,Zhou B,Zhu H

更新日期：2019-01-01 00:00:00

abstract：:The aim of this study was to investigate the effect of lysosomal and ubiquitin-proteasome system dysfunction on the abnormal aggregation of α-synuclein, and to analyze its role in the pathogenesis of Parkinson's disease (PD). PC12 cells subjected to nerve growth factor-induced differentiation were used as the cell mod...

journal_title：Experimental and therapeutic medicine

authors： Wang R,Zhao J,Zhang J,Liu W,Zhao M,Li J,Lv J,Li Y

更新日期：2015-06-01 00:00:00

abstract：:The use of intravenous dexmedetomidine during surgery has been shown to suppress inflammatory cytokines peri-operatively. It has also been demonstrated that dexmedetomidine may benefit cognitive function in elderly patients following surgery; however, it is not clear whether dexmedetomidine reduces postoperative cogni...

journal_title：Experimental and therapeutic medicine

authors： Li Y,He R,Chen S,Qu Y

更新日期：2015-11-01 00:00:00

abstract：:A major consequence of obstructive jaundice (OJ) in clinical practice is the development of severe liver injury, and at present, no effective treatments have been developed to protect against it. Preconditioning with damage-associated molecular pattern (DAMP) molecules has been demonstrated to protect multiple organs ...

journal_title：Experimental and therapeutic medicine

authors： Zhou YX,Ni Y,Liu YB,Liu X

更新日期：2014-07-01 00:00:00

abstract：:Icariin (ICA), the main active flavonoid glucoside isolated from Herba Epimedii, has been shown to prevent postmenopausal bone loss in vitro. However, the mechanisms by which ICA prevents bone loss in vivo remain poorly understood. In the present study, the effect of ICA in an ovariectomized (OVX) rat model of osteopo...

journal_title：Experimental and therapeutic medicine

authors： Chen G,Wang C,Wang J,Yin S,Gao H,Xiang LU,Liu H,Xiong Y,Wang P,Zhu X,Yang LI,Zhang R

更新日期：2016-07-01 00:00:00

abstract：:Different neoadjuvant therapy regimens are available for rectal cancer, but the relative effects are controversial. The aim of the present network meta-analysis (NMA) was to estimate the relative efficacy and safety of neoadjuvant therapies for resectable rectal cancer. MEDLINE, EMBASE and Cochrane Central Registry of...

journal_title：Experimental and therapeutic medicine

authors： Zhong W,Xue X,Dai L,Li R,Nie K,Zhou S

更新日期：2020-04-01 00:00:00

abstract：:Hypophosphatasia (HPP) is a rare hereditary systemic disease that is characterized by defective bone and/or dental mineralization, and is caused by mutations in the alkaline phosphatase gene (ALPL). The present study investigated the ALPL mutation in a Chinese Han family with HPP and studied the pathogenesis of the mu...

journal_title：Experimental and therapeutic medicine

authors： Huang H,Wang J,Liang Y,Wei X,Guo D,Sun H,Zhang X,Xu X,Xiong F

更新日期：2020-12-01 00:00:00

abstract：:Expression and characteristics of matrix metalloproteinase-9 (MMP-9) and TIMP metallopeptidase inhibitor-1 (TIMP-1) in the placenta of pregnancy induced hypertension (PIH) were detected in Uygur to analyze its correlation with PIH, and to provide a theoretical basis for clinical work. Ninety cases of placental tissue ...

journal_title：Experimental and therapeutic medicine

authors： Zhang Y,Li P,Guo Y,Liu X,Zhang Y

更新日期：2019-07-01 00:00:00

abstract：:Simple bone cysts (SBCs) are uncommon lesions that usually occur in the long bones of the skeleton and in the body of the mandible. Displacement of the mandibular canal due to cystic lesions have been reported previously. However, there have been no reports in which endoscopy has been utilized to observe an inferior a...

journal_title：Experimental and therapeutic medicine

authors： Matsuda S,Yoshimura H,Sano K

更新日期：2019-06-01 00:00:00

abstract：:We previously reported on single-incision laparoscopic surgery applied to laparoscopically assisted vaginal hysterectomy (LAVH) cases. We accumulated single-incision LAVH cases to evaluate this operation, including its learning curve. Since July 2009, we planned to perform single-incision LAVH in 50 cases. Operative t...

journal_title：Experimental and therapeutic medicine

authors： Koyanagi T,Motomura S

更新日期：2011-09-01 00:00:00

abstract：:The Global Registry of Acute Coronary Events (GRACE) risk score and the mean platelet volume to lymphocyte count ratio (MPVLR) can be used independently to predict adverse outcomes in patients with acute coronary syndromes. However, the level of MPVLR in relation to the GRACE score, and whether a combination of these ...

journal_title：Experimental and therapeutic medicine

authors： Chen X,Shao M,Zhang T,Zhang W,Meng Y,Zhang H,Hai H,Li G

更新日期：2020-06-01 00:00:00

abstract：:Collecting duct carcinoma (CDC), which is also known as Bellini duct carcinoma, accounts for less than 1% of all renal cell carcinoma, which has a poor prognosis. Predominantly, clinicians recognize this disease due to past experience and case reports, and a standard treatment is yet to be established. The present cas...

journal_title：Experimental and therapeutic medicine

authors： Zhu L,Wang Z,Pan C,Peng R,Wei X,Zhong Z

更新日期：2016-08-01 00:00:00

abstract：:Glucagon-like peptide-1 (GLP-1) has been demonstrated to affect the oxidative stress status in several in vitro, in vivo and clinical studies. The aim of the present study was to evaluate the effect of a GLP-1 analogue, exenatide, on oxidative stress parameters and apoptotic markers in testicular cells in an iron over...

journal_title：Experimental and therapeutic medicine

authors： Yesil S,Sungu N,Kilicarslan A,Kuskonmaz SM,Kara H,Kucuk A,Polat F,Kavutcu M,Arslan M

更新日期：2018-12-01 00:00:00

abstract：:The activation of monocytes and macrophages is associated with steroid-resistant (SR) asthma. Interleukin-35 (IL-35) is an important anti-inflammatory cytokine, but its regulatory effects on monocytes in patients with SR asthma is not fully understood. Based on clinical response to oral prednisolone, 34 patients with ...

journal_title：Experimental and therapeutic medicine

authors： Qian L,Xu D,Xue F,Li M,Wang X,Liu G

更新日期：2020-05-01 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) has a high prevalence in type 2 diabetes mellitus (T2DM) patients, being one of the disorders with a relevant global burden. Cross-sectional studies have shown that patients with T2DM and NAFLD have a higher prevalence of liver fibrosis, compared with the general population. P...

journal_title：Experimental and therapeutic medicine

authors： Bica C,Sandu C,Suceveanu AI,Sarbu E,Stoica RA,Gherghiceanu F,Bohiltea RE,Stefan SD,Stoian AP

更新日期：2020-09-01 00:00:00

abstract：:The aim of the present study was to investigate the optimum composition of Polycan (β-glucan complex) and calcium lactate-gluconate (CaLG) that exhibited the most beneficial effects in ovariectomy (OVX)-induced osteoporotic rats. Polycan and CaLG single formulas (100 mg/kg each), and three doses (50, 100 and 200 mg/kg...

journal_title：Experimental and therapeutic medicine

authors： Choi JS,Kim JW,Kim KY,Cho HR,Choi IS,Ku SK

更新日期：2014-09-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is a primary malignancy in the liver, which is a global health problem. The present study aimed to observe the apoptotic effects of berbamine on SMMC-7721 cell lines and to investigate the effects of berbamine on induction of the intrinsic apoptotic pathway. The human HCC SMMC-7721 cells...

journal_title：Experimental and therapeutic medicine

authors： Cao Y,Cao J,Yu B,Wang S,Liu L,Tao L,Sun W

更新日期：2018-02-01 00:00:00

abstract：:Sepsis is a complication of infection caused by disease or trauma. Increasing evidence have shown that long noncoding RNAs (lncRNAs) are involved in the regulation of sepsis. However, the mechanism of lncRNA nuclear enriched abundant transcript 1 (NEAT1) in the regulation of sepsis progression remains to be elucidated...

journal_title：Experimental and therapeutic medicine

authors： Liu L,Liu F,Sun Z,Peng Z,You T,Yu Z

更新日期：2020-10-01 00:00:00

abstract：:Acute cerebral ischemia/reperfusion injury (ACIR) rat model was used to investigate the effect of spermine on oxidative stress and apoptosis. Sixty healthy and clean male Sprague-Dawley rats were randomly divided into 3 groups: The sham-operated group (n=12), the model group (n=12) and the experiment group (n=36). The...

journal_title：Experimental and therapeutic medicine

authors： Du H,Ming X,Zhou S

更新日期：2017-07-01 00:00:00

abstract：:The alleviation of brain injury is a key issue following cardiopulmonary resuscitation (CPR). Hydrogen sulfide (H2S) is hypothesized to be involved in the pathophysiological process of ischemia-reperfusion injury, and exerts a protective effect on neurons. The aim of the present study was to investigate the effects of...

journal_title：Experimental and therapeutic medicine

authors： Lin JY,Zhang MW,Wang JG,Li H,Wei HY,Liu R,Dai G,Liao XX

更新日期：2016-02-01 00:00:00

abstract：:The aim of the present study was to investigate the association between polymorphism in the serotonin transporter (5-HTT) gene-linked polymorphic region (5-HTTLPR) in the promoter region of the 5-HTT gene and the pathogenesis of postpartum depression (PPD). Blood samples were collected from 120 female patients with PP...

journal_title：Experimental and therapeutic medicine

authors： Zhang X,Wang L,Huang F,Li J,Xiong L,Xue H,Zhang Y

更新日期：2015-01-01 00:00:00

abstract：:The C-X-C Motif Chemokine Receptor 4/C-X-C Motif Chemokine Ligand 12 (CXCR4/CXCL12) axis has been implicated in the pathogenesis of pulmonary fibrosis. However, the mechanisms governing this remain to be determined. The current study demonstrated that human lung fibroblasts (HLFs) exhibit high CXCL12 expression and al...

journal_title：Experimental and therapeutic medicine

authors： Li F,Xu X,Geng J,Wan X,Dai H

更新日期：2020-03-01 00:00:00