Diagnostic value of platelet-derived microparticles in pulmonary thromboembolism: A population-based study.

abstract：:Eukaryotic translation initiation factor (EIF) 5A2 exerts important functions that regulate the development and progression of cancers. The present study aimed to investigate the expression of EIF5A2 in prostate cancer (PCa) and its association with biological and prognostic significance. EIF5A2 mRNA and protein level...

journal_title：Experimental and therapeutic medicine

authors： Lu J,Zhao HW,Chen Y,Wei JH,Chen ZH,Feng ZH,Huang Y,Chen W,Luo JH,Fang Y

更新日期：2019-05-01 00:00:00

abstract：:The C-X-C Motif Chemokine Receptor 4/C-X-C Motif Chemokine Ligand 12 (CXCR4/CXCL12) axis has been implicated in the pathogenesis of pulmonary fibrosis. However, the mechanisms governing this remain to be determined. The current study demonstrated that human lung fibroblasts (HLFs) exhibit high CXCL12 expression and al...

journal_title：Experimental and therapeutic medicine

authors： Li F,Xu X,Geng J,Wan X,Dai H

更新日期：2020-03-01 00:00:00

abstract：:The present study investigated the effect of the phytochemical genistein on the proliferation and differentiation of MCF-7 and 3T3-L1 cells via the regulation of estrogen receptor-α (ERα) expression and the induction of apoptosis. When MCF-7 human breast cancer cells were treated with 50, 100, 150 and 200 μM genistein...

journal_title：Experimental and therapeutic medicine

authors： Choi EJ,Jung JY,Kim GH

更新日期：2014-08-01 00:00:00

abstract：:The present study aimed to examine the effects of rivastigmine hydrogen tartrate and donepezil hydrochloride on the cognitive function and mental behavior of patients with Alzheimer's disease (AD). For this purpose, a total of 126 patients with AD admitted to Luoyang Central Hospital from January, 2018 to December, 20...

journal_title：Experimental and therapeutic medicine

authors： Zhang X,Yu R,Wang H,Zheng R

更新日期：2020-08-01 00:00:00

abstract：:The present study aimed to investigate the expression of microRNA (miRNA or miR)-186 in tumor tissue, blood and urine from patients with bladder cancer. The mechanism by which miR-186 regulates the invasion and metastasis of bladder cancer was also assessed. A total of 76 patients who underwent surgical resection of b...

journal_title：Experimental and therapeutic medicine

authors： He X,Ping J,Wen D

更新日期：2017-10-01 00:00:00

abstract：:The present study retrospectively analyzed 19 patients diagnosed with paraquat (PQ) poisoning with the aim to investigate the effect of activated charcoal hemoperfusion on renal function and PQ elimination. The results indicated that 7 patients died and 12 survived. Non-oliguric renal failure occurred in all of the 7 ...

journal_title：Experimental and therapeutic medicine

authors： Sun L,Yan PB,Zhang Y,Wei LQ,Li GQ

更新日期：2018-03-01 00:00:00

abstract：:Dimethyl carbonate (DMC) is a widely used industrial chemical, which may be increasingly used in the future. However, its toxicity profile remains largely unknown. The present study was designed to investigate the effects of DMC exposure on the ovaries and the effect of autophagy activation on follicular development. ...

journal_title：Experimental and therapeutic medicine

authors： Tang Z,Zhang Z,Tang Y,Qi L,Yang F,Wang Z

更新日期：2017-12-01 00:00:00

abstract：:Aggressive behavior is one of the main characteristics of different psychiatric disorders such as: personality disorders (antisocial personality disorder, borderline personality disorder), schizophrenia, intermittent explosive disorder, post-traumatic stress disorder, bipolar disorder, depression, alcohol/substance in...

journal_title：Experimental and therapeutic medicine

authors： Trifu SC,Tudor A,Radulescu I

更新日期：2020-10-01 00:00:00

abstract：:Expression and characteristics of matrix metalloproteinase-9 (MMP-9) and TIMP metallopeptidase inhibitor-1 (TIMP-1) in the placenta of pregnancy induced hypertension (PIH) were detected in Uygur to analyze its correlation with PIH, and to provide a theoretical basis for clinical work. Ninety cases of placental tissue ...

journal_title：Experimental and therapeutic medicine

authors： Zhang Y,Li P,Guo Y,Liu X,Zhang Y

更新日期：2019-07-01 00:00:00

abstract：:Previous studies have indicated pro-tumor functions of macrophages in tumor progression in different types of malignant tumors. The detailed mechanisms of cell-cell interaction between macrophages and tumor cells have been investigated by means of in vitro co-culture experiments. The present study developed magnetite ...

journal_title：Experimental and therapeutic medicine

authors： Komohara Y,Kawauchi R,Makiyama E,Mikami K,Horlad H,Fujiwara Y,Kida T,Takeya M,Niidome T

更新日期：2017-08-01 00:00:00

abstract：:MicroRNA (miR) are short non-coding RNA that bind to the 3'-untranslational region of their target genes, inhibiting translation and causing mRNA degradation. miR deregulation has been implicated in human cancer; however, the detailed regulatory mechanism of miR-137 in osteosarcoma (OS) remains largely unknown. In the...

journal_title：Experimental and therapeutic medicine

authors： Feng Q,Wu Q,Liu X,Xiong Y,Li H

更新日期：2017-06-01 00:00:00

abstract：:The aim of this study was to explore the etiology and diagnosis of multiple intracranial hemorrhages (ICHs) following severe burns, with a retrospective review of 16 cases of severe burns further complicated by multiple ICHs. Using cranial CT scans of the brains, we identified that all patients presented with low plat...

journal_title：Experimental and therapeutic medicine

authors： Zhou J,Liu J,Luo C,Hu F,Liu R,Chen Z,Chen Y,Xiong W,Xie J,He Q,Yin C,Wang S,Zhang Y,Zeng S

更新日期：2013-07-01 00:00:00

abstract：:Sodium 4-phenylbutyrate (PBA) exerts therapeutic effects in a wide range of pathologies. A previous study by the present authors revealed that intraperitoneal administration of PBA suppresses the onset of dextran sulfate sodium (DSS)-induced colitis in mice. In the present study, the effects of orally administered PBA...

journal_title：Experimental and therapeutic medicine

authors： Ono K,Nimura S,Hideshima Y,Nabeshima K,Nakashima M

更新日期：2017-12-01 00:00:00

abstract：:Primary congenital glaucoma (PCG) is one of the primary causes of blindness in children and is characterized by congenital trabecular meshwork and anterior chamber angle dysplasia. While being a rare condition, PCG severely impairs the quality of life of affected patients. However, the pathogenesis of PCG remains to b...

journal_title：Experimental and therapeutic medicine

authors： Ling C,Zhang D,Zhang J,Sun H,Du Q,Li X

更新日期：2020-08-01 00:00:00

abstract：:Uterine cervical adenocarcinoma has a poor clinical prognosis when compared with squamous cell carcinoma. Therefore, the development of new treatment strategies for uterine cervical adenocarcinoma is necessary. Src is a proto-oncogene that is important in cancer progression. Dasatinib is a Src inhibitor that has been ...

journal_title：Experimental and therapeutic medicine

authors： Takiguchi E,Nishimura M,Mineda A,Kawakita T,Abe A,Irahara M

更新日期：2017-11-01 00:00:00

abstract：:Ischemic heart diseases are a serious health problem worldwide. The transplantation of mesenchymal stem cells (MSCs) has been investigated in numerous clinical trials on various other diseases due to the self-renewal capacity of these cells and their potential to differentiate into a variety of cell types. The presenc...

journal_title：Experimental and therapeutic medicine

authors： Nimsanor N,Phetfong J,Plabplueng C,Jangpatarapongsa K,Prachayasittikul V,Supokawej A

更新日期：2017-12-01 00:00:00

abstract：:The present study aimed to investigate the association between high mobility group protein B1 (HMGB1), transforming growth factor-β1 (TGF-β1), nuclear factor-κB (NF-κB) and chronic allograft nephropathy (CAN) and to identify the clinical significance of HMGB1, TGF-β1, NF-κB on patients with CAN. Between September 2012...

journal_title：Experimental and therapeutic medicine

authors： Zhao SQ,Xue ZZ,Wang LZ

更新日期：2017-12-01 00:00:00

abstract：:Septic encephalopathy (SE) is a diffuse cerebral dysfunction resulting from a systemic inflammatory response, and is associated with an increased risk of mortality. The pathogenesis of SE is complex and multifactorial, but unregulated immune imbalance may be an important factor. The current retrospective study examine...

journal_title：Experimental and therapeutic medicine

authors： Lu CX,Qiu T,Tong HS,Liu ZF,Su L,Cheng B

更新日期：2016-03-01 00:00:00

abstract：:The aim of the present study was to investigate the changes in mitotic reorientation and relative differential gene expression in rat prostate epithelial cells following long-term exposure to testosterone propionate (TP). Sprague-Dawley rats were randomly divided into two groups as follows: TP group, which received 3....

journal_title：Experimental and therapeutic medicine

authors： Liu X,Cheng YI,Pan QI,Hu W,Xu LI,Meng X,Wu J,Xie C,Yan H,Sun Z

更新日期：2016-04-01 00:00:00

abstract：:Gastrointestinal (GI) mucormycosis is a rare and life-threatening invasive fungal infection. GI mucormycosis occur in all parts of the alimentary tract, with the stomach being the most common site. Diabetes mellitus and other types of conditions associated with immunodeficiency, including hematologic malignancies, sol...

journal_title：Experimental and therapeutic medicine

authors： Lee SH,Son YG,Sohn SS,Ryu SW

更新日期：2014-08-01 00:00:00

abstract：:Herpes Zoster (HZ) is reported as the most prevalent viral infection in patients with systemic lupus erythematosus (SLE). The aim of the present study was to investigate the clinical features, complications, and potential risk factors of HZ in patients with SLE from Southern China. A retrospective study was performed ...

journal_title：Experimental and therapeutic medicine

authors： Chen D,Li H,Xie J,Zhan Z,Liang L,Yang X

更新日期：2017-12-01 00:00:00

abstract：:In patients with chronic kidney disease (CKD), hypertension (HP) is associated with the development of left ventricular (LV) diastolic dysfunction. However, the impact of antihypertensive treatment on LV diastolic function has not been well studied in CKD patients. Recently, two-dimensional speckle-tracking echocardio...

journal_title：Experimental and therapeutic medicine

authors： Li KL,Wang RX,Dai M,Lu J,Xue J,Yang XJ

更新日期：2015-05-01 00:00:00

abstract：:Bacterial infection is a key factor in airway inflammation. The present study describes the time-dependent changes in the leukocyte counts and cytokine levels of the bronchoalveolar lavage fluid (BALF) following subacute airway inflammation induced by lipopolysaccharide (LPS), a major component of the outer membranes ...

journal_title：Experimental and therapeutic medicine

authors： Liu L,Chen L,Wang Y,Yang H,Chen Y,Xu X,Zhou H,Jiang F,Li T,Wang J

更新日期：2012-12-01 00:00:00

abstract：:Fistular onion stalk is used as a traditional herbal medicine, and its extract exhibits certain beneficial effects on cardiovascular disease. In this study, the effects of fistular onion stalk extract on the pathological features, circulating inflammatory cytokines, local renin-angiotensin-aldosterone system (RAAS) an...

journal_title：Experimental and therapeutic medicine

authors： He B,Hao J,Sheng W,Xiang Y,Zhang J,Zhu H,Tian J,Zhu X,Feng Y,Xia H

更新日期：2014-09-01 00:00:00

abstract：:Chemotherapy-induced anorexia (CIA), which may lead to severe nutrition-associated problems, is a common complication associated with anti-cancer therapies. In the present study, the anti-anorexigenic effect of electroacupuncture (EA) was explored through assessing a change in appetite-associated peptides and c-Fos ex...

journal_title：Experimental and therapeutic medicine

authors： Kang KS,Huh W,Bang Y,Choi HJ,Baek JY,Song JH,Kang JW,Kim TH

更新日期：2019-04-01 00:00:00

abstract：:In the present study, the predictive value of glycosylated hemoglobin (HbA1c), microalbuminuria (24 h mAlb) and serum cystatin C (Cys-C) levels on the outcome of pregnancy in patients with gestational diabetes mellitus (GDM) was investigated. Samples of 144 females with GDM and 117 normal pregnant females as controls ...

journal_title：Experimental and therapeutic medicine

authors： Jin H

更新日期：2020-02-01 00:00:00

abstract：:Professor Alan Michael Weindling, Emeritus Professor of Perinatal Medicine at the University of Liverpool in the UK, is one of the pioneers of modern neonatal care worldwide with an enormous contribution to the care of premature babies in the city of Liverpool. During the last 3 decades, his contributions focused on t...

journal_title：Experimental and therapeutic medicine

authors： Mammas IN,Spandidos DA

更新日期：2018-09-01 00:00:00

abstract：:The aim of this study was to evaluate the clinical value of multidetector-row computed tomography (MDCT) and magnetic resonance imaging (MRI) in the diagnosis and treatment of complex fractures of the tibial plateau. A total of 71 patients with complex fractures of the tibial plateau (estimated Schatzker classificatio...

journal_title：Experimental and therapeutic medicine

authors： Xu Y,Li Q,Su P,Shen T,Zhu Y

更新日期：2014-01-01 00:00:00

abstract：:Although studies using animal models have demonstrated that nonhemodynamic factors, including inflammatory cells and cytokines, contribute to left ventricular hypertrophy (LVH), there is little clinical data to confirm this association. Therefore in the present study, levels of circulating specific types of leukocyte ...

journal_title：Experimental and therapeutic medicine

authors： Shi H,Chu H,Lv Z,Qi G,Guo J,Fu W,Wang X,Guo X,Ge J,Yin C

更新日期：2017-04-01 00:00:00

abstract：:Bisphenol A (BPA) is an environmental pollutant that is widely produced throughout the world. It is primarily used in the manufacture of polycarbonate plastics, epoxy resins, paints and dental materials. BPA has been reported to promote hepatotoxicity and cardiotoxicity. The antioxidant activity of sesame lignans is w...

journal_title：Experimental and therapeutic medicine

authors： Eweda SM,Newairy ASA,Abdou HM,Gaber AS

更新日期：2020-01-01 00:00:00