Correlation between serum 25-OH vitamin D expression and non-alcoholic fatty liver disease.

abstract：:Eosinophilia has been implicated in the pathophysiology of acute exacerbation of chronic obstructive pulmonary disease (AECOPD). However, the role of eosinophil activation in the development of AECOPD remains unclear. In the present study, the reliability of plasma levels of eosinophil activation markers, including eo...

journal_title：Experimental and therapeutic medicine

authors： Yang QF,Lu TT,Shu CM,Feng LF,Chang HT,Ji QY

更新日期：2017-10-01 00:00:00

abstract：:The present study reported a case of portopulmonary hypertension (POPH) that was secondary to underlying liver cirrhosis in a 58-year-old woman, who was successfully treated with low-dose tolvaptan. The patient had suffered from refractory peripheral edema and electrolyte abnormalities, including severe hypokalemia, u...

journal_title：Experimental and therapeutic medicine

authors： Ogihara Y,Yamada N,Dohi K,Matsuda A,Ota S,Ishikura K,Nakamura M,Ito M

更新日期：2017-01-01 00:00:00

abstract：:A mutation in the IIb sodium phosphate transporter SLC34A2 gene has recently been described in pulmonary alveolar microlithiasis (PAM) patients. Experiments in this study were aimed at confirming the role of the gene product in PAM by comparing phosphorylated products in extracellular fluid of alveolar epithelial cell...

journal_title：Experimental and therapeutic medicine

authors： Ma T,Qu D,Yan B,Zhang Q,Ren J,Hu Y

更新日期：2018-01-01 00:00:00

abstract：:Cyclooxygenase (COX)-2 inhibitors are widely used for postoperative pain control in clinical practice. However, it is unknown whether spinal sensitization is involved in the analgesic effects of COX-2 inhibitors on surgical pain. Extracellular signal-regulated kinase (ERK) in the spinal cord is implicated in various t...

journal_title：Experimental and therapeutic medicine

authors： Guo YJ,Shi XD,Fu D,Yang Y,Wang YP,Dai RP

更新日期：2013-07-01 00:00:00

abstract：:The epileptic state, or status epilepticus (SE), is the most serious situation manifested by individuals with epilepsy, and SE events can lead to neuronal damage. An understanding of the molecular, biochemical and physiopathological mechanisms involved in this type of neurological disease will enable the identificatio...

journal_title：Experimental and therapeutic medicine

authors： Carmona-Aparicio L,Zavala-Tecuapetla C,González-Trujano ME,Sampieri AI,Montesinos-Correa H,Granados-Rojas L,Floriano-Sánchez E,Coballase-Urrutía E,Cárdenas-Rodríguez N

更新日期：2016-10-01 00:00:00

abstract：:The complex network of etiological factors, signals and tissue responses involved in chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) cannot be successfully targeted by a single therapeutic agent. Multimodal approaches to the therapy of CP/CPPS have been and are currently being tested, as in the frame of com...

journal_title：Experimental and therapeutic medicine

authors： Magri V,Marras E,Restelli A,Wagenlehner FM,Perletti G

更新日期：2015-03-01 00:00:00

abstract：:Rhynchophylline (Rhy) is a major active component of Uncaria rhynchophylla and exhibits the potential to inhibit the proliferation of airway smooth muscle cells (ASMCs). In the current study, it was hypothesized that Rhy serves a key role in the anti-asthma effect of Uncaria rhynchophylla by inhibiting transforming gr...

journal_title：Experimental and therapeutic medicine

authors： Wang M,Li H,Zhao Y,Lv C,Zhou G

更新日期：2019-01-01 00:00:00

abstract：:Choroidal neovascularization secondary to retinitis pigmentosa is rarely observed in clinical practice. The present study describes a case of atypical retinitis pigmentosa, crystalline retinal pigmentary degeneration, complicated by choroidal neovascularization (CNV) in a 26-year-old man presenting with blurred vision...

journal_title：Experimental and therapeutic medicine

authors： Hua R,Chen K,Hu Y,Wang X,Chen L

更新日期：2015-11-01 00:00:00

abstract：:Recurrent patellar dislocations were treated via knee arthroscopy combined with C-arm fluoroscopy, and reconstruction of the medial patellofemoral ligaments. Between October 2013 and March 2017, 52 cases of recurrent patellar dislocation [27 males and 25 females; age, 16-47 years (mean, 21.90 years)] were treated. Art...

journal_title：Experimental and therapeutic medicine

authors： Li L,Wang H,He Y,Si Y,Zhou H,Wang X

更新日期：2018-06-01 00:00:00

abstract：:Vascular smooth muscle cell (VSMC) accumulation and hypertrophy are common in vascular disorders, and inflammation has a crucial role in the development of these diseases. To investigate the effect of inflammation on the neurotransmission of VSMC, bioinformatic analysis was performed, following next generation sequenc...

journal_title：Experimental and therapeutic medicine

authors： Gan S,Qiu S,Feng Y,Zhang Y,Qian Q,Wan Z,Tang J

更新日期：2017-04-01 00:00:00

abstract：:The role of contaminated clothing in the transmission of influenza A virus during an epidemic period was investigated by examining the recovery of infectious influenza virus from experimentally virus-contaminated clothing, which had been subejected to routine wearing and washing for several months or years. The amount...

journal_title：Experimental and therapeutic medicine

authors： Ikeda K,Tsujimoto K,Suzuki Y,Koyama AH

更新日期：2015-04-01 00:00:00

abstract：:Survival periods of patients following surgical therapy of oral squamous cell carcinoma (OSCC) have previously been demonstrated to decrease over recent decades. Epidermal growth factor receptor (EGFR) and Cortactin are molecular markers that are important in tumour progression and development, and interact within the...

journal_title：Experimental and therapeutic medicine

authors： Bissinger O,Kolk A,Drecoll E,Straub M,Lutz C,Wolff KD,Götz C

更新日期：2017-11-01 00:00:00

abstract：:Renal ischemia reperfusion (IR) is a major cause of acute kidney injury with no effective treatment. Chrysin is an anti-inflammatory, anti-oxidant and anti-cancer agent. However, the effect of chrysin on renal IR injury remains unknown. In this study, sham operation, IR and IR+chrysin group mice were treated with or w...

journal_title：Experimental and therapeutic medicine

authors： Xu M,Shi H,Liu D

更新日期：2019-03-01 00:00:00

abstract：:Previous studies have suggested that 2,3,5,4'-tetrahydroxy-stilbene-2-O-β-D-glucoside (TSG) prevents progression of non-alcoholic fatty liver disease (NAFLD) induced by high-fat diet. The present study aimed to evaluate whether TSG could reverse NAFLD induced by a methionine and choline-deficient (MCD) diet and identi...

journal_title：Experimental and therapeutic medicine

authors： Han M,Zhang T,Gu W,Yang X,Zhao R,Yu J

更新日期：2018-08-01 00:00:00

abstract：:The aim of this study was to investigate the anticarcinogenic effects of silymarin in diethylnitrosamine (DEN)-induced hepatocarcinogenic rat models. Severe and mild models of hepatocellular carcinoma (HCC) were generated by the intraperitoneal administration of 40 mg/kg DEN once a week for 18 weeks and 100 mg/kg DEN ...

journal_title：Experimental and therapeutic medicine

authors： Imamoto R,Okano JI,Sawada S,Fujise Y,Abe R,Murawaki Y

更新日期：2014-01-01 00:00:00

abstract：:The objective of the study was to evaluate the effect of abdominal fat proportion on hepatic computed tomography (CT) enhancement. CT data for 87 patients (47 men, mean age 55.09±13.27 years; 40 women, mean age 60.43±11.29 years) were analyzed by linear regression to assess the association of patient age and abdominal...

journal_title：Experimental and therapeutic medicine

authors： Zhang Q,Guo MJ,Wu YF

更新日期：2015-07-01 00:00:00

abstract：:Embelin is a small-molecule inhibitor extracted from plants of the Myrsinaceae family demonstrating specific inhibition of the X-linked inhibitor of apoptosis protein (XIAP) to affect the proliferation and apoptosis of various types of tumor cells. However, the mechanism of action for this effect remains unclear. The ...

journal_title：Experimental and therapeutic medicine

authors： Taghiyev A,Sun D,Gao ZM,Liang R,Wang L

更新日期：2012-10-01 00:00:00

abstract：:MicroRNAs (miRNAs) are small, non-coding RNAs that are key regulators of gene expression by directly binding to the 3'-untranslated region of their target mRNAs, resulting in translational repression or degradation of mRNA. It has been demonstrated that miRNAs have key roles in a variety of human malignancies, includi...

journal_title：Experimental and therapeutic medicine

authors： He Y,Yu B

更新日期：2017-05-01 00:00:00

abstract：:E-cadherin is a key cell adhesion molecule implicated in tumor suppression that is frequently altered in hepatocellular carcinoma (HCC), particularly in hepatitis B virus-related tumors. Here, we report that the epigenetic drugs 5-azacytidine and trichostatin A up-regulated E-cadherin expression in HCC cells. The depl...

journal_title：Experimental and therapeutic medicine

authors： Qiu X,Qiao F,Su X,Zhao Z,Fan H

更新日期：2010-05-01 00:00:00

abstract：:Guillain-Barré syndrome is a type of acute inflammatory neuropathy that causes ataxia and is associated with the IgG anti-GM1 antibody. However, the pathogenic role of the IgG anti-GM1 antibody and calcium channels in neuromuscular junctions (NMJs) remains unclear. Thus, the aim of the present study was to investigate...

journal_title：Experimental and therapeutic medicine

authors： Hotta S,Nakatani Y,Kambe T,Abe K,Masuda Y,Utsumomiya I,Taguchi K

更新日期：2015-08-01 00:00:00

abstract：:While tissue-resident monocytes and macrophages are considered to be vital players in the in vivo interaction between biomaterials and surrounding tissue, their isolation is limited. In order to establish in vitro models elucidating implant and tissue interactions, peripheral blood mononuclear cells (PBMCs) represent ...

journal_title：Experimental and therapeutic medicine

authors： Klinder A,Markhoff J,Jonitz-Heincke A,Sterna P,Salamon A,Bader R

更新日期：2019-03-01 00:00:00

abstract：:Limited data exist concerning the long-term (≥5 year) survival rates of patients with stage IIIB and IV non-small cell lung carcinoma (NSCLC) receiving chemotherapy. We aimed to determine the long-term results of cisplatin plus third-generation (vinorelbine or gemcitabine) cytotoxic chemotherapy in patients with local...

journal_title：Experimental and therapeutic medicine

authors： Ozkaya S,Findik S,Dirican A,Atici AG

更新日期：2012-12-01 00:00:00

abstract：:This study describes the case of a 41-year-old woman admitted for anterograde memory loss, right facial grimacing and right arm posturing that had begun 1 month previously. Cranial magnetic resonance-diffusion weighted imaging and -fluid-attenuated inversion recovery imaging revealed a hyperintense signal in the left ...

journal_title：Experimental and therapeutic medicine

authors： Liu J,Li M,Li G,Zhou C,Zhang R

更新日期：2016-01-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a chronic disease of connective tissue caused by intolerance to self-antigens. Regulatory T cells (Tregs) are key players in maintaining autotolerance through a variety of suppressor mechanisms. RA is generally believed to develop due to disorders in Tregs; however, there is no consensus o...

journal_title：Experimental and therapeutic medicine

authors： Shevyrev D,Tereshchenko V,Kozlov V,Sizikov A,Chumasova O,Koksharova V

更新日期：2021-03-01 00:00:00

abstract：:Evaluation of multi-slice CT angiography (MSCTA) and digital subtraction angiography (DSA) was made through the comparison of the two methods in detecting the blood supply of meningiomas, providing further clues for the improved application of MSCTA and DSA in the blood supply of meningiomas. In this study, 20 patient...

journal_title：Experimental and therapeutic medicine

authors： Han X,Zhan Y,Chen J

更新日期：2012-01-01 00:00:00

abstract：:Relative changes in B-type natriuretic peptide (BNP) and amino terminal pro-BNP (NT-proBNP) levels may help to assess the risk of congestive heart failure (CHF). However, whether these levels at the time of admission enable the prediction of outcomes with acute exacerbation remains unknown. The current study determine...

journal_title：Experimental and therapeutic medicine

authors： Dai Y,Yang J,Takagi A,Konishi H,Miyazaki T,Masuda H,Shimada K,Miyauchi K,Daida H

更新日期：2017-08-01 00:00:00

abstract：:Peptide P7 specifically binds with basic fibroblast growth factor (bFGF) to inhibit the proliferation and invasion of numerous types of cancer cell. However, this effect has remained to be demonstrated in ovarian cancer-derived cell lines. In the present study, the protein P7 was used treat bFGF-stimulated SKOV3 epith...

journal_title：Experimental and therapeutic medicine

authors： Chen Q,Yang Z,Chen X,Shu L,Qu W

更新日期：2019-04-01 00:00:00

abstract：:The diagnostic value of detection of serum β-human chorionic gonadotropin (β-HCG) and Chlamydia trachomatis immunoglobulin G (CT-IgG) combined with transvaginal ultrasonography in early tubal pregnancy was investigated. A total of 55 patients with early tubal pregnancy were selected as the tubal pregnancy group, while...

journal_title：Experimental and therapeutic medicine

authors： Xin H,Liu W,Li P

更新日期：2018-07-01 00:00:00

abstract：:Doxorubicin (DOX), a potent and widely used anticancer agent, can give rise to severe cardiotoxicity that limits its clinical use by inducing oxidative stress. Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is the central regulator of cellular responses to electrophilic/oxidative stress, which serves a critical ro...

journal_title：Experimental and therapeutic medicine

authors： Guo Z,Yan M,Chen L,Fang P,Li Z,Wan Z,Cao S,Hou Z,Wei S,Li W,Zhang B

更新日期：2018-10-01 00:00:00

abstract：:Carotid artery stenosis is a notable cause of ocular ischemic disease. To analyze the ocular ischemic diseases caused by carotid artery stenosis and to seek effective treatment, a retrospective review of 182 patients with carotid artery stenosis was performed. These patients were administered medical treatment, caroti...

journal_title：Experimental and therapeutic medicine

authors： Yan Y,Zhang X,Yang Y,Han L,Wang H,Hu J

更新日期：2013-05-01 00:00:00