Relapse of choroidal neovascularization in Bietti's crystalline retinopathy following anti-vascular endothelial growth factor therapy: A case report.

abstract：:Glucagon-like peptide-1 (GLP-1) has been demonstrated to affect the oxidative stress status in several in vitro, in vivo and clinical studies. The aim of the present study was to evaluate the effect of a GLP-1 analogue, exenatide, on oxidative stress parameters and apoptotic markers in testicular cells in an iron over...

journal_title：Experimental and therapeutic medicine

authors： Yesil S,Sungu N,Kilicarslan A,Kuskonmaz SM,Kara H,Kucuk A,Polat F,Kavutcu M,Arslan M

更新日期：2018-12-01 00:00:00

abstract：:The effects of recombinant human growth hormone (rhGH) in the treatment of dwarfism and the relationship between insulin-like growth factor (IGF)-1, IGF-binding protein (IGFBP)-3 and thyroid hormone were examined in the present study. For this purpose, 66 patients diagnosed with dwarfism were selected retrospectively,...

journal_title：Experimental and therapeutic medicine

authors： Ren S,Nie Y,Wang A

更新日期：2016-12-01 00:00:00

abstract：:Certain microRNAs (miRs) regulate the progression and metastasis of various cancer types. In the present study, the role of miR-370 in the progression and proliferation of human astrocytoma and glioblastoma cells was assessed and the underlying molecular mechanism was investigated. miR-370 levels in clinical specimens...

journal_title：Experimental and therapeutic medicine

authors： Lu M,Wang Y,Zhou S,Xu J,Li J,Tao R,Zhu Y

更新日期：2018-01-01 00:00:00

abstract：:Malignant hyperthermia (MH) is a rare life threatening inherited disorder that is triggered by drugs used for general anesthesia in susceptible persons. The symptoms include rapid increase of body temperature and severe muscle contractions. The present study includes 3 cases of MH and highlights the timely identificat...

journal_title：Experimental and therapeutic medicine

authors： Pan T,Ji W,Nie M,Li Y

更新日期：2016-11-01 00:00:00

abstract：:Enamel matrix derivative (EMD) is a commercially available protein extract, mainly comprising amelogenins. A number of other polypeptides have been identified in EMD, mostly growth factors, which promote cementogenesis and osteogenesis during the regeneration processes through the regulation of cell proliferation, dif...

journal_title：Experimental and therapeutic medicine

authors： Wyganowska-Świątkowska M,Urbaniak P,Nohawica MM,Kotwicka M,Jankun J

更新日期：2015-06-01 00:00:00

abstract：:Paraneoplastic autoimmune multiorgan syndrome (PAMS), also known as paraneoplasic pemphigus, involves the skin, internal organs and mucosa. PAMS-associated mortality may occur as a result of autoantibody formation against internal tumors and their infiltration into organs other than the skin lesions that characterize ...

journal_title：Experimental and therapeutic medicine

authors： Lee SY,Kim JH,Cho DH

更新日期：2016-09-01 00:00:00

abstract：:Postmenopausal osteoporosis is a degenerative disease caused by lack of estrogen whereby bone degeneration exceeds bone formation, resulting in loss of bone mass. Various drugs have been utilized in an attempt to ameliorate bone strength in such patients. The aim of the present study was to compare the effects of vita...

journal_title：Experimental and therapeutic medicine

authors： Huang Y

更新日期：2018-01-01 00:00:00

abstract：:Atherosclerosis is caused by various factors, and Glabridin may have protective effects on the cardiovascular system. The purpose of the present study was to evaluate the effects of Glabridin on atherosclerosis and evaluate whether Glabridin attenuates arteriosclerosis and endothelial permeability by suppressing the m...

journal_title：Experimental and therapeutic medicine

authors： Wang G,Sun G,Wang Y,Yu P,Wang X,Zhou B,Zhu H

更新日期：2019-01-01 00:00:00

abstract：:The present study evaluated the effects of calcitonin gene-related peptide (CGRP) on bone marrow mesenchymal stem cells (BMMSCs) in vitro and in a rat model of mandibular distraction osteogenesis (MDO). Rat BMMSCs were isolated then treated with CGRP or CGRP antagonist (CGRP8-37). The proliferation and migration abili...

journal_title：Experimental and therapeutic medicine

authors： Jia S,Zhang SJ,Wang XD,Yang ZH,Sun YN,Gupta A,Hou R,Lei DL,Hu KJ,Ye WM,Wang L

更新日期：2019-08-01 00:00:00

abstract：:The present study aims to investigate the effects and underlying mechanisms of miRNA-145 (miR-145) in rat models of chronic constriction injury (CCI). Rats were randomly divided into control, sham, CCI, agomiRNA (agomiR)-normal control (NC) and agomiR-145 groups (n=25 in each group); in addition, 30 rats with CCI were...

journal_title：Experimental and therapeutic medicine

authors： Pang X,Tang Y,Zhang D

更新日期：2016-12-01 00:00:00

abstract：:This study aims to investigate the function and related mechanism of P27 gene in intervertebral disc (IVD) degeneration of mice. X-ray, immunohistochemical staining, and alkaline phosphatase (ALP) histochemical staining were used to analyze the phenotypic difference of the intervertebral discs of 4-week-old mice with ...

journal_title：Experimental and therapeutic medicine

authors： Liu X,Wang D,Zhang Z,Zhu F,Yao A,Tian J,Miao D

更新日期：2017-08-01 00:00:00

abstract：:The application value of conventional ultrasound and ultrasonic elastography (UE) in preoperative diagnosis and combined diagnosis of malignant anus neoplasms was investigated. One hundred and twenty patients, whose mass was detected by digital rectal examination, were examined using UE and conventional ultrasound bef...

journal_title：Experimental and therapeutic medicine

authors： Zhu Y,Deng S,Zhang Y,Jiang Q

更新日期：2018-03-01 00:00:00

abstract：:The aim of the present study was to examine whether the expression of focal adhesion kinase (FAK) is altered in the eutopic endometrium of female patients with adenomyosis, as compared with that of females without adenomyosis. The expression of FAK was assessed by immunohistochemical, western blot and reverse transcri...

journal_title：Experimental and therapeutic medicine

authors： Mu L,Chen W,Ma Y,Zheng W

更新日期：2015-11-01 00:00:00

abstract：:The oxidation of tyrosine to 3-nitrotyrosine is irreversible, and due to this characteristic, 3-nitrotyrosine is used as a marker for oxidative stress in a range of diverse chronic and degenerative diseases. It has been established that the yeast Debaryomyces hansenii (D. hansenii) can assimilate free 3-nitrotyrosine ...

journal_title：Experimental and therapeutic medicine

authors： Calderón-Torres CM,Sarabia-Curz L,Ledesma-Soto Y,Murguía-Romero M,Terrazas LI

更新日期：2019-05-01 00:00:00

abstract：:Cardiovascular disease is the main cause of morbidity and mortality in end-stage renal disease (ESRD) patients. Recent population based epidemiological studies demonstrated a correlation between reduced renal function and risk for all causes and cardiovascular mortality, 50% of patients dying before the commencement o...

journal_title：Experimental and therapeutic medicine

authors： Timofte D,Dragoș D,Balcangiu-Stroescu AE,Tănăsescu MD,Gabriela Bălan D,Răducu L,Tulin A,Stiru O,Ionescu D

更新日期：2020-07-01 00:00:00

abstract：:Previous studies have indicated pro-tumor functions of macrophages in tumor progression in different types of malignant tumors. The detailed mechanisms of cell-cell interaction between macrophages and tumor cells have been investigated by means of in vitro co-culture experiments. The present study developed magnetite ...

journal_title：Experimental and therapeutic medicine

authors： Komohara Y,Kawauchi R,Makiyama E,Mikami K,Horlad H,Fujiwara Y,Kida T,Takeya M,Niidome T

更新日期：2017-08-01 00:00:00

abstract：:Lung cancer is an aggressive type of cancer that is associated with a high mortality rate. Lung cancer-initiating cells are populations of self-renewing cancer cells with pluripotent differentiation ability. Cancers typically originate from multiple phenotypically distinct cancer-initiating cells. CD133 and CD44 are s...

journal_title：Experimental and therapeutic medicine

authors： Huang X,Wan J,Leng D,Zhang Y,Yang S

更新日期：2020-01-01 00:00:00

abstract：:The aim of this study was to explore the clinical characteristics of and treatment strategies for interstitial pneumonia induced by gefitinib in patients with advanced non-small cell lung cancer (NSCLC). The detailed clinical data of one patient with NSCLC and gefitinib-induced interstitial pneumonia were compiled and...

journal_title：Experimental and therapeutic medicine

authors： Luo C,Lv M,Li Y,Liu P,Yang J

更新日期：2014-04-01 00:00:00

abstract：:It has been widely reported that the serum anion gap is significantly associated with mortality in intensive care unit (ICU); however, it remains unknown whether the association is present in aortic aneurysm (AA) patients. The present study aimed to investigate the association between the admission serum anion gap and...

journal_title：Experimental and therapeutic medicine

authors： Chen Q,Chen Q,Li L,Lin X,Chang SI,Li Y,Tian Z,Liu W,Huang K

更新日期：2018-09-01 00:00:00

abstract：:We investigated the clinical value of fractional flow reserve (FFR) for the prognostic evaluation of patients with percutaneous coronary intervention. We enrolled 120 patients who were admitted to the hospital to undergo percutaneous coronary intervention for acute coronary syndromes between May 2014 and June 2015. Th...

journal_title：Experimental and therapeutic medicine

authors： Zhao Q,Ji Z,Li X,Di Y,An H,Wei B,Yang L,Chen W

更新日期：2018-01-01 00:00:00

abstract：:Jiawei Shenqi-wan (JSQW), which comprises Shenqi-wan and two additional medicinal herbs, has been widely used for the treatment of various growth impairments, including cerebral palsy. In the present study, JSQW was administered to hypoxic-ischemic Sprague-Dawley rats that underwent treadmill training from 4-7 weeks o...

journal_title：Experimental and therapeutic medicine

authors： Kim HN,Pak ME,Shin MJ,Kim SY,Shin YB,Yun YJ,Shin HK,Choi BT

更新日期：2017-05-01 00:00:00

abstract：:Chitosan, a naturally derived polymer, has been shown to possess antimicrobial and anti-inflammatory properties; however, little is known about the effect of chitosan on the immune responses and glutamic oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT) and lactate dehydrogenase (LDH) activities in n...

journal_title：Experimental and therapeutic medicine

authors： Yeh MY,Shih YL,Chung HY,Chou J,Lu HF,Liu CH,Liu JY,Huang WW,Peng SF,Wu LY,Chung JG

更新日期：2016-04-01 00:00:00

abstract：:The present study aimed to investigate the effects of levodopa (LEV) on cellular apoptosis in a rabbit model of steroid-associated necrosis of the femoral head (SANFH). A total of 44 healthy adult Chinese rabbits were randomly divided into three groups: Group A (n=15), administered a combination of lipopolysaccharide ...

journal_title：Experimental and therapeutic medicine

authors： Xi H,Tao W,Jian Z,Sun X,Gong X,Huang L,Dong T

更新日期：2017-01-01 00:00:00

abstract：:The aim of this meta-analysis was to investigate the accuracy of subtraction computed tomography angiography (CTA) for diagnosing intracranial aneurysms. A systematic literature search up to January 1, 2013 was performed in PubMed. Two independent reviewers selected 8 studies that compared subtraction CTA with digital...

journal_title：Experimental and therapeutic medicine

authors： Feng TY,Han XF,Lang R,Wang F,Wu Q

更新日期：2016-05-01 00:00:00

abstract：:The present study aimed to determine the expression of microRNA (miRNA or miR)-145 in hypertrophic scars at the tissue and cellular levels, and to investigate its biological functions and mechanism of action. A total of 36 patients who were diagnosed with hypertrophic scar were included in the present study. Reverse t...

journal_title：Experimental and therapeutic medicine

authors： Wang S,Li C,Yu Y,Qiao J

更新日期：2019-11-01 00:00:00

abstract：:MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate the expression of targeted genes in a post-transcriptional manner. Increasing evidence indicates that miRNAs play important roles in cancer pathogenesis, including apoptosis, proliferation and differentiation, as oncogenes or tumor suppressors. Previo...

journal_title：Experimental and therapeutic medicine

authors： Shen ZY,Zhang ZZ,Liu H,Zhao EH,Cao H

更新日期：2014-06-01 00:00:00

abstract：:Previously, we performed a molecular pharmacological study that applied a combination of DNA microarray-based gene expression profiling and drug sensitivity tests in vitro with a view to designing an improved chemotherapeutic strategy for advanced lung cancer. Utilizing recent key technological advances in proteomics,...

journal_title：Experimental and therapeutic medicine

authors： Hino M,Matsuda K,Miyanaga A,Kuribayasi H,Mizutani H,Noro R,Minegishi Y,Okano T,Seike M,Kawakami A,Yoshimura A,Ogawa N,Uesaka H,Kudoh S,Gemma A

更新日期：2010-01-01 00:00:00

abstract：:Aortic valve (AoV) stenosis is the third most common cardiovascular disease. The pathogenesis of AoV stenosis is associated with an inflammatory process where MMPs serve important roles. The aim of the present study was to determine the association between matrix metalloproteinases (MMPs), tissue inhibitors of metallo...

journal_title：Experimental and therapeutic medicine

authors： Lurins J,Lurina D,Svirskis S,Nora-Krukle Z,Tretjakovs P,Mackevics V,Lejnieks A,Rapisarda V,Baylon V

更新日期：2019-04-01 00:00:00

abstract：:Toxoplasmosis is a zoonotic infection caused by the obligate intracellular apicomplexan parasite Toxoplasma gondii (T. gondii). T. gondii infection is a cause of congenital infection worldwide. Primary infection or the reactivation of latent infection during pregnancy may lead to fetal infection and to congenital toxo...

journal_title：Experimental and therapeutic medicine

authors： Motoi S,Navolan DB,Malita D,Ciohat I,Nemescu D,Manciuc C,Gorun F,Vilibic-Cavlek T,Boda D,Craina M,Dobrescu A

更新日期：2020-10-01 00:00:00

abstract：:The aim of the present study was to investigate the effects of decorin (DCN) on the proliferation of human hepatoma HepG2 cells and the involvement of transforming growth factor-β (TGF-β) signaling pathway. A vector containing DCN was transfected into HepG2 cells with the use of Lipofectamine 2000. Cell proliferation ...

journal_title：Experimental and therapeutic medicine

authors： Liu Y,Wang X,Wang Z,Ju W,Wang D

更新日期：2016-10-01 00:00:00