Abstract:
:Cardiovascular disease is the main cause of morbidity and mortality in end-stage renal disease (ESRD) patients. Recent population based epidemiological studies demonstrated a correlation between reduced renal function and risk for all causes and cardiovascular mortality, 50% of patients dying before the commencement of renal replacement therapy. Vascular calcifications (VC) and arterial stiffness are major contributors to cardiovascular disease and are independent predictors of cardiovascular mortality in ESRD patients. Scarce information is available on the risk factors and prognosis of predialysis patients with VC. The aim of this study was to evaluate the contribution of traditional and uremia related risk factors to abdominal aortic calcification in predialysis patients. A single center, retrospective study was performed on 305 adult patients monitored at the Bucharest University Emergency Hospital for at least 6 months. Our study reports an increased incidence of VC in predialysis chronic kidney disease (CKD) patients, higher in those with advanced age, history of cardiovascular disease, osteoporosis, and declining renal function.
journal_name
Exp Ther Medjournal_title
Experimental and therapeutic medicineauthors
Timofte D,Dragoș D,Balcangiu-Stroescu AE,Tănăsescu MD,Gabriela Bălan D,Răducu L,Tulin A,Stiru O,Ionescu Ddoi
10.3892/etm.2020.8607subject
Has Abstractpub_date
2020-07-01 00:00:00pages
97-102issue
1eissn
1792-0981issn
1792-1015pii
ETM-0-0-8607journal_volume
20pub_type
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