Reduced expression of TRF1 is associated with tumor progression and poor prognosis in oral squamous cell carcinoma.

abstract：:The aim of the present study was to screen for biomarkers of Parkinson's disease (PD) using proteomics and bioinformatics approaches. PD patients were divided into three groups: Those without surgery (PD1 group); those who had undergone deep brain stimulation (DBS) surgery without electrode stimulation (PD2 group); an...

journal_title：Experimental and therapeutic medicine

authors： Dong W,Qiu C,Gong D,Jiang X,Liu W,Liu W,Zhang L,Zhang W

更新日期：2019-10-01 00:00:00

abstract：:This study aims to investigate the function and related mechanism of P27 gene in intervertebral disc (IVD) degeneration of mice. X-ray, immunohistochemical staining, and alkaline phosphatase (ALP) histochemical staining were used to analyze the phenotypic difference of the intervertebral discs of 4-week-old mice with ...

journal_title：Experimental and therapeutic medicine

authors： Liu X,Wang D,Zhang Z,Zhu F,Yao A,Tian J,Miao D

更新日期：2017-08-01 00:00:00

abstract：:Achondroplasia (ACH) is a hereditary dwarfism caused by the disturbed proliferation and differentiation of growth plate chondrocytes, followed by impaired endochondral bone growth. ACH is caused by mutations in the gene encoding the transmembrane receptor, fibroblast growth factor receptor 3 (FGFR3). In total, >90% of...

journal_title：Experimental and therapeutic medicine

authors： Liu J,Tang X,Cheng J,Wang L,Yang X,Wang Y

更新日期：2015-05-01 00:00:00

abstract：:Sepsis is a complication of infection caused by disease or trauma. Increasing evidence have shown that long noncoding RNAs (lncRNAs) are involved in the regulation of sepsis. However, the mechanism of lncRNA nuclear enriched abundant transcript 1 (NEAT1) in the regulation of sepsis progression remains to be elucidated...

journal_title：Experimental and therapeutic medicine

authors： Liu L,Liu F,Sun Z,Peng Z,You T,Yu Z

更新日期：2020-10-01 00:00:00

abstract：:The present study aimed to investigate the role and mechanism of microRNA-539 (miR-539) in rheumatoid arthritis (RA). A total of 68 RA patients and 46 osteoarthritis patients were enrolled into the current study. Peripheral blood and joint fluid were collected prior to treatment. Reverse transcription-quantitative pol...

journal_title：Experimental and therapeutic medicine

authors： Liu Y,Qian K,Li C,Ma Y,Chen X

更新日期：2018-03-01 00:00:00

abstract：:Spinal cord injury (SCI) may lead to a devastating and permanent loss of neurological function, which may place a great economic burden on the family of the patient and society. Methods for reducing the death of neuronal cells, inhibiting immune and inflammatory reactions, and promoting the growth of axons in order to...

journal_title：Experimental and therapeutic medicine

authors： Ji W,Hu S,Zhou J,Wang G,Wang K,Zhang Y

更新日期：2014-03-01 00:00:00

abstract：:This study investigated the expression of C-C chemokine receptor type 3 (CCR3), transcription factor SOX5 (SOX5) and microtubule-associated protein 1 light chain 3 (LC3) in patients with elderly onset rheumatoid arthritis (EORA) and the clinical significance. Ninety patients with elderly onset rheumatoid arthritis wer...

journal_title：Experimental and therapeutic medicine

authors： Wang J,Zhao Q

更新日期：2017-10-01 00:00:00

abstract：:The global incidence of melanoma is increasing. Mortality from melanoma is influenced primarily by metastasis in advanced stages of the disease. Current treatments are largely ineffective; thus, novel gene delivery approaches that target tumor-specific markers may be useful for the treatment of melanoma. Systemic admi...

journal_title：Experimental and therapeutic medicine

authors： Saavedra-Alonso S,Zapata-Benavides P,Chavez-Escamilla AK,Manilla-Muñoz E,Zamora-Avila DE,Franco-Molina MA,Rodriguez-Padilla C

更新日期：2016-12-01 00:00:00

abstract：:The aim of this study was to evaluate the clincal value of multi-slice spiral computed tomography (MSCT) in the diagnosis of double aortic arch (DAA) and analyze the associated angiography and 3D reconstruction imaging to increase the accuracy of DAA diagnosis. Clinical and imaging data from 15 patients diagnosed with...

journal_title：Experimental and therapeutic medicine

authors： Chen X,Qu Y,Peng ZY,Lu J,Ma X,Hu W

更新日期：2014-08-01 00:00:00

abstract：:The aim of the present study was to summarize the clinical characteristics of nocardiosis caused by Nocardia otitidiscaviarum in order to improve the knowledge of nocardiosis. A case of dissemination nocardiosis caused by N. otitidiscaviarum in an immunocompetent host is reported and the associated literature reviewed...

journal_title：Experimental and therapeutic medicine

authors： Jiang Y,Huang A,Fang Q

更新日期：2016-11-01 00:00:00

abstract：:The aim of the present study was to evaluate the diagnostic value of interferon-γ release assays for the detection of active tuberculosis (ATB) in patients previously vaccinated with Bacillus Calmette-Guérin (BCG). In total, 540 patients underwent the T-SPOT.TB test, including 295 patients with active pulmonary TB (PT...

journal_title：Experimental and therapeutic medicine

authors： Yan L,Xiao H,Han M,Zhang Q

更新日期：2015-07-01 00:00:00

abstract：:Chemotherapy-induced anorexia (CIA), which may lead to severe nutrition-associated problems, is a common complication associated with anti-cancer therapies. In the present study, the anti-anorexigenic effect of electroacupuncture (EA) was explored through assessing a change in appetite-associated peptides and c-Fos ex...

journal_title：Experimental and therapeutic medicine

authors： Kang KS,Huh W,Bang Y,Choi HJ,Baek JY,Song JH,Kang JW,Kim TH

更新日期：2019-04-01 00:00:00

abstract：:The presence of an occluded culprit artery or collaterals in non-ST-segment elevation myocardial infarction (NSTEMI) is relatively common; however, limited data are available regarding their clinical significance. The aim of the current study was to determine the clinical characteristics of occluded culprit arteries a...

journal_title：Experimental and therapeutic medicine

authors： Hwang HJ,Park CB,Cho JM,Jin ES,Sohn IS,Kim DH,Kim CJ

更新日期：2018-10-01 00:00:00

abstract：:The present study aimed to analyze the expression and effects of NUAK2 in gastric cancer and adjacent normal gastric tissues. The protein expression levels of NUAK2 were detected by western blot analysis. The effects of NUAK2 expression on the proliferation of gastric cancer cells was detected using an MTT and BrdU in...

journal_title：Experimental and therapeutic medicine

authors： Tang L,Tong SJ,Zhan Z,Wang Q,Tian Y,Chen F

更新日期：2017-02-01 00:00:00

abstract：:Expression and characteristics of matrix metalloproteinase-9 (MMP-9) and TIMP metallopeptidase inhibitor-1 (TIMP-1) in the placenta of pregnancy induced hypertension (PIH) were detected in Uygur to analyze its correlation with PIH, and to provide a theoretical basis for clinical work. Ninety cases of placental tissue ...

journal_title：Experimental and therapeutic medicine

authors： Zhang Y,Li P,Guo Y,Liu X,Zhang Y

更新日期：2019-07-01 00:00:00

abstract：:Gilbert syndrome (GS) is a hereditary unconjugated hyperbilirubinemia that results from mutations in the bilirubin uridine diphosphate-glucuronosyltransferase (UGT1A1) gene. To the best of our knowledge, there are currently no reports that focus on patients with systemic lupus erythematosus (SLE) coexisting with GS. T...

journal_title：Experimental and therapeutic medicine

authors： Ye N,Zhou Z,Gong H,Teng J,Han Y,Yang C,Ye J

更新日期：2020-11-01 00:00:00

abstract：:We previously reported on single-incision laparoscopic surgery applied to laparoscopically assisted vaginal hysterectomy (LAVH) cases. We accumulated single-incision LAVH cases to evaluate this operation, including its learning curve. Since July 2009, we planned to perform single-incision LAVH in 50 cases. Operative t...

journal_title：Experimental and therapeutic medicine

authors： Koyanagi T,Motomura S

更新日期：2011-09-01 00:00:00

abstract：:It is hypothesized that there may be common characteristics between the genetic regulatory networks of different diseases. To identify these potential similarities, analysis of overlapping differentially expressed genes (DEGs) in several diseases, which are believed to be associated in traditional Chinese medicine (TC...

journal_title：Experimental and therapeutic medicine

authors： Tang H,Zhang Y

更新日期：2018-06-01 00:00:00

abstract：:The aim of this study was to investigate the effect of montelukast on the expression of CD4+CD25+ regulatory T cells in children with acute bronchial asthma. Fifty-six child patients with acute bronchial asthma treated in the Department of Pneumology at the Shangluo Central Hospital were selected and randomly divided ...

journal_title：Experimental and therapeutic medicine

authors： Qu X,Chen Y,Yin C

更新日期：2018-09-01 00:00:00

abstract：:An increasing number of studies have shown that the hsa-miR-196a2 rs11614913 polymorphism occurs in different types of cancer, but the results are generally controversial and inadequate, mainly due to limited statistical power. To resolve this issue, the present meta-analysis was carried out. Databases, including PubM...

journal_title：Experimental and therapeutic medicine

authors： Wang P,Xie S,Cui A,Zhang Y,Jiang B

更新日期：2012-02-01 00:00:00

abstract：:Activation of telomerase is involved in carcinogenesis in most types of cancers. However, the prognostic value of telomerase activity (TA) in patients with gastric carcinoma (GC) remains controversial. We conducted a meta-analysis to assess the relationship between TA and the clinical outcome of GC. A meta-analysis of...

journal_title：Experimental and therapeutic medicine

authors： Lü MH,Deng JQ,Cao YL,Fang DC,Zhang Y,Yang SM

更新日期：2012-04-01 00:00:00

abstract：:The aim of the present study was to evaluate the protective effects and safety aspects of recombinant human brain natriuretic peptide (rhBNP) on cardiac functions of patients undergoing open-heart surgery during perioperative period. In total, 150 patients undergoing open heart surgery in the Second Hospital of Shando...

journal_title：Experimental and therapeutic medicine

authors： Xu Y,Li Y,Bao W,Qiu S

更新日期：2018-03-01 00:00:00

abstract：:Preeclampsia is a major cause of maternal and perinatal mortality and morbidity, characterized by gestational hypertension, proteinuria, systemic endothelial cell activation and an exaggerated inflammatory response. The precise cause of preeclampsia is not currently known; however, it is widely accepted that the patho...

journal_title：Experimental and therapeutic medicine

authors： Liu X,Dai LI,Zhou R

更新日期：2015-05-01 00:00:00

abstract：:The aim of the present study was to evaluate the concentrations of fetuin-A, osteoprotegerin (OPG) and α-Klotho protein in patients with alcoholic cirrhosis at different stages of the disease, and to demonstrate that fetuin-A, osteoprotegin and α-Klotho may be used as markers of the severity of cirrhosis. A total of 5...

journal_title：Experimental and therapeutic medicine

authors： Prystupa A,Dąbrowska A,Sak JJ,Tarach J,Toruń-Jurkowska A,Lachowska-Kotowska P,Dzida G

更新日期：2016-11-01 00:00:00

abstract：:We report a case of a 10-year-old female patient who survived ring-sling complex without surgery. The patient had congenital wheezing from the neonatal period and was treated after a tentative diagnosis of infantile asthma. The patient suffered from allergy and was hospitalized several times due to severe wheezing, an...

journal_title：Experimental and therapeutic medicine

authors： Fukuda H,Imataka G,Drago F,Maeda K,Yoshihara S

更新日期：2017-09-01 00:00:00

abstract：:The value of Sonoclot detection technology to guide the clinical medication of the perioperative anticoagulation and antiplatelet therapy in patients with acute myocardial infarction (AMI) undergoing emergent percutaneous coronary intervention (PCI) was estimated. One hundred and twenty-eight patients were randomly di...

journal_title：Experimental and therapeutic medicine

authors： Yang WX,Lai CL,Chen FH,Wang JR,Ji YR,Wang DX

更新日期：2017-06-01 00:00:00

abstract：:The aim of the present study was to examine the clinical value of continuously monitoring serum CC16 levels in diagnosing pulmonary contusion, estimating its severity degree and predicting disease progression. Thirty-one acute trauma patients with lung contusion diagnosed by chest computed tomography (CT) were include...

journal_title：Experimental and therapeutic medicine

authors： Wen MN,Zhao G,Zhang JY,Zhao YH

更新日期：2017-09-01 00:00:00

abstract：:Therapy using acellular spinal cord (ASC) scaffolds seeded with bone marrow stromal cells (BMSCs) has previously been shown to restore function of the damaged spinal cord and improve functional recovery in a rat model of acute hemisected spinal cord injury (SCI). The aim of the present study was to determine whether B...

journal_title：Experimental and therapeutic medicine

authors： Wang YH,Chen J,Zhou J,Nong F,Lv JH,Liu J

更新日期：2017-01-01 00:00:00

abstract：:Hericium erinaceus (HEP) is a notable medicinal fungus grown in China and other oriental countries. Polysaccharides from HEP have recently attracted considerable attention due to their numerous physiological activities. The objective of this study was to evaluate the anti-fatigue activity of HEP in a mouse model. Afte...

journal_title：Experimental and therapeutic medicine

authors： Liu J,DU C,Wang Y,Yu Z

更新日期：2015-02-01 00:00:00

abstract：:The aim of the present study was to investigate the effects of urantide on the expression status of C-reactive protein (CRP) and the inflammatory cytokines monocyte chemotactic protein (MCP)-1 and transforming growth factor (TGF)-β in the aortas of rats with atherosclerosis (AS), and to identify its underlying mechani...

journal_title：Experimental and therapeutic medicine

authors： Zhao J,Xie LD,Song CJ,Mao XX,Yu HR,Yu QX,Ren LQ,Shi Y,Xie YQ,Li Y,Liu SS,Yang XH

更新日期：2014-06-01 00:00:00